Linshang Chemical
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4-(Bromomethyl)-1-Chloro-2-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
109591 |
| Chemical Formula | C8H5BrClF3 |
| Molecular Weight | 287.48 |
As an accredited 4-(Bromomethyl)-1-Chloro-2-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4-(bromomethyl)-1 -chloro-2-(trifluoromethyl)benzene in a sealed glass bottle. |
| Storage | 4-(Bromomethyl)-1-chloro-2-(trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area away from sources of heat, ignition, and incompatible substances. Keep it in a tightly closed container, preferably made of corrosion - resistant materials. Due to its reactivity and potential hazards, store it separately from oxidizing agents, bases, and reducing agents to prevent unwanted reactions. |
| Shipping | 4-(Bromomethyl)-1-chloro-2-(trifluoromethyl)benzene is shipped in well - sealed, corrosion - resistant containers. Strict adherence to hazardous chemical shipping regulations ensures safe transportation to prevent spills and environmental or safety risks. |
Competitive 4-(Bromomethyl)-1-Chloro-2-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 4-(Bromomethyl)-1-Chloro-2-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of this product 4- (bromomethyl) -1-chloro-2- (trifluoromethyl) benzene?
This substance is 4 - (bromomethyl) -1 -chloro-2 - (trifluoromethyl) benzene, and its chemical properties are quite unique.
From the perspective of the properties of halogenated hydrocarbons, it contains bromomethyl, and the bromine atom has high activity, which is prone to nucleophilic substitution. If it encounters nucleophilic reagents, such as alkoxy anions of alcohols, it can generate corresponding ether compounds; if it encounters ammonia or amine nucleophilic reagents, it will form nitrogen-containing derivatives. In an alkaline environment, the bromine atom may also initiate elimination reactions and form unsaturated bonds.
Chlorine atom also has certain activity, although it is slightly inferior to bromine atom, it can also participate in nucleophilic substitution reactions under appropriate conditions For example, at high temperatures and in the presence of strong nucleophiles, chlorine atoms can be replaced.
The presence of trifluoromethyl has a significant impact on the electron cloud density of the benzene ring. Because of its strong electron-absorbing effect, it will reduce the electron cloud density of the benzene ring, making the electrophilic substitution reaction on the benzene ring more difficult. At the same time, the strong electron-absorbing property of trifluoromethyl will also affect the chemical activity of the carbon atoms connected to it, change the overall polarity of the molecule, and also play a role in its physical properties such as boiling point and solubility. This substance can be used as a key intermediate in the field of organic synthesis to build more complex organic compounds through various reactions.
From the perspective of the properties of halogenated hydrocarbons, it contains bromomethyl, and the bromine atom has high activity, which is prone to nucleophilic substitution. If it encounters nucleophilic reagents, such as alkoxy anions of alcohols, it can generate corresponding ether compounds; if it encounters ammonia or amine nucleophilic reagents, it will form nitrogen-containing derivatives. In an alkaline environment, the bromine atom may also initiate elimination reactions and form unsaturated bonds.
Chlorine atom also has certain activity, although it is slightly inferior to bromine atom, it can also participate in nucleophilic substitution reactions under appropriate conditions For example, at high temperatures and in the presence of strong nucleophiles, chlorine atoms can be replaced.
The presence of trifluoromethyl has a significant impact on the electron cloud density of the benzene ring. Because of its strong electron-absorbing effect, it will reduce the electron cloud density of the benzene ring, making the electrophilic substitution reaction on the benzene ring more difficult. At the same time, the strong electron-absorbing property of trifluoromethyl will also affect the chemical activity of the carbon atoms connected to it, change the overall polarity of the molecule, and also play a role in its physical properties such as boiling point and solubility. This substance can be used as a key intermediate in the field of organic synthesis to build more complex organic compounds through various reactions.
What are the common synthesis methods of 4- (bromomethyl) -1-chloro-2- (trifluoromethyl) benzene?
4- (bromomethyl) -1 -chloro-2- (trifluoromethyl) benzene is also an important intermediate in organic synthesis. The common synthesis methods are as follows.
First, the method of using halogenated benzyl derivatives as starting materials. You can first take benzyl compounds containing corresponding substituents, such as benzyl derivatives containing chlorine and trifluoromethyl, and introduce bromomethyl through bromination reaction. Commonly used bromination reagents include N-bromosuccinimide (NBS). In the presence of initiators such as benzoyl peroxide (BPO), hydrogen at the benzyl position can be replaced by bromine atoms under light or heating conditions to obtain the target product. The reaction conditions are mild, the selectivity is good, the benzyl position hydrogen is active, and it is easy to undergo free radical substitution reaction with NBS.
Second, the synthesis path starting from aromatic derivatives. Select aromatic hydrocarbons containing suitable substituents, such as benzene derivatives containing chlorine and trifluoromethyl, and introduce bromomethyl through Friedel-Crafts alkylation reaction. The halogenated methyl reagent, such as bromomethane, undergoes electrophilic substitution reaction with aromatic hydrocarbons under the action of Lewis acid catalyst such as anhydrous aluminum chloride. This reaction requires an anhydrous environment. Lewis acid catalyst can enhance the electrophilicity of halogenated methyl reagents and promote the smooth progress of the reaction.
