Linshang Chemical
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4-Chloro-1-(Chloromethyl)-2-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
654884 |
| Chemical Formula | C8H5Cl2F3 |
| Molar Mass | 227.026 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Around 190 - 195 °C |
| Density | Approx. 1.45 - 1.55 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Flash Point | Caution: Flammable, flash point around 70 - 80 °C |
| Vapor Pressure | Low vapor pressure at room temperature |
| Odor | Pungent, characteristic odor |
As an accredited 4-Chloro-1-(Chloromethyl)-2-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chloro - 1 - (chloromethyl)-2-(trifluoromethyl)benzene in a sealed chemical - grade bottle. |
| Storage | 4 - chloro - 1 - (chloromethyl)-2 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area. Keep it away from sources of ignition, heat, and incompatible substances like strong oxidizers. Store in a tightly sealed container, preferably made of corrosion - resistant materials, to prevent leakage and exposure to air and moisture. |
| Shipping | 4 - chloro - 1 - (chloromethyl) - 2 - (trifluoromethyl)benzene is shipped in tightly sealed, corrosion - resistant containers. Shipment adheres to strict chemical transport regulations, ensuring safety during transit to prevent spills and environmental hazards. |
Competitive 4-Chloro-1-(Chloromethyl)-2-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 4-chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene
4-Chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene, this is an organic compound, which has many unique chemical properties.
View its structure, containing chlorine atoms, chloromethyl and trifluoromethyl. Chlorine atoms have electron absorption, which can affect the electron cloud density of benzene ring, reduce the electron cloud density of benzene ring ortho and para-site, and change the activity of electrophilic substitution. Compared with benzene, electrophilic substitution is more difficult to occur, and the reaction check point may be different. When the electrophilic reagent attacks, due to the positioning effect of chlorine atoms, it tends to be meta-substitution.
In chloromethyl, the chlorine atom is connected to the methyl group, Chlorine atoms can be used as leaving groups to undergo nucleophilic substitution reactions. In case of nucleophilic reagents, such as sodium alcohols, amines, etc., chlorine atoms leave, and nucleophilic reagents replace them to form new compounds such as ethers and amines.
Trifluoromethyl is a strong electron-absorbing group with high electronegativity, which greatly affects the distribution of benzene ring electron cloud, greatly reduces the density of benzene ring electron cloud, and strengthens molecular stability and chemical inertness. Due to its existence, the compound has unique chemical properties and is often used as a special structural unit in the field of organic synthesis for the preparation of materials with specific properties or bioactive molecules.
In addition, the compound has a certain fat solubility due to chlorine and fluorine atoms, and has good solubility in organic solvents, which is of great significance for its participation in reactions or separation and purification in organic reaction systems. And fluorine-containing and chlorine-containing organic compounds are widely used in medicine, pesticides, materials and other industries. This compound may have potential application value in related fields and can be used as an intermediate for the synthesis of more complex functional molecules.
View its structure, containing chlorine atoms, chloromethyl and trifluoromethyl. Chlorine atoms have electron absorption, which can affect the electron cloud density of benzene ring, reduce the electron cloud density of benzene ring ortho and para-site, and change the activity of electrophilic substitution. Compared with benzene, electrophilic substitution is more difficult to occur, and the reaction check point may be different. When the electrophilic reagent attacks, due to the positioning effect of chlorine atoms, it tends to be meta-substitution.
In chloromethyl, the chlorine atom is connected to the methyl group, Chlorine atoms can be used as leaving groups to undergo nucleophilic substitution reactions. In case of nucleophilic reagents, such as sodium alcohols, amines, etc., chlorine atoms leave, and nucleophilic reagents replace them to form new compounds such as ethers and amines.
Trifluoromethyl is a strong electron-absorbing group with high electronegativity, which greatly affects the distribution of benzene ring electron cloud, greatly reduces the density of benzene ring electron cloud, and strengthens molecular stability and chemical inertness. Due to its existence, the compound has unique chemical properties and is often used as a special structural unit in the field of organic synthesis for the preparation of materials with specific properties or bioactive molecules.
