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4-Bromo-3-Chloroiodobenzene
Linshang Chemical
|
HS Code |
969494 |
| Chemical Formula | C6H3BrClI |
| Molecular Weight | 329.35 |
| Appearance | Solid (Typical for aromatic halides) |
| Melting Point | Data may vary, needs experimental determination |
| Boiling Point | Data may vary, needs experimental determination |
| Density | Data may vary, needs experimental determination |
| Solubility In Water | Low (organic halide, hydrophobic) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Stability | Stable under normal conditions, but can react with strong bases, nucleophiles |
| Odor | May have a characteristic aromatic odor |
As an accredited 4-Bromo-3-Chloroiodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 g of 4 - bromo - 3 - chloroiodobenzene packaged in a sealed, chemical - resistant bottle. |
| Storage | 4 - bromo - 3 - chloroiodobenzene should be stored in a cool, dry, well - ventilated area away from sources of heat and ignition. Keep it in a tightly sealed container to prevent vapor release. Store it separately from oxidizing agents, reducing agents, and reactive chemicals to avoid potential reactions. Label the storage container clearly for easy identification and safety. |
| Shipping | 4 - bromo - 3 - chloroiodobenzene is shipped in sealed, corrosion - resistant containers. They are carefully packed to prevent breakage. Shipment follows strict hazardous chemical regulations to ensure safe transport. |
Competitive 4-Bromo-3-Chloroiodobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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As a leading 4-Bromo-3-Chloroiodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of 4-bromo-3-chloroiodobenzene?
4-Bromo-3-chloroiodobenzene is also an organic compound. Its chemical structure can be analyzed as follows: The benzene ring is a six-membered carbon ring with a conjugated π electronic system, which is very stable. Above the benzene ring, there are three-position and four-position substituents. At three-position, there is a chlorine atom, and chlorine is also a halogen element. The electron cloud distribution interacts with the benzene ring, which affects the electron density and reactivity of the benzene ring. At four positions, there is a bromine atom, which is also a halogen element. It shares the characteristics of a halogen atom with chlorine and has a significant impact on the chemical properties of the benzene ring. The iodine atom is also connected to the benzene ring, and coexists with bromine and chlorine The three halogen atoms, due to their high electronegativity and strong ability to attract electrons, reduce the electron cloud density of the benzene ring, resulting in a decrease in the electrophilic substitution activity of the benzene ring. And the spatial position of each halogen atom and the electronic effect interact, so that 4-bromo-3-chloroiodobenzene has unique physical and chemical properties. In its structure, carbon and halogen atoms are connected by covalent bonds, and each atom is arranged according to a certain spatial configuration to form a specific molecular shape, which also plays a role in its physical and chemical properties.
What are the physical properties of 4-bromo-3-chloroiodobenzene?
4-Bromo-3-chloroiodobenzene is also an organic compound. Its physical properties are worth a detailed investigation.
First of all, its shape, at room temperature, is either a crystalline solid or a viscous liquid, which is related to the intermolecular interaction and structure. The coexistence of halogen atoms of bromine, chlorine and iodine in the molecule causes the polarity of the molecule to change and affects its aggregation state.
When it comes to the melting point, due to the introduction of halogen atoms, the intermolecular force is enhanced, and the melting point is higher than that of benzene. Each halogen atom has different electronegativity and contributes differently to the intermolecular force. The exact melting point must be tested experimentally. However, it can be inferred that the melting point of simple aromatics must be higher.
The boiling point is the same, due to the increase in molecular polarity and the increase in intermolecular forces, the boiling point also rises. The mass of halogen atoms increases the intermolecular dispersion force, which increases the energy required for gasification.
In terms of solubility, in water, because water is a solvent with strong polarity, while 4-bromo-3-chloroiodobenzene contains polar halogen atoms, the organic skeleton still accounts for the main body, and the polarity is not strong, so it is difficult to dissolve in water. In organic solvents, such as ethanol, ether, dichloromethane, etc., due to the principle of "similar miscibility", such organic solvents have moderate polarity and organic structure, and are similar to them, so they are soluble.
Its density is also considerable, because the relative atomic weight of bromine, chlorine and iodine atoms is heavier than that of ordinary benzene derivatives.
The physical properties of 4-bromo-3-chloroiodobenzene are different from those of benzene due to the presence of halogen atoms. The melting point and boiling point increase, the solubility is different, and the density increases. This is of great significance in organic synthesis, chemical applications and other fields, and is related to its separation, purification, and reaction conditions.
First of all, its shape, at room temperature, is either a crystalline solid or a viscous liquid, which is related to the intermolecular interaction and structure. The coexistence of halogen atoms of bromine, chlorine and iodine in the molecule causes the polarity of the molecule to change and affects its aggregation state.
