Linshang Chemical
PRODUCTS
4-Bromo-3-Chlorofluorobenzene
Linshang Chemical
|
HS Code |
142102 |
| Chemical Formula | C6H3BrClF |
| Appearance | Liquid (likely) |
| Odor | Characteristic aromatic odor (expected) |
| Solubility In Water | Low solubility, as halobenzenes are generally hydrophobic |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
As an accredited 4-Bromo-3-Chlorofluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 g of 4 - bromo - 3 - chlorofluorobenzene packaged in a sealed glass bottle. |
| Storage | 4 - bromo - 3 - chlorofluorobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly - sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, reducing agents, and reactive chemicals to prevent potential chemical reactions. |
| Shipping | 4 - bromo - 3 - chlorofluorobenzene is shipped in well - sealed, corrosion - resistant containers. It adheres to strict hazardous chemical shipping regulations, ensuring safe transport to prevent any environmental or safety risks. |
Competitive 4-Bromo-3-Chlorofluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4-Bromo-3-Chlorofluorobenzene in China?
As a trusted 4-Bromo-3-Chlorofluorobenzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-Bromo-3-Chlorofluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of 4-bromo-3-chlorofluorobenzene?
4-Bromo-3-chlorofluorobenzene is an organic compound. In its chemical structure, the benzene ring is a six-membered ring structure, and the carbon and carbon are connected by a conjugated double bond, which has stable characteristics.
On the benzene ring, there are three different substituents. One is the bromine atom (Br), located at position 4. For the bromine atom, the halogen element also has a large atomic radius and high electronegativity. In chemical reactions, it can affect the electron cloud density distribution of the benzene ring and cause changes in the electrophilic substitution reaction activity of the benzene ring.
The second is the chlorine atom (Cl), which is at position 3. Chlorine and halogen elements, although electronegativity is different from bromine, interact with bromine atoms in the benzene ring system and contribute to the electronic and spatial effects of the benzene ring.
Three of them are fluorine atoms (F). This halogen element has the most electronegativity in the halogen group. Fluorine atoms have a significant attraction to the electron cloud of the benzene ring due to their small radius and large electronegativity, which greatly affects the chemical properties of the benzene ring.
The substitution of these three halogen atoms at specific positions in the benzene ring endows 4-bromo-3-chlorofluorobenzene with unique physical and chemical properties. In the field of organic synthesis, it is often used as a key intermediate, which can be derived from various chemical reactions and used in medicine, pesticides, materials and many other aspects. Its special structure makes the molecule exhibit a certain polarity, which affects its solubility, boiling point and other physical properties. It is of great value in chemical research and industrial production.
On the benzene ring, there are three different substituents. One is the bromine atom (Br), located at position 4. For the bromine atom, the halogen element also has a large atomic radius and high electronegativity. In chemical reactions, it can affect the electron cloud density distribution of the benzene ring and cause changes in the electrophilic substitution reaction activity of the benzene ring.
The second is the chlorine atom (Cl), which is at position 3. Chlorine and halogen elements, although electronegativity is different from bromine, interact with bromine atoms in the benzene ring system and contribute to the electronic and spatial effects of the benzene ring.
Three of them are fluorine atoms (F). This halogen element has the most electronegativity in the halogen group. Fluorine atoms have a significant attraction to the electron cloud of the benzene ring due to their small radius and large electronegativity, which greatly affects the chemical properties of the benzene ring.
The substitution of these three halogen atoms at specific positions in the benzene ring endows 4-bromo-3-chlorofluorobenzene with unique physical and chemical properties. In the field of organic synthesis, it is often used as a key intermediate, which can be derived from various chemical reactions and used in medicine, pesticides, materials and many other aspects. Its special structure makes the molecule exhibit a certain polarity, which affects its solubility, boiling point and other physical properties. It is of great value in chemical research and industrial production.
What are the main physical properties of 4-bromo-3-chlorofluorobenzene?
4-Bromo-3-chlorofluorobenzene is an organohalogenated aromatic hydrocarbon with a variety of important physical properties.
Looking at its properties, it is mostly colorless to light yellow liquid under normal conditions, and is quite common in the field of chemical raw materials or pharmaceutical intermediates. This substance has a unique odor, which can be felt by smell, but the odor intensity is related to the specific environment.
