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4-Carboxy-3-Chlorobenzeneboronic Acid 98%
Linshang Chemical
|
HS Code |
976884 |
| Name | 4-Carboxy-3-Chlorobenzeneboronic Acid 98% |
| Chemical Formula | C7H6BClO4 |
| Appearance | Solid (usually white to off - white powder) |
| Purity | 98% |
| Solubility | Soluble in some polar organic solvents like DMSO, slightly soluble in water |
| Melting Point | Typically in the range of 230 - 235 °C |
| Density | Data may vary, but approximate density can be around 1.5 - 1.6 g/cm³ |
| Stability | Stable under normal storage conditions, avoid strong oxidizing agents |
As an accredited 4-Carboxy-3-Chlorobenzeneboronic Acid 98% factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 98% 4 - carboxy - 3 - chlorobenzeneboronic acid in sealed chemical - grade packaging. |
| Storage | Store 4 - carboxy - 3 - chlorobenzeneboronic Acid (98%) in a cool, dry place away from heat sources and direct sunlight. Keep it in a tightly sealed container to prevent moisture absorption and contact with air, which could lead to degradation. Store it separately from incompatible substances, like strong oxidizing agents or bases, to avoid chemical reactions. |
| Shipping | 4 - carboxy - 3 - chlorobenzeneboronic Acid 98% will be shipped in well - sealed containers, compliant with chemical transportation regulations. Shipment will ensure protection from moisture and physical damage during transit. |
Competitive 4-Carboxy-3-Chlorobenzeneboronic Acid 98% prices that fit your budget—flexible terms and customized quotes for every order.
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4-carboxy-3-chlorobenzeneboronic Acid 98% of the main application fields
4-Carboxyl-3-chlorophenylboronic acid, with a purity of 98%, has a wide range of main application fields. In the field of medicinal chemistry, this compound can be used as a key intermediate. When synthesizing many biologically active drug molecules, its unique structure can be skillfully spliced with other molecular fragments by organic synthesis, so as to construct a drug structure with specific pharmacological effects. Because it contains active groups such as boron and carboxyl groups, it can participate in a variety of chemical reactions, such as coupling reactions, providing the possibility for the creation of new drugs.
In the field of materials science, this substance also has important uses. For example, in the preparation of functionalized organic-inorganic hybrid materials, 4-carboxyl-3-chlorophenylboronic acid can be used as an organic ligand to combine with metal ions or inorganic skeletons. Due to its structural properties, the material can be imparted special optical, electrical or catalytic properties. For example, sensing materials with high sensitivity and selectivity to specific gases can be prepared, and the interaction between them and the target gas molecules can initiate changes in the physical or chemical properties of the material, thereby enabling the detection of gases.
Furthermore, in the field of organic synthetic chemistry, 4-carboxyl-3-chlorophenylboronic acid is often used to construct complex aromatic compounds. In the palladium-catalyzed cross-coupling reaction, it can react with halogenated aromatics or olefins to achieve efficient construction of carbon-carbon bonds. This reaction is of key significance for the synthesis of polycyclic aromatic hydrocarbons and biphenyl compounds with specific substitution modes, and provides a powerful tool for organic synthesis chemists to prepare organic molecules with novel structures and unique functions, which are widely used in fine chemicals, total synthesis of natural products, and many other aspects.
In the field of materials science, this substance also has important uses. For example, in the preparation of functionalized organic-inorganic hybrid materials, 4-carboxyl-3-chlorophenylboronic acid can be used as an organic ligand to combine with metal ions or inorganic skeletons. Due to its structural properties, the material can be imparted special optical, electrical or catalytic properties. For example, sensing materials with high sensitivity and selectivity to specific gases can be prepared, and the interaction between them and the target gas molecules can initiate changes in the physical or chemical properties of the material, thereby enabling the detection of gases.
Furthermore, in the field of organic synthetic chemistry, 4-carboxyl-3-chlorophenylboronic acid is often used to construct complex aromatic compounds. In the palladium-catalyzed cross-coupling reaction, it can react with halogenated aromatics or olefins to achieve efficient construction of carbon-carbon bonds. This reaction is of key significance for the synthesis of polycyclic aromatic hydrocarbons and biphenyl compounds with specific substitution modes, and provides a powerful tool for organic synthesis chemists to prepare organic molecules with novel structures and unique functions, which are widely used in fine chemicals, total synthesis of natural products, and many other aspects.
