Linshang Chemical
PRODUCTS
4-Chloro-1-Fluoro-2-Nitrobenzene
Linshang Chemical
|
HS Code |
339533 |
| Chemical Formula | C6H3ClFNO2 |
| Molar Mass | 177.545 g/mol |
| Appearance | Yellow to light brown solid |
| Melting Point | 34 - 38 °C |
| Boiling Point | 225 - 227 °C |
| Density | 1.496 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | 100 °C |
| Purity | Typically available in high purity, e.g., 98%+ |
As an accredited 4-Chloro-1-Fluoro-2-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chloro - 1 - fluoro - 2 - nitrobenzene packaged in a sealed, corrosion - resistant bottle. |
| Storage | 4 - chloro - 1 - fluoro - 2 - nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be isolated from oxidizing agents, reducing agents, and substances that can react with it. Store in a tightly - sealed container made of suitable materials like glass or certain plastics to prevent leakage and maintain its stability. |
| Shipping | 4 - chloro - 1 - fluoro - 2 - nitrobenzene is shipped in well - sealed, corrosion - resistant containers. It's transported as a hazardous chemical, following strict regulations, with proper labeling and handling to ensure safety during transit. |
Competitive 4-Chloro-1-Fluoro-2-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4-Chloro-1-Fluoro-2-Nitrobenzene in China?
As a trusted 4-Chloro-1-Fluoro-2-Nitrobenzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-Chloro-1-Fluoro-2-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemistry of 4-chloro-1-fluoro-2-nitrobenzene?
4-Chloro-1-fluoro-2-nitrobenzene is also an organic compound. Its molecule contains chlorine, fluorine, and nitro functional groups, which give the compound unique chemical properties.
In terms of reactivity, the nitro group is a strong electron-absorbing group, which can reduce the electron cloud density of the benzene ring and the electrophilic substitution activity of the benzene ring. However, the electron cloud density of the benzene ring o-carbon atom and the para-carbon atom is relatively low, so the nucleophilic substitution reaction is more likely to occur in the adjacent and para-position of the nitro group. In this compound, the carbon atom connected to the chlorine and fluorine is in the nitro o-ortho and para-position, so the chlorine and fluorine atoms are easily replaced by nucleophiles. For example, in the case of strong nucleophiles such as hydroxide ions, amino anions, etc., chlorine or fluorine atoms can be replaced by them to produce corresponding hydroxyl or amino substitutes.
Furthermore, the presence of halogen atoms also affects its chemical properties. Although fluorine atoms are highly electronegative, their atomic radius is small, and the C-F bond energy formed with the benzene ring is large; the radius of chlorine atoms is slightly larger, and the C-Cl bond energy is relatively small. This difference makes it easier for chlorine atoms to leave than fluorine atoms in some reactions. For example, under specific nucleophilic substitution conditions, the possibility of chlorine atoms being replaced first is higher.
In addition, 4-chloro-1-fluoro-2-nitrophenyl contains multiple polar functional groups, has a certain polarity, has a certain solubility in organic solvents, and is also affected by its polarity in the process of mass transfer in the reaction system. And due to the presence of nitro groups, the compound has certain oxidation, and can participate in redox-related reactions under specific conditions.
In terms of reactivity, the nitro group is a strong electron-absorbing group, which can reduce the electron cloud density of the benzene ring and the electrophilic substitution activity of the benzene ring. However, the electron cloud density of the benzene ring o-carbon atom and the para-carbon atom is relatively low, so the nucleophilic substitution reaction is more likely to occur in the adjacent and para-position of the nitro group. In this compound, the carbon atom connected to the chlorine and fluorine is in the nitro o-ortho and para-position, so the chlorine and fluorine atoms are easily replaced by nucleophiles. For example, in the case of strong nucleophiles such as hydroxide ions, amino anions, etc., chlorine or fluorine atoms can be replaced by them to produce corresponding hydroxyl or amino substitutes.
Furthermore, the presence of halogen atoms also affects its chemical properties. Although fluorine atoms are highly electronegative, their atomic radius is small, and the C-F bond energy formed with the benzene ring is large; the radius of chlorine atoms is slightly larger, and the C-Cl bond energy is relatively small. This difference makes it easier for chlorine atoms to leave than fluorine atoms in some reactions. For example, under specific nucleophilic substitution conditions, the possibility of chlorine atoms being replaced first is higher.
In addition, 4-chloro-1-fluoro-2-nitrophenyl contains multiple polar functional groups, has a certain polarity, has a certain solubility in organic solvents, and is also affected by its polarity in the process of mass transfer in the reaction system. And due to the presence of nitro groups, the compound has certain oxidation, and can participate in redox-related reactions under specific conditions.
