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4-(Bromomethyl)-2-Chloro-1-(Trifluoromethoxy)Benzene
Linshang Chemical
|
HS Code |
761050 |
| Chemical Formula | C8H5BrClF3O |
| Molecular Weight | 291.48 |
| Appearance | Solid (likely) |
| Boiling Point | Unknown |
| Melting Point | Unknown |
| Density | Unknown |
| Solubility In Water | Low (hydrophobic due to fluorine and bromine groups) |
| Solubility In Organic Solvents | Good solubility in common organic solvents like dichloromethane, chloroform |
| Vapor Pressure | Low (due to its relatively high molecular weight and non - volatile groups) |
| Flash Point | Unknown |
| Stability | Stable under normal conditions, but may react with strong oxidizing or reducing agents |
As an accredited 4-(Bromomethyl)-2-Chloro-1-(Trifluoromethoxy)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4-(bromomethyl)-2 -chloro-1-(trifluoromethoxy)benzene in sealed chemical - grade vial. |
| Storage | Store 4-(bromomethyl)-2-chloro-1-(trifluoromethoxy)benzene in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Use a tightly - sealed container made of corrosion - resistant material, such as glass or specific plastics, to prevent leakage and contact with air and moisture, which could potentially lead to decomposition or reaction. |
| Shipping | 4-(Bromomethyl)-2-chloro-1-(trifluoromethoxy)benzene is shipped in well - sealed, corrosion - resistant containers. Special care is taken to ensure compliance with chemical transportation regulations to prevent leakage and ensure safety during transit. |
Competitive 4-(Bromomethyl)-2-Chloro-1-(Trifluoromethoxy)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What is the main use of 4- (bromomethyl) -2-chloro-1- (trifluoromethoxy) benzene?
4- (bromomethyl) -2 -chloro-1- (trifluoromethoxy) benzene is one of the organic compounds. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
In pharmaceutical chemistry, this compound can be used as a starting material to prepare drug molecules with specific biological activities. Because its structure contains functional groups such as bromomethyl, chlorine atom and trifluoromethoxy group, these functional groups endow the molecule with unique physical and chemical properties, can interact with targets in organisms, or lay the foundation for the development of new drugs.
In the field of materials science, it also has potential applications. By means of organic synthesis, introducing it into the structure of polymer materials may improve the properties of materials, such as improving the thermal stability and chemical stability of materials, or even endowing materials with special optical and electrical properties to meet the needs of high-performance materials in different fields.
In addition, in the field of pesticide chemistry, this compound may also have a place. Due to its functional group characteristics, it may be used to synthesize pesticide ingredients with insecticidal, bactericidal or herbicidal activities, contributing to the pest control of agricultural production. In conclusion, 4 - (bromomethyl) - 2 - chloro - 1 - (trifluoromethoxy) benzene has shown important application value in many fields due to its unique structure, providing an important material basis for the development of organic synthetic chemistry and related industries.
In pharmaceutical chemistry, this compound can be used as a starting material to prepare drug molecules with specific biological activities. Because its structure contains functional groups such as bromomethyl, chlorine atom and trifluoromethoxy group, these functional groups endow the molecule with unique physical and chemical properties, can interact with targets in organisms, or lay the foundation for the development of new drugs.
In the field of materials science, it also has potential applications. By means of organic synthesis, introducing it into the structure of polymer materials may improve the properties of materials, such as improving the thermal stability and chemical stability of materials, or even endowing materials with special optical and electrical properties to meet the needs of high-performance materials in different fields.
In addition, in the field of pesticide chemistry, this compound may also have a place. Due to its functional group characteristics, it may be used to synthesize pesticide ingredients with insecticidal, bactericidal or herbicidal activities, contributing to the pest control of agricultural production. In conclusion, 4 - (bromomethyl) - 2 - chloro - 1 - (trifluoromethoxy) benzene has shown important application value in many fields due to its unique structure, providing an important material basis for the development of organic synthetic chemistry and related industries.
What are the synthesis methods of 4- (bromomethyl) -2-chloro-1- (trifluoromethoxy) benzene
To prepare 4 - (bromomethyl) -2 - chloro-1 - (trifluoromethoxy) benzene, it can be done by number method.
First, the benzene derivative containing the corresponding substituent is used as the starting material, and bromomethyl is introduced by halogenation reaction. For example, take 2-chloro-1 - (trifluoromethoxy) benzene first, and under suitable reaction conditions, use N-bromosuccinimide (NBS) as the bromine source and azobisisobutyronitrile (AIBN) as the initiator. In an inert solvent such as carbon tetrachloride, the hydrogen atom at a specific position on the benzene ring can be replaced by bromomethyl, and then the target product can be obtained. The key to this reaction is to control the reaction temperature and the amount of reagents to ensure the selectivity and yield of the reaction.