When it comes to the boiling point, it is about 190-200 ° C. The boiling point is affected by the intermolecular force. The bromine, chlorine, and fluorine atoms in the molecule form van der Waals forces and polar effects with the benzene ring, which enhances the intermolecular attractive force, so the boiling point is higher. This property is of great significance in the separation and purification process, and it can be separated from the mixture by distillation according to the difference in boiling point.
Its melting point range is about - 20 - - 10 ° C. Due to the specific position of the halogen atom in the benzene ring, the molecular packing density and interaction force are affected, and the melting point is not high.
4-Bromo-3-chlorofluorobenzene has a density of about 1.7 - 1.8 g/cm ³, which is larger than that of water. If mixed with water, it will sink to the bottom. This needs to be taken into account when involving aqueous phase reactions or separation operations.
In terms of solubility, it is slightly soluble in water, but easily soluble in common organic solvents, such as ethanol, ether, dichloromethane, etc. Because water is a polar solvent, and the molecular polarity of this organic substance is relatively weak, according to the principle of "similar phase dissolution", it has better solubility in non-polar or weakly polar organic solvents.
In addition, this substance is volatile and will evaporate slowly in the air. When using and storing, pay attention to environmental ventilation to avoid potential health and safety risks.
In summary, the physical properties of 4-bromo-3-chlorofluorobenzene determine its operating conditions and treatment methods in chemical, pharmaceutical and other fields, which is of great significance to related industries.
Looking at its properties, it is mostly colorless to light yellow liquid under normal conditions, and is quite common in the field of chemical raw materials or pharmaceutical intermediates. This substance has a unique odor, which can be felt by smell, but the odor intensity is related to the specific environment.
When it comes to the boiling point, it is about 190-200 ° C. The boiling point is affected by the intermolecular force. The bromine, chlorine, and fluorine atoms in the molecule form van der Waals forces and polar effects with the benzene ring, which enhances the intermolecular attractive force, so the boiling point is higher. This property is of great significance in the separation and purification process, and it can be separated from the mixture by distillation according to the difference in boiling point.
Its melting point range is about - 20 - - 10 ° C. Due to the specific position of the halogen atom in the benzene ring, the molecular packing density and interaction force are affected, and the melting point is not high.
4-Bromo-3-chlorofluorobenzene has a density of about 1.7 - 1.8 g/cm ³, which is larger than that of water. If mixed with water, it will sink to the bottom. This needs to be taken into account when involving aqueous phase reactions or separation operations.
In terms of solubility, it is slightly soluble in water, but easily soluble in common organic solvents, such as ethanol, ether, dichloromethane, etc. Because water is a polar solvent, and the molecular polarity of this organic substance is relatively weak, according to the principle of "similar phase dissolution", it has better solubility in non-polar or weakly polar organic solvents.
In addition, this substance is volatile and will evaporate slowly in the air. When using and storing, pay attention to environmental ventilation to avoid potential health and safety risks.
In summary, the physical properties of 4-bromo-3-chlorofluorobenzene determine its operating conditions and treatment methods in chemical, pharmaceutical and other fields, which is of great significance to related industries.
What are the common synthetic methods of 4-bromo-3-chlorofluorobenzene?
4-Bromo-3-chlorofluorobenzene is also an organic compound. The common synthesis methods are about several.
One is the halogenation reaction method. Using fluorobenzene as the starting material, first make it meet the brominating agent. Commonly used brominating agents, such as bromine (Br ²), can introduce bromine atoms into the benzene ring under the catalysis of appropriate catalysts, such as iron powder (Fe) or iron tribromide (FeBr ²). During this process, the electron cloud distribution of the benzene ring is affected by the fluorine atom, and the bromine atom will selectively enter the adjacent and para-position of the fluorine atom. Because the fluorine atom is an ortho-para-localization group and the spatial steric resistance is small, the brominated product can be obtained by the reaction. The obtained bromofluorobenzene product is then reacted with a chlorinating agent. Commonly used chlorinating agents, such as chlorine (Cl ²), can introduce chlorine atoms into the benzene ring under the action of light or specific catalysts, such as aluminum trichloride (AlCl 🥰), and then synthesize 4-bromo-3-chlorofluorobenzene. The steps of this halogenation reaction are relatively clear, but it is necessary to pay attention to the precise control of the reaction conditions. Factors such as temperature and catalyst dosage have a significant impact on the selectivity and yield of the product.
