Linshang Chemical
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4-Chloro-1,2-Dihydroxybenzene
Linshang Chemical
|
HS Code |
764511 |
| Chemical Formula | C6H5ClO2 |
| Molar Mass | 144.555 g/mol |
| Appearance | Solid |
| Color | Off - white to light brown |
| Odor | Characteristic |
| Solubility In Water | Slightly soluble |
| Melting Point | 104 - 108 °C |
| Boiling Point | 278 - 280 °C |
| Density | 1.49 g/cm³ |
| Flash Point | 152 °C |
| Cas Number | 95 - 88 - 5 |
As an accredited 4-Chloro-1,2-Dihydroxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - chloro - 1,2 - dihydroxybenzene packaged in a sealed, labeled bottle. |
| Storage | 4 - chloro - 1,2 - dihydroxybenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store it in a tightly closed container made of a suitable material, like glass or plastic that resists corrosion by this chemical, to prevent leakage and contamination. |
| Shipping | 4 - chloro - 1,2 - dihydroxybenzene should be shipped in well - sealed, corrosion - resistant containers. Label it clearly as a chemical. Ensure compliance with transportation regulations for hazardous or specialty chemicals during shipping to prevent spills and ensure safety. |
Competitive 4-Chloro-1,2-Dihydroxybenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 4-Chloro-1,2-Dihydroxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 4-chloro-1,2-dihydroxybenzene?
4-Bromo-1,2-difluorobenzoyl has the following chemical properties:
This substance is an organohalogenated aromatic hydrocarbon derivative, in which bromine (Br) and fluorine (F) atoms give their unique activities. From the perspective of the reaction activity of halogen atoms, bromine atoms are relatively active and can participate in various nucleophilic substitution reactions. For example, in the presence of appropriate nucleophilic reagents, such as alkoxides and amines, bromine atoms can be replaced by nucleophilic reagents, and then new carbon-heteroatomic bonds can be formed to derive a variety of compounds containing different functional groups. During this reaction, the nucleophilic reagent attacks the carbon atom connected to the bromine atom, and the bromine ion leaves to achieve substitution.
Although fluorine atoms are less likely to undergo nucleophilic substitution than bromine atoms, their electronegativity is large, which has a significant impact on the distribution of molecular electron clouds. Due to the strong electron-absorbing effect of fluorine atoms, the electron cloud density of the benzene ring decreases, resulting in a decrease in the electrophilic substitution activity of the benzene ring. If electrophilic substitution is carried out, the substituents tend to enter the position where the electron cloud density is relatively high.
In addition, the carbonyl group of 4-bromo-1,2-difluorobenzoyl (C = O) is also an important reaction check point. Carbonyl groups are polar, carbon is positively charged, and are vulnerable to attack by nucleophiles, resulting in nucleophilic addition reactions. Nucleophiles such as Grignard reagents and organolithium reagents can be added to carbonyl carbons to form corresponding alcohol derivatives. This process enriches the molecular carbon skeleton and provides multiple paths for organic synthesis.
In redox reactions, 4-bromo-1,2-difluorobenzoyl can be reduced with the reagents used according to the reaction conditions, such as carbonyl reduction to alcohol hydroxyl groups; or oxidized, such as ring-opening reactions on the benzene ring. In short, 4-bromo-1,2-difluorobenzoyl has rich chemical properties and is widely used in the field of organic synthesis. Many complex organic compounds can be prepared through various reaction paths.
This substance is an organohalogenated aromatic hydrocarbon derivative, in which bromine (Br) and fluorine (F) atoms give their unique activities. From the perspective of the reaction activity of halogen atoms, bromine atoms are relatively active and can participate in various nucleophilic substitution reactions. For example, in the presence of appropriate nucleophilic reagents, such as alkoxides and amines, bromine atoms can be replaced by nucleophilic reagents, and then new carbon-heteroatomic bonds can be formed to derive a variety of compounds containing different functional groups. During this reaction, the nucleophilic reagent attacks the carbon atom connected to the bromine atom, and the bromine ion leaves to achieve substitution.
Although fluorine atoms are less likely to undergo nucleophilic substitution than bromine atoms, their electronegativity is large, which has a significant impact on the distribution of molecular electron clouds. Due to the strong electron-absorbing effect of fluorine atoms, the electron cloud density of the benzene ring decreases, resulting in a decrease in the electrophilic substitution activity of the benzene ring. If electrophilic substitution is carried out, the substituents tend to enter the position where the electron cloud density is relatively high.
In addition, the carbonyl group of 4-bromo-1,2-difluorobenzoyl (C = O) is also an important reaction check point. Carbonyl groups are polar, carbon is positively charged, and are vulnerable to attack by nucleophiles, resulting in nucleophilic addition reactions. Nucleophiles such as Grignard reagents and organolithium reagents can be added to carbonyl carbons to form corresponding alcohol derivatives. This process enriches the molecular carbon skeleton and provides multiple paths for organic synthesis.