Second, the target molecule can be constructed by nucleophilic substitution reaction. First prepare benzene intermediates containing suitable leaving groups, such as 2-chloro-1- (trifluoromethoxy) -4 - (halomethyl) benzene (halogen atoms can be chlorine, iodine, etc.), and then use brominating reagents such as potassium bromide or sodium bromide, in polar aprotic solvents such as dimethylformamide (DMF), react at appropriate temperatures, and the halogen atoms are replaced by bromide ion nucleophilic to generate 4- (bromomethyl) -2 -chloro-1- (trifluoromethoxy) benzene. This process requires attention to the choice of solvent and the control of reaction time to improve the reaction efficiency.
Or, to gradually construct a substituent strategy. First, chlorine atoms and trifluoromethoxy groups are introduced into the benzene ring, and then bromomethyl groups are introduced through a series of reactions. It can be started from benzene, chlorinated to obtain chlorobenzene, and then trifluoromethoxy groups are introduced through a specific reaction, and then bromomethyl groups are introduced according to the above similar method. Although this approach has many steps, the selectivity of each step is easy to control, which is beneficial for obtaining high-purity target products.
In conclusion, the methods for synthesizing 4- (bromomethyl) -2 -chloro-1- (trifluoromethoxy) benzene are diverse, and the optimal synthesis route should be carefully selected according to the actual situation, such as the availability of raw materials, the controllability of reaction conditions, and the purity requirements of the target product.
First, the benzene derivative containing the corresponding substituent is used as the starting material, and bromomethyl is introduced by halogenation reaction. For example, take 2-chloro-1 - (trifluoromethoxy) benzene first, and under suitable reaction conditions, use N-bromosuccinimide (NBS) as the bromine source and azobisisobutyronitrile (AIBN) as the initiator. In an inert solvent such as carbon tetrachloride, the hydrogen atom at a specific position on the benzene ring can be replaced by bromomethyl, and then the target product can be obtained. The key to this reaction is to control the reaction temperature and the amount of reagents to ensure the selectivity and yield of the reaction.
Second, the target molecule can be constructed by nucleophilic substitution reaction. First prepare benzene intermediates containing suitable leaving groups, such as 2-chloro-1- (trifluoromethoxy) -4 - (halomethyl) benzene (halogen atoms can be chlorine, iodine, etc.), and then use brominating reagents such as potassium bromide or sodium bromide, in polar aprotic solvents such as dimethylformamide (DMF), react at appropriate temperatures, and the halogen atoms are replaced by bromide ion nucleophilic to generate 4- (bromomethyl) -2 -chloro-1- (trifluoromethoxy) benzene. This process requires attention to the choice of solvent and the control of reaction time to improve the reaction efficiency.
Or, to gradually construct a substituent strategy. First, chlorine atoms and trifluoromethoxy groups are introduced into the benzene ring, and then bromomethyl groups are introduced through a series of reactions. It can be started from benzene, chlorinated to obtain chlorobenzene, and then trifluoromethoxy groups are introduced through a specific reaction, and then bromomethyl groups are introduced according to the above similar method. Although this approach has many steps, the selectivity of each step is easy to control, which is beneficial for obtaining high-purity target products.
In conclusion, the methods for synthesizing 4- (bromomethyl) -2 -chloro-1- (trifluoromethoxy) benzene are diverse, and the optimal synthesis route should be carefully selected according to the actual situation, such as the availability of raw materials, the controllability of reaction conditions, and the purity requirements of the target product.
What are the physical properties of 4- (bromomethyl) -2-chloro-1- (trifluoromethoxy) benzene
4- (bromomethyl) -2 -chloro-1- (trifluoromethoxy) benzene, the properties of this substance, let me come to you.
Looking at its properties, at room temperature, it is probably a colorless to light yellow liquid, or a white solid, depending on environmental conditions. Its odor may have a slightly special aromatic smell, but its taste is not strong and pungent, and it is still within the range of perception.
When it comes to solubility, this substance has a certain solubility in organic solvents, such as common ethanol, ether, dichloromethane, etc. This is because the molecular structure of organic solvents is similar to 4- (bromomethyl) -2 -chloro-1- (trifluoromethoxy) benzene, and follows the principle of similar compatibility. However, in water, its solubility is very small, because its molecular structure contains more hydrophobic groups, such as trifluoromethoxy, etc., so it is difficult to mix with water.
