Linshang Chemical
PRODUCTS
4-Chloro-1,2-Difluorobenzene
Linshang Chemical
|
HS Code |
205287 |
| Chemical Formula | C6H3ClF2 |
| Molar Mass | 148.54 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 143 - 145 °C |
| Density | 1.326 g/cm³ |
| Solubility In Water | Insoluble |
| Flash Point | 35 °C |
| Refractive Index | 1.475 |
As an accredited 4-Chloro-1,2-Difluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500 - gram bottle packaging for 4 - chloro - 1,2 - difluorobenzene chemical. |
| Storage | 4 - chloro - 1,2 - difluorobenzene should be stored in a cool, well - ventilated area, away from heat, sparks, and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials due to its chemical nature. Store separately from oxidizing agents and incompatible substances to prevent potential reactions. Ensure proper labeling for easy identification and handling. |
| Shipping | 4 - chloro - 1,2 - difluorobenzene is shipped in well - sealed, corrosion - resistant containers. Shipment follows strict chemical transport regulations to ensure safety during transit, protecting from physical damage and environmental exposure. |
Competitive 4-Chloro-1,2-Difluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4-Chloro-1,2-Difluorobenzene in China?
As a trusted 4-Chloro-1,2-Difluorobenzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-Chloro-1,2-Difluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 4-chloro-1,2-difluorobenzene?
4-Chloro-1,2-difluorobenzene is also an organic compound. It has a wide range of uses and is used in various fields of chemical industry.
First, it is often a key intermediate in the synthesis of medicine. The preparation of many drugs depends on its participation in the reaction to build a specific chemical structure, which in turn imparts a specific pharmacological activity to the drug. For example, when synthesizing some drugs with antibacterial and antiviral effects, the chlorine and fluorine atoms of 4-chloro-1,2-difluorobenzene can be combined with other compounds through organic reactions, and through a series of transformations, the desired drug molecules are generated.
Second, in the field of pesticides, it is also an important raw material. It is used to create new pesticides. With its special chemical properties, it can effectively improve the performance of pesticides such as insecticides, sterilization, and weeding. After reacting with other chemical substances, pesticide products with high efficiency, low toxicity, and environmental friendliness can be generated, providing strong support for agricultural pest control.
Third, in the field of materials science, 4-chloro-1,2-difluorobenzene can participate in the synthesis of special materials. Such as the synthesis of some high-performance engineering plastics, liquid crystal materials, etc. The introduction of fluorine atoms can significantly improve the thermal stability, chemical stability, and electrical properties of materials, so that materials can meet the stringent requirements of high-end fields such as electronics and aerospace.
Furthermore, in the study of organic synthetic chemistry, this compound is often used as a model substrate. Chemists can deeply understand the mechanism and law of reactions by exploring various chemical reactions, such as nucleophilic substitution, electrophilic substitution, etc., and provide important theoretical and practical basis for the development of organic synthesis methodologies.
In short, 4-chloro-1,2-difluorobenzene plays an indispensable role in many aspects of medicine, pesticides, materials and organic synthesis research due to its unique chemical structure and properties.
First, it is often a key intermediate in the synthesis of medicine. The preparation of many drugs depends on its participation in the reaction to build a specific chemical structure, which in turn imparts a specific pharmacological activity to the drug. For example, when synthesizing some drugs with antibacterial and antiviral effects, the chlorine and fluorine atoms of 4-chloro-1,2-difluorobenzene can be combined with other compounds through organic reactions, and through a series of transformations, the desired drug molecules are generated.
Second, in the field of pesticides, it is also an important raw material. It is used to create new pesticides. With its special chemical properties, it can effectively improve the performance of pesticides such as insecticides, sterilization, and weeding. After reacting with other chemical substances, pesticide products with high efficiency, low toxicity, and environmental friendliness can be generated, providing strong support for agricultural pest control.
