Linshang Chemical
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4-(Bromomethyl)-2-Chloro-1-Fluorobenzene
Linshang Chemical
|
HS Code |
621900 |
| Chemical Formula | C7H5BrClF |
| Molecular Weight | 223.47 |
As an accredited 4-(Bromomethyl)-2-Chloro-1-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4-(bromomethyl)-2 -chloro-1 -fluorobenzene in a sealed glass bottle. |
| Storage | 4-(Bromomethyl)-2-chloro-1-fluorobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. It must be kept in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, bases, and other reactive chemicals to prevent hazardous reactions. |
| Shipping | 4-(Bromomethyl)-2-chloro-1-fluorobenzene is shipped in accordance with strict chemical transportation regulations. Packed in suitable containers, it's transported with care to prevent spills and ensure safe delivery. |
Competitive 4-(Bromomethyl)-2-Chloro-1-Fluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What is the main use of 4- (bromomethyl) -2-chloro-1-fluorobenzene?
4- (bromomethyl) -2 -chloro-1 -fluorobenzene is one of the organic compounds. Its main use is crucial in the field of organic synthesis.
First, it can be used as a building block for building complex organic molecules. Because its structure contains bromomethyl, chlorine and fluorine atoms, these functional groups give it unique reactivity. Bromomethyl can participate in nucleophilic substitution reactions, and halogen atoms can also undergo various transformations under specific conditions, such as interacting with metal reagents to form carbon-carbon bonds, and then build complex carbon skeletons.
Second, it may have potential applications in the field of medicinal chemistry. Organic molecules containing halogen atoms often exhibit unique biological activities, or can be used to develop new drugs. For example, the introduction of fluorine atoms can change the fat solubility and metabolic stability of compounds, which is conducive to improving drug efficacy and pharmacokinetic properties.
Third, in the field of materials science, it may also have its uses. Its special structure may be able to assist in the synthesis of materials with specific properties, such as optoelectronic materials. By chemical modification, the optical and electrical properties of materials can be adjusted to meet different application needs.
In conclusion, the unique structure of 4- (bromomethyl) -2 -chloro-1 -fluorobenzene has important potential applications in many fields such as organic synthesis, drug development and materials science, providing rich possibilities for the development of related fields.
First, it can be used as a building block for building complex organic molecules. Because its structure contains bromomethyl, chlorine and fluorine atoms, these functional groups give it unique reactivity. Bromomethyl can participate in nucleophilic substitution reactions, and halogen atoms can also undergo various transformations under specific conditions, such as interacting with metal reagents to form carbon-carbon bonds, and then build complex carbon skeletons.
Second, it may have potential applications in the field of medicinal chemistry. Organic molecules containing halogen atoms often exhibit unique biological activities, or can be used to develop new drugs. For example, the introduction of fluorine atoms can change the fat solubility and metabolic stability of compounds, which is conducive to improving drug efficacy and pharmacokinetic properties.
Third, in the field of materials science, it may also have its uses. Its special structure may be able to assist in the synthesis of materials with specific properties, such as optoelectronic materials. By chemical modification, the optical and electrical properties of materials can be adjusted to meet different application needs.
In conclusion, the unique structure of 4- (bromomethyl) -2 -chloro-1 -fluorobenzene has important potential applications in many fields such as organic synthesis, drug development and materials science, providing rich possibilities for the development of related fields.
What are the physical properties of 4- (bromomethyl) -2-chloro-1-fluorobenzene
4- (bromomethyl) -2 -chloro-1 -fluorobenzene is one of the organic compounds. Its physical properties have unique characteristics.
Looking at its appearance, it is a colorless to light yellow liquid at room temperature and pressure, with a clear quality and a slightly special smell. Although its taste is not stinky and pungent, it is also recognizable.
When it comes to the melting point, its melting point is quite low, the intermolecular force is not very strong, and it is difficult to condense into a solid state at room temperature. The boiling point is slightly higher than that of ordinary hydrocarbons due to the halogen atoms in the molecular structure, but it is not a very high value. This is because the halogen atoms increase the intermolecular force, and more energy is required to cause gasification.
Its density is greater than that of water, and when it is mixed with water, it can be seen that it sinks to the bottom of the water, and the two are clearly defined and do not dissolve. Because it is an organic compound, the molecular polarity is quite different from that of water molecules, and according to the principle of "similar miscibility", the two are difficult to mix into one.
