4-Bromo-2-Chloronitrobenzene

Linshang Chemical

Specifications

HS Code

178530

Chemical Formula C6H3BrClNO2
Molar Mass 240.45 g/mol
Appearance Yellow to light brown solid
Boiling Point Approximately 280 - 282 °C
Melting Point 63 - 67 °C
Density 1.87 g/cm³ (estimated)
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, acetone
Flash Point 122.5 °C
Odor Pungent

As an accredited 4-Bromo-2-Chloronitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 4 - bromo - 2 - chloronitrobenzene packaged in a sealed, chemical - resistant bottle.
Storage 4 - bromo - 2 - chloronitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. Keep it in a tightly closed container to prevent leakage. Since it is a potentially hazardous chemical, store it separately from oxidizing agents, reducing agents, and other incompatible substances to avoid dangerous reactions.
Shipping 4 - bromo - 2 - chloronitrobenzene is shipped in well - sealed containers, often within a climate - controlled environment. It adheres to strict chemical shipping regulations to prevent spills and ensure safe transportation due to its potentially hazardous nature.
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4-Bromo-2-Chloronitrobenzene 4-Bromo-2-Chloronitrobenzene
General Information
Where to Buy 4-Bromo-2-Chloronitrobenzene in China?
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Frequently Asked Questions

