Linshang Chemical
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4-Bromo-2-Fluorochlorobenzene
Linshang Chemical
|
HS Code |
429995 |
| Chemical Formula | C6H3BrClF |
| Molar Mass | 225.44 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 193 - 195 °C |
| Melting Point | N/A |
| Density | 1.75 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | 75 °C |
| Pungency | May have a pungent odor |
| Stability | Stable under normal conditions, but may react with strong oxidizing agents |
As an accredited 4-Bromo-2-Fluorochlorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - bromo - 2 - fluorochlorobenzene packaged in a sealed glass bottle. |
| Storage | Store 4 - bromo - 2 - fluorochlorobenzene in a cool, dry, well - ventilated area away from heat sources and ignition sources. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Separate it from oxidizing agents, acids, and bases to prevent chemical reactions. Ensure proper labeling for easy identification and safety. |
| Shipping | 4 - bromo - 2 - fluorochlorobenzene is a chemical. Ship it in well - sealed, corrosion - resistant containers. Follow all relevant hazardous material shipping regulations to ensure safe transportation. |
Competitive 4-Bromo-2-Fluorochlorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-Bromo-2-Fluorochlorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of 4-bromo-2-fluorochlorobenzene?
4-Bromo-2-fluorochlorobenzene is also an organic compound. In its molecular structure, the benzene ring is a group, and there are three substituents on it. One is a bromine atom, which is in the fourth position of the benzene ring; the other is a fluorine atom, which is in the second position of the benzene ring; the third is a chlorine atom.
Looking at the naming of this compound, according to the naming rules of organic chemistry, benzene is used as the parent body, and bromine, fluorine, and chlorine are regarded as substituents. The position is marked first, and the number represents the position of the carbon atom of the "Bromine", "fluorine" and "chlorine" are named according to their element names, and in alphabetical order, bromo (bromo) is first, fluoro (fluoro) is second, chloro (chloro) is connected by a hyphen, placed before the name of benzene, and then becomes the name "4 - bromo - 2 - fluorochlorobenzene".
The structure of this compound, the benzene ring has six carbon atoms, forming a plane hexagonal shape, and the carbon-carbon bond is between the single bond and the double bond, which has the characteristics of a conjugated system. The radius of the bromine atom is large, and the electronegativity also has its value, which affects the distribution of electron clouds in the molecule; the fluorine atom is extremely electronegative and has a strong electron-absorbing effect; the chlorine atom is also These three substitutions in different positions of the benzene ring have an effect on the physical and chemical properties of the molecule due to their respective electronic effects and spatial effects. For example, it affects the polarity, boiling point, and solubility of the compound, and in the chemical reaction, the change of the electron cloud density of the benzene ring makes the reaction activity of different positions of the benzene ring different. In the reaction of electrophilic substitution, it presents a unique reaction law.
Looking at the naming of this compound, according to the naming rules of organic chemistry, benzene is used as the parent body, and bromine, fluorine, and chlorine are regarded as substituents. The position is marked first, and the number represents the position of the carbon atom of the "Bromine", "fluorine" and "chlorine" are named according to their element names, and in alphabetical order, bromo (bromo) is first, fluoro (fluoro) is second, chloro (chloro) is connected by a hyphen, placed before the name of benzene, and then becomes the name "4 - bromo - 2 - fluorochlorobenzene".
The structure of this compound, the benzene ring has six carbon atoms, forming a plane hexagonal shape, and the carbon-carbon bond is between the single bond and the double bond, which has the characteristics of a conjugated system. The radius of the bromine atom is large, and the electronegativity also has its value, which affects the distribution of electron clouds in the molecule; the fluorine atom is extremely electronegative and has a strong electron-absorbing effect; the chlorine atom is also These three substitutions in different positions of the benzene ring have an effect on the physical and chemical properties of the molecule due to their respective electronic effects and spatial effects. For example, it affects the polarity, boiling point, and solubility of the compound, and in the chemical reaction, the change of the electron cloud density of the benzene ring makes the reaction activity of different positions of the benzene ring different. In the reaction of electrophilic substitution, it presents a unique reaction law.