The second is the method of aromatic nucleophilic substitution. A suitable fluorine-containing aromatic compound is used as the substrate, and the benzene ring is connected with a replaceable group, such as nitro (-NO 2O). First, it reacts with a brominating reagent to introduce bromine atoms. Then, using the characteristics of aromatic nucleophilic substitution reaction, under alkaline conditions, using potassium halide (such as potassium chloride KCl) as the chlorine source, the chlorine atom replaces the replaceable group such as nitro on the benzene ring to generate 4-bromo-3-chlorofluorobenzene. This method requires more consideration of the selection of substrates and the optimization of reaction conditions, because the activity and selectivity of aromatic nucleophilic substitution are closely related to the structure and reaction conditions of the substrate.
The third is the coupling reaction catalyzed by transition metals. If fluorine-containing halogenated benzene derivatives are used as raw materials, first they are coupled with organoboron reagents or organozinc reagents under the action of transition metal catalysts such as palladium (Pd) catalysts, and bromine atoms are introduced. Then, chlorine atoms are introduced through similar coupling reactions. Such transition metal-catalyzed coupling reactions have the advantages of high efficiency and good selectivity, but the catalyst cost is higher, and the reaction conditions are more demanding, which also requires high reaction equipment and operation.
Each of these methods has its own advantages and disadvantages. In actual synthesis, it is necessary to weigh and choose according to many factors such as the availability of raw materials, cost, and purity requirements of the product.
One is the halogenation reaction method. Using fluorobenzene as the starting material, first make it meet the brominating agent. Commonly used brominating agents, such as bromine (Br ²), can introduce bromine atoms into the benzene ring under the catalysis of appropriate catalysts, such as iron powder (Fe) or iron tribromide (FeBr ²). During this process, the electron cloud distribution of the benzene ring is affected by the fluorine atom, and the bromine atom will selectively enter the adjacent and para-position of the fluorine atom. Because the fluorine atom is an ortho-para-localization group and the spatial steric resistance is small, the brominated product can be obtained by the reaction. The obtained bromofluorobenzene product is then reacted with a chlorinating agent. Commonly used chlorinating agents, such as chlorine (Cl ²), can introduce chlorine atoms into the benzene ring under the action of light or specific catalysts, such as aluminum trichloride (AlCl 🥰), and then synthesize 4-bromo-3-chlorofluorobenzene. The steps of this halogenation reaction are relatively clear, but it is necessary to pay attention to the precise control of the reaction conditions. Factors such as temperature and catalyst dosage have a significant impact on the selectivity and yield of the product.
The second is the method of aromatic nucleophilic substitution. A suitable fluorine-containing aromatic compound is used as the substrate, and the benzene ring is connected with a replaceable group, such as nitro (-NO 2O). First, it reacts with a brominating reagent to introduce bromine atoms. Then, using the characteristics of aromatic nucleophilic substitution reaction, under alkaline conditions, using potassium halide (such as potassium chloride KCl) as the chlorine source, the chlorine atom replaces the replaceable group such as nitro on the benzene ring to generate 4-bromo-3-chlorofluorobenzene. This method requires more consideration of the selection of substrates and the optimization of reaction conditions, because the activity and selectivity of aromatic nucleophilic substitution are closely related to the structure and reaction conditions of the substrate.
The third is the coupling reaction catalyzed by transition metals. If fluorine-containing halogenated benzene derivatives are used as raw materials, first they are coupled with organoboron reagents or organozinc reagents under the action of transition metal catalysts such as palladium (Pd) catalysts, and bromine atoms are introduced. Then, chlorine atoms are introduced through similar coupling reactions. Such transition metal-catalyzed coupling reactions have the advantages of high efficiency and good selectivity, but the catalyst cost is higher, and the reaction conditions are more demanding, which also requires high reaction equipment and operation.
Each of these methods has its own advantages and disadvantages. In actual synthesis, it is necessary to weigh and choose according to many factors such as the availability of raw materials, cost, and purity requirements of the product.
In what areas is 4-bromo-3-chlorofluorobenzene applied?