What are the 98% physical and chemical properties of 4-carboxy-3-chlorobenzeneboronic Acid?
4-Carboxyl-3-chlorophenylboronic acid, with a content of 98%, is an important member of organic chemicals. This substance is a white to quasi-white solid and is quite stable at room temperature and pressure. Its melting point is in a specific range, which has a profound impact on its application in chemical synthesis. The exact value of the melting point is of great significance in accurately controlling the reaction conditions and determining the reaction process.
In terms of solubility, 4-carboxyl-3-chlorophenylboronic acid has a certain solubility in common organic solvents such as methanol and ethanol, but is insoluble in non-polar solvents such as n-hexane. This difference in solubility is a key consideration in the separation, purification and choice of reaction solvents.
In chemical reactions, both the boron group and the carboxyl group of the compound have high reactivity. Boron groups can participate in classic organic synthesis reactions such as Suzuki coupling reactions. With such reactions, carbon-carbon bonds can be efficiently constructed, which is widely used in drug synthesis, materials science and many other fields. Carboxyl groups can be esterified, amidated and other reactions. Through these reactions, the structure of the compound can be modified, giving it more unique properties.
In addition, 4-carboxyl-3-chlorophenylboronic acid is sensitive to humidity, and moisture can easily cause it to deteriorate, which affects the reaction effect. Therefore, it is necessary to ensure that the environment is dry and sealed properly when storing. In practical operation, it should be sealed quickly after use to avoid long-term exposure to air. This compound is widely used in the field of organic synthesis, and understanding its physicochemical properties is essential for rational application and optimization of the reaction.
In terms of solubility, 4-carboxyl-3-chlorophenylboronic acid has a certain solubility in common organic solvents such as methanol and ethanol, but is insoluble in non-polar solvents such as n-hexane. This difference in solubility is a key consideration in the separation, purification and choice of reaction solvents.
In chemical reactions, both the boron group and the carboxyl group of the compound have high reactivity. Boron groups can participate in classic organic synthesis reactions such as Suzuki coupling reactions. With such reactions, carbon-carbon bonds can be efficiently constructed, which is widely used in drug synthesis, materials science and many other fields. Carboxyl groups can be esterified, amidated and other reactions. Through these reactions, the structure of the compound can be modified, giving it more unique properties.
In addition, 4-carboxyl-3-chlorophenylboronic acid is sensitive to humidity, and moisture can easily cause it to deteriorate, which affects the reaction effect. Therefore, it is necessary to ensure that the environment is dry and sealed properly when storing. In practical operation, it should be sealed quickly after use to avoid long-term exposure to air. This compound is widely used in the field of organic synthesis, and understanding its physicochemical properties is essential for rational application and optimization of the reaction.
What are the 98% synthesis methods of 4-carboxy-3-chlorobenzeneboronic Acid?
The preparation of 4-carboxy-3-chlorophenylboronic acid (4-carboxy-3-chlorobenzeneboronic Acid) is often obtained by multi-step reaction with the corresponding halogenated aromatics as the starting material.
The starting material or 3-chloro-4-halobenzoic acid is selected, and the halogen atom can be bromine or iodine. First, in a low temperature and anhydrous environment, it is treated with a strong base such as n-butyllithium or isopropyl magnesium chloride-lithium chloride complex. n-butyllithium has very high activity and reacts violently in contact with water, so the operation needs to be operated in an anhydrous and oxygen-free nitrogen or argon protective atmosphere. During the reaction, the strong base captures the hydrogen atom in the ortho-position of the halogen atom to form a highly reactive aryl lithium intermediate.
Subsequently, this aryl lithium intermediate is mixed with borate esters, such as trimethyl borate or triisopropyl borate. The aryl lithium and borate esters undergo nucleophilic substitution, and the lithium atom is replaced by borate ester groups to form boron-containing intermediates.
Next, the above boron-containing intermediates are treated with dilute acids, such as dilute hydrochloric acid or dilute sulfuric acid. This step aims to hydrolyze the borate ester and convert it into a boric acid group, resulting in a crude product of 4-carboxyl-3-chlorophenylboronic acid.
