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4-Bromo-2-(Chloromethyl)-1-Methoxybenzene
Linshang Chemical
|
HS Code |
492980 |
| Name | 4-Bromo-2-(Chloromethyl)-1-Methoxybenzene |
| Molecular Formula | C8H8BrClO |
| Molecular Weight | 235.505 g/mol |
| Appearance | Typically a colorless to light - yellow liquid or solid (depending on temperature) |
| Boiling Point | Approximately 240 - 250 °C (estimated, can vary based on purity and pressure) |
| Density | Estimated around 1.5 - 1.7 g/cm³ (density of similar aromatic halides) |
| Solubility | Soluble in organic solvents like dichloromethane, chloroform, ethyl acetate; insoluble in water |
| Flash Point | Caution, likely flammable, flash point estimated around 100 - 120 °C (approximate, for similar compounds) |
| Purity | Can be available in different purity levels, commonly 95%+ in commercial products |
As an accredited 4-Bromo-2-(Chloromethyl)-1-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - bromo - 2 - (chloromethyl)-1 - methoxybenzene in sealed, labeled container. |
| Storage | 4 - bromo - 2 - (chloromethyl)-1 - methoxybenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container to prevent vapor leakage. Given its potential toxicity and reactivity, it should be separated from incompatible substances, and stored in accordance with local safety regulations. |
| Shipping | 4 - bromo - 2 - (chloromethyl)-1 - methoxybenzene is shipped in sealed, corrosion - resistant containers. Strict adherence to chemical transportation regulations ensures safe transit, avoiding exposure to heat, moisture, and incompatible substances. |
Competitive 4-Bromo-2-(Chloromethyl)-1-Methoxybenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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As a leading 4-Bromo-2-(Chloromethyl)-1-Methoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 4-bromo-2- (chloromethyl) -1-methoxybenzene?
4-Bromo-2- (chloromethyl) -1-methoxybenzene is also an organic compound. Its molecular structure contains bromine atoms, chloromethyl groups and methoxy groups, and the interaction of these groups endows it with unique chemical properties.
In terms of reactivity, bromine atoms are substituents on aromatic rings. Due to the electronegativity of bromine, the electron cloud density of the benzene ring is reduced, and the electrophilic substitution reaction is more difficult than that of benzene. However, the electron cloud density of the adjacent and para-site of bromine is relatively high, and the electrophilic reagents still tend to attack these two positions. For example, when reacting with nucleophiles, bromine can be replaced by nucleophilic groups to form new derivatives. In chloromethyl chloride, the chlorine atom has strong electronegativity, causing the α-carbon to have a partial positive charge, making chloromethyl chloride an active group and prone to nucleophilic substitution. If it reacts with nucleophilic reagents such as alcohols and amines, it can form compounds such as ethers and amines. And because of its activity, under certain conditions, it can initiate free radical reactions and participate in complex organic synthesis.
Methoxy group is the power supply radical, which can increase the electron cloud density of the benzene ring, making the benzene ring more prone to electrophilic substitution reactions, and the localization effect makes the reaction mainly occur in the adjacent and para-position of the methoxy group. This interacts with the localization effect of bromine, which affects the regioselectivity of the product in the multi-step reaction.
In addition, 4-bromo-2- (chloromethyl) -1-methoxybenzene can participate in many organic reactions under suitable solvents and catalysts, such as the Foucault reaction, to construct more complex organic molecular structures. Its chemical properties are complex and variable, and it is an important intermediate in the field of organic synthesis. By regulating its reaction conditions, a variety of organic compounds can be prepared.
In terms of reactivity, bromine atoms are substituents on aromatic rings. Due to the electronegativity of bromine, the electron cloud density of the benzene ring is reduced, and the electrophilic substitution reaction is more difficult than that of benzene. However, the electron cloud density of the adjacent and para-site of bromine is relatively high, and the electrophilic reagents still tend to attack these two positions. For example, when reacting with nucleophiles, bromine can be replaced by nucleophilic groups to form new derivatives. In chloromethyl chloride, the chlorine atom has strong electronegativity, causing the α-carbon to have a partial positive charge, making chloromethyl chloride an active group and prone to nucleophilic substitution. If it reacts with nucleophilic reagents such as alcohols and amines, it can form compounds such as ethers and amines. And because of its activity, under certain conditions, it can initiate free radical reactions and participate in complex organic synthesis.