In addition, the compound has a certain fat solubility due to chlorine and fluorine atoms, and has good solubility in organic solvents, which is of great significance for its participation in reactions or separation and purification in organic reaction systems. And fluorine-containing and chlorine-containing organic compounds are widely used in medicine, pesticides, materials and other industries. This compound may have potential application value in related fields and can be used as an intermediate for the synthesis of more complex functional molecules.
What is the main use of 4-chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene?
4-Chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene, this substance has a wide range of uses. In the field of organic synthesis, it is often a key raw material and participates in the construction of many complex organic compounds. Because of its unique chemical structure, it contains chlorine atoms, chloromethyl and trifluoromethyl, giving it special reactivity and properties.
In the creation of pesticides, it can be used as a starting material, and through a series of chemical reactions, pesticide products with high insecticidal, bactericidal or herbicidal activities can be derived. Because of the presence of halogen atoms in its structure, it helps to improve the affinity and biological activity of pesticides to specific targets and enhance their effectiveness in controlling pests and diseases.
In the field of medicinal chemistry, it is also of great value. It can be used to synthesize drug molecules with specific pharmacological activities. For example, the introduction of trifluoromethyl can often significantly change the lipophilicity, metabolic stability and interaction with biological targets of drug molecules, thereby optimizing the pharmacokinetic properties and efficacy of drugs.
In the field of materials science, polymer materials or functional materials synthesized from this raw material can exhibit unique properties. For example, fluoropolymer materials may have excellent chemical resistance, low surface energy and good thermal stability, and have potential applications in coatings, plastics and other industries.
Furthermore, in the production of fine chemicals, it can be used as an intermediate to prepare various fine chemicals with special functions, such as electronic chemicals, fragrances, additives, etc., to meet the special needs of different industrial fields. In short, 4-chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene plays an indispensable role in many chemical related fields, and is of great significance for promoting technological progress and product innovation in various industries.
In the creation of pesticides, it can be used as a starting material, and through a series of chemical reactions, pesticide products with high insecticidal, bactericidal or herbicidal activities can be derived. Because of the presence of halogen atoms in its structure, it helps to improve the affinity and biological activity of pesticides to specific targets and enhance their effectiveness in controlling pests and diseases.
In the field of medicinal chemistry, it is also of great value. It can be used to synthesize drug molecules with specific pharmacological activities. For example, the introduction of trifluoromethyl can often significantly change the lipophilicity, metabolic stability and interaction with biological targets of drug molecules, thereby optimizing the pharmacokinetic properties and efficacy of drugs.
In the field of materials science, polymer materials or functional materials synthesized from this raw material can exhibit unique properties. For example, fluoropolymer materials may have excellent chemical resistance, low surface energy and good thermal stability, and have potential applications in coatings, plastics and other industries.
Furthermore, in the production of fine chemicals, it can be used as an intermediate to prepare various fine chemicals with special functions, such as electronic chemicals, fragrances, additives, etc., to meet the special needs of different industrial fields. In short, 4-chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene plays an indispensable role in many chemical related fields, and is of great significance for promoting technological progress and product innovation in various industries.
What are the synthesis methods of 4-chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene
The synthesis of 4-chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene is an important research topic in the field of organic synthesis. There are many common ways to synthesize it.
One of them can be started from benzene derivatives containing corresponding substituents. For example, using 2- (trifluoromethyl) benzoic acid as the initial raw material, the carboxyl group is first converted into an ester group through an esterification reaction. In this step, alcohols and acids are often co-heated in the presence of a catalyst to obtain esters. Then, the ester is halogenated, and under certain conditions, chlorine atoms are introduced to specific positions in the benzene ring, such as in the presence of light or initiators, with chlorine gas or chlorine-containing reagents, chlorine atoms can be substituted for hydrogen on the benzene ring. Finally, the ester group is reduced to chloromethyl. This process can be reacted in a suitable solvent with strong reducing agents such as lithium aluminum hydride, so as to achieve the synthesis of 4-chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene.