In terms of solubility, it has good solubility in common organic solvents such as ethanol, ether, and dichloromethane. This is because the intermolecular forces between organic solvents and the compound are similar, and they can be interspersed and mixed with each other to achieve a dissolved state.
The physical properties of 4- (bromomethyl) -2 -chloro-1 -fluorobenzene are determined by its molecular structure. In the fields of organic synthesis and chemical production, this property is crucial for its separation, purification and use.
Looking at its appearance, it is a colorless to light yellow liquid at room temperature and pressure, with a clear quality and a slightly special smell. Although its taste is not stinky and pungent, it is also recognizable.
When it comes to the melting point, its melting point is quite low, the intermolecular force is not very strong, and it is difficult to condense into a solid state at room temperature. The boiling point is slightly higher than that of ordinary hydrocarbons due to the halogen atoms in the molecular structure, but it is not a very high value. This is because the halogen atoms increase the intermolecular force, and more energy is required to cause gasification.
Its density is greater than that of water, and when it is mixed with water, it can be seen that it sinks to the bottom of the water, and the two are clearly defined and do not dissolve. Because it is an organic compound, the molecular polarity is quite different from that of water molecules, and according to the principle of "similar miscibility", the two are difficult to mix into one.
In terms of solubility, it has good solubility in common organic solvents such as ethanol, ether, and dichloromethane. This is because the intermolecular forces between organic solvents and the compound are similar, and they can be interspersed and mixed with each other to achieve a dissolved state.
The physical properties of 4- (bromomethyl) -2 -chloro-1 -fluorobenzene are determined by its molecular structure. In the fields of organic synthesis and chemical production, this property is crucial for its separation, purification and use.
What are the synthesis methods of 4- (bromomethyl) -2-chloro-1-fluorobenzene
There are several ways to synthesize 4- (bromomethyl) -2 -chloro-1 -fluorobenzene.
First, 2-chloro-1 -fluorobenzoic acid is used as the starting material. First, it is esterified with methanol under the catalysis of concentrated sulfuric acid to generate methyl 2-chloro-1 -fluorobenzoate. This process requires heating and reflux to make the reaction fully proceed. After that, the methyl ester is reduced to 2-chloro-1 -fluorobenzyl alcohol with a reducing agent such as sodium borohydride. The reaction conditions are relatively mild, and the reaction temperature and the amount of reducing agent need to be controlled. 4- (bromomethyl) -2 -chloro-1 -fluorobenzene was prepared by substituting the hydroxyl group in 2-chloro-1 -fluorobenzyl alcohol with bromine atom with phosphorus tribromide or hydrobromic acid. In this step, the reaction should pay attention to the dropwise addition speed and reaction time of the reaction reagent.
Second, 2-chloro-1 -fluorotoluene is used as the starting material. Using N-bromosuccinimide (NBS) as the bromination reagent, in the presence of an initiator such as benzoyl peroxide, it is heated and refluxed in an inert solvent such as carbon tetrachloride to carry out a free radical substitution reaction. The key to this reaction is to control the amount of NBS, the amount of initiator and the reaction temperature to ensure that the bromine atom selectively replaces the hydrogen atom at the benzyl position to generate the target product 4- (bromomethyl) -2 -chloro-1 -fluorobenzene.
Third, start from 2-chloro-1 -fluorobenzaldehyde. First, the aldehyde group is reduced to hydroxymethyl with a reducing agent such as sodium borohydride to obtain 2-chloro-1 -fluorobenzyl alcohol. Pay attention to the pH and temperature of the reaction system during operation. Subsequently, the same as the above method with 2-chloro-1-fluorobenzyl alcohol as the intermediate, the hydroxyl group is converted into bromine atom with a suitable brominating agent to achieve the synthesis of 4- (bromomethyl) -2 -chloro-1 -fluorobenzene.
The above synthesis methods have their own advantages and disadvantages. In actual operation, it is necessary to comprehensively consider the availability of raw materials, the difficulty of reaction conditions, and the purity of the product to choose the appropriate method.
