Linshang Chemical
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4-Chloro-1-Fluoro-2-Methylbenzene
Linshang Chemical
|
HS Code |
866497 |
| Chemical Formula | C7H6ClF |
| Molar Mass | 144.573 g/mol |
| Appearance | Liquid |
| Boiling Point | 162 - 164 °C |
| Density | 1.176 g/mL at 25 °C |
| Solubility In Water | Insoluble |
| Flash Point | 54 °C |
| Refractive Index | 1.507 at 20 °C |
As an accredited 4-Chloro-1-Fluoro-2-Methylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500 mL bottle of 4 - chloro - 1 - fluoro - 2 - methylbenzene, well - sealed for storage. |
| Storage | 4 - chloro - 1 - fluoro - 2 - methylbenzene should be stored in a cool, well - ventilated area away from heat, sparks, and open flames. It should be kept in a tightly sealed container, preferably made of a material resistant to corrosion. Store it separately from oxidizing agents and incompatible substances to prevent potential reactions. Ensure proper labeling for easy identification. |
| Shipping | 4 - chloro - 1 - fluoro - 2 - methylbenzene is shipped in well - sealed, corrosion - resistant containers. Compliance with hazardous chemical shipping regulations is ensured, with proper labeling indicating its nature for safe transport. |
Competitive 4-Chloro-1-Fluoro-2-Methylbenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 4-chloro-1-fluoro-2-methylbenzene?
4-Chloro-1-fluoro-2-methylbenzene is also an organic compound. It has the basic structure of an aromatic hydrocarbon. It is based on a benzene ring and is superimposed on a chlorine atom, a fluorine atom and a methyl group.
The chemical properties of this compound vary depending on the functional groups it contains. Both chlorine and fluorine atoms are halogen atoms and have electron-absorbing properties, which can affect the electron cloud density of the benzene ring. If the electron cloud density of the benzene ring changes, its electrophilic substitution reaction activity is also different. Compared with benzene, this molecule has a lower electron cloud density of the benzene ring due to the electron-absorbing induction effect of the halogen atom, and the electrophilic substitution reaction activity
Methyl group is a donator group, and its donator effect can partially cancel the electron-absorbing effect of the halogen atom, but in general, the influence of the halogen atom is still there. In the electrophilic substitution reaction, the halogen atom is an ortho-para-locator, which reduces the activity of the benzene ring, but makes it easy for the electrophilic reagent to attack its ortho-site and para-site. Methyl group is also an ortho-para-locator, and the positioning effects of the two are superimposed, and when they are different, the choice of the reaction check point is more complicated.
In addition, halogen atoms can participate in nucleophilic substitution reactions. Under appropriate conditions, chlorine atoms or fluorine atoms can be replaced by nucleophiles. Because the halogen atoms are connected to the benzene ring, the carbon-halogen bond has a certain polarity, which is conducive to the attack of nucleophiles.
The chemical properties of 4-chloro-1-fluoro-2-methylbenzene depend on the interaction between the benzene ring and the chlorine, fluorine and methyl functional groups. In the field of organic synthesis, it can derive a variety of reactions based on its characteristics and is of great value.
The chemical properties of this compound vary depending on the functional groups it contains. Both chlorine and fluorine atoms are halogen atoms and have electron-absorbing properties, which can affect the electron cloud density of the benzene ring. If the electron cloud density of the benzene ring changes, its electrophilic substitution reaction activity is also different. Compared with benzene, this molecule has a lower electron cloud density of the benzene ring due to the electron-absorbing induction effect of the halogen atom, and the electrophilic substitution reaction activity
Methyl group is a donator group, and its donator effect can partially cancel the electron-absorbing effect of the halogen atom, but in general, the influence of the halogen atom is still there. In the electrophilic substitution reaction, the halogen atom is an ortho-para-locator, which reduces the activity of the benzene ring, but makes it easy for the electrophilic reagent to attack its ortho-site and para-site. Methyl group is also an ortho-para-locator, and the positioning effects of the two are superimposed, and when they are different, the choice of the reaction check point is more complicated.
In addition, halogen atoms can participate in nucleophilic substitution reactions. Under appropriate conditions, chlorine atoms or fluorine atoms can be replaced by nucleophiles. Because the halogen atoms are connected to the benzene ring, the carbon-halogen bond has a certain polarity, which is conducive to the attack of nucleophiles.
The chemical properties of 4-chloro-1-fluoro-2-methylbenzene depend on the interaction between the benzene ring and the chlorine, fluorine and methyl functional groups. In the field of organic synthesis, it can derive a variety of reactions based on its characteristics and is of great value.
What are the common uses of 4-chloro-1-fluoro-2-methylbenzene?
