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(4-Carboxy-3-Chloro)Benzeneboronic Acid
Linshang Chemical
|
HS Code |
657233 |
| Name | (4 - Carboxy - 3 - Chloro)Benzeneboronic Acid |
| Chemical Formula | C7H6BClO4 |
| Molar Mass | 200.39 g/mol |
| Appearance | Solid (usually white or off - white powder) |
| Solubility | Soluble in some polar solvents like DMSO, methanol |
| Pka Carboxyl Group | Around 3 - 5 |
| Pka Boronic Acid Group | Around 8 - 10 |
| Melting Point | Typically in the range of 150 - 180 °C (approximate, can vary depending on purity) |
| Boiling Point | Decomposes before boiling |
| Density | Approx. 1.5 - 1.7 g/cm³ (estimated) |
| Reactivity | Reacts with alcohols to form boronate esters, can participate in Suzuki - Miyaura coupling reactions |
As an accredited (4-Carboxy-3-Chloro)Benzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of (4 - carboxy - 3 - chloro)benzeneboronic Acid in sealed chemical - grade packaging. |
| Storage | (4 - carboxy - 3 - chloro)benzeneboronic acid should be stored in a cool, dry place. Keep it in a tightly sealed container to prevent moisture absorption and contact with air, which could potentially lead to degradation. Avoid storing near heat sources or reactive chemicals. Store at a temperature range of around 2 - 8°C if possible for optimal preservation of its chemical integrity. |
| Shipping | (4 - carboxy - 3 - chloro)benzeneboronic Acid is shipped in well - sealed containers, compliant with chemical transport regulations. Packaging ensures protection from moisture, heat, and physical damage during transit. |
Competitive (4-Carboxy-3-Chloro)Benzeneboronic Acid prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemical structure of (4-carboxy-3-chloro) benzeneboronic Acid?
(4-Carboxyl-3-chloro) phenylboronic acid, according to its name, is a kind of organic compound. Its core structure is a benzene ring, which is a common cyclic structure in organic chemistry. On the benzene ring, there are specific substituents.
First, there is a carboxyl group (-COOH), which is acidic and can often exhibit unique chemical properties in many organic reactions. It can participate in esterification, salt formation and other reactions. Second, the introduction of chlorine atoms (-Cl), the introduction of chlorine atoms will affect the polarity, spatial structure and reactivity of molecules, and it can participate in nucleophilic substitution and other reactions. Third, there are boric acid groups (-B (OH) -2), which are widely used in the field of organic synthesis. They are often used as key reaction check points and can participate in important reactions such as the construction of carbon-carbon bonds.
Placing these three on the benzene ring, the substitution of different positions will make the electron cloud distribution and steric hindrance of the molecule as a whole different, thus endowing (4-carboxyl-3-chloro) phenylboronic acid with unique physical and chemical properties. It may have important uses in many fields such as organic synthesis and pharmaceutical chemistry, or can be used as a key intermediate in the synthesis of specific drugs and functional materials.
First, there is a carboxyl group (-COOH), which is acidic and can often exhibit unique chemical properties in many organic reactions. It can participate in esterification, salt formation and other reactions. Second, the introduction of chlorine atoms (-Cl), the introduction of chlorine atoms will affect the polarity, spatial structure and reactivity of molecules, and it can participate in nucleophilic substitution and other reactions. Third, there are boric acid groups (-B (OH) -2), which are widely used in the field of organic synthesis. They are often used as key reaction check points and can participate in important reactions such as the construction of carbon-carbon bonds.
Placing these three on the benzene ring, the substitution of different positions will make the electron cloud distribution and steric hindrance of the molecule as a whole different, thus endowing (4-carboxyl-3-chloro) phenylboronic acid with unique physical and chemical properties. It may have important uses in many fields such as organic synthesis and pharmaceutical chemistry, or can be used as a key intermediate in the synthesis of specific drugs and functional materials.
What are the main uses of (4-carboxy-3-chloro) benzeneboronic Acid
(4-Carboxyl-3-chloro) phenylboronic acid is a crucial chemical reagent in organic synthesis. It has a wide range of uses and is often a key building block for the construction of new drug molecules in the field of medicinal chemistry. Due to its unique structure, it can be coupled with many organic halides through the formation of boron-carbon bonds, thus accurately building a complex drug skeleton and assisting in the development of new anti-infection, anti-tumor and other drugs.
In the field of materials science, it also has important applications. It can participate in the preparation of functionalized organic materials, such as for the synthesis of conjugated polymers with specific photoelectric properties. By copolymerizing with other monomers, materials are endowed with unique electron transport and optical properties, which have broad prospects in the field of optoelectronic devices such as organic Light Emitting Diodes (OLEDs) and organic solar cells.