First, 2-chloro-1 -fluorobenzoic acid is used as the starting material. First, it is esterified with methanol under the catalysis of concentrated sulfuric acid to generate methyl 2-chloro-1 -fluorobenzoate. This process requires heating and reflux to make the reaction fully proceed. After that, the methyl ester is reduced to 2-chloro-1 -fluorobenzyl alcohol with a reducing agent such as sodium borohydride. The reaction conditions are relatively mild, and the reaction temperature and the amount of reducing agent need to be controlled. 4- (bromomethyl) -2 -chloro-1 -fluorobenzene was prepared by substituting the hydroxyl group in 2-chloro-1 -fluorobenzyl alcohol with bromine atom with phosphorus tribromide or hydrobromic acid. In this step, the reaction should pay attention to the dropwise addition speed and reaction time of the reaction reagent.
Second, 2-chloro-1 -fluorotoluene is used as the starting material. Using N-bromosuccinimide (NBS) as the bromination reagent, in the presence of an initiator such as benzoyl peroxide, it is heated and refluxed in an inert solvent such as carbon tetrachloride to carry out a free radical substitution reaction. The key to this reaction is to control the amount of NBS, the amount of initiator and the reaction temperature to ensure that the bromine atom selectively replaces the hydrogen atom at the benzyl position to generate the target product 4- (bromomethyl) -2 -chloro-1 -fluorobenzene.
Third, start from 2-chloro-1 -fluorobenzaldehyde. First, the aldehyde group is reduced to hydroxymethyl with a reducing agent such as sodium borohydride to obtain 2-chloro-1 -fluorobenzyl alcohol. Pay attention to the pH and temperature of the reaction system during operation. Subsequently, the same as the above method with 2-chloro-1-fluorobenzyl alcohol as the intermediate, the hydroxyl group is converted into bromine atom with a suitable brominating agent to achieve the synthesis of 4- (bromomethyl) -2 -chloro-1 -fluorobenzene.
The above synthesis methods have their own advantages and disadvantages. In actual operation, it is necessary to comprehensively consider the availability of raw materials, the difficulty of reaction conditions, and the purity of the product to choose the appropriate method.
4- (bromomethyl) -2-chloro-1-fluorobenzene what are the precautions during storage and transportation
4- (bromomethyl) -2 -chloro-1 -fluorobenzene is an organic compound. When storing and transporting, many matters should be paid attention to.
It is active and has certain reactivity. When exposed to heat, open flame or oxidant, it is easy to cause violent reactions, and even combustion and explosion. Therefore, when storing, it should be placed in a cool, well-ventilated place, away from fire and heat sources. The temperature of the warehouse should not exceed 30 ° C, and the relative humidity should not exceed 80%.
Because of its halogen atom, it may be toxic and irritating to the human body. It can cause health damage through inhalation, ingestion or skin contact. During storage and transportation, operators must wear appropriate protective equipment, such as gas masks, chemical protective clothing, and protective gloves, to prevent contact and inhalation.
Furthermore, 4- (bromomethyl) -2-chloro-1-fluorobenzene may be harmful to the environment and should be avoided from leaking into the environment. If a leak occurs during transportation, it is necessary to quickly isolate the leaked contaminated area and restrict personnel from entering and leaving. Emergency personnel should wear self-contained positive pressure breathing apparatus and protective clothing. Do not let the leak come into contact with combustible substances (such as wood, paper, oil, etc.). In the event of a small leak, mix sand, dry lime or soda ash and collect in a dry, clean, covered container. When there is a large amount of leakage, a dike or a pit should be built to contain it, covered with foam to reduce steam disasters, and then transferred to a tanker or a special collector by pump, recycled or transported to a waste treatment site for disposal.
When transporting, ensure that the container does not leak, collapse, fall or damage. It is strictly forbidden to mix and transport with oxidants, acids, edible chemicals, etc. During transportation, it should be protected from sun exposure, rain and high temperature. When transporting by road, follow the prescribed route and do not stop in residential areas and densely populated areas. In this way, the safety of storage and transportation can be guaranteed.
It is active and has certain reactivity. When exposed to heat, open flame or oxidant, it is easy to cause violent reactions, and even combustion and explosion. Therefore, when storing, it should be placed in a cool, well-ventilated place, away from fire and heat sources. The temperature of the warehouse should not exceed 30 ° C, and the relative humidity should not exceed 80%.