4-Chloro-1-fluoro-2-methylbenzene is an organic compound with a wide range of common uses.
First, in the field of pharmaceutical synthesis, it is often used as a key intermediate. For example, when synthesizing specific anti-infective drugs, 4-chloro-1-fluoro-2-methylbenzene can be converted into a molecular structure with antibacterial activity through a series of reactions. Because of its chlorine, fluorine and methyl groups, it can endow drugs with unique chemical properties and biological activities, help drugs better fit targets and improve efficacy.
Second, it also plays an important role in the creation of pesticides. It can be used to synthesize high-efficiency insecticides, fungicides, etc. Due to its structural characteristics, pesticides can be more easily attached to the surface of pests or pathogens, enhancing their efficacy. At the same time, some groups can improve the stability of pesticides and prolong their effective period in the environment.
Furthermore, in the field of materials science, 4-chloro-1-fluoro-2-methylbenzene can participate in the synthesis of high-performance polymers. Using it as a raw material and polymerizing with other monomers can prepare polymer materials with special properties, such as some engineering plastics with good heat resistance and chemical stability, which are widely used in electronics, automotive and other industries.
In addition, in the fragrance industry, due to its unique chemical structure, through appropriate modification and transformation, it can become a raw material for synthesizing new fragrances, endowing fragrances with unique odor and stability, and meeting the needs of different consumer markets for fragrances.
In short, 4-chloro-1-fluoro-2-methylbenzene plays an indispensable role in many fields such as medicine, pesticides, materials, and fragrances due to its own structural characteristics, providing important chemical support for the development of various industries.
First, in the field of pharmaceutical synthesis, it is often used as a key intermediate. For example, when synthesizing specific anti-infective drugs, 4-chloro-1-fluoro-2-methylbenzene can be converted into a molecular structure with antibacterial activity through a series of reactions. Because of its chlorine, fluorine and methyl groups, it can endow drugs with unique chemical properties and biological activities, help drugs better fit targets and improve efficacy.
Second, it also plays an important role in the creation of pesticides. It can be used to synthesize high-efficiency insecticides, fungicides, etc. Due to its structural characteristics, pesticides can be more easily attached to the surface of pests or pathogens, enhancing their efficacy. At the same time, some groups can improve the stability of pesticides and prolong their effective period in the environment.
Furthermore, in the field of materials science, 4-chloro-1-fluoro-2-methylbenzene can participate in the synthesis of high-performance polymers. Using it as a raw material and polymerizing with other monomers can prepare polymer materials with special properties, such as some engineering plastics with good heat resistance and chemical stability, which are widely used in electronics, automotive and other industries.
In addition, in the fragrance industry, due to its unique chemical structure, through appropriate modification and transformation, it can become a raw material for synthesizing new fragrances, endowing fragrances with unique odor and stability, and meeting the needs of different consumer markets for fragrances.
In short, 4-chloro-1-fluoro-2-methylbenzene plays an indispensable role in many fields such as medicine, pesticides, materials, and fragrances due to its own structural characteristics, providing important chemical support for the development of various industries.
What are 4-chloro-1-fluoro-2-methylbenzene synthesis methods?
The synthesis of 4-chloro-1-fluoro-2-methylbenzene is an important topic in organic synthetic chemistry. The synthesis methods are rich and diverse, and the following are all common methods.
First, it can be achieved by halogenation of aromatic hydrocarbons. Using o-methylaniline as the starting material, the amino group is first converted into a diazo salt by diazotization reaction. Under specific conditions, the diazo salt interacts with fluoroboronic acid to form a fluoroborate salt, which is then decomposed by heating to obtain 2-methylfluorobenzene. Subsequent to the chlorination of 2-methyl fluorobenzene, by selecting a suitable chlorination reagent, such as chlorine gas, in the presence of a catalyst, at a specific temperature and reaction environment, chlorination can occur at a specific position on the benzene ring, resulting in 4-chloro-1-fluoro-2-methylbenzene. Although this path step is slightly complicated, the conditions of each step are relatively easy to control, and it is widely used in laboratory synthesis.
Second, it is also possible to use 2-methylbenzoic acid as the starting material. First, 2-methylbenzoic acid is esterified and converted into the corresponding ester. After that, the benzene ring is halogenated with a halogenating reagent, and chlorine atoms and fluorine atoms are introduced. After the halogenation is completed, the ester group is reduced to methyl group through a specific reduction reaction, and the target product 4-chloro-1-fluoro-2-methylbenzene is obtained. In this process, the selectivity of the halogenation step is particularly critical, and the reaction conditions need to be carefully regulated to ensure that the substituted positions of chlorine atoms and fluorine atoms on the benzene ring are in line with expectations.