Third, in the field of materials science, 4-chloro-1,2-difluorobenzene can participate in the synthesis of special materials. Such as the synthesis of some high-performance engineering plastics, liquid crystal materials, etc. The introduction of fluorine atoms can significantly improve the thermal stability, chemical stability, and electrical properties of materials, so that materials can meet the stringent requirements of high-end fields such as electronics and aerospace.
Furthermore, in the study of organic synthetic chemistry, this compound is often used as a model substrate. Chemists can deeply understand the mechanism and law of reactions by exploring various chemical reactions, such as nucleophilic substitution, electrophilic substitution, etc., and provide important theoretical and practical basis for the development of organic synthesis methodologies.
In short, 4-chloro-1,2-difluorobenzene plays an indispensable role in many aspects of medicine, pesticides, materials and organic synthesis research due to its unique chemical structure and properties.
What are the physical properties of 4-chloro-1,2-difluorobenzene?
4-Chloro-1,2-difluorobenzene is one of the organic compounds. It has unique physical properties and is described as follows:
Looking at its properties, under normal temperature and pressure, 4-chloro-1,2-difluorobenzene is a colorless to light yellow transparent liquid, with a pure appearance and fluidity.
The boiling point is about 124-126 ° C. At this temperature, the substance gradually changes from liquid to gaseous, the intermolecular force weakens, and the molecular activity intensifies and escapes the liquid surface. This boiling point value is related to the molecular structure. The introduction of chlorine and fluorine atoms changes the intermolecular force, causing the boiling point to change compared with benzene.
In terms of melting point, it is about -39 ° C. When the temperature drops to the melting point, the substance changes from liquid to solid, and the molecular arrangement tends to be orderly, forming a regular lattice structure.
The density is about 1.35g/cm ³, which is heavier than water. This density characteristic makes the substance sink to the bottom if mixed with water. This is due to the large relative atomic mass of chlorine and fluorine atoms in the molecule, resulting in an increase in mass per unit volume.
4-chloro-1,2-difluorobenzene is insoluble in water, because water is a polar molecule, and 4-chloro-1,2-difluorobenzene molecules contain polar bonds, but the overall molecular structure has a certain symmetry, and the polarity is weak. According to the principle of "similar miscibility", it is insoluble in polar water. However, it is soluble in most organic solvents, such as ethanol, ether, acetone, etc. Organic solvents are mostly non-polar or weakly polar, and the intermolecular force of 4-chloro-1,2-difluorobenzene is similar, and it can be mixed and dissolved with each other.
The vapor pressure has a corresponding value at a specific temperature, and the vapor pressure reflects the difficulty of volatilization of the substance. When the temperature increases, the vapor pressure increases, and the tendency of molecules to escape from the liquid level and enter the gas phase increases, that is, the volatility increases.
4-chloro-1,2-difluorobenzene has a certain odor, but its odor description is more subjective. It is mostly said to have a special odor similar to aromatic hydrocarbons, or it is slightly irritating. The sense of this odor also varies slightly due to individual olfactory differences.
Looking at its properties, under normal temperature and pressure, 4-chloro-1,2-difluorobenzene is a colorless to light yellow transparent liquid, with a pure appearance and fluidity.
The boiling point is about 124-126 ° C. At this temperature, the substance gradually changes from liquid to gaseous, the intermolecular force weakens, and the molecular activity intensifies and escapes the liquid surface. This boiling point value is related to the molecular structure. The introduction of chlorine and fluorine atoms changes the intermolecular force, causing the boiling point to change compared with benzene.
In terms of melting point, it is about -39 ° C. When the temperature drops to the melting point, the substance changes from liquid to solid, and the molecular arrangement tends to be orderly, forming a regular lattice structure.
The density is about 1.35g/cm ³, which is heavier than water. This density characteristic makes the substance sink to the bottom if mixed with water. This is due to the large relative atomic mass of chlorine and fluorine atoms in the molecule, resulting in an increase in mass per unit volume.