Second, halogenated aromatics can also be used as starting materials. Select a suitable halogenated benzene with some desired substituents, such as 2-halo-1- (trifluoromethyl) benzene. First, the halogenated benzene is chloromethylated with formaldehyde and hydrogen chloride under the action of a specific catalyst, so that chloromethyl can be introduced. Then, under suitable conditions, the benzene ring is further halogenated to precisely introduce chlorine atoms at the target position, and finally 4-chloro-1- (chloromethyl) -2 - (trifluoromethyl) benzene is synthesized.
Furthermore, it can also be synthesized by a reaction involving organometallic reagents. For example, an organometallic reagent containing trifluoromethyl is prepared first, and the coupling reaction with halogenated benzene derivatives is carried out to construct a benzene ring structure with trifluoromethyl. Subsequently, through a series of reactions such as halogenation and chloromethylation, chlorine atoms and chloromethyl are gradually introduced to achieve the synthesis of the target product. Each step of the reaction requires fine regulation of reaction conditions, such as temperature, solvent, catalyst dosage, etc., to ensure the selectivity and yield of the reaction, so that 4-chloro-1 - (chloromethyl) - 2 - (trifluoromethyl) benzene can be effectively synthesized.
One of them can be started from benzene derivatives containing corresponding substituents. For example, using 2- (trifluoromethyl) benzoic acid as the initial raw material, the carboxyl group is first converted into an ester group through an esterification reaction. In this step, alcohols and acids are often co-heated in the presence of a catalyst to obtain esters. Then, the ester is halogenated, and under certain conditions, chlorine atoms are introduced to specific positions in the benzene ring, such as in the presence of light or initiators, with chlorine gas or chlorine-containing reagents, chlorine atoms can be substituted for hydrogen on the benzene ring. Finally, the ester group is reduced to chloromethyl. This process can be reacted in a suitable solvent with strong reducing agents such as lithium aluminum hydride, so as to achieve the synthesis of 4-chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene.
Second, halogenated aromatics can also be used as starting materials. Select a suitable halogenated benzene with some desired substituents, such as 2-halo-1- (trifluoromethyl) benzene. First, the halogenated benzene is chloromethylated with formaldehyde and hydrogen chloride under the action of a specific catalyst, so that chloromethyl can be introduced. Then, under suitable conditions, the benzene ring is further halogenated to precisely introduce chlorine atoms at the target position, and finally 4-chloro-1- (chloromethyl) -2 - (trifluoromethyl) benzene is synthesized.
Furthermore, it can also be synthesized by a reaction involving organometallic reagents. For example, an organometallic reagent containing trifluoromethyl is prepared first, and the coupling reaction with halogenated benzene derivatives is carried out to construct a benzene ring structure with trifluoromethyl. Subsequently, through a series of reactions such as halogenation and chloromethylation, chlorine atoms and chloromethyl are gradually introduced to achieve the synthesis of the target product. Each step of the reaction requires fine regulation of reaction conditions, such as temperature, solvent, catalyst dosage, etc., to ensure the selectivity and yield of the reaction, so that 4-chloro-1 - (chloromethyl) - 2 - (trifluoromethyl) benzene can be effectively synthesized.
What are the precautions for 4-chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene during storage and transportation?
4-Chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene is an organic compound. When storing and transporting, many matters must be paid attention to.
First words storage, this material is a chemical reagent, when stored in a cool, dry and well ventilated place. Do not place it in a high temperature or humid place. High temperature can enhance its chemical reactivity, or cause decomposition, polymerization and other reactions. Humid environment can easily make it damp and deteriorate, affecting quality and performance. And it must be kept away from fire and heat sources, because the compound may be flammable, and there is a risk of combustion and explosion in case of open flame and hot topic.
Furthermore, when storing, it should be stored separately from oxidants, acids, alkalis, etc., and should not be mixed. The lid is prone to violent chemical reactions due to its active chemical properties and contact with the above substances, resulting in accidents. In the choice of storage containers, be sure to use corrosion-resistant materials, such as specific plastic drums or glass bottles, and ensure that the container is well sealed to prevent leakage.
As for transportation, it should not be ignored. Before transportation, it must be properly packaged to comply with relevant transportation regulations. Packaging materials must be sturdy and durable, and can withstand certain external shocks to prevent damage to the container during transportation. During transportation, it is also necessary to maintain low temperature, dry conditions, and avoid vibration and collision. Transport vehicles should also be equipped with corresponding fire protection equipment and leakage emergency treatment equipment for emergencies. Escort personnel must also be familiar with the characteristics of the substance and emergency disposal methods. In case of emergencies, they can respond quickly and properly to ensure transportation safety.