What are the main uses of 4-chloro-1-fluoro-2-nitrobenzene?
4-Chloro-1-fluoro-2-nitrobenzene is one of the organic compounds. Its main uses are as follows.
First, it is often an important intermediate in the field of pharmaceutical synthesis. With this compound as a starting material, through various chemical reactions, a variety of drugs with specific pharmacological activities can be prepared. Due to the unique properties of chlorine, fluorine, nitro and other functional groups in its structure, it can participate in many reactions to construct complex drug molecular structures, which help to regulate the interaction between drugs and biological targets, so as to achieve the effect of treating diseases and saving people.
Second, it also plays a key role in the creation of pesticides. After chemical modification and derivatization, pesticide varieties with high insecticidal, bactericidal or herbicidal properties can be obtained. For example, by using its special electronic effects and spatial resistance, the obtained pesticides can precisely act on the specific physiological processes of pests, block their growth and reproduction, and have relatively little impact on the environment, so as to protect agricultural production.
Third, in the field of materials science, 4-chloro-1-fluoro-2-nitrobenzene can be used to synthesize polymer materials with special functions. Because its functional groups can initiate polymerization reactions and copolymerize with other monomers, they give polymer materials special properties such as heat resistance and chemical corrosion resistance. These materials may be used in high-end fields such as aerospace and electronic devices to meet the needs of specific environments.
Fourth, in the dye industry, it can be used as a raw material for the synthesis of new dyes. With its structural characteristics, the dyes produced may have excellent dyeing properties, such as high color fastness, bright colors, etc., and can be widely used in textiles, leather and other industries to make the products show a colorful appearance.
In summary, although 4-chloro-1-fluoro-2-nitrobenzene is an organic small molecule, it has shown great use in many fields such as medicine, pesticides, materials and dyes, and has great contribution to promoting the development of related industries.
First, it is often an important intermediate in the field of pharmaceutical synthesis. With this compound as a starting material, through various chemical reactions, a variety of drugs with specific pharmacological activities can be prepared. Due to the unique properties of chlorine, fluorine, nitro and other functional groups in its structure, it can participate in many reactions to construct complex drug molecular structures, which help to regulate the interaction between drugs and biological targets, so as to achieve the effect of treating diseases and saving people.
Second, it also plays a key role in the creation of pesticides. After chemical modification and derivatization, pesticide varieties with high insecticidal, bactericidal or herbicidal properties can be obtained. For example, by using its special electronic effects and spatial resistance, the obtained pesticides can precisely act on the specific physiological processes of pests, block their growth and reproduction, and have relatively little impact on the environment, so as to protect agricultural production.
Third, in the field of materials science, 4-chloro-1-fluoro-2-nitrobenzene can be used to synthesize polymer materials with special functions. Because its functional groups can initiate polymerization reactions and copolymerize with other monomers, they give polymer materials special properties such as heat resistance and chemical corrosion resistance. These materials may be used in high-end fields such as aerospace and electronic devices to meet the needs of specific environments.
Fourth, in the dye industry, it can be used as a raw material for the synthesis of new dyes. With its structural characteristics, the dyes produced may have excellent dyeing properties, such as high color fastness, bright colors, etc., and can be widely used in textiles, leather and other industries to make the products show a colorful appearance.
In summary, although 4-chloro-1-fluoro-2-nitrobenzene is an organic small molecule, it has shown great use in many fields such as medicine, pesticides, materials and dyes, and has great contribution to promoting the development of related industries.
What are 4-chloro-1-fluoro-2-nitrobenzene synthesis methods?
The synthesis method of 4-chloro-1-fluoro-2-nitrobenzene has been explored by various parties throughout the ages, and the following methods are briefly described.
First, halogenated aromatic hydrocarbons are used as starting materials. First, suitable chlorobenzene is taken. Under specific reaction conditions, fluorine ions are nucleophilic substitution reaction to replace chlorine atoms at specific positions on the benzene ring to obtain chlorofluorobenzene-containing benzene. Subsequently, nitrogenation is used to introduce nitro groups. During this process, the reaction temperature, the proportion of reactants, and the type and amount of catalyst need to be carefully adjusted. If the temperature is too high, it is easy to form by-products of polynitrofication; if the ratio is improper, it will also affect the purity and yield of the product.
Second, nitroaromatic hydrocarbons are used as the starting material. First, nitrobenzene is halogenated to introduce chlorine atoms and fluorine atoms. During the halogenation reaction, suitable halogenating reagents and reaction conditions need to be selected. For example, a specific chlorination agent and fluorinating agent are selected, and the reaction is carried out in an orderly manner in the presence of suitable solvents and catalysts. Because nitro is a strong electron-absorbing group, it will affect the localization effect of the substitution reaction on the benzene ring, so the reaction steps need to be carefully designed to ensure that chlorine atoms and fluorine atoms are introduced at the target position.