4-chloro-1,2-difluorobenzene is insoluble in water, because water is a polar molecule, and 4-chloro-1,2-difluorobenzene molecules contain polar bonds, but the overall molecular structure has a certain symmetry, and the polarity is weak. According to the principle of "similar miscibility", it is insoluble in polar water. However, it is soluble in most organic solvents, such as ethanol, ether, acetone, etc. Organic solvents are mostly non-polar or weakly polar, and the intermolecular force of 4-chloro-1,2-difluorobenzene is similar, and it can be mixed and dissolved with each other.
The vapor pressure has a corresponding value at a specific temperature, and the vapor pressure reflects the difficulty of volatilization of the substance. When the temperature increases, the vapor pressure increases, and the tendency of molecules to escape from the liquid level and enter the gas phase increases, that is, the volatility increases.
4-chloro-1,2-difluorobenzene has a certain odor, but its odor description is more subjective. It is mostly said to have a special odor similar to aromatic hydrocarbons, or it is slightly irritating. The sense of this odor also varies slightly due to individual olfactory differences.
Is 4-chloro-1,2-difluorobenzene chemically stable?
4-Chloro-1,2-difluorobenzene, the stability of its chemical properties is related to many aspects and cannot be generalized.
In this compound, chlorine and fluorine are both halogen elements and are connected to the benzene ring. The benzene ring has a conjugated system and is quite stable. However, the introduction of halogen atoms will affect its properties.
Chlorine atoms and fluorine atoms, because their electronegativity is higher than that of carbon, will reduce the electron cloud density of the benzene ring. Fluorine atoms are particularly high electronegativity and attract the electron cloud of the benzene ring more strongly. In this way, the activity of the benzene ring to undergo electrophilic substitution reactions will be affected. Generally speaking, when the electron cloud density decreases, the electrophilic substitution reaction activity will also decrease.
In terms of stability, 4-chloro-1,2-difluorobenzene can remain relatively stable under normal conditions without the action of special reagents. In case of extreme conditions such as high temperature, strong oxidants, and strong bases, chemical reactions may occur. For example, at high temperatures and in the presence of suitable catalysts, the reaction of halogen atoms being replaced by other groups may occur. For example, in case of strong oxidants, the benzene ring may be oxidized to open the ring, although this situation is relatively rare.
Furthermore, from the perspective of intermolecular forces, there is a van der Waals force between 4-chloro-1,2-difluorobenzene molecules. Due to its structure containing halogen atoms, the polarity of the halogen atoms enhances the intermolecular force compared with benzene. This also affects its physical and chemical stability to a certain extent. Overall, 4-chloro-1,2-difluorobenzene has certain chemical stability under conventional environments and operations, but under specific conditions, a variety of chemical reactions can occur.
In this compound, chlorine and fluorine are both halogen elements and are connected to the benzene ring. The benzene ring has a conjugated system and is quite stable. However, the introduction of halogen atoms will affect its properties.
Chlorine atoms and fluorine atoms, because their electronegativity is higher than that of carbon, will reduce the electron cloud density of the benzene ring. Fluorine atoms are particularly high electronegativity and attract the electron cloud of the benzene ring more strongly. In this way, the activity of the benzene ring to undergo electrophilic substitution reactions will be affected. Generally speaking, when the electron cloud density decreases, the electrophilic substitution reaction activity will also decrease.
In terms of stability, 4-chloro-1,2-difluorobenzene can remain relatively stable under normal conditions without the action of special reagents. In case of extreme conditions such as high temperature, strong oxidants, and strong bases, chemical reactions may occur. For example, at high temperatures and in the presence of suitable catalysts, the reaction of halogen atoms being replaced by other groups may occur. For example, in case of strong oxidants, the benzene ring may be oxidized to open the ring, although this situation is relatively rare.