When it comes to the melting point, due to the introduction of halogen atoms, the intermolecular force is enhanced, and the melting point is higher than that of benzene. Each halogen atom has different electronegativity and contributes differently to the intermolecular force. The exact melting point must be tested experimentally. However, it can be inferred that the melting point of simple aromatics must be higher.
The boiling point is the same, due to the increase in molecular polarity and the increase in intermolecular forces, the boiling point also rises. The mass of halogen atoms increases the intermolecular dispersion force, which increases the energy required for gasification.
In terms of solubility, in water, because water is a solvent with strong polarity, while 4-bromo-3-chloroiodobenzene contains polar halogen atoms, the organic skeleton still accounts for the main body, and the polarity is not strong, so it is difficult to dissolve in water. In organic solvents, such as ethanol, ether, dichloromethane, etc., due to the principle of "similar miscibility", such organic solvents have moderate polarity and organic structure, and are similar to them, so they are soluble.
Its density is also considerable, because the relative atomic weight of bromine, chlorine and iodine atoms is heavier than that of ordinary benzene derivatives.
The physical properties of 4-bromo-3-chloroiodobenzene are different from those of benzene due to the presence of halogen atoms. The melting point and boiling point increase, the solubility is different, and the density increases. This is of great significance in organic synthesis, chemical applications and other fields, and is related to its separation, purification, and reaction conditions.
What are the common synthetic methods of 4-bromo-3-chloroiodobenzene?
4-Bromo-3-chloroiodobenzene is also an organic compound. Its common synthesis method follows the rules of organic synthesis and is formed by chemical reactions.
One method often begins with a halogenation reaction. The derivative of benzene can be taken first, and it can be encountered with the brominating agent to guide the bromine atom into the benzene ring. The brominating agent used, such as bromine and a suitable catalyst, or N-bromosuccinimide (NBS) under suitable conditions, can make the bromine atom selectively attached to the benzene ring to obtain a bromine-containing intermediate.
Next, the chlorine atom is introduced. Chlorination can be used to react with a suitable chlorinating agent, such as chlorine, in the presence of catalysts such as iron powder or ferric chloride, and interact with the first-obtained bromine-containing intermediate, so that the chlorine atom is connected to the benzene ring in the desired position, that is, ortho-position with the bromine atom, to obtain the benzene derivative co-contained in bromine and chlorine.
As for the introduction of iodine atoms, the method of nucleophilic substitution is commonly used. Using bromine and chlorine-containing benzene intermediates and iodides, such as potassium iodide, in organic solvents, adding appropriate catalysts, such as copper salts, and the like, through nucleophilic substitution, the iodine atom is replaced by a specific halogen atom on
There may also be other methods, such as using a protective group strategy, first masking the specific position of the benzene ring with a protective group, completing the halogenation reaction, and then removing the protective group to achieve the purpose of precise synthesis. The synthesis process requires good control of reaction conditions, such as temperature, pH, reaction time, etc., so that the reaction can obtain a high-purity product according to the expected route.
One method often begins with a halogenation reaction. The derivative of benzene can be taken first, and it can be encountered with the brominating agent to guide the bromine atom into the benzene ring. The brominating agent used, such as bromine and a suitable catalyst, or N-bromosuccinimide (NBS) under suitable conditions, can make the bromine atom selectively attached to the benzene ring to obtain a bromine-containing intermediate.
Next, the chlorine atom is introduced. Chlorination can be used to react with a suitable chlorinating agent, such as chlorine, in the presence of catalysts such as iron powder or ferric chloride, and interact with the first-obtained bromine-containing intermediate, so that the chlorine atom is connected to the benzene ring in the desired position, that is, ortho-position with the bromine atom, to obtain the benzene derivative co-contained in bromine and chlorine.
As for the introduction of iodine atoms, the method of nucleophilic substitution is commonly used. Using bromine and chlorine-containing benzene intermediates and iodides, such as potassium iodide, in organic solvents, adding appropriate catalysts, such as copper salts, and the like, through nucleophilic substitution, the iodine atom is replaced by a specific halogen atom on
There may also be other methods, such as using a protective group strategy, first masking the specific position of the benzene ring with a protective group, completing the halogenation reaction, and then removing the protective group to achieve the purpose of precise synthesis. The synthesis process requires good control of reaction conditions, such as temperature, pH, reaction time, etc., so that the reaction can obtain a high-purity product according to the expected route.
4-bromo-3-chloroiodobenzene commonly used in which chemical reactions?
4-Bromo-3-chloroiodobenzene is often used as a key raw material in many reactions in organic synthesis. In the nucleophilic substitution reaction, due to the difference in the activity of halogen atoms on the benzene ring, it can interact with various nucleophilic reagents. For example, when encountering a nucleophilic reagent containing hydroxyl groups, substitution can occur, and the hydroxyl group enters and the halogen atom exits. This reaction mechanism is exquisite, just like the ancient art of war, which breaks the game with ingenuity and rearranges the molecular structure.