Crude products often contain impurities and need to be purified by recrystallization or column During recrystallization, depending on the difference in solubility of the product in different solvents, select a suitable solvent, such as ethanol-water mixed solvent, heat to dissolve the crude product, and cool the crystallization to obtain a pure product. Column chromatography uses a stationary phase such as silica gel to elute with a suitable eluent, such as a petroleum ether-ethyl acetate mixture, and separates impurities and products according to the difference between adsorption and elution.
In addition, there are also methods for preparation by palladium-catalyzed coupling reaction as a key step. Using 3-chloro-4-halobenzoic acid and pinacol borane as raw materials, the reaction is carried out in the presence of palladium catalysts such as tetrakis (triphenylphosphine) palladium (0), ligands and bases Palladium catalyst activates halogen atom and boron reagent, promotes coupling to form corresponding boron ester, and then hydrolyzes to obtain the target product 4-carboxyl-3-chlorophenylboronic acid. The subsequent purification steps are also required to achieve 98% purity requirements.
The starting material or 3-chloro-4-halobenzoic acid is selected, and the halogen atom can be bromine or iodine. First, in a low temperature and anhydrous environment, it is treated with a strong base such as n-butyllithium or isopropyl magnesium chloride-lithium chloride complex. n-butyllithium has very high activity and reacts violently in contact with water, so the operation needs to be operated in an anhydrous and oxygen-free nitrogen or argon protective atmosphere. During the reaction, the strong base captures the hydrogen atom in the ortho-position of the halogen atom to form a highly reactive aryl lithium intermediate.
Subsequently, this aryl lithium intermediate is mixed with borate esters, such as trimethyl borate or triisopropyl borate. The aryl lithium and borate esters undergo nucleophilic substitution, and the lithium atom is replaced by borate ester groups to form boron-containing intermediates.
Next, the above boron-containing intermediates are treated with dilute acids, such as dilute hydrochloric acid or dilute sulfuric acid. This step aims to hydrolyze the borate ester and convert it into a boric acid group, resulting in a crude product of 4-carboxyl-3-chlorophenylboronic acid.
Crude products often contain impurities and need to be purified by recrystallization or column During recrystallization, depending on the difference in solubility of the product in different solvents, select a suitable solvent, such as ethanol-water mixed solvent, heat to dissolve the crude product, and cool the crystallization to obtain a pure product. Column chromatography uses a stationary phase such as silica gel to elute with a suitable eluent, such as a petroleum ether-ethyl acetate mixture, and separates impurities and products according to the difference between adsorption and elution.
In addition, there are also methods for preparation by palladium-catalyzed coupling reaction as a key step. Using 3-chloro-4-halobenzoic acid and pinacol borane as raw materials, the reaction is carried out in the presence of palladium catalysts such as tetrakis (triphenylphosphine) palladium (0), ligands and bases Palladium catalyst activates halogen atom and boron reagent, promotes coupling to form corresponding boron ester, and then hydrolyzes to obtain the target product 4-carboxyl-3-chlorophenylboronic acid. The subsequent purification steps are also required to achieve 98% purity requirements.
4-carboxy-3-chlorobenzeneboronic 98% of the market price of Acid
The market price of 4-carboxyl-3-chlorophenylboronic acid, with a purity of 98%, is difficult to determine. The price of this chemical often changes for many reasons.
First, the price fluctuation of raw materials is the main reason. If the price of the raw materials required for the preparation of this boric acid increases, such as the price of special halides and boron-containing raw materials used in the preparation process, the price of this boric acid will also increase. On the contrary, if the price of raw materials decreases, the price of boric acid may decrease.
Second, the ease of preparation is closely related to the cost. If the process of preparing 4-carboxyl-3-chlorophenylboronic acid is complicated, it requires high-end equipment, harsh reaction conditions, such as high temperature and high pressure, and there are many steps, which consume manpower and material resources. Its cost is high, and the price is not cheap. If the process is refined, the cost is reduced, and the price may be reduced.
Third, the market supply and demand situation also affects its price. If the market has strong demand for this boric acid, such as in the fields of pharmaceutical synthesis and materials science, the demand far exceeds the supply, and the price will rise; if the demand is low and the supply is excessive, the price will easily fall.
Fourth, the price varies depending on the manufacturer. Well-known large factories, due to good quality control, high brand reputation, product prices may be high; while small factories compete for the market, prices may be lower.