Third, the synthesis method involving organometallic reagents. First prepare chlorine and trifluoromethyl aromatic fund reagents, such as aryl magnesium reagents or aryl lithium reagents, and then react with bromomethyl-containing halogenated hydrocarbons or other suitable electrophilic reagents. In this process, organometallic reagents have high activity and can undergo nucleophilic substitution reactions with a variety of electrophilic reagents to form carbon-carbon bonds, thereby constructing the target molecular structure.
The above synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider factors such as the availability of raw materials, the difficulty of reaction conditions, and the requirements of product purity. An appropriate method is selected to achieve the efficient synthesis of 4- (bromomethyl) -1 -chloro-2- (trifluoromethyl) benzene.
First, the method of using halogenated benzyl derivatives as starting materials. You can first take benzyl compounds containing corresponding substituents, such as benzyl derivatives containing chlorine and trifluoromethyl, and introduce bromomethyl through bromination reaction. Commonly used bromination reagents include N-bromosuccinimide (NBS). In the presence of initiators such as benzoyl peroxide (BPO), hydrogen at the benzyl position can be replaced by bromine atoms under light or heating conditions to obtain the target product. The reaction conditions are mild, the selectivity is good, the benzyl position hydrogen is active, and it is easy to undergo free radical substitution reaction with NBS.
Second, the synthesis path starting from aromatic derivatives. Select aromatic hydrocarbons containing suitable substituents, such as benzene derivatives containing chlorine and trifluoromethyl, and introduce bromomethyl through Friedel-Crafts alkylation reaction. The halogenated methyl reagent, such as bromomethane, undergoes electrophilic substitution reaction with aromatic hydrocarbons under the action of Lewis acid catalyst such as anhydrous aluminum chloride. This reaction requires an anhydrous environment. Lewis acid catalyst can enhance the electrophilicity of halogenated methyl reagents and promote the smooth progress of the reaction.
Third, the synthesis method involving organometallic reagents. First prepare chlorine and trifluoromethyl aromatic fund reagents, such as aryl magnesium reagents or aryl lithium reagents, and then react with bromomethyl-containing halogenated hydrocarbons or other suitable electrophilic reagents. In this process, organometallic reagents have high activity and can undergo nucleophilic substitution reactions with a variety of electrophilic reagents to form carbon-carbon bonds, thereby constructing the target molecular structure.
The above synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider factors such as the availability of raw materials, the difficulty of reaction conditions, and the requirements of product purity. An appropriate method is selected to achieve the efficient synthesis of 4- (bromomethyl) -1 -chloro-2- (trifluoromethyl) benzene.
What are the main applications of 4- (bromomethyl) -1-chloro-2- (trifluoromethyl) benzene?
4- (bromomethyl) -1 -chloro-2- (trifluoromethyl) benzene is widely used in the field of organic synthesis. It can be used to create new pesticides to protect the fields from pests. In agriculture, pests are infested, often making the harvest poor. This compound can be a good medicine for insecticides after clever transformation. With its special structure, it can precisely act on the physiological function of pests, making it difficult to survive in the world.
In the field of pharmaceutical research and development, it also has its uses. Physicians want to make special drugs, and this compound can be used as a key raw material. With its unique chemical properties, it can participate in the construction of drug molecules, or enhance the medicinal power, or improve the absorption and metabolism of drugs, and bring good news to patients.
Furthermore, in the field of materials science, it also has potential. When developing new functional materials, this compound can be used as an important structural unit. Or give materials special properties, such as improving the stability and solubility of materials, so that they can play a unique role in electronic devices, optical materials, etc., and contribute to the development of materials science. In short, 4- (bromomethyl) -1-chloro-2- (trifluoromethyl) benzene is of great value in many fields, contributing to the progress of science and technology and the improvement of production and life.
In the field of pharmaceutical research and development, it also has its uses. Physicians want to make special drugs, and this compound can be used as a key raw material. With its unique chemical properties, it can participate in the construction of drug molecules, or enhance the medicinal power, or improve the absorption and metabolism of drugs, and bring good news to patients.
Furthermore, in the field of materials science, it also has potential. When developing new functional materials, this compound can be used as an important structural unit. Or give materials special properties, such as improving the stability and solubility of materials, so that they can play a unique role in electronic devices, optical materials, etc., and contribute to the development of materials science. In short, 4- (bromomethyl) -1-chloro-2- (trifluoromethyl) benzene is of great value in many fields, contributing to the progress of science and technology and the improvement of production and life.
What is the approximate market price of 4- (bromomethyl) -1-chloro-2- (trifluoromethyl) benzene?
I don't know what the market price of 4- (bromomethyl) -1 -chloro-2- (trifluoromethyl) benzene is. However, if you want to know its price, you can explore it from many sources.