As for the melting point, the melting point is about [X] ℃, and the boiling point is about [X] ℃. The value of the melting boiling point in this way is determined by the intermolecular force. The presence of bromomethyl, chlorine atoms and trifluoromethoxy in the molecule enhances the intermolecular force, which in turn affects the melting boiling point.
In terms of density, it is about [X] g/cm ³, which is heavier than water, so if placed in water, it should sink to the bottom.
In addition, 4- (bromomethyl) -2 -chloro-1- (trifluoromethoxy) benzene has a certain chemical activity. Its bromomethyl part has high bromine atom activity and is prone to substitution reactions, which can be a key check point for many organic synthesis reactions. The existence of trifluoromethoxy also gives this substance its unique chemical properties and plays an important role in specific reactions.
This means that the physical properties of 4- (bromomethyl) -2 -chloro-1- (trifluoromethoxy) benzene are rough, and its application in the field of organic chemistry also depends on these physical properties.
Looking at its properties, at room temperature, it is probably a colorless to light yellow liquid, or a white solid, depending on environmental conditions. Its odor may have a slightly special aromatic smell, but its taste is not strong and pungent, and it is still within the range of perception.
When it comes to solubility, this substance has a certain solubility in organic solvents, such as common ethanol, ether, dichloromethane, etc. This is because the molecular structure of organic solvents is similar to 4- (bromomethyl) -2 -chloro-1- (trifluoromethoxy) benzene, and follows the principle of similar compatibility. However, in water, its solubility is very small, because its molecular structure contains more hydrophobic groups, such as trifluoromethoxy, etc., so it is difficult to mix with water.
As for the melting point, the melting point is about [X] ℃, and the boiling point is about [X] ℃. The value of the melting boiling point in this way is determined by the intermolecular force. The presence of bromomethyl, chlorine atoms and trifluoromethoxy in the molecule enhances the intermolecular force, which in turn affects the melting boiling point.
In terms of density, it is about [X] g/cm ³, which is heavier than water, so if placed in water, it should sink to the bottom.
In addition, 4- (bromomethyl) -2 -chloro-1- (trifluoromethoxy) benzene has a certain chemical activity. Its bromomethyl part has high bromine atom activity and is prone to substitution reactions, which can be a key check point for many organic synthesis reactions. The existence of trifluoromethoxy also gives this substance its unique chemical properties and plays an important role in specific reactions.
This means that the physical properties of 4- (bromomethyl) -2 -chloro-1- (trifluoromethoxy) benzene are rough, and its application in the field of organic chemistry also depends on these physical properties.
What are the chemical properties of 4- (bromomethyl) -2-chloro-1- (trifluoromethoxy) benzene
4- (bromomethyl) -2 -chloro-1- (trifluoromethoxy) benzene, this substance is an organic compound with unique chemical properties. In its structure, bromomethyl, chlorine atoms and trifluoromethoxy groups each show unique reactivity.
Let's talk about bromomethyl first, bromine atoms have high activity and are prone to nucleophilic substitution reactions. For example, in case of alcohols, bromine can be replaced by alkoxy groups to form corresponding ether compounds; in case of amines, bromine can be replaced by amino groups to construct nitrogen-containing organic compounds, which is crucial for the preparation of substances containing specific functional groups in organic synthesis.
Looking at the chlorine atom, although its activity is slightly less than that of bromomethyl, it can also participate in nucleophilic substitution. Under appropriate conditions, chlorine can be replaced by other nucleophilic reagents, such as cyanyl groups, which can grow the carbon chain and lay the foundation for the synthesis of complex organic molecules.
The trifluoromethoxy group, due to the extremely high electronegativity of fluorine atoms, makes the group have strong electron absorption. This property affects the electron cloud density of the benzene ring, reducing the electron cloud density of the benzene ring o and para-position, which in turn decreases the activity of the electrophilic substitution reaction of the benzene ring, and the reaction conditions are more harsh. At the same time, the trifluoromethoxy group endows compounds with a certain lipid solubility and chemical stability. In the field of
In addition, due to the presence of multiple halogen atoms, the compound may undergo elimination reactions at high temperatures or in the presence of specific catalysts, forming unsaturated bonds, introducing new reaction check points and structural diversity for organic synthesis.
Overall, 4- (bromomethyl) -2-chloro-1- (trifluoromethoxy) benzene has rich chemical properties and has important application potential in organic synthesis, drug development and other fields. By rationally designing the reaction, a variety of organic compounds with unique functions can be prepared.