Methoxy group is the power supply radical, which can increase the electron cloud density of the benzene ring, making the benzene ring more prone to electrophilic substitution reactions, and the localization effect makes the reaction mainly occur in the adjacent and para-position of the methoxy group. This interacts with the localization effect of bromine, which affects the regioselectivity of the product in the multi-step reaction.
In addition, 4-bromo-2- (chloromethyl) -1-methoxybenzene can participate in many organic reactions under suitable solvents and catalysts, such as the Foucault reaction, to construct more complex organic molecular structures. Its chemical properties are complex and variable, and it is an important intermediate in the field of organic synthesis. By regulating its reaction conditions, a variety of organic compounds can be prepared.
What are the common synthesis methods of 4-bromo-2- (chloromethyl) -1-methoxybenzene?
4-Bromo-2- (chloromethyl) -1-methoxybenzene is also an organic compound. Its common synthesis method depends on the technique of organic synthesis.
First, it can be started by benzene derivatives containing methoxy groups. Before introducing bromine atoms at specific positions in the benzene ring, brominating reagents, such as bromine and suitable catalysts, can be used to replace the hydrogen of the benzene ring at a suitable temperature and reaction environment to obtain bromine-containing methoxybenzene.
Next, to introduce chloromethyl, chloromethyl reagents, such as chloromethyl ether, are often used in synergy with catalysts such as anhydrous zinc chloride. This process requires attention to the control of reaction conditions, such as temperature, proportion of reactants, etc., due to different reaction conditions, or the product is impure, or the yield is affected.
There are also those who use other benzene-based compounds as starting materials and obtain them through multi-step reactions. Methoxy groups are first introduced through substitution reactions, and then bromine atoms and chloromethyl groups are introduced in an orderly manner. Each step of the reaction requires fine operation and close monitoring of the reaction process, such as the use of chromatography and other analytical methods to determine the purity and composition of the product.
When synthesizing, the choice of solvent is also key. Different solvents have an impact on the reaction rate and selectivity. Commonly selected organic solvents, such as dichloromethane and toluene, have good solubility to the reactants and are relatively stable under reaction conditions.
In addition, the design of the reaction device and the post-reaction processing steps, such as the separation and purification of the product, are all related to the quality of the final product. Separation is often carried out by distillation, extraction, column chromatography, etc. to remove impurities to obtain pure 4-bromo-2 - (chloromethyl) -1-methoxybenzene.
First, it can be started by benzene derivatives containing methoxy groups. Before introducing bromine atoms at specific positions in the benzene ring, brominating reagents, such as bromine and suitable catalysts, can be used to replace the hydrogen of the benzene ring at a suitable temperature and reaction environment to obtain bromine-containing methoxybenzene.
Next, to introduce chloromethyl, chloromethyl reagents, such as chloromethyl ether, are often used in synergy with catalysts such as anhydrous zinc chloride. This process requires attention to the control of reaction conditions, such as temperature, proportion of reactants, etc., due to different reaction conditions, or the product is impure, or the yield is affected.
There are also those who use other benzene-based compounds as starting materials and obtain them through multi-step reactions. Methoxy groups are first introduced through substitution reactions, and then bromine atoms and chloromethyl groups are introduced in an orderly manner. Each step of the reaction requires fine operation and close monitoring of the reaction process, such as the use of chromatography and other analytical methods to determine the purity and composition of the product.
When synthesizing, the choice of solvent is also key. Different solvents have an impact on the reaction rate and selectivity. Commonly selected organic solvents, such as dichloromethane and toluene, have good solubility to the reactants and are relatively stable under reaction conditions.