Third, the synthesis can also be achieved by means of the Fu-g reaction. Using fluorobenzene as the substrate, under the action of the Lewis acid catalyst, it reacts with the chloromethylation reagent to introduce chloromethyl groups on After that, chloromethyl is converted into methyl by reduction reaction, and 4-chloro-1-fluoro-2-methylbenzene is finally obtained. The advantage of this method is that the reaction conditions are relatively mild, and the position and selectivity of substituents can be effectively controlled according to the characteristics of the substrate and reagent. However, it should be noted that the choice and dosage of catalysts in the Fu-Ke reaction, as well as the properties of the reaction solvent, will have a significant impact on the reaction results.
The above methods have their own advantages and disadvantages. In actual synthesis, the appropriate synthesis path needs to be carefully selected according to specific needs, such as the availability of raw materials, cost considerations, and purity requirements of the target product.
First, it can be achieved by halogenation of aromatic hydrocarbons. Using o-methylaniline as the starting material, the amino group is first converted into a diazo salt by diazotization reaction. Under specific conditions, the diazo salt interacts with fluoroboronic acid to form a fluoroborate salt, which is then decomposed by heating to obtain 2-methylfluorobenzene. Subsequent to the chlorination of 2-methyl fluorobenzene, by selecting a suitable chlorination reagent, such as chlorine gas, in the presence of a catalyst, at a specific temperature and reaction environment, chlorination can occur at a specific position on the benzene ring, resulting in 4-chloro-1-fluoro-2-methylbenzene. Although this path step is slightly complicated, the conditions of each step are relatively easy to control, and it is widely used in laboratory synthesis.
Second, it is also possible to use 2-methylbenzoic acid as the starting material. First, 2-methylbenzoic acid is esterified and converted into the corresponding ester. After that, the benzene ring is halogenated with a halogenating reagent, and chlorine atoms and fluorine atoms are introduced. After the halogenation is completed, the ester group is reduced to methyl group through a specific reduction reaction, and the target product 4-chloro-1-fluoro-2-methylbenzene is obtained. In this process, the selectivity of the halogenation step is particularly critical, and the reaction conditions need to be carefully regulated to ensure that the substituted positions of chlorine atoms and fluorine atoms on the benzene ring are in line with expectations.
Third, the synthesis can also be achieved by means of the Fu-g reaction. Using fluorobenzene as the substrate, under the action of the Lewis acid catalyst, it reacts with the chloromethylation reagent to introduce chloromethyl groups on After that, chloromethyl is converted into methyl by reduction reaction, and 4-chloro-1-fluoro-2-methylbenzene is finally obtained. The advantage of this method is that the reaction conditions are relatively mild, and the position and selectivity of substituents can be effectively controlled according to the characteristics of the substrate and reagent. However, it should be noted that the choice and dosage of catalysts in the Fu-Ke reaction, as well as the properties of the reaction solvent, will have a significant impact on the reaction results.
The above methods have their own advantages and disadvantages. In actual synthesis, the appropriate synthesis path needs to be carefully selected according to specific needs, such as the availability of raw materials, cost considerations, and purity requirements of the target product.
4-chloro-1-fluoro-2-methylbenzene What are the precautions in storage and transportation?
4-Chloro-1-fluoro-2-methylbenzene is also an organic compound. During storage and transportation, many matters must be paid attention to.
First words storage. This compound should be placed in a cool and ventilated warehouse. Because of its volatility and flammability, high temperature environment can easily cause its volatilization to increase, and even cause fire and other hazards, so a cool place can ensure its stability. Ventilation in the warehouse is also crucial. Good ventilation can disperse steam that may leak, avoid its accumulation in the air, and reduce the risk of explosion.
Furthermore, keep away from fire and heat sources. Both fire and heat sources can cause the combustion of this compound, so smoking and fire are strictly prohibited in storage places. At the same time, it should be stored separately from oxidants and edible chemicals, and must not be mixed. Oxidants have strong oxidizing properties, or react violently with the compound; while mixed with edible chemicals, once leaked, it may contaminate food and endanger human health.
When storing, it is also necessary to pay attention to the integrity of the package. If the package is damaged, the compound is easy to leak, which not only causes material loss, but also poses a threat to the environment and personnel safety. Regularly check the packaging status and deal with problems in a timely manner.
As for transportation, the transportation vehicle must be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. This is due to accidents that may occur during transportation, such as leaks caused by collisions. At this time, fire equipment can deal with possible fires, and emergency treatment equipment can control leaks in time to reduce hazards.
During transportation, the speed of the vehicle should not be too fast, nor should it be forcibly overtaken. Sudden braking, sharp turns, etc. can easily cause the goods to shake, increasing the risk of package damage. Transportation vehicles should travel according to the specified route, and do not stop in densely populated areas and residential areas to prevent leakage from causing harm to the public.