Because of its halogen atom, it may be toxic and irritating to the human body. It can cause health damage through inhalation, ingestion or skin contact. During storage and transportation, operators must wear appropriate protective equipment, such as gas masks, chemical protective clothing, and protective gloves, to prevent contact and inhalation.
Furthermore, 4- (bromomethyl) -2-chloro-1-fluorobenzene may be harmful to the environment and should be avoided from leaking into the environment. If a leak occurs during transportation, it is necessary to quickly isolate the leaked contaminated area and restrict personnel from entering and leaving. Emergency personnel should wear self-contained positive pressure breathing apparatus and protective clothing. Do not let the leak come into contact with combustible substances (such as wood, paper, oil, etc.). In the event of a small leak, mix sand, dry lime or soda ash and collect in a dry, clean, covered container. When there is a large amount of leakage, a dike or a pit should be built to contain it, covered with foam to reduce steam disasters, and then transferred to a tanker or a special collector by pump, recycled or transported to a waste treatment site for disposal.
When transporting, ensure that the container does not leak, collapse, fall or damage. It is strictly forbidden to mix and transport with oxidants, acids, edible chemicals, etc. During transportation, it should be protected from sun exposure, rain and high temperature. When transporting by road, follow the prescribed route and do not stop in residential areas and densely populated areas. In this way, the safety of storage and transportation can be guaranteed.
What are the effects of 4- (bromomethyl) -2-chloro-1-fluorobenzene on the environment and human health?
4- (bromomethyl) -2 -chloro-1 -fluorobenzene is one of the organic compounds. Such halogenated aromatic compounds have potential effects on the environment and human health.
At the environmental level, this compound is difficult to be degraded by the natural environment due to its stable chemical structure. If released in the environment, it can be retained for a long time. It may migrate and diffuse through water, soil, air and other media. Inflow into water bodies can cause water pollution and endanger the survival of aquatic organisms. After ingestion by aquatic organisms, or enrichment in the body, it can be transmitted along the food chain, affecting higher trophic organisms. Entering soil can change the physical and chemical properties of soil, affect the activities of soil microorganisms and plant growth.
Related to human health, 4- (bromomethyl) -2-chloro-1-fluorobenzene may be toxic. It enters the human body through respiratory inhalation, skin contact or accidental ingestion. It may interfere with the normal physiological functions of the human body, affect the nervous system, endocrine system, etc. Studies have shown that such halogenated aromatics may have the risk of mutation and carcinogenesis. Long-term exposure to this compound environment may damage the genetic material of human cells, causing genetic mutations and increasing the risk of cancer. And it also has irritating effects on the skin, eyes, respiratory tract, etc., causing skin allergies, eye pain, cough and other symptoms.
In conclusion, 4- (bromomethyl) -2-chloro-1-fluorobenzene poses a potential threat to both the environment and human health, and should be treated with caution and strengthened control to reduce its harm to the ecological environment and human health.
At the environmental level, this compound is difficult to be degraded by the natural environment due to its stable chemical structure. If released in the environment, it can be retained for a long time. It may migrate and diffuse through water, soil, air and other media. Inflow into water bodies can cause water pollution and endanger the survival of aquatic organisms. After ingestion by aquatic organisms, or enrichment in the body, it can be transmitted along the food chain, affecting higher trophic organisms. Entering soil can change the physical and chemical properties of soil, affect the activities of soil microorganisms and plant growth.
Related to human health, 4- (bromomethyl) -2-chloro-1-fluorobenzene may be toxic. It enters the human body through respiratory inhalation, skin contact or accidental ingestion. It may interfere with the normal physiological functions of the human body, affect the nervous system, endocrine system, etc. Studies have shown that such halogenated aromatics may have the risk of mutation and carcinogenesis. Long-term exposure to this compound environment may damage the genetic material of human cells, causing genetic mutations and increasing the risk of cancer. And it also has irritating effects on the skin, eyes, respiratory tract, etc., causing skin allergies, eye pain, cough and other symptoms.
In conclusion, 4- (bromomethyl) -2-chloro-1-fluorobenzene poses a potential threat to both the environment and human health, and should be treated with caution and strengthened control to reduce its harm to the ecological environment and human health.
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