In summary, according to past market conditions, the purity of 4-carboxyl-3-chlorophenylboronic acid, the price per gram may be between tens of yuan and hundreds of yuan, but this is only an approximate number. The actual price must be carefully studied according to various factors in the current market.
First, the price fluctuation of raw materials is the main reason. If the price of the raw materials required for the preparation of this boric acid increases, such as the price of special halides and boron-containing raw materials used in the preparation process, the price of this boric acid will also increase. On the contrary, if the price of raw materials decreases, the price of boric acid may decrease.
Second, the ease of preparation is closely related to the cost. If the process of preparing 4-carboxyl-3-chlorophenylboronic acid is complicated, it requires high-end equipment, harsh reaction conditions, such as high temperature and high pressure, and there are many steps, which consume manpower and material resources. Its cost is high, and the price is not cheap. If the process is refined, the cost is reduced, and the price may be reduced.
Third, the market supply and demand situation also affects its price. If the market has strong demand for this boric acid, such as in the fields of pharmaceutical synthesis and materials science, the demand far exceeds the supply, and the price will rise; if the demand is low and the supply is excessive, the price will easily fall.
Fourth, the price varies depending on the manufacturer. Well-known large factories, due to good quality control, high brand reputation, product prices may be high; while small factories compete for the market, prices may be lower.
In summary, according to past market conditions, the purity of 4-carboxyl-3-chlorophenylboronic acid, the price per gram may be between tens of yuan and hundreds of yuan, but this is only an approximate number. The actual price must be carefully studied according to various factors in the current market.
4-carboxy-3-chlorobenzeneboronic Acid 98% What are the precautions when storing and transporting
4-Carboxy-3-chlorophenylboronic acid (4-carboxy-3-chlorobenzeneboronic Acid) contains 98%. When storing and transporting, pay attention to many matters.
This chemical has certain chemical activity. When storing, the first environment is dry. If the environment is humid, water vapor is easy to interact with the product, or cause it to react such as hydrolysis, which will damage the purity and quality. Therefore, it should be placed in a dry and well-ventilated place, away from water sources and moisture that may invade.
Temperature is also a key factor. It should be avoided in a high temperature environment. Due to high temperature, the chemical may decompose and deteriorate. Generally speaking, it should be stored in a cool place, preferably at conventional room temperature, generally between 15 ° C and 25 ° C. It must not be exposed to the hot sun or close to heat sources, such as heating, furnaces, etc.
During transportation, the packaging must be stable and tight. Because it is a chemical product, if the packaging is not good, it may not only cause pollution to the surrounding environment, but also endanger the safety of transporters due to bumps, collisions, or package damage during transportation.
In addition, it is necessary to pay attention to its compatibility with other substances. Do not store or transport with substances with strong oxidizing, strong reducing or excessive acid and alkali differences to prevent violent chemical reactions and cause danger. Transportation and storage sites should be equipped with corresponding emergency treatment equipment and materials. If accidents such as leakage unfortunately occur, they can be disposed of in time to minimize the harm.
This chemical has certain chemical activity. When storing, the first environment is dry. If the environment is humid, water vapor is easy to interact with the product, or cause it to react such as hydrolysis, which will damage the purity and quality. Therefore, it should be placed in a dry and well-ventilated place, away from water sources and moisture that may invade.
Temperature is also a key factor. It should be avoided in a high temperature environment. Due to high temperature, the chemical may decompose and deteriorate. Generally speaking, it should be stored in a cool place, preferably at conventional room temperature, generally between 15 ° C and 25 ° C. It must not be exposed to the hot sun or close to heat sources, such as heating, furnaces, etc.
During transportation, the packaging must be stable and tight. Because it is a chemical product, if the packaging is not good, it may not only cause pollution to the surrounding environment, but also endanger the safety of transporters due to bumps, collisions, or package damage during transportation.
In addition, it is necessary to pay attention to its compatibility with other substances. Do not store or transport with substances with strong oxidizing, strong reducing or excessive acid and alkali differences to prevent violent chemical reactions and cause danger. Transportation and storage sites should be equipped with corresponding emergency treatment equipment and materials. If accidents such as leakage unfortunately occur, they can be disposed of in time to minimize the harm.
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