What are the main uses of 4-bromo-2-fluorochlorobenzene?
4-Bromo-2-fluorochlorobenzene is one of the organic compounds. It has a wide range of uses and is involved in various fields.
First and foremost in the field of medicinal chemistry. In this field, it is often used as a key intermediate to help synthesize a variety of specific drugs. Due to its special molecular structure, it can be derived from substances with specific pharmacological activities after ingenious chemical modification, such as antibacterial and antiviral drugs. By precisely controlling its structure, the drugs can be made with high selectivity and affinity for pathogens, thereby improving the efficacy and reducing side effects.
Furthermore, in the field of materials science, 4-bromo-2-fluorochlorobenzene also has wonderful uses. It can be used as a raw material for the preparation of functional materials with excellent performance. For example, the synthesis of polymer materials with unique optical and electrical properties. After a specific polymerization reaction, its structure is integrated into the polymer skeleton, giving the material special photoluminescence, electrical conductivity and other characteristics, which are very useful in photoelectric display, semiconductor devices and so on.
In pesticide chemistry, this compound is also indispensable. It is often an important starting material for the synthesis of high-efficiency and low-toxicity pesticides. Through chemical transformation, pesticide products with high-efficiency killing effect on pests and less harm to the environment and non-target organisms can be created. Using its structural characteristics, targets for specific pest physiological mechanisms can be designed to enhance pesticide targeting and durability.
In addition, in the study of organic synthesis chemistry, 4-bromo-2-fluorochlorobenzene is a commonly used reagent. Because it contains bromine, fluorine, chlorine and other halogen atoms, it can participate in many classical organic reactions, such as nucleophilic substitution, coupling reactions, etc. This provides an effective way to construct complex organic molecular structures, helps organic chemists explore new compound synthesis methods and routes, and promotes the continuous development and progress of organic synthesis chemistry.
First and foremost in the field of medicinal chemistry. In this field, it is often used as a key intermediate to help synthesize a variety of specific drugs. Due to its special molecular structure, it can be derived from substances with specific pharmacological activities after ingenious chemical modification, such as antibacterial and antiviral drugs. By precisely controlling its structure, the drugs can be made with high selectivity and affinity for pathogens, thereby improving the efficacy and reducing side effects.
Furthermore, in the field of materials science, 4-bromo-2-fluorochlorobenzene also has wonderful uses. It can be used as a raw material for the preparation of functional materials with excellent performance. For example, the synthesis of polymer materials with unique optical and electrical properties. After a specific polymerization reaction, its structure is integrated into the polymer skeleton, giving the material special photoluminescence, electrical conductivity and other characteristics, which are very useful in photoelectric display, semiconductor devices and so on.
In pesticide chemistry, this compound is also indispensable. It is often an important starting material for the synthesis of high-efficiency and low-toxicity pesticides. Through chemical transformation, pesticide products with high-efficiency killing effect on pests and less harm to the environment and non-target organisms can be created. Using its structural characteristics, targets for specific pest physiological mechanisms can be designed to enhance pesticide targeting and durability.
In addition, in the study of organic synthesis chemistry, 4-bromo-2-fluorochlorobenzene is a commonly used reagent. Because it contains bromine, fluorine, chlorine and other halogen atoms, it can participate in many classical organic reactions, such as nucleophilic substitution, coupling reactions, etc. This provides an effective way to construct complex organic molecular structures, helps organic chemists explore new compound synthesis methods and routes, and promotes the continuous development and progress of organic synthesis chemistry.
What are the physical properties of 4-bromo-2-fluorochlorobenzene?
4-Bromo-2-fluorochlorobenzene is one of the organic compounds. Its physical properties are crucial and related to many practical applications.
