4-(Bromomethyl)-1,2-Dichlorobenzene
Linshang Chemical
HS Code |
756167 |
Chemical Formula | C7H5BrCl2 |
Molar Mass | 223.92 g/mol |
Appearance | Liquid (likely, based on similar compounds) |
Solubility In Water | Low (hydrophobic due to non - polar benzene ring and halogens) |
Solubility In Organic Solvents | Good (in common organic solvents like ethanol, acetone, etc. due to non - polar nature) |
Vapor Pressure | Low (due to relatively high molar mass and intermolecular forces from halogens) |
Stability | Stable under normal conditions, but may react with strong bases, nucleophiles due to bromomethyl group |
As an accredited 4-(Bromomethyl)-1,2-Dichlorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
Packing | 500g of 4-(bromomethyl)-1,2 - dichlorobenzene packaged in a sealed glass bottle. |
Storage | 4-(Bromomethyl)-1,2 - dichlorobenzene should be stored in a cool, dry, well - ventilated area away from heat sources, ignition sources, and oxidizing agents. It should be placed in a tightly - sealed container, preferably made of corrosion - resistant materials. Keep it out of reach of unauthorized personnel and follow all safety regulations regarding its storage. |
Shipping | 4-(Bromomethyl)-1,2 - dichlorobenzene is shipped in accordance with chemical transportation regulations. Packed in well - sealed, corrosion - resistant containers, transported by specialized carriers ensuring safety from spillage and environmental exposure. |
Competitive 4-(Bromomethyl)-1,2-Dichlorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 4-(Bromomethyl)-1,2-Dichlorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
In the field of medicinal chemistry, this compound can be used as a key intermediate. Due to its unique structure, it contains bromomethyl and dichlorobenzene groups. It can introduce other specific functional groups through a series of organic reactions, such as nucleophilic substitution reactions, to build complex drug molecular structures. For example, it can be used to synthesize certain compounds with specific pharmacological activities, or to lay the foundation for the development of new drugs.
In the field of materials science, 4- (bromomethyl) -1,2-dichlorobenzene is also useful. Due to its functional groups, it can participate in the polymerization reaction to form polymer materials with special properties. Such materials may exhibit unique properties in electrical and optical aspects, such as the preparation of polymer polymers with specific electrical conductivity or optical properties, which can be used in electronic devices, optical materials and other fields.
In organic synthesis chemistry, this compound is an extremely important starting material. With its bromomethyl activity, chemists can use it to design a variety of reaction paths and synthesize many organic compounds with different structures, greatly enriching the variety of organic compounds, providing a rich material basis and reaction strategies for the development of organic synthesis chemistry.
Looking at its properties, at room temperature, it is mostly colorless to light yellow liquid. This color state is easy to identify with the naked eye. In practical application and research, it can be used to preliminarily judge its state.
When it comes to the melting point, the melting point is within a specific range, and the boiling point also has a certain value. The characteristics of the melting point make it change from solid to liquid at a specific temperature environment; the boiling point determines the temperature at which it changes from liquid to gaseous. Both of these are crucial for the setting of the separation, purification and storage conditions of the compound.
Furthermore, its density is also an important physical property. Compared with water, it has a specific density value, which is related to the distribution of the substance in the liquid phase system. If mixed with other liquids, according to the density difference, the level of the substance can be known, which is helpful for the separation operation.
In terms of solubility, it shows a certain solubility in common organic solvents such as ethanol and ether. It can be dissolved in such organic solvents, so that in the process of organic synthesis reaction, a suitable solvent can be selected to promote the reaction. However, in water, its solubility is poor, and this property also affects its behavior in different environments.
In addition, 4- (bromomethyl) -1,2-dichlorobenzene has certain volatility. In an open environment, it will gradually evaporate into the air. This volatility has corresponding requirements on the ventilation conditions of its storage and use environment to prevent it from accumulating in local space, causing safety hazards or affecting the accuracy of experiments and production.
In summary, the physical properties of 4- (bromomethyl) -1,2-dichlorobenzene, such as color state, melting boiling point, density, solubility and volatility, play an indispensable role in its application and treatment in chemical production, scientific research and many other fields.
In this compound, bromomethyl is connected to the dichlorobenzene ring. In bromomethyl, the activity of bromine atoms is quite high. Due to the strong electronegativity of bromine atoms and the polarity of carbon-bromine bonds, it is easily attacked by nucleophiles and nucleophilic substitution reactions occur. For example, when encountering hydroxyl negative ions (OH), bromine ions (Br) can be replaced by hydroxyl groups to produce corresponding alcohols.