Furthermore, from the perspective of intermolecular forces, there is a van der Waals force between 4-chloro-1,2-difluorobenzene molecules. Due to its structure containing halogen atoms, the polarity of the halogen atoms enhances the intermolecular force compared with benzene. This also affects its physical and chemical stability to a certain extent. Overall, 4-chloro-1,2-difluorobenzene has certain chemical stability under conventional environments and operations, but under specific conditions, a variety of chemical reactions can occur.
What is the production process of 4-chloro-1,2-difluorobenzene?
4-Chloro-1,2-difluorobenzene is also an organic compound. Its preparation process is quite exquisite, and it is described in detail below.
Usually 1,2-difluorobenzene is used as the starting material. This raw material is easily available in the chemical market, but the purity must be carefully selected to ensure the smooth subsequent reaction. Place 1,2-difluorobenzene in a special reactor, which is made of excellent material, temperature and pressure resistance, to prevent the reaction from being violent.
Subsequently, chlorination reagents are introduced, often chlorine gas is preferred. When chlorine gas is introduced, the rate should be precisely controlled. If it is too fast, the reaction will be out of control, and if it is too slow, it will take too much time. In this reactor, 1,2-difluorobenzene and chlorine are reacted at a suitable temperature. Temperature regulation is crucial, and it is generally maintained in a specific range, which varies slightly depending on the catalyst.
To promote the high efficiency of the reaction, a catalyst is often used. The choice of catalyst is mostly a specific metal halide, which can reduce the activation energy of the reaction and make the reaction easier to occur. Under the action of the catalyst, the chlorine atom of the chlorine gas ingeniously replaces the hydrogen atom at a specific position on the 1,2-difluorobenzene ring to precisely generate 4-chloro-1,2-difluorobenzene.
After the reaction is completed, the product is often mixed with unreacted raw materials, by-products, etc. At this time, it must be purified by delicate separation and purification. First, by distillation, using the different boiling points of each component, preliminary separation. Then, supplemented by extraction, crystallization and other means, the product is further purified. The solvent used for extraction should be selected with good solubility to 4-chloro-1,2-difluorobenzene and good separation from impurities. When crystallizing, control the temperature and solution concentration to precipitate the product in a pure crystalline state.
Through these various processes, high-purity 4-chloro-1,2-difluorobenzene can be obtained to meet the needs of various fields such as medicine, pesticides, and materials.
Usually 1,2-difluorobenzene is used as the starting material. This raw material is easily available in the chemical market, but the purity must be carefully selected to ensure the smooth subsequent reaction. Place 1,2-difluorobenzene in a special reactor, which is made of excellent material, temperature and pressure resistance, to prevent the reaction from being violent.
Subsequently, chlorination reagents are introduced, often chlorine gas is preferred. When chlorine gas is introduced, the rate should be precisely controlled. If it is too fast, the reaction will be out of control, and if it is too slow, it will take too much time. In this reactor, 1,2-difluorobenzene and chlorine are reacted at a suitable temperature. Temperature regulation is crucial, and it is generally maintained in a specific range, which varies slightly depending on the catalyst.
To promote the high efficiency of the reaction, a catalyst is often used. The choice of catalyst is mostly a specific metal halide, which can reduce the activation energy of the reaction and make the reaction easier to occur. Under the action of the catalyst, the chlorine atom of the chlorine gas ingeniously replaces the hydrogen atom at a specific position on the 1,2-difluorobenzene ring to precisely generate 4-chloro-1,2-difluorobenzene.
After the reaction is completed, the product is often mixed with unreacted raw materials, by-products, etc. At this time, it must be purified by delicate separation and purification. First, by distillation, using the different boiling points of each component, preliminary separation. Then, supplemented by extraction, crystallization and other means, the product is further purified. The solvent used for extraction should be selected with good solubility to 4-chloro-1,2-difluorobenzene and good separation from impurities. When crystallizing, control the temperature and solution concentration to precipitate the product in a pure crystalline state.
Through these various processes, high-purity 4-chloro-1,2-difluorobenzene can be obtained to meet the needs of various fields such as medicine, pesticides, and materials.