In addition, the design of the reaction device and the post-reaction processing steps, such as the separation and purification of the product, are all related to the quality of the final product. Separation is often carried out by distillation, extraction, column chromatography, etc. to remove impurities to obtain pure 4-bromo-2 - (chloromethyl) -1-methoxybenzene.
Where is 4-bromo-2- (chloromethyl) -1-methoxybenzene used?
4-Bromo-2- (chloromethyl) -1-methoxybenzene, an organic compound, is useful in many fields.
In the field of organic synthesis, it has a wide range of uses. Because its structure contains bromine atoms, chloromethyl groups and methoxy groups, these functional groups give it unique reactivity. Bromine atoms can participate in nucleophilic substitution reactions, such as reactions with nucleophiles such as nitrogen and oxygen, thereby introducing a variety of functional groups to lay the foundation for the construction of complex organic molecules. Chloromethyl groups are also highly active and can undergo reactions such as substitution and condensation, which contribute to the formation of carbon-carbon bonds or carbon-heteroatomic bonds. Methoxy groups can affect the electron cloud density of the benzene ring, which in turn affects the regioselectivity of the reaction. By cleverly exploiting the characteristics of these functional groups, chemists can use this to synthesize many organic compounds with specific structures and functions, such as pharmaceutical intermediates, natural product analogs, etc.
In the field of materials science, it also shows certain value. After appropriate chemical modification and polymerization, it can be introduced into the structure of polymer materials. The presence of bromine and chloromethyl may enhance the flame retardancy of materials, because during combustion, halogen atoms can capture free radicals and inhibit the progress of combustion reactions. At the same time, the presence of methoxy groups may improve the solubility, processing properties, and compatibility of materials with other materials, resulting in the preparation of polymer materials with better properties, which can be used in coatings, plastics, fibers, and many other aspects.
In the field of pharmaceutical chemistry, such compounds also have potential applications. Their structures can be modified to meet the needs of specific biological targets. For example, by changing the type, location and quantity of substituents on the benzene ring, adjusting the physical and chemical properties and biological activities of the molecule, and then screening lead compounds with pharmacological activity. After further structural optimization and activity studies, it is expected to develop new drugs for the treatment of various diseases.
In summary, 4-bromo-2- (chloromethyl) -1-methoxybenzene plays an important role in the fields of organic synthesis, materials science and medicinal chemistry, and has broad application prospects.
In the field of organic synthesis, it has a wide range of uses. Because its structure contains bromine atoms, chloromethyl groups and methoxy groups, these functional groups give it unique reactivity. Bromine atoms can participate in nucleophilic substitution reactions, such as reactions with nucleophiles such as nitrogen and oxygen, thereby introducing a variety of functional groups to lay the foundation for the construction of complex organic molecules. Chloromethyl groups are also highly active and can undergo reactions such as substitution and condensation, which contribute to the formation of carbon-carbon bonds or carbon-heteroatomic bonds. Methoxy groups can affect the electron cloud density of the benzene ring, which in turn affects the regioselectivity of the reaction. By cleverly exploiting the characteristics of these functional groups, chemists can use this to synthesize many organic compounds with specific structures and functions, such as pharmaceutical intermediates, natural product analogs, etc.
In the field of materials science, it also shows certain value. After appropriate chemical modification and polymerization, it can be introduced into the structure of polymer materials. The presence of bromine and chloromethyl may enhance the flame retardancy of materials, because during combustion, halogen atoms can capture free radicals and inhibit the progress of combustion reactions. At the same time, the presence of methoxy groups may improve the solubility, processing properties, and compatibility of materials with other materials, resulting in the preparation of polymer materials with better properties, which can be used in coatings, plastics, fibers, and many other aspects.
In the field of pharmaceutical chemistry, such compounds also have potential applications. Their structures can be modified to meet the needs of specific biological targets. For example, by changing the type, location and quantity of substituents on the benzene ring, adjusting the physical and chemical properties and biological activities of the molecule, and then screening lead compounds with pharmacological activity. After further structural optimization and activity studies, it is expected to develop new drugs for the treatment of various diseases.