First of all, its appearance, at room temperature, is mostly colorless to light yellow liquid, clear and transparent in appearance, with moderate luster. This appearance characteristic is very important for the identification and preliminary cognition of this substance.
Times and boiling points are about a certain range. The specific value is about [X] ° C due to different or slightly different measurement conditions. The characteristics of boiling point play a decisive role in the process of separating and purifying this compound. It can be effectively separated from the mixture by distillation according to the difference in boiling point.
In addition, the melting point is also a specific value, which is about [X] ° C. The data of the melting point is not only helpful to identify the purity of this compound, but also of great significance in the study of its phase changes.
Its density also has a specific value, which is about [X] g/cm ³. This density characteristic provides an important basis for material measurement and mixing ratio in chemical production and laboratory operations.
In terms of solubility, 4-bromo-2-fluorochlorobenzene exhibits good solubility in organic solvents such as ethanol and ether, and can be miscible with these organic solvents in a certain proportion; in water, it has poor solubility and is almost insoluble. This difference in solubility provides a theoretical basis for selecting suitable solvents in extraction, separation and other operation steps.
In addition, 4-bromo-2-fluorochlorobenzene has a certain volatility and will evaporate slowly in the air. This characteristic needs to be paid attention to during storage and use. Proper sealing measures must be taken to prevent its volatilization and escape, which will affect its quality and use effect.
In summary, the physical properties of 4-bromo-2-fluorochlorobenzene, from appearance, melting point, density to solubility and volatility, have a profound impact on its application in chemical industry, scientific research and many other fields. It is necessary to have a deep understanding and accurate grasp of it.
First of all, its appearance, at room temperature, is mostly colorless to light yellow liquid, clear and transparent in appearance, with moderate luster. This appearance characteristic is very important for the identification and preliminary cognition of this substance.
Times and boiling points are about a certain range. The specific value is about [X] ° C due to different or slightly different measurement conditions. The characteristics of boiling point play a decisive role in the process of separating and purifying this compound. It can be effectively separated from the mixture by distillation according to the difference in boiling point.
In addition, the melting point is also a specific value, which is about [X] ° C. The data of the melting point is not only helpful to identify the purity of this compound, but also of great significance in the study of its phase changes.
Its density also has a specific value, which is about [X] g/cm ³. This density characteristic provides an important basis for material measurement and mixing ratio in chemical production and laboratory operations.
In terms of solubility, 4-bromo-2-fluorochlorobenzene exhibits good solubility in organic solvents such as ethanol and ether, and can be miscible with these organic solvents in a certain proportion; in water, it has poor solubility and is almost insoluble. This difference in solubility provides a theoretical basis for selecting suitable solvents in extraction, separation and other operation steps.
In addition, 4-bromo-2-fluorochlorobenzene has a certain volatility and will evaporate slowly in the air. This characteristic needs to be paid attention to during storage and use. Proper sealing measures must be taken to prevent its volatilization and escape, which will affect its quality and use effect.
In summary, the physical properties of 4-bromo-2-fluorochlorobenzene, from appearance, melting point, density to solubility and volatility, have a profound impact on its application in chemical industry, scientific research and many other fields. It is necessary to have a deep understanding and accurate grasp of it.
What are 4-bromo-2-fluorochlorobenzene synthesis methods?
The synthesis method of 4-bromo-2-fluorochlorobenzene is a subject of great concern in organic synthetic chemistry. There are several common synthesis paths.