4-Bromo-3-chlorofluorobenzene is also an organic compound. It is used in the fields of chemical industry, medicine and materials.
In the chemical industry, it is often used as a raw material for the synthesis of other complex organic compounds. Because of its halogen atom, it can be substituted and added to various reactions to introduce other functional groups to build a multi-component organic molecular structure and form chemicals with special properties.
In the field of medicine, this compound has a wide range of uses. The presence of halogen atoms can change the physical and chemical properties of compounds, such as fat solubility, stability, etc., affecting their biological activity and pharmacological effects. Or as a key intermediate for the creation of new drugs, through a series of reactions, synthesized into drug molecules with specific curative effects for disease prevention and treatment.
In the field of materials, 4-bromo-3-chlorofluorobenzene also plays a role. It can participate in the synthesis of polymer materials and introduce it into the polymer main chain or side chain to endow the material with special properties, such as improving the thermal stability, chemical resistance, and optical properties of the material, so as to be suitable for the special needs of materials in high-tech fields such as electronics and optics.
In summary, 4-bromo-3-chlorofluorobenzene plays an important role in many fields such as chemical engineering, medicine, and materials, and plays a significant role in promoting technological development and innovation in various fields.
In the chemical industry, it is often used as a raw material for the synthesis of other complex organic compounds. Because of its halogen atom, it can be substituted and added to various reactions to introduce other functional groups to build a multi-component organic molecular structure and form chemicals with special properties.
In the field of medicine, this compound has a wide range of uses. The presence of halogen atoms can change the physical and chemical properties of compounds, such as fat solubility, stability, etc., affecting their biological activity and pharmacological effects. Or as a key intermediate for the creation of new drugs, through a series of reactions, synthesized into drug molecules with specific curative effects for disease prevention and treatment.
In the field of materials, 4-bromo-3-chlorofluorobenzene also plays a role. It can participate in the synthesis of polymer materials and introduce it into the polymer main chain or side chain to endow the material with special properties, such as improving the thermal stability, chemical resistance, and optical properties of the material, so as to be suitable for the special needs of materials in high-tech fields such as electronics and optics.
In summary, 4-bromo-3-chlorofluorobenzene plays an important role in many fields such as chemical engineering, medicine, and materials, and plays a significant role in promoting technological development and innovation in various fields.
What is the market price range for 4-bromo-3-chlorofluorobenzene?
4-Bromo-3-chlorofluorobenzene is one of the organic compounds. Its market price range is difficult to sum up, because of the interaction of many factors.
The first to bear the brunt is the situation of market supply and demand. If there are many people who want it, but the supply is small, the price will rise; on the contrary, if the supply exceeds the demand, the price will be depressed.
Furthermore, the difficulty and cost of preparation are also key. The synthesis of this compound may require specific raw materials and exquisite processes. If the raw materials are rare and the process is complicated, the cost will be high, and the price will also rise.
The origin and quality also affect its price. Different origins, depending on the source of raw materials and preparation technology, the quality may vary, and the price is also different. Those with high quality often have higher prices.
According to past market conditions, the price of 4-bromo-3-chlorofluorobenzene may range from tens to hundreds of yuan per gram. However, this is only a rough figure, and the actual price depends on the specific time, place and transaction situation. For accurate prices, you need to consult the relevant chemical raw material suppliers in detail, or study them in detail on the chemical product trading platform.
The first to bear the brunt is the situation of market supply and demand. If there are many people who want it, but the supply is small, the price will rise; on the contrary, if the supply exceeds the demand, the price will be depressed.
Furthermore, the difficulty and cost of preparation are also key. The synthesis of this compound may require specific raw materials and exquisite processes. If the raw materials are rare and the process is complicated, the cost will be high, and the price will also rise.
The origin and quality also affect its price. Different origins, depending on the source of raw materials and preparation technology, the quality may vary, and the price is also different. Those with high quality often have higher prices.
According to past market conditions, the price of 4-bromo-3-chlorofluorobenzene may range from tens to hundreds of yuan per gram. However, this is only a rough figure, and the actual price depends on the specific time, place and transaction situation. For accurate prices, you need to consult the relevant chemical raw material suppliers in detail, or study them in detail on the chemical product trading platform.
Scan to WhatsApp