First, the chemical product trading platform, in today's world, many chemical materials are traded on the online platform, which lists the prices of various products, or you can get the recent quotation of this compound, and you can compare the prices of various companies to know their prices.
Second, ask chemical raw material suppliers. Many suppliers specialize in the trading of such chemicals, contact them, and ask their selling prices. Because they have actual business, the prices they tell may be more accurate, and they can know whether there are discounts when purchasing in bulk.
Third, the chemical exhibition is also a way. At the exhibition, chemical companies gather, and they can consult the manufacturers, not only to know the price, but also to know the product quality, supply cycle, etc.
It is unfortunate that I cannot directly tell its market price. The price often changes from time to time, and is affected by various factors such as raw material cost, market supply and demand, and production process difficulties. If you want to get a price, you can follow the above methods to explore it.
First, the chemical product trading platform, in today's world, many chemical materials are traded on the online platform, which lists the prices of various products, or you can get the recent quotation of this compound, and you can compare the prices of various companies to know their prices.
Second, ask chemical raw material suppliers. Many suppliers specialize in the trading of such chemicals, contact them, and ask their selling prices. Because they have actual business, the prices they tell may be more accurate, and they can know whether there are discounts when purchasing in bulk.
Third, the chemical exhibition is also a way. At the exhibition, chemical companies gather, and they can consult the manufacturers, not only to know the price, but also to know the product quality, supply cycle, etc.
It is unfortunate that I cannot directly tell its market price. The price often changes from time to time, and is affected by various factors such as raw material cost, market supply and demand, and production process difficulties. If you want to get a price, you can follow the above methods to explore it.
What are the precautions for 4- (bromomethyl) -1-chloro-2- (trifluoromethyl) benzene during storage and transportation?
4 - (bromomethyl) -1 - chloro - 2 - (trifluoromethyl) benzene, during storage and transportation, all precautions should not be ignored.
This compound has the properties of halogenated aromatics and has high chemical activity. When storing, it should be placed in a cool, dry and well-ventilated place. Because of humid gas, it is easy to cause hydrolysis and deterioration, and high temperature may promote chemical reactions, which will damage its quality. And it must be kept away from fire and heat sources to prevent the risk of fire. This is because of its organic structure, in case of open flame and hot topic, there is a risk of combustion and explosion.
In addition, it also has strict requirements for packaging. The packaging container must be tight to prevent the intrusion of air and moisture. Usually it should be packed in glass bottles or metal drums, and reinforced with wooden or plastic boxes to prevent damage during handling.
When transporting, caution is also required. This compound is classified as a hazardous chemical and must be transported by a professional transportation team, in accordance with relevant regulations and standards. Transportation vehicles should be equipped with corresponding fire fighting equipment and leakage emergency treatment equipment. When driving on the way, be steady and slow, avoid bumps and sudden brakes, and prevent material leakage caused by damaged packaging.
If a leak unfortunately occurs, do not panic. In the event of a small leak, it can be absorbed by inert materials such as sand and vermiculite, and collected in an airtight container for proper disposal. If there is a large amount of leakage, the scene should be quickly isolated, the surrounding people should be evacuated, emergency plans should be activated, and professional personnel should wear protective equipment to clean up and recover to prevent it from polluting the environment and endangering the safety of everyone.
All of these are what should be paid attention to when storing and transporting 4- (bromomethyl) -1-chloro-2- (trifluoromethyl) benzene.
This compound has the properties of halogenated aromatics and has high chemical activity. When storing, it should be placed in a cool, dry and well-ventilated place. Because of humid gas, it is easy to cause hydrolysis and deterioration, and high temperature may promote chemical reactions, which will damage its quality. And it must be kept away from fire and heat sources to prevent the risk of fire. This is because of its organic structure, in case of open flame and hot topic, there is a risk of combustion and explosion.
In addition, it also has strict requirements for packaging. The packaging container must be tight to prevent the intrusion of air and moisture. Usually it should be packed in glass bottles or metal drums, and reinforced with wooden or plastic boxes to prevent damage during handling.
When transporting, caution is also required. This compound is classified as a hazardous chemical and must be transported by a professional transportation team, in accordance with relevant regulations and standards. Transportation vehicles should be equipped with corresponding fire fighting equipment and leakage emergency treatment equipment. When driving on the way, be steady and slow, avoid bumps and sudden brakes, and prevent material leakage caused by damaged packaging.
If a leak unfortunately occurs, do not panic. In the event of a small leak, it can be absorbed by inert materials such as sand and vermiculite, and collected in an airtight container for proper disposal. If there is a large amount of leakage, the scene should be quickly isolated, the surrounding people should be evacuated, emergency plans should be activated, and professional personnel should wear protective equipment to clean up and recover to prevent it from polluting the environment and endangering the safety of everyone.
All of these are what should be paid attention to when storing and transporting 4- (bromomethyl) -1-chloro-2- (trifluoromethyl) benzene.
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