Furthermore, in the field of chemical biology, it may be used as a key component of biological probes. Using the interaction between boron atoms and specific molecules in organisms to realize the labeling and detection of biomolecules is conducive to in-depth study of physiological and pathological processes in organisms. In short, (4-carboxyl-3-chloro) phenylboronic acid plays an important role in many fields and promotes the development and progress of related disciplines due to its own structural characteristics.
In the field of materials science, it also has important applications. It can participate in the preparation of functionalized organic materials, such as for the synthesis of conjugated polymers with specific photoelectric properties. By copolymerizing with other monomers, materials are endowed with unique electron transport and optical properties, which have broad prospects in the field of optoelectronic devices such as organic Light Emitting Diodes (OLEDs) and organic solar cells.
Furthermore, in the field of chemical biology, it may be used as a key component of biological probes. Using the interaction between boron atoms and specific molecules in organisms to realize the labeling and detection of biomolecules is conducive to in-depth study of physiological and pathological processes in organisms. In short, (4-carboxyl-3-chloro) phenylboronic acid plays an important role in many fields and promotes the development and progress of related disciplines due to its own structural characteristics.
What is the synthesis method of (4-carboxy-3-chloro) benzeneboronic Acid
The synthesis of (4-carboxyl-3-chloro) phenylboronic acid is an important task in organic synthetic chemistry. To prepare this substance, a common method can be started from a suitable aromatic halide.
First take the chlorine-containing and carboxylated aromatic halide. The halogen atom of this halide can react with the boron reagent under specific conditions through a metal-catalyzed reaction. For example, with a metal catalyst such as palladium or nickel, in the presence of suitable ligands and bases, halogenated aromatics react with boron reagents such as diphenol diboron (pinacol borane), which is a key step in the formation of carbon-boron bonds. After this reaction, boron-containing intermediates can be obtained.
Subsequently, the intermediate product is carboxylated. Carboxyl groups can be introduced by the reaction of metal-organic reagents with carbon dioxide, such as Grignard reagents with carbon dioxide, or organic lithium reagents with carbon dioxide. Grignard reagents can be prepared from boron-containing intermediates and magnesium in ether solvents, and then introduced into carbon dioxide gas, and hydrolyzed to obtain (4-carboxyl-3-chloro) phenylboronic acid.
Or there may be other methods, starting from carboxyl-containing aromatic compounds, boron groups are introduced first. However, this approach requires attention to the control of reaction conditions, because carboxyl groups may affect the reaction of boron group introduction. At this time, it is necessary to choose a suitable protecting group to protect the carboxyl group when the boron group is introduced into the reaction. After the reaction is completed, the protecting group is removed to obtain the target product. In short, the synthesis of (4-carboxyl-3-chloro) phenylboronic acid needs to be weighed according to the availability of raw materials, the ease of control of reaction conditions and the yield, and the appropriate method is selected.
First take the chlorine-containing and carboxylated aromatic halide. The halogen atom of this halide can react with the boron reagent under specific conditions through a metal-catalyzed reaction. For example, with a metal catalyst such as palladium or nickel, in the presence of suitable ligands and bases, halogenated aromatics react with boron reagents such as diphenol diboron (pinacol borane), which is a key step in the formation of carbon-boron bonds. After this reaction, boron-containing intermediates can be obtained.
Subsequently, the intermediate product is carboxylated. Carboxyl groups can be introduced by the reaction of metal-organic reagents with carbon dioxide, such as Grignard reagents with carbon dioxide, or organic lithium reagents with carbon dioxide. Grignard reagents can be prepared from boron-containing intermediates and magnesium in ether solvents, and then introduced into carbon dioxide gas, and hydrolyzed to obtain (4-carboxyl-3-chloro) phenylboronic acid.
Or there may be other methods, starting from carboxyl-containing aromatic compounds, boron groups are introduced first. However, this approach requires attention to the control of reaction conditions, because carboxyl groups may affect the reaction of boron group introduction. At this time, it is necessary to choose a suitable protecting group to protect the carboxyl group when the boron group is introduced into the reaction. After the reaction is completed, the protecting group is removed to obtain the target product. In short, the synthesis of (4-carboxyl-3-chloro) phenylboronic acid needs to be weighed according to the availability of raw materials, the ease of control of reaction conditions and the yield, and the appropriate method is selected.
What are the physical properties of (4-carboxy-3-chloro) benzeneboronic Acid
(4-Carboxyl-3-chloro) phenylboronic acid, this substance is white to light yellow crystalline powder. Looking at its properties, it is often in a solid state and has good stability. However, in the environment of high temperature, high humidity or strong acid and alkali, it may decompose.