Let's talk about bromomethyl first, bromine atoms have high activity and are prone to nucleophilic substitution reactions. For example, in case of alcohols, bromine can be replaced by alkoxy groups to form corresponding ether compounds; in case of amines, bromine can be replaced by amino groups to construct nitrogen-containing organic compounds, which is crucial for the preparation of substances containing specific functional groups in organic synthesis.
Looking at the chlorine atom, although its activity is slightly less than that of bromomethyl, it can also participate in nucleophilic substitution. Under appropriate conditions, chlorine can be replaced by other nucleophilic reagents, such as cyanyl groups, which can grow the carbon chain and lay the foundation for the synthesis of complex organic molecules.
The trifluoromethoxy group, due to the extremely high electronegativity of fluorine atoms, makes the group have strong electron absorption. This property affects the electron cloud density of the benzene ring, reducing the electron cloud density of the benzene ring o and para-position, which in turn decreases the activity of the electrophilic substitution reaction of the benzene ring, and the reaction conditions are more harsh. At the same time, the trifluoromethoxy group endows compounds with a certain lipid solubility and chemical stability. In the field of
In addition, due to the presence of multiple halogen atoms, the compound may undergo elimination reactions at high temperatures or in the presence of specific catalysts, forming unsaturated bonds, introducing new reaction check points and structural diversity for organic synthesis.
Overall, 4- (bromomethyl) -2-chloro-1- (trifluoromethoxy) benzene has rich chemical properties and has important application potential in organic synthesis, drug development and other fields. By rationally designing the reaction, a variety of organic compounds with unique functions can be prepared.
What are the precautions for 4- (bromomethyl) -2-chloro-1- (trifluoromethoxy) benzene during storage and transportation?
For 4- (bromomethyl) -2 -chloro-1- (trifluoromethoxy) benzene, many matters should be paid attention to during storage and transportation.
This compound has the characteristics of halogenated hydrocarbons. Bromomethyl and chlorine atoms are highly active. In contact with water or moisture, it is easy to hydrolyze and cause product deterioration. Therefore, it must be stored in a dry place, and the container used should be well airtight to prevent moisture from invading.
In addition, it contains trifluoromethoxy, and fluorine-containing organic compounds are mostly toxic and corrosive. When storing, it should be kept away from fire and heat sources, because it is heated or exposed to open flames, or it may cause danger, and even cause combustion and explosion. During transportation, it is also necessary to strictly control the temperature to avoid it in a high temperature environment.
This compound may be harmful to the human body, and safety procedures should be strictly followed during operation. The storage place should be well ventilated to reduce the concentration of compounds in the air and prevent the operator from inhaling. During transportation, the packaging materials must have good protective properties and be marked with clear warning labels so that the transporter can understand its danger.
In addition, 4- (bromomethyl) -2 -chloro-1- (trifluoromethoxy) benzene may react with other chemicals. When storing, it should be stored separately from oxidants, reducing agents, alkalis, etc., and mixed storage and mixed transportation are prohibited to prevent dangerous interactions. Before transportation, it is also necessary to know the surrounding environment of the transportation route in detail and avoid densely populated areas or environmentally sensitive areas to prevent accidental leakage from causing serious consequences.
This compound has the characteristics of halogenated hydrocarbons. Bromomethyl and chlorine atoms are highly active. In contact with water or moisture, it is easy to hydrolyze and cause product deterioration. Therefore, it must be stored in a dry place, and the container used should be well airtight to prevent moisture from invading.
In addition, it contains trifluoromethoxy, and fluorine-containing organic compounds are mostly toxic and corrosive. When storing, it should be kept away from fire and heat sources, because it is heated or exposed to open flames, or it may cause danger, and even cause combustion and explosion. During transportation, it is also necessary to strictly control the temperature to avoid it in a high temperature environment.
This compound may be harmful to the human body, and safety procedures should be strictly followed during operation. The storage place should be well ventilated to reduce the concentration of compounds in the air and prevent the operator from inhaling. During transportation, the packaging materials must have good protective properties and be marked with clear warning labels so that the transporter can understand its danger.
In addition, 4- (bromomethyl) -2 -chloro-1- (trifluoromethoxy) benzene may react with other chemicals. When storing, it should be stored separately from oxidants, reducing agents, alkalis, etc., and mixed storage and mixed transportation are prohibited to prevent dangerous interactions. Before transportation, it is also necessary to know the surrounding environment of the transportation route in detail and avoid densely populated areas or environmentally sensitive areas to prevent accidental leakage from causing serious consequences.
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