In redox reactions, 4-bromo-1,2-difluorobenzoyl can be reduced with the reagents used according to the reaction conditions, such as carbonyl reduction to alcohol hydroxyl groups; or oxidized, such as ring-opening reactions on the benzene ring. In short, 4-bromo-1,2-difluorobenzoyl has rich chemical properties and is widely used in the field of organic synthesis. Many complex organic compounds can be prepared through various reaction paths.
What are the physical properties of 4-chloro-1,2-dihydroxybenzene?
4-Bromo-1,2-difluorobenzene is an organic compound, and its physical properties are quite characteristic, as described below:
Viewed, this compound is mostly colorless to light yellow transparent liquid at room temperature, its color is related to purity, and high purity is light color. This color state characteristic is conducive to intuitive identification and observation in various reactions and applications.
Smell, has a special odor, although it is difficult to describe accurately, it is obviously different from common odorless or other specific odor substances. This odor should be paid attention to in industrial production and laboratory operations, because it may warn of latent risks such as leakage.
When it comes to the melting point, the melting point is about -40 ° C, and the boiling point is about 156-158 ° C. The lower melting point causes it to be a liquid at room temperature, and the specific boiling point allows separation and purification to be achieved by means of distillation. In chemical production, the temperature can be precisely controlled to obtain high-purity products.
Its density is about 1.72 g/cm ³, which is greater than that of water, so it will sink to the bottom when mixed with water. This property is of great significance in the reaction or separation process involving the aqueous phase, which is conducive to the design of separation processes according to density differences.
In terms of solubility, it is slightly soluble in water. Because water is a polar molecule, while 4-bromo-1,2-difluorobenzene has a weaker polarity. According to the principle of "similar miscibility", it is difficult to dissolve in water. However, it is soluble in many organic solvents, such as ether, acetone, dichloromethane, etc. This property provides a basis for the selection of suitable reaction solvents in organic synthesis, which can fully contact the reactants and improve the reaction efficiency.
In addition, 4-bromo-1,2-difluorobenzene is volatile to a certain extent. In poorly ventilated environments, its vapor may accumulate. When using, it needs to be operated in a well-ventilated environment or with the help of ventilation equipment for safety.
Viewed, this compound is mostly colorless to light yellow transparent liquid at room temperature, its color is related to purity, and high purity is light color. This color state characteristic is conducive to intuitive identification and observation in various reactions and applications.
Smell, has a special odor, although it is difficult to describe accurately, it is obviously different from common odorless or other specific odor substances. This odor should be paid attention to in industrial production and laboratory operations, because it may warn of latent risks such as leakage.
When it comes to the melting point, the melting point is about -40 ° C, and the boiling point is about 156-158 ° C. The lower melting point causes it to be a liquid at room temperature, and the specific boiling point allows separation and purification to be achieved by means of distillation. In chemical production, the temperature can be precisely controlled to obtain high-purity products.
Its density is about 1.72 g/cm ³, which is greater than that of water, so it will sink to the bottom when mixed with water. This property is of great significance in the reaction or separation process involving the aqueous phase, which is conducive to the design of separation processes according to density differences.
In terms of solubility, it is slightly soluble in water. Because water is a polar molecule, while 4-bromo-1,2-difluorobenzene has a weaker polarity. According to the principle of "similar miscibility", it is difficult to dissolve in water. However, it is soluble in many organic solvents, such as ether, acetone, dichloromethane, etc. This property provides a basis for the selection of suitable reaction solvents in organic synthesis, which can fully contact the reactants and improve the reaction efficiency.
In addition, 4-bromo-1,2-difluorobenzene is volatile to a certain extent. In poorly ventilated environments, its vapor may accumulate. When using, it needs to be operated in a well-ventilated environment or with the help of ventilation equipment for safety.
What are the main uses of 4-chloro-1,2-dihydroxybenzene?
4-Bromo-1,2-difluorobenzoyl has important uses in many fields.
In the field of pharmaceutical synthesis, this compound plays the role of a key intermediate. Due to its unique chemical structure, it can participate in a variety of chemical reactions and help build complex drug molecular structures. For example, in the development of some new antibacterial drugs, 4-bromo-1,2-difluorobenzoyl can be substituted with specific nitrogen-containing heterocyclic compounds to generate a compound skeleton with antibacterial activity. After further modification and optimization, it is expected to develop high-efficiency and low-toxicity new antibacterial drugs.