When it comes to solubility, it has a certain solubility in common organic solvents, such as methanol, ethanol, dichloromethane, etc., and is also slightly soluble in water. This solubility property makes it affected by many chemical operations, such as mixing and separation of substances during the reaction process.
Its melting point range is about 160-165 ° C. The value of this melting point is one of the important physical basis for identifying this compound. When heated to this temperature range, the substance will melt from the solid state to the liquid state. This phase transition process is of great significance in the purification and identification of compounds.
And because its molecular structure contains boron-oxygen bonds and carboxyl groups, it has a certain acidity. This acidic property plays a key role in the reaction mechanism of organic synthesis, can neutralize with bases, and can also participate in many catalytic reactions, showing unique chemical activities. And because of the specific electronic effect of its structure, its spectral properties are unique, and there are characteristic peaks in infrared spectroscopy and nuclear magnetic resonance spectroscopy, providing strong evidence for its structure identification and purity analysis.
When it comes to solubility, it has a certain solubility in common organic solvents, such as methanol, ethanol, dichloromethane, etc., and is also slightly soluble in water. This solubility property makes it affected by many chemical operations, such as mixing and separation of substances during the reaction process.
Its melting point range is about 160-165 ° C. The value of this melting point is one of the important physical basis for identifying this compound. When heated to this temperature range, the substance will melt from the solid state to the liquid state. This phase transition process is of great significance in the purification and identification of compounds.
And because its molecular structure contains boron-oxygen bonds and carboxyl groups, it has a certain acidity. This acidic property plays a key role in the reaction mechanism of organic synthesis, can neutralize with bases, and can also participate in many catalytic reactions, showing unique chemical activities. And because of the specific electronic effect of its structure, its spectral properties are unique, and there are characteristic peaks in infrared spectroscopy and nuclear magnetic resonance spectroscopy, providing strong evidence for its structure identification and purity analysis.
What is the market prospect of (4-carboxy-3-chloro) benzeneboronic Acid
(4-Carboxyl-3-chloro) phenylboronic acid, which has a promising future in today's chemical market.
Guanfu Chemical Industry, the demand for it in the field of organic synthesis is increasing. Due to its unique structure, the cover can be a key building block when building complex organic molecular structures. With the special reactivity of boron-carbon bonds, the transformation and connection of various functional groups can be conveniently realized, such as the Suzuki-Miyaura coupling reaction, which is a core step in pharmaceutical chemistry, materials science, and many other aspects. (4-carboxyl-3-chloro) phenylboronic acid is often an indispensable raw material to assist in the synthesis of novel drug molecules and high-performance materials, so it is increasingly important in the purchase list of pharmaceutical and materials companies.
Furthermore, in the field of materials science, with the exploration and research and development of new functional materials, (4-carboxyl-3-chloro) phenylboronic acid can be introduced into polymer systems by ingenious design to endow materials with specific properties such as fluorescence and self-assembly. It is suitable for the preparation of sensors, optical materials and other cutting-edge fields, which also opens up its wide field in the emerging material market.
From the perspective of market supply, although some companies are involved in its production, due to the rapid growth in demand, the overall supply is still in short supply. Therefore, many chemical producers are looking to expand their production capacity to meet the urgent needs of the market. And with the advancement of technology, the synthesis process is expected to be optimized, and the cost may be reduced. By then, its market competitiveness will be even stronger, and it will surely bloom more brilliantly on the stage of chemical products, leading related industries to new heights.
Guanfu Chemical Industry, the demand for it in the field of organic synthesis is increasing. Due to its unique structure, the cover can be a key building block when building complex organic molecular structures. With the special reactivity of boron-carbon bonds, the transformation and connection of various functional groups can be conveniently realized, such as the Suzuki-Miyaura coupling reaction, which is a core step in pharmaceutical chemistry, materials science, and many other aspects. (4-carboxyl-3-chloro) phenylboronic acid is often an indispensable raw material to assist in the synthesis of novel drug molecules and high-performance materials, so it is increasingly important in the purchase list of pharmaceutical and materials companies.
Furthermore, in the field of materials science, with the exploration and research and development of new functional materials, (4-carboxyl-3-chloro) phenylboronic acid can be introduced into polymer systems by ingenious design to endow materials with specific properties such as fluorescence and self-assembly. It is suitable for the preparation of sensors, optical materials and other cutting-edge fields, which also opens up its wide field in the emerging material market.
From the perspective of market supply, although some companies are involved in its production, due to the rapid growth in demand, the overall supply is still in short supply. Therefore, many chemical producers are looking to expand their production capacity to meet the urgent needs of the market. And with the advancement of technology, the synthesis process is expected to be optimized, and the cost may be reduced. By then, its market competitiveness will be even stronger, and it will surely bloom more brilliantly on the stage of chemical products, leading related industries to new heights.
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