One of them can be started from benzene. First, chlorination is used to make benzene and chlorine under the action of an appropriate catalyst, such as ferric trichloride, to form chlorobenzene. This reaction condition needs to be properly controlled at temperature, usually under heating conditions, so that the reactants can be fully contacted to make the reaction proceed smoothly. Then, the p-chlorobenzene is brominated again, and bromine and chlorobenzene are reacted in a suitable reaction system under the action of a catalyst, and bromine atoms can be introduced. This step requires fine regulation of the reaction conditions, because the selectivity of the bromination reaction is very important. Finally, through the fluorination reaction, a specific fluorine source is introduced into the molecule to obtain the target product 4-bromo-2-fluorochlorobenzene. The choice of fluorine source and the control of reaction conditions are extremely important in this fluorination reaction. Common fluorine sources such as potassium fluoride are often required in organic solvents, and a phase transfer catalyst may be added to promote the reaction.
Second, it can also be started from other aromatic compounds. If 2-fluoroaniline is used as a raw material, the amino group is first converted into a diazonium salt through a diazotization reaction. This diazotization reaction needs to be carried out at a low temperature and in an acidic environment to ensure the stability of the diazonium salt. Then, the diazonium salt is reacted with reagents such as cuprous bromide to undergo a Sandmeier reaction, and bromine atoms are introduced. Then, through appropriate halogenation reactions, such as reacting with chlorine gas, chlorine atoms are introduced, and finally the synthesis of 4-bromo-2-fluorochlorobenzene is achieved. In this path, the separation and purification of intermediates in each step of the reaction are also key links, which affect the purity and yield of the final product.
Furthermore, using halobenzoic acid derivatives as starting materials, the decarboxylation and halogenation reaction can be carried out first, and chlorine atoms or bromine atoms can be selectively introduced. Through the nucleophilic substitution reaction, fluorine atoms are introduced, and the synthesis of 4-bromo-2-fluorochlorobenzene can also be achieved through the ingenious design and fine operation of the multi-step reaction. In this process, the optimization of reaction conditions, such as temperature, solvent, reactant ratio and other factors, need to be considered in depth to achieve the best synthesis effect.
There are various methods for synthesizing 4-bromo-2-fluorochlorobenzene, and each method has its own advantages and disadvantages. In practical applications, the appropriate synthesis path needs to be weighed according to specific needs and conditions.
One of them can be started from benzene. First, chlorination is used to make benzene and chlorine under the action of an appropriate catalyst, such as ferric trichloride, to form chlorobenzene. This reaction condition needs to be properly controlled at temperature, usually under heating conditions, so that the reactants can be fully contacted to make the reaction proceed smoothly. Then, the p-chlorobenzene is brominated again, and bromine and chlorobenzene are reacted in a suitable reaction system under the action of a catalyst, and bromine atoms can be introduced. This step requires fine regulation of the reaction conditions, because the selectivity of the bromination reaction is very important. Finally, through the fluorination reaction, a specific fluorine source is introduced into the molecule to obtain the target product 4-bromo-2-fluorochlorobenzene. The choice of fluorine source and the control of reaction conditions are extremely important in this fluorination reaction. Common fluorine sources such as potassium fluoride are often required in organic solvents, and a phase transfer catalyst may be added to promote the reaction.
Second, it can also be started from other aromatic compounds. If 2-fluoroaniline is used as a raw material, the amino group is first converted into a diazonium salt through a diazotization reaction. This diazotization reaction needs to be carried out at a low temperature and in an acidic environment to ensure the stability of the diazonium salt. Then, the diazonium salt is reacted with reagents such as cuprous bromide to undergo a Sandmeier reaction, and bromine atoms are introduced. Then, through appropriate halogenation reactions, such as reacting with chlorine gas, chlorine atoms are introduced, and finally the synthesis of 4-bromo-2-fluorochlorobenzene is achieved. In this path, the separation and purification of intermediates in each step of the reaction are also key links, which affect the purity and yield of the final product.
Furthermore, using halobenzoic acid derivatives as starting materials, the decarboxylation and halogenation reaction can be carried out first, and chlorine atoms or bromine atoms can be selectively introduced. Through the nucleophilic substitution reaction, fluorine atoms are introduced, and the synthesis of 4-bromo-2-fluorochlorobenzene can also be achieved through the ingenious design and fine operation of the multi-step reaction. In this process, the optimization of reaction conditions, such as temperature, solvent, reactant ratio and other factors, need to be considered in depth to achieve the best synthesis effect.