As a leading 4-Bromo-2-Chloronitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the chemical properties of 4-bromo-2-chloronitrobenzene?
4-Bromo-2-chloronitrobenzene is one of the organic compounds. Its chemical properties are interesting and have unique reactivity.
Looking at its structure, the nitro group, bromine atom and chlorine atom are all connected to the benzene ring. The nitro group is a strong electron-absorbing group, which reduces the electron cloud density of the benzene ring and greatly reduces the electrophilic substitution activity of the benzene ring. And the presence of the nitro group decreases the electron cloud density of the adjacent and para-potential of the benzene ring even more, so the electrophilic reagents often attack the intermediate position.
Although the bromine atom and the chlorine atom are also electron-absorbing groups, their conjugation effect makes the adjacent and para-potential electron cloud density relatively high. Therefore, under specific reaction conditions, there will also be ortho and para-substitution products.
4-Bromo-2-chloronitrobenzene can participate in a variety of reactions. In the nucleophilic substitution reaction, bromine atoms or chlorine atoms can be replaced by nucleophilic reagents. Because the carbon atoms connected to the halogen atoms are affected by the benzene ring and the nitro group, they have a certain degree of positive electricity and are easily attacked by nucleophilic reagents. If the nucleophilic reagents such as alkoxides and amines interact with them, the halogen atoms can be replaced by the corresponding groups, thereby forming new carbon-heteroatomic bonds.
can also undergo a reduction reaction, and the nitro group can be reduced to an amino group. Commonly used reducing agents include iron and hydrochloric acid, tin and hydrochloric acid. After this reduction, compounds containing amino groups can be obtained, which are important intermediates for the synthesis of many drugs, dyes, etc.
In addition, in organic synthesis, by selecting suitable reaction conditions and reagents, functional group transformation and modification can be carried out to achieve the synthesis of required complex organic compounds, which has important application value in the field of organic chemistry.
What are the physical properties of 4-bromo-2-chloronitrobenzene?
4-Bromo-2-chloronitrobenzene is one of the organic compounds. Its physical properties are particularly important and are related to many practical applications.
First of all, under room temperature, 4-bromo-2-chloronitrobenzene is mostly solid, dense and solid. Looking at its color, it is usually light yellow to light brown. The difference in this color can help to identify.
times and melting point, about 60-64 ℃. When the temperature gradually rises, this material gradually melts from a solid state to a liquid state. This melting point characteristic is quite valuable in the process of separation and purification.
Furthermore, the boiling point is about 286-288 ° C. At this high temperature, 4-bromo-2-chloronitrobenzene will be liquefied into a gaseous state. This boiling point is indispensable for operations such as distillation.
Solubility is also an important physical property. It is extremely difficult to dissolve in water, due to the polarity of water molecules and the molecular structure of 4-bromo-2-chloronitrobenzene. However, in organic solvents such as ethanol, ether, and dichloromethane, it has good solubility. This difference in solubility can be used as a basis for solvent selection in organic synthesis.
In terms of density, it is about 1.8 g/cm ³, which is heavier than water. When liquid-liquid separation, this characteristic can be used as a basis for judgment.
In addition, the vapor pressure of 4-bromo-2-chloronitrobenzene is very low, and the volatilization rate is slow at room temperature and pressure. This characteristic is related to its stability and safety during storage and use.
In summary, the physical properties of 4-bromo-2-chloronitrobenzene, such as melting point, boiling point, solubility, density, and vapor pressure, are of great significance in the fields of chemical production and organic synthesis, and are the basis for related operations and research.
What are the common synthetic methods of 4-bromo-2-chloronitrobenzene?
The common synthesis methods of 4-bromo-2-chloronitrobenzene are generally as follows.
One is halogenated nitration. First, benzene is taken as the starting material, and brominating agents, such as liquid bromine and iron powder, are used as catalysts. Bromobenzene is then reacted with chlorinated reagents, such as chlorine gas, under specific conditions to introduce chlorine atoms to generate corresponding halogenated benzene. After nitration, a mixed acid (a mixture of concentrated sulfuric acid and concentrated nitric acid) is used as the nitrifying reagent. At an appropriate temperature, nitro groups are introduced into the benzene ring to obtain 4-bromo-2-chloronitrobenzene. In this process, it is necessary to pay attention to the precise control of the reaction conditions, such as temperature, the proportion of reactants, etc., because different conditions will significantly affect the selectivity and yield of the product.
The second is the nitrohalogenation method. First, benzene is used as a raw material, and through nitration reaction, nitro is introduced into the benzene ring to make nitrobenzene. Nitrobenzene is then reacted with brominating agents and chlorine reagents in turn, and bromine atoms and chlorine atoms are introduced successively, and finally 4-bromo-2-chloronitrobenzene are obtained. This path also needs to pay attention to the regulation of the reaction conditions at each step, and because nitro groups are meta-localization groups, the selectivity of substitution positions needs to be paid attention to during halogenation reactions.
There are other synthesis methods using If a suitable halogenated aromatic hydrocarbon is selected, through a series of functional group transformation, nitro groups are first introduced, and then the position and type of halogen atoms are adjusted to achieve the purpose of synthesizing 4-bromo-2-chloronitrobenzene. This approach requires careful design of the reaction route according to the characteristics of the selected starting material, and comprehensive consideration of the feasibility and efficiency of each step of the reaction.
There are various methods for synthesizing 4-bromo-2-chloronitrobenzene. In practical application, the appropriate synthesis path needs to be carefully selected according to many factors such as specific needs, raw material availability and cost.
In what areas is 4-bromo-2-chloronitrobenzene applied?
4-Bromo-2-chloronitrobenzene is useful in the fields of chemical synthesis, pharmaceutical creation, and material research and development.
In the field of chemical synthesis, it is often a key intermediate in organic synthesis. It can introduce other functional groups through many chemical reactions, such as nucleophilic substitution reactions, to build complex organic compounds. With its bromine, chlorine, and nitro properties, the reaction can be advanced in a specific direction, and many organic molecules with special structures and properties can be prepared, paving the way for the synthesis of fine chemical products.
In the process of pharmaceutical creation, its importance should not be underestimated. Because the design of drug molecules often depends on the combination of specific structures and functional groups. The functional group of 4-bromo-2-chloronitrobenzene can be chemically modified and transformed to meet the needs of drug-target interaction. Or it can be used to synthesize drug intermediates with biological activities such as antibacterial and anti-inflammatory, and then provide the cornerstone for the development of new drugs.
In the field of material research and development, this compound can also play a role. In the preparation of functional materials, it can participate in reactions and endow materials with special electrical, optical or mechanical properties. For example, in the synthesis of organic photovoltaic materials, by introducing 4-bromo-2-chloronitrobenzene structural units, or by adjusting the electron transport and optical absorption characteristics of the materials, excellent photovoltaic materials can be prepared, which can be used in Light Emitting Diodes, solar cells and other devices.
What are 4-bromo-2-chloronitrobenzene storage conditions?
4-Bromo-2-chloronitrobenzene is also an organic compound. Its storage conditions are crucial to its nature and safety.
This compound has certain toxicity and chemical activity, so the storage place should be cool and dry. Cover because it is in a hot and humid environment, or cause chemical changes, damage its quality, or even cause danger. Keep away from fire and heat sources to prevent fire and explosion.
Furthermore, it should be stored in isolation from oxidants, alkalis, etc. It is dangerous when it encounters with oxidants or reacts violently. Coexistence with alkalis may also trigger chemical reactions and cause compound deterioration. Storage containers must be well sealed to prevent leakage. If it leaks outside, it not only pollutes the environment, but also is harmful to the human body.
Storage sites should be equipped with suitable materials to contain leaks. Once a leak occurs, it can be treated in time to reduce its harm. At the same time, the site should be well ventilated to avoid the accumulation of volatile gas and reduce the risk of poisoning and explosion.
Storage of this compound requires strict adherence to the above conditions to ensure its quality and safety and prevent problems before they occur.