In the metal-catalyzed coupling reaction, 4-bromo-3-chloroiodobenzene also plays an important role. Like palladium-catalyzed coupling, it can be connected with alkenyl groups, aryl halides, etc., to expand the carbon chain and build a complex aromatic system. This process is like building a delicate pavilion, and the components are combined according to specific rules to eventually form a grand structure.
In the reduction reaction, 4-bromo-3-chloroiodobenzene can be reduced, and the halogen atoms are partially or completely removed, transforming into simpler aromatic hydrocarbons. This change is like a masterpiece of simplification, removing barren and storing cyanine, and obtaining pure new substances.
In conclusion, 4-bromo-3-chloroiodobenzene is widely used in the field of organic chemical synthesis, such as a sharp tool for craftsmen, in various reactions, to help create a variety of organic compounds, and to promote the development of organic chemistry. Just like the stars, adorn the firmament of synthetic chemistry.
In the metal-catalyzed coupling reaction, 4-bromo-3-chloroiodobenzene also plays an important role. Like palladium-catalyzed coupling, it can be connected with alkenyl groups, aryl halides, etc., to expand the carbon chain and build a complex aromatic system. This process is like building a delicate pavilion, and the components are combined according to specific rules to eventually form a grand structure.
In the reduction reaction, 4-bromo-3-chloroiodobenzene can be reduced, and the halogen atoms are partially or completely removed, transforming into simpler aromatic hydrocarbons. This change is like a masterpiece of simplification, removing barren and storing cyanine, and obtaining pure new substances.
In conclusion, 4-bromo-3-chloroiodobenzene is widely used in the field of organic chemical synthesis, such as a sharp tool for craftsmen, in various reactions, to help create a variety of organic compounds, and to promote the development of organic chemistry. Just like the stars, adorn the firmament of synthetic chemistry.
What are 4-bromo-3-chloroiodobenzene main application fields?
4-Bromo-3-chloroiodobenzene is also an organic compound. It has important uses in various fields.
In the field of medicinal chemistry, such halogenated aromatics are often key intermediates in the synthesis of drugs. With its unique structure, it can introduce different functional groups through a variety of chemical reactions to build complex drug molecular structures. Due to the activity of halogen atoms, it can participate in reactions such as nucleophilic substitution and help synthesize compounds with specific pharmacological activities. For example, when developing antibacterial, antiviral and other drugs, it is often relied on as a starting material to obtain the required pharmaceutical ingredients through ingeniously designed reaction routes.
In the field of materials science, 4-bromo-3-chloroiodobenzene is also very important. It can be used to prepare special polymer materials. By polymerizing with monomers containing specific functional groups, the material can be endowed with unique properties. For example, the polymer formed by polymerization may have excellent photoelectric properties, which can be applied to optoelectronic devices such as organic Light Emitting Diode (OLED) and solar cells, which contribute greatly to the improvement of materials' conductivity and luminous efficiency.
In the field of organic synthetic chemistry, this compound is an important synthetic building block. Chemists can use their halogen atoms for cross-coupling reactions by selecting different reaction conditions and reagents, such as Suzuki coupling, Stille coupling, etc. With this, carbon-carbon bonds can be accurately constructed, and aromatic compounds with diverse structures can be synthesized, which greatly enriches the types of organic compounds. It contributes to the development of organic synthetic chemistry and promotes the creation of new organic functional molecules.
In the field of medicinal chemistry, such halogenated aromatics are often key intermediates in the synthesis of drugs. With its unique structure, it can introduce different functional groups through a variety of chemical reactions to build complex drug molecular structures. Due to the activity of halogen atoms, it can participate in reactions such as nucleophilic substitution and help synthesize compounds with specific pharmacological activities. For example, when developing antibacterial, antiviral and other drugs, it is often relied on as a starting material to obtain the required pharmaceutical ingredients through ingeniously designed reaction routes.
In the field of materials science, 4-bromo-3-chloroiodobenzene is also very important. It can be used to prepare special polymer materials. By polymerizing with monomers containing specific functional groups, the material can be endowed with unique properties. For example, the polymer formed by polymerization may have excellent photoelectric properties, which can be applied to optoelectronic devices such as organic Light Emitting Diode (OLED) and solar cells, which contribute greatly to the improvement of materials' conductivity and luminous efficiency.
In the field of organic synthetic chemistry, this compound is an important synthetic building block. Chemists can use their halogen atoms for cross-coupling reactions by selecting different reaction conditions and reagents, such as Suzuki coupling, Stille coupling, etc. With this, carbon-carbon bonds can be accurately constructed, and aromatic compounds with diverse structures can be synthesized, which greatly enriches the types of organic compounds. It contributes to the development of organic synthetic chemistry and promotes the creation of new organic functional molecules.
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