There are various methods for synthesizing 4-bromo-2-fluorochlorobenzene, and each method has its own advantages and disadvantages. In practical applications, the appropriate synthesis path needs to be weighed according to specific needs and conditions.
4-bromo-2-fluorochlorobenzene what are the precautions during use?
4-Bromo-2-fluorochlorobenzene is also a complex organic compound. During use, many precautions should be kept in mind.
The first thing to pay attention to is its toxicity. This compound may be toxic and can harm the human body by inhalation, ingestion or skin contact. Therefore, when operating, it is necessary to wear appropriate protective equipment, such as gas masks, protective gloves and protective clothing, to avoid direct contact. And the operation should be carried out in a well-ventilated place, or in a fume hood, to promote the dissipation of toxic gases as soon as possible, so as to avoid human inhalation.
The second is its chemical activity. 4-Bromo-2-fluorochlorobenzene contains bromine, fluorine, chlorine and other halogen atoms, and its chemical activity is quite high. In case of active metals or strong reducing agents, it is easy to cause chemical reactions, or even dangerous. When using, its chemical properties should be detailed to avoid contact with incompatible substances. When configuring solutions or participating in reactions, it is necessary to operate in the correct order and proportion, and strictly follow the operating procedures to prevent accidents.
In addition, storage is also critical. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources. Avoid mixing with oxidants, acids, alkalis, etc. to prevent chemical reactions. Storage containers must be tightly sealed to prevent leakage. Regularly check the storage environment and container condition. If there is any abnormality such as leakage, it must be properly disposed of immediately.
In addition, disposal should not be ignored. When this compound is discarded, it should not be discarded at will. It should be handed over to a professional organization for harmless treatment in accordance with relevant regulations and environmental protection requirements. It must not be directly discharged into the environment to avoid polluting soil, water sources, etc., causing serious damage to the ecological environment.
In short, when using 4-bromo-2-fluorochlorobenzene, whether it is operated, stored or discarded, it needs to be treated strictly to ensure that personal safety and the environment are not endangered.
The first thing to pay attention to is its toxicity. This compound may be toxic and can harm the human body by inhalation, ingestion or skin contact. Therefore, when operating, it is necessary to wear appropriate protective equipment, such as gas masks, protective gloves and protective clothing, to avoid direct contact. And the operation should be carried out in a well-ventilated place, or in a fume hood, to promote the dissipation of toxic gases as soon as possible, so as to avoid human inhalation.
The second is its chemical activity. 4-Bromo-2-fluorochlorobenzene contains bromine, fluorine, chlorine and other halogen atoms, and its chemical activity is quite high. In case of active metals or strong reducing agents, it is easy to cause chemical reactions, or even dangerous. When using, its chemical properties should be detailed to avoid contact with incompatible substances. When configuring solutions or participating in reactions, it is necessary to operate in the correct order and proportion, and strictly follow the operating procedures to prevent accidents.
In addition, storage is also critical. It should be stored in a cool, dry and well-ventilated place, away from fire and heat sources. Avoid mixing with oxidants, acids, alkalis, etc. to prevent chemical reactions. Storage containers must be tightly sealed to prevent leakage. Regularly check the storage environment and container condition. If there is any abnormality such as leakage, it must be properly disposed of immediately.
In addition, disposal should not be ignored. When this compound is discarded, it should not be discarded at will. It should be handed over to a professional organization for harmless treatment in accordance with relevant regulations and environmental protection requirements. It must not be directly discharged into the environment to avoid polluting soil, water sources, etc., causing serious damage to the ecological environment.
In short, when using 4-bromo-2-fluorochlorobenzene, whether it is operated, stored or discarded, it needs to be treated strictly to ensure that personal safety and the environment are not endangered.
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