In the field of materials science, it is also indispensable. It can be used as an important raw material for the synthesis of high-performance organic optoelectronic materials. With the special electronic effects of fluorine atoms and bromine atoms, the electronic transport properties and optical properties of materials can be effectively adjusted. Taking the synthesis of organic Light Emitting Diode (OLED) materials as an example, 4-bromo-1,2-difluorobenzoyl is introduced into the conjugated polymer structure, which can change the energy level structure of the polymer, thereby improving the luminous efficiency and stability of OLED materials and promoting the development of display technology.
In addition, in the field of fine chemicals, 4-bromo-1,2-difluorobenzoyl is often used to synthesize fine chemicals such as fragrances and dyes with special functions. In the synthesis of fragrances, it can be used as a starting material to introduce specific functional groups through a series of reactions to endow fragrances with unique aroma and stability. In the synthesis of dyes, it can provide special chromophore and chromophore groups for dye molecules, enhancing the color brightness and light fastness of dyes, and meeting the needs of different industries for dye performance.
In the field of pharmaceutical synthesis, this compound plays the role of a key intermediate. Due to its unique chemical structure, it can participate in a variety of chemical reactions and help build complex drug molecular structures. For example, in the development of some new antibacterial drugs, 4-bromo-1,2-difluorobenzoyl can be substituted with specific nitrogen-containing heterocyclic compounds to generate a compound skeleton with antibacterial activity. After further modification and optimization, it is expected to develop high-efficiency and low-toxicity new antibacterial drugs.
In the field of materials science, it is also indispensable. It can be used as an important raw material for the synthesis of high-performance organic optoelectronic materials. With the special electronic effects of fluorine atoms and bromine atoms, the electronic transport properties and optical properties of materials can be effectively adjusted. Taking the synthesis of organic Light Emitting Diode (OLED) materials as an example, 4-bromo-1,2-difluorobenzoyl is introduced into the conjugated polymer structure, which can change the energy level structure of the polymer, thereby improving the luminous efficiency and stability of OLED materials and promoting the development of display technology.
In addition, in the field of fine chemicals, 4-bromo-1,2-difluorobenzoyl is often used to synthesize fine chemicals such as fragrances and dyes with special functions. In the synthesis of fragrances, it can be used as a starting material to introduce specific functional groups through a series of reactions to endow fragrances with unique aroma and stability. In the synthesis of dyes, it can provide special chromophore and chromophore groups for dye molecules, enhancing the color brightness and light fastness of dyes, and meeting the needs of different industries for dye performance.
What is the preparation method of 4-chloro-1,2-dihydroxybenzene?
To prepare 4-bromo-1,2-difluorobenzyl, the method is as follows:
The first raw material is to take a compound containing benzene ring, such as o-difluorobenzene, which is the basis of the reaction. Pure products are required, but impurities hinder the reaction. Also prepare brominating reagents, such as bromine or N-bromosuccinimide (NBS), which have high activity and introduce bromine atoms into the appropriate position.
Next, in a suitable reaction vessel, use o-difluorobenzene as the substrate, and add an appropriate amount of initiator, such as benzoyl peroxide. The effect of the initiator is to produce free radicals and promote the initiation of the reaction. Introduce brominating reagents to control the reaction temperature and time. If bromine is used, carbon tetrachloride is often used as a solvent. Under light or heating conditions, bromine is homogenized into bromine free radicals, and radical substitution reactions occur with benzyl hydrogen of the side chain of o-difluorobenzene. If the temperature is too high, side reactions will occur, and if it is too low, the reaction will be delayed.
When NBS is used as a brominating agent, in an inert solvent such as dichloromethane, under the action of an initiator, NBS gradually releases bromine free radicals and replaces them with benzyl hydrogen. This process requires monitoring the progress of the reaction. Thin-layer chromatography (TLC) can be used to observe the changes in the spots of the raw material and the product to judge the progress of the reaction.
After the reaction is completed, the reaction solution will be reprocessed. If there is any excess brominating reagent The organic phase is dried with anhydrous sodium sulfate to remove the water content. Then, the product is separated and purified by reduced pressure distillation or column chromatography. According to the difference in boiling point of each component, the column chromatography is based on the principle of adsorption and elution to obtain pure 4-bromo-1,2-difluorobenzyl.
In this way, the target product 4-bromo-1,2-difluorobenzyl can be obtained through the steps of raw material preparation, reaction control, post-treatment and purification.
The first raw material is to take a compound containing benzene ring, such as o-difluorobenzene, which is the basis of the reaction. Pure products are required, but impurities hinder the reaction. Also prepare brominating reagents, such as bromine or N-bromosuccinimide (NBS), which have high activity and introduce bromine atoms into the appropriate position.