Third, benzene is used as the initial raw material. First, benzene is nitrified to obtain nitrobenzene. Then a halogenation reaction is carried out to introduce chlorine atoms and fluorine atoms. Although there are many steps in this path, the However, each step of the reaction needs to be carefully controlled to achieve the desired synthesis effect. For example, in the nitration reaction, the mixed acid ratio of nitric acid and sulfuric acid, the reaction temperature and other factors have a great influence on the yield and purity of nitrobenzene; the halogenation reaction also needs to be based on the introduction sequence and location requirements of halogen atoms, and the halogenation reagents and reaction conditions should be carefully selected.
All synthesis methods have their own advantages and disadvantages, and the choice should be made according to actual needs, such as raw material availability, cost considerations, product purity requirements and other factors.
First, halogenated aromatic hydrocarbons are used as starting materials. First, suitable chlorobenzene is taken. Under specific reaction conditions, fluorine ions are nucleophilic substitution reaction to replace chlorine atoms at specific positions on the benzene ring to obtain chlorofluorobenzene-containing benzene. Subsequently, nitrogenation is used to introduce nitro groups. During this process, the reaction temperature, the proportion of reactants, and the type and amount of catalyst need to be carefully adjusted. If the temperature is too high, it is easy to form by-products of polynitrofication; if the ratio is improper, it will also affect the purity and yield of the product.
Second, nitroaromatic hydrocarbons are used as the starting material. First, nitrobenzene is halogenated to introduce chlorine atoms and fluorine atoms. During the halogenation reaction, suitable halogenating reagents and reaction conditions need to be selected. For example, a specific chlorination agent and fluorinating agent are selected, and the reaction is carried out in an orderly manner in the presence of suitable solvents and catalysts. Because nitro is a strong electron-absorbing group, it will affect the localization effect of the substitution reaction on the benzene ring, so the reaction steps need to be carefully designed to ensure that chlorine atoms and fluorine atoms are introduced at the target position.
Third, benzene is used as the initial raw material. First, benzene is nitrified to obtain nitrobenzene. Then a halogenation reaction is carried out to introduce chlorine atoms and fluorine atoms. Although there are many steps in this path, the However, each step of the reaction needs to be carefully controlled to achieve the desired synthesis effect. For example, in the nitration reaction, the mixed acid ratio of nitric acid and sulfuric acid, the reaction temperature and other factors have a great influence on the yield and purity of nitrobenzene; the halogenation reaction also needs to be based on the introduction sequence and location requirements of halogen atoms, and the halogenation reagents and reaction conditions should be carefully selected.
All synthesis methods have their own advantages and disadvantages, and the choice should be made according to actual needs, such as raw material availability, cost considerations, product purity requirements and other factors.
4-chloro-1-fluoro-2-nitrobenzene What are the precautions during storage and transportation?
4-Chloro-1-fluoro-2-nitrobenzene is also an organic compound. During storage and transportation, many matters must not be ignored.
Bear the brunt, the storage place must be cool and dry. This compound is active, hot or wet, easy to deteriorate, or even cause danger. Therefore, choose a well-ventilated and sun-proof warehouse for good storage.
In addition, it is toxic and corrosive, and when stored, it must be separated from oxidants, reducing agents, alkalis, etc. Mixed with each other, or react violently, causing accidents. Containers must also be made of suitable materials to prevent corrosion and leakage.
When transporting, the packaging must be sturdy. In accordance with relevant regulations, wrap it in suitable packaging materials to ensure that there is no damage and leakage during the journey. Transportation personnel should be familiar with its hazardous characteristics and prepare for emergency treatment.
In addition, this compound is a dangerous chemical, and transportation qualifications are essential. The carrier must have the corresponding permission to travel the transportation route according to the regulations, and cannot change it without authorization.
In short, the storage and transportation of 4-chloro-1-fluoro-2-nitrobenzene should be treated with caution. From the choice of storage environment, to the transportation packaging, personnel qualifications, etc., all are related to safety.
Bear the brunt, the storage place must be cool and dry. This compound is active, hot or wet, easy to deteriorate, or even cause danger. Therefore, choose a well-ventilated and sun-proof warehouse for good storage.
In addition, it is toxic and corrosive, and when stored, it must be separated from oxidants, reducing agents, alkalis, etc. Mixed with each other, or react violently, causing accidents. Containers must also be made of suitable materials to prevent corrosion and leakage.
When transporting, the packaging must be sturdy. In accordance with relevant regulations, wrap