When loading and unloading, operators should load and unload lightly. It is strictly forbidden to drop, touch, and collide. Avoid package damage caused by rough operation, resulting in leakage of 4-chloro-1-fluoro-2-methylbenzene. Therefore, strict attention should be paid to all points during storage and transportation to ensure the safety of the compound.
First words storage. This compound should be placed in a cool and ventilated warehouse. Because of its volatility and flammability, high temperature environment can easily cause its volatilization to increase, and even cause fire and other hazards, so a cool place can ensure its stability. Ventilation in the warehouse is also crucial. Good ventilation can disperse steam that may leak, avoid its accumulation in the air, and reduce the risk of explosion.
Furthermore, keep away from fire and heat sources. Both fire and heat sources can cause the combustion of this compound, so smoking and fire are strictly prohibited in storage places. At the same time, it should be stored separately from oxidants and edible chemicals, and must not be mixed. Oxidants have strong oxidizing properties, or react violently with the compound; while mixed with edible chemicals, once leaked, it may contaminate food and endanger human health.
When storing, it is also necessary to pay attention to the integrity of the package. If the package is damaged, the compound is easy to leak, which not only causes material loss, but also poses a threat to the environment and personnel safety. Regularly check the packaging status and deal with problems in a timely manner.
As for transportation, the transportation vehicle must be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment. This is due to accidents that may occur during transportation, such as leaks caused by collisions. At this time, fire equipment can deal with possible fires, and emergency treatment equipment can control leaks in time to reduce hazards.
During transportation, the speed of the vehicle should not be too fast, nor should it be forcibly overtaken. Sudden braking, sharp turns, etc. can easily cause the goods to shake, increasing the risk of package damage. Transportation vehicles should travel according to the specified route, and do not stop in densely populated areas and residential areas to prevent leakage from causing harm to the public.
When loading and unloading, operators should load and unload lightly. It is strictly forbidden to drop, touch, and collide. Avoid package damage caused by rough operation, resulting in leakage of 4-chloro-1-fluoro-2-methylbenzene. Therefore, strict attention should be paid to all points during storage and transportation to ensure the safety of the compound.
What are the effects of 4-chloro-1-fluoro-2-methylbenzene on the environment and human health?
4-Chloro-1-fluoro-2-methylbenzene is an organic compound. Its impact on the environment and human health cannot be ignored.
In the environment, if this compound is released, it may be stored in the air, water, and soil. In the atmosphere, it may be transformed due to photolysis, or it may be transported to distant places through the atmosphere. In water bodies, it may be stored in sediments due to adsorption, etc., affecting aquatic ecology. If aquatic organisms touch it, it may cause physiological disturbance. In the soil, it may affect the activity and community structure of soil microorganisms, and then affect the ecological function of soil.
As for human health, if people ingest 4-chloro-1-fluoro-2-methylbenzene through breathing, diet, skin contact, etc., it may cause various hazards. In acute exposure, it may cause irritation to the eyes and respiratory tract, causing discomfort, such as eye pain, cough, shortness of breath, etc. If exposed for a long time, it may damage the nervous system, cause dizziness, fatigue, and memory loss. It may also involve the liver, kidneys and other organs, affecting their normal function. What's more, this compound may be potentially carcinogenic, long-term exposure, or increase the risk of cancer.
In summary, 4-chloro-1-fluoro-2-methylbenzene can cause adverse effects on the environment and human health, so when it is produced, used, and disposed of, care should be taken to reduce its harm to the environment and people.
In the environment, if this compound is released, it may be stored in the air, water, and soil. In the atmosphere, it may be transformed due to photolysis, or it may be transported to distant places through the atmosphere. In water bodies, it may be stored in sediments due to adsorption, etc., affecting aquatic ecology. If aquatic organisms touch it, it may cause physiological disturbance. In the soil, it may affect the activity and community structure of soil microorganisms, and then affect the ecological function of soil.
As for human health, if people ingest 4-chloro-1-fluoro-2-methylbenzene through breathing, diet, skin contact, etc., it may cause various hazards. In acute exposure, it may cause irritation to the eyes and respiratory tract, causing discomfort, such as eye pain, cough, shortness of breath, etc. If exposed for a long time, it may damage the nervous system, cause dizziness, fatigue, and memory loss. It may also involve the liver, kidneys and other organs, affecting their normal function. What's more, this compound may be potentially carcinogenic, long-term exposure, or increase the risk of cancer.
In summary, 4-chloro-1-fluoro-2-methylbenzene can cause adverse effects on the environment and human health, so when it is produced, used, and disposed of, care should be taken to reduce its harm to the environment and people.
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