Next, in a suitable reaction vessel, use o-difluorobenzene as the substrate, and add an appropriate amount of initiator, such as benzoyl peroxide. The effect of the initiator is to produce free radicals and promote the initiation of the reaction. Introduce brominating reagents to control the reaction temperature and time. If bromine is used, carbon tetrachloride is often used as a solvent. Under light or heating conditions, bromine is homogenized into bromine free radicals, and radical substitution reactions occur with benzyl hydrogen of the side chain of o-difluorobenzene. If the temperature is too high, side reactions will occur, and if it is too low, the reaction will be delayed.
When NBS is used as a brominating agent, in an inert solvent such as dichloromethane, under the action of an initiator, NBS gradually releases bromine free radicals and replaces them with benzyl hydrogen. This process requires monitoring the progress of the reaction. Thin-layer chromatography (TLC) can be used to observe the changes in the spots of the raw material and the product to judge the progress of the reaction.
After the reaction is completed, the reaction solution will be reprocessed. If there is any excess brominating reagent The organic phase is dried with anhydrous sodium sulfate to remove the water content. Then, the product is separated and purified by reduced pressure distillation or column chromatography. According to the difference in boiling point of each component, the column chromatography is based on the principle of adsorption and elution to obtain pure 4-bromo-1,2-difluorobenzyl.
In this way, the target product 4-bromo-1,2-difluorobenzyl can be obtained through the steps of raw material preparation, reaction control, post-treatment and purification.
What are the precautions for 4-chloro-1,2-dihydroxybenzene during storage and transportation?
4-Bromo-1,2-difluorobenzene should pay attention to the following matters during storage and transportation:
First, when storing, be sure to choose a cool, dry and well-ventilated place. This substance is quite sensitive to heat, and high temperature can easily cause adverse changes such as decomposition, so it should be kept away from heat sources and open flames. The warehouse temperature should be maintained within a specific range to prevent danger caused by excessive temperature. And it needs to be stored separately from oxidants, acids, bases and other substances. Because 4-bromo-1,2-difluorobenzene is in contact with these substances, it is very likely that chemical reactions will occur, which will endanger safety.
Second, the packaging must be tight and stable. It is necessary to choose packaging materials that meet relevant standards, such as sealed drums of specific materials, to prevent the leakage of the substance. Key information such as its name, nature, and hazardous characteristics should be clearly marked on the outside of the package to facilitate identification and handling.
Third, during transportation, the transportation vehicle must have corresponding safety facilities. Such as fire prevention and explosion-proof devices, etc., to deal with possible unexpected situations. Transport personnel should be professionally trained and familiar with the dangerous characteristics of 4-bromo-1,2-difluorobenzene and emergency treatment methods. During driving, avoid severe bumps and vibrations in the vehicle to prevent leakage caused by damaged packaging. At the same time, strictly follow the specified transportation route and keep away from densely populated areas and important places.
Fourth, whether it is storage or transportation, it should be equipped with complete emergency treatment equipment and materials. Such as fire extinguishers, adsorption materials, etc., in the event of leakage or other accidents, emergency response can be carried out quickly to minimize the harm. And relevant places should develop detailed and comprehensive emergency plans and conduct regular drills to ensure that staff can respond skillfully and efficiently in emergency situations.
First, when storing, be sure to choose a cool, dry and well-ventilated place. This substance is quite sensitive to heat, and high temperature can easily cause adverse changes such as decomposition, so it should be kept away from heat sources and open flames. The warehouse temperature should be maintained within a specific range to prevent danger caused by excessive temperature. And it needs to be stored separately from oxidants, acids, bases and other substances. Because 4-bromo-1,2-difluorobenzene is in contact with these substances, it is very likely that chemical reactions will occur, which will endanger safety.
Second, the packaging must be tight and stable. It is necessary to choose packaging materials that meet relevant standards, such as sealed drums of specific materials, to prevent the leakage of the substance. Key information such as its name, nature, and hazardous characteristics should be clearly marked on the outside of the package to facilitate identification and handling.
Third, during transportation, the transportation vehicle must have corresponding safety facilities. Such as fire prevention and explosion-proof devices, etc., to deal with possible unexpected situations. Transport personnel should be professionally trained and familiar with the dangerous characteristics of 4-bromo-1,2-difluorobenzene and emergency treatment methods. During driving, avoid severe bumps and vibrations in the vehicle to prevent leakage caused by damaged packaging. At the same time, strictly follow the specified transportation route and keep away from densely populated areas and important places.
Fourth, whether it is storage or transportation, it should be equipped with complete emergency treatment equipment and materials. Such as fire extinguishers, adsorption materials, etc., in the event of leakage or other accidents, emergency response can be carried out quickly to minimize the harm. And relevant places should develop detailed and comprehensive emergency plans and conduct regular drills to ensure that staff can respond skillfully and efficiently in emergency situations.
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