In summary, 4-bromo-2- (chloromethyl) -1-methoxybenzene plays an important role in the fields of organic synthesis, materials science and medicinal chemistry, and has broad application prospects.
What are the physical properties of 4-bromo-2- (chloromethyl) -1-methoxybenzene
4-Bromo-2- (chloromethyl) -1-methoxybenzene is also an organic compound. Its physical properties are quite important and are related to many chemical and industrial uses.
In terms of its properties, it is mostly a colorless to light yellow liquid under normal conditions. The view is clear and there is no special color. Smell it, it has a special aromatic smell, although it is not pungent and intolerable, it is also a significant sign of it.
As for the melting point and boiling point, these two are the keys to characterize the physical properties of the substance. Its melting point is about [X] ° C. When the temperature drops to this value, the substance gradually solidifies from the liquid state, the morphology changes, and the molecular arrangement changes from disorder to order. The boiling point is about [X] ° C, the temperature rises to the value of Si, the liquid boils, and the molecules are able to break free from the liquid phase and escape into a gaseous state.
In terms of solubility, 4-bromo-2- (chloromethyl) -1-methoxybenzene is quite soluble in organic solvents such as ethanol, ether, dichloromethane, etc. This is because the intermolecular forces between organic substances are similar, and they are "similarly soluble". However, in water, its solubility is very small. Water is a solvent with strong polarity, and the polar compound is weak. The intermolecular forces between the two are quite different, so it is difficult to dissolve.
Density is also one of its important physical properties. Its density is about [X] g/cm ³, which is heavier than water. Therefore, if mixed with water, it will sink to the bottom.
In addition, 4-bromo-2- (chloromethyl) -1-methoxybenzene is moderately volatile. Although it is not as volatile as light alkanes, it is not completely stable and difficult to escape. In an open environment, it will also evaporate over time. This volatility needs to be carefully considered during storage and use to prevent material loss and safety risks.
All kinds of physical properties are important guidelines in the fields of organic synthesis, chemical production, etc. Practitioners must know in detail in order to make good use of this material.
In terms of its properties, it is mostly a colorless to light yellow liquid under normal conditions. The view is clear and there is no special color. Smell it, it has a special aromatic smell, although it is not pungent and intolerable, it is also a significant sign of it.
As for the melting point and boiling point, these two are the keys to characterize the physical properties of the substance. Its melting point is about [X] ° C. When the temperature drops to this value, the substance gradually solidifies from the liquid state, the morphology changes, and the molecular arrangement changes from disorder to order. The boiling point is about [X] ° C, the temperature rises to the value of Si, the liquid boils, and the molecules are able to break free from the liquid phase and escape into a gaseous state.
In terms of solubility, 4-bromo-2- (chloromethyl) -1-methoxybenzene is quite soluble in organic solvents such as ethanol, ether, dichloromethane, etc. This is because the intermolecular forces between organic substances are similar, and they are "similarly soluble". However, in water, its solubility is very small. Water is a solvent with strong polarity, and the polar compound is weak. The intermolecular forces between the two are quite different, so it is difficult to dissolve.
Density is also one of its important physical properties. Its density is about [X] g/cm ³, which is heavier than water. Therefore, if mixed with water, it will sink to the bottom.
In addition, 4-bromo-2- (chloromethyl) -1-methoxybenzene is moderately volatile. Although it is not as volatile as light alkanes, it is not completely stable and difficult to escape. In an open environment, it will also evaporate over time. This volatility needs to be carefully considered during storage and use to prevent material loss and safety risks.
All kinds of physical properties are important guidelines in the fields of organic synthesis, chemical production, etc. Practitioners must know in detail in order to make good use of this material.
What is the market price of 4-bromo-2- (chloromethyl) -1-methoxybenzene?
4-Bromo-2- (chloromethyl) -1-methoxybenzene, an organic compound, is widely used in chemical, pharmaceutical and other fields. However, its market price is difficult to determine abruptly, because it is affected by many factors.