What are the precautions for 4-chloro-1,2-difluorobenzene during storage and transportation?
4-Chloro-1,2-difluorobenzene is an organic compound. When storing and transporting, pay attention to many matters.
First word storage. This substance should be stored in a cool and ventilated warehouse. Because of the cool and ventilated place, it can reduce the risk of deterioration or danger caused by temperature, air and other factors. The temperature of the warehouse should be strictly controlled, not too high, to prevent its volatilization from intensifying, or even chemical reactions caused by temperature. And keep away from fire and heat sources, both of which are major hidden dangers that may cause fire or explosion. 4-Chloro-1,2-difluorobenzene has certain flammability and is dangerous in case of fire, so fire heat sources must be avoided.
In addition, it should be stored separately from oxidants and edible chemicals. The oxidant has strong oxidizing properties and is in contact with 4-chloro-1,2-difluorobenzene, which is easy to induce violent chemical reactions; if edible chemicals are mixed with it, if there is leakage, it may cause pollution and endanger food safety. The storage area should be equipped with suitable materials to contain the leakage, just in case of leakage, and it can be dealt with in time to avoid greater harm caused by its diffusion.
Second talk about transportation. Before transportation, the container must be carefully inspected to ensure that it is intact. If the container is damaged, 4-chloro-1,2-difluorobenzene is easy to leak during transportation, polluting the environment and endangering the safety of transporters and surrounding areas. Vehicles used during transportation should have corresponding safety facilities, such as fire protection and explosion-proof devices, to deal with possible emergencies.
The transportation process must be stable to avoid severe bumps and collisions. Violent bumps and collisions or rupture of containers, causing leakage. And transport personnel should be professionally trained to be familiar with the characteristics of 4-chloro-1,2-difluorobenzene and emergency treatment methods. Once an accident such as leakage occurs, it can be dealt with quickly and correctly to reduce hazards. Transportation routes should also be reasonably planned to avoid crowded areas and environmentally sensitive areas to reduce the impact of leaks and other accidents on the public and the environment.
First word storage. This substance should be stored in a cool and ventilated warehouse. Because of the cool and ventilated place, it can reduce the risk of deterioration or danger caused by temperature, air and other factors. The temperature of the warehouse should be strictly controlled, not too high, to prevent its volatilization from intensifying, or even chemical reactions caused by temperature. And keep away from fire and heat sources, both of which are major hidden dangers that may cause fire or explosion. 4-Chloro-1,2-difluorobenzene has certain flammability and is dangerous in case of fire, so fire heat sources must be avoided.
In addition, it should be stored separately from oxidants and edible chemicals. The oxidant has strong oxidizing properties and is in contact with 4-chloro-1,2-difluorobenzene, which is easy to induce violent chemical reactions; if edible chemicals are mixed with it, if there is leakage, it may cause pollution and endanger food safety. The storage area should be equipped with suitable materials to contain the leakage, just in case of leakage, and it can be dealt with in time to avoid greater harm caused by its diffusion.
Second talk about transportation. Before transportation, the container must be carefully inspected to ensure that it is intact. If the container is damaged, 4-chloro-1,2-difluorobenzene is easy to leak during transportation, polluting the environment and endangering the safety of transporters and surrounding areas. Vehicles used during transportation should have corresponding safety facilities, such as fire protection and explosion-proof devices, to deal with possible emergencies.
The transportation process must be stable to avoid severe bumps and collisions. Violent bumps and collisions or rupture of containers, causing leakage. And transport personnel should be professionally trained to be familiar with the characteristics of 4-chloro-1,2-difluorobenzene and emergency treatment methods. Once an accident such as leakage occurs, it can be dealt with quickly and correctly to reduce hazards. Transportation routes should also be reasonably planned to avoid crowded areas and environmentally sensitive areas to reduce the impact of leaks and other accidents on the public and the environment.
Scan to WhatsApp