In addition, although the benzene ring has certain stability, the distribution of electron clouds is different due to the influence of chlorine atoms and bromomethyl atoms. Both chlorine atoms and bromomethyl groups are electron-withdrawing groups, which reduce the electron cloud density of the benzene ring. During the electrophilic substitution reaction, the reactivity is slightly lower than that of benzene, and the substitution check point is also affected by the group positioning effect.
In addition, under the influence of molecular structure, 4- (bromomethyl) -1,2-dichlorobenzene may initiate a free radical reaction under light or heating conditions, and the hydrogen atom on bromomethyl can be captured, and a series of free radical reaction products can be derived.
From this perspective, the chemical properties of 4- (bromomethyl) -1,2-dichlorobenzene are unstable, and various chemical reactions can occur under various conditions.
First, halogenated alkylation method. 1,2-dichlorobenzene can be taken as the starting material and reacted with paraformaldehyde and hydrogen bromide under the action of a specific catalyst. In this case, paraformaldehyde will decompose into formaldehyde in the reaction system, and formaldehyde and hydrogen bromide will further interact to form bromomethanol intermediates. 1,2-Dichlorobenzene will undergo electrophilic substitution reaction with bromomethanol intermediates to form the target product 4- (bromomethyl) -1,2-dichlorobenzene. This reaction requires attention to the choice and dosage of catalyst, and the reaction temperature, time and other conditions are also very important, which will affect the reaction yield and selectivity.
Second, benzyl halogenation method. If 4-methyl-1,2-dichlorobenzene is used as the raw material, the halogenation reaction can be used to achieve the goal. N-bromosuccinimide (NBS) is often used as a brominating reagent. In the presence of an initiator, such as benzoyl peroxide, under light or heating conditions, N-bromosuccinimide will produce bromine free radicals, which will then undergo a free radical substitution reaction with the methyl of 4-methyl-1,2-dichlorobenzene to generate 4- (bromomethyl) -1,2-dichlorobenzene. In this reaction, the amount of initiator, reaction temperature and solvent selection are all key factors, and careful regulation is required to obtain the best reaction effect.
Third, Grignard reagent method. First, 4-chloromethyl-1,2-dichlorobenzene is used as raw material to make Grignard reagent, and then reacts with brominating reagent. For example, 4-chloromethyl-1,2-dichlorobenzene is first reacted with magnesium chips in anhydrous ether or tetrahydrofuran solvent to make Grignard reagent. Then a suitable brominating reagent, such as copper bromide, is added to this Grignard reagent system, and through metal transfer reaction, 4- (bromomethyl) -1,2-dichlorobenzene can be obtained. In this route, the preparation conditions of Grignard reagent are strict, and the reaction system must be anhydrous and oxygen-free, and the choice and dosage of brominating reagents also have a great impact on the reaction process
All synthesis methods have their own advantages and disadvantages. In practical application, the appropriate synthesis path should be carefully selected according to various factors such as the availability of raw materials, the difficulty of controlling reaction conditions, cost considerations, and product purity requirements.
Safety first. This compound is toxic and irritating to a certain extent, touching the human body, or causing discomfort to the skin, eyes and other parts. Therefore, when storing, it must be placed in a cool and well-ventilated place, away from fire and heat sources, and stored separately from oxidants, strong alkalis and other substances. It must not be mixed to prevent dangerous chemical reactions. During transportation, it is also necessary to ensure that the container is well sealed to avoid leakage, so as to prevent harm to transporters and the surrounding environment.
The second time is packaging. Appropriate packaging materials need to be selected to ensure that the packaging is sturdy and can effectively prevent collision and vibration from causing damage to the container. Commonly used packaging materials may include glass bottles, plastic drums, etc. However, no matter what kind, they must be able to withstand certain pressure and environmental changes to ensure the stability of the substance.
Furthermore, attention must be paid to the environmental impact. If accidentally leaks, 4- (bromomethyl) -1,2-dichlorobenzene may cause pollution to soil, water sources, etc. Therefore, the storage place should be equipped with leakage emergency treatment equipment and suitable containment materials. When transporting, relevant environmental regulations should also be followed. In the event of leakage, effective emergency measures, such as containment and adsorption, should be taken immediately to reduce the damage to the environment.
In addition, storage and transportation personnel should be professionally trained to be familiar with the characteristics, hazards and emergency treatment methods of this compound. When working, they must wear appropriate protective equipment, such as protective gloves, goggles, gas masks, etc., to ensure their own safety.

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