The first to bear the brunt is the cost of raw materials. The price fluctuations of bromide, chloride and methoxylation reagents required to prepare this compound have a huge impact on product costs. If the supply of raw materials is tight, or the price rises due to market supply and demand, the climate of the place of origin, geopolitics, etc., the cost of 4-bromo-2- (chloromethyl) -1-methoxybenzene will also rise, and the price will also rise.
Furthermore, the difficulty of the production process is closely related to the cost. If the production process requires high temperature, high pressure, special catalysts or complex separation and purification steps, it will greatly increase energy consumption, equipment input and labor costs. For example, some high-precision synthesis processes have strict control over the reaction conditions, and a slight difference will affect the purity and yield of the product. These processes are expensive and the product price will not be low.
The relationship between supply and demand in the market is also a key factor in determining the price. If the market demand for 4-bromo-2- (chloromethyl) -1-methoxybenzene is strong, such as the development of new drugs in the pharmaceutical industry, the demand for it will increase greatly, and the supply is relatively insufficient, and the price will rise; conversely, if the market demand is weak, the manufacturer may lower the price to promote sales in order to sell.
In addition, the purity and quality grade of the product have a significant impact on the price. High-purity products are mostly used in fields with extremely high quality requirements such as medicine and electronics, and their production is difficult, and the price is much higher than that of ordinary industrial-grade products. For products used in pharmaceutical intermediates, the impurity content needs to be strictly controlled, the production process is more refined, and the price is much higher than that of general chemical raw material products.
Regional factors should not be underestimated. Production costs, transportation costs, and tax policies vary in different regions, resulting in differences in product prices. In economically developed regions, labor costs and land costs are higher, and product prices may be relatively high; while in some chemical industry clusters, due to the improvement of industrial support, raw material procurement and transportation costs are lower, and product prices may be more competitive.
In summary, the market price of 4-bromo-2- (chloromethyl) -1-methoxybenzene ranges from tens of yuan per kilogram to thousands of yuan per kilogram, depending on the above factors.
The first to bear the brunt is the cost of raw materials. The price fluctuations of bromide, chloride and methoxylation reagents required to prepare this compound have a huge impact on product costs. If the supply of raw materials is tight, or the price rises due to market supply and demand, the climate of the place of origin, geopolitics, etc., the cost of 4-bromo-2- (chloromethyl) -1-methoxybenzene will also rise, and the price will also rise.
Furthermore, the difficulty of the production process is closely related to the cost. If the production process requires high temperature, high pressure, special catalysts or complex separation and purification steps, it will greatly increase energy consumption, equipment input and labor costs. For example, some high-precision synthesis processes have strict control over the reaction conditions, and a slight difference will affect the purity and yield of the product. These processes are expensive and the product price will not be low.
The relationship between supply and demand in the market is also a key factor in determining the price. If the market demand for 4-bromo-2- (chloromethyl) -1-methoxybenzene is strong, such as the development of new drugs in the pharmaceutical industry, the demand for it will increase greatly, and the supply is relatively insufficient, and the price will rise; conversely, if the market demand is weak, the manufacturer may lower the price to promote sales in order to sell.
In addition, the purity and quality grade of the product have a significant impact on the price. High-purity products are mostly used in fields with extremely high quality requirements such as medicine and electronics, and their production is difficult, and the price is much higher than that of ordinary industrial-grade products. For products used in pharmaceutical intermediates, the impurity content needs to be strictly controlled, the production process is more refined, and the price is much higher than that of general chemical raw material products.
Regional factors should not be underestimated. Production costs, transportation costs, and tax policies vary in different regions, resulting in differences in product prices. In economically developed regions, labor costs and land costs are higher, and product prices may be relatively high; while in some chemical industry clusters, due to the improvement of industrial support, raw material procurement and transportation costs are lower, and product prices may be more competitive.
In summary, the market price of 4-bromo-2- (chloromethyl) -1-methoxybenzene ranges from tens of yuan per kilogram to thousands of yuan per kilogram, depending on the above factors.
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