First words storage, this material is a chemical reagent, when stored in a cool, dry and well ventilated place. Do not place it in a high temperature or humid place. High temperature can enhance its chemical reactivity, or cause decomposition, polymerization and other reactions. Humid environment can easily make it damp and deteriorate, affecting quality and performance. And it must be kept away from fire and heat sources, because the compound may be flammable, and there is a risk of combustion and explosion in case of open flame and hot topic.
Furthermore, when storing, it should be stored separately from oxidants, acids, alkalis, etc., and should not be mixed. The lid is prone to violent chemical reactions due to its active chemical properties and contact with the above substances, resulting in accidents. In the choice of storage containers, be sure to use corrosion-resistant materials, such as specific plastic drums or glass bottles, and ensure that the container is well sealed to prevent leakage.
As for transportation, it should not be ignored. Before transportation, it must be properly packaged to comply with relevant transportation regulations. Packaging materials must be sturdy and durable, and can withstand certain external shocks to prevent damage to the container during transportation. During transportation, it is also necessary to maintain low temperature, dry conditions, and avoid vibration and collision. Transport vehicles should also be equipped with corresponding fire protection equipment and leakage emergency treatment equipment for emergencies. Escort personnel must also be familiar with the characteristics of the substance and emergency disposal methods. In case of emergencies, they can respond quickly and properly to ensure transportation safety.
What are the effects of 4-chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene on the environment?
4-Chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene, this is an organic compound. Its impact on the environment needs to be carefully examined.
In the atmosphere, this compound may be volatile to a certain extent. After escaping into the air, it will affect the air quality. Because it contains chlorine and fluorine elements, it may participate in photochemical reactions and have an effect on atmospheric chemical processes. If its concentration in the air is too high, it may irritate the human respiratory tract and affect people's health.
As for the aquatic ecological environment, if this substance enters the water body, it may be difficult to be rapidly degraded by microorganisms in the natural water body due to its chemical structure. Its residue in the water will cause harm to aquatic organisms. It may interfere with the physiological processes of aquatic organisms, affect their growth, reproduction, and even cause their death, thereby destroying the balance of aquatic ecosystems.
In terms of soil environment, after entering the soil, it may be adsorbed on the soil particles, changing the physical and chemical properties of the soil. Because it contains halogen elements, it may affect the structure and function of microbial communities in the soil, hindering the normal material circulation and energy conversion process in the soil. And this substance remains in the soil, or it may be absorbed into the food chain through plant roots, and eventually endanger human health through bioaccumulation. Therefore, in the production, use and disposal of related products containing 4-chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene, appropriate measures must be taken to reduce its adverse impact on the environment and protect the safety of the ecological environment.
In the atmosphere, this compound may be volatile to a certain extent. After escaping into the air, it will affect the air quality. Because it contains chlorine and fluorine elements, it may participate in photochemical reactions and have an effect on atmospheric chemical processes. If its concentration in the air is too high, it may irritate the human respiratory tract and affect people's health.
As for the aquatic ecological environment, if this substance enters the water body, it may be difficult to be rapidly degraded by microorganisms in the natural water body due to its chemical structure. Its residue in the water will cause harm to aquatic organisms. It may interfere with the physiological processes of aquatic organisms, affect their growth, reproduction, and even cause their death, thereby destroying the balance of aquatic ecosystems.
In terms of soil environment, after entering the soil, it may be adsorbed on the soil particles, changing the physical and chemical properties of the soil. Because it contains halogen elements, it may affect the structure and function of microbial communities in the soil, hindering the normal material circulation and energy conversion process in the soil. And this substance remains in the soil, or it may be absorbed into the food chain through plant roots, and eventually endanger human health through bioaccumulation. Therefore, in the production, use and disposal of related products containing 4-chloro-1- (chloromethyl) -2- (trifluoromethyl) benzene, appropriate measures must be taken to reduce its adverse impact on the environment and protect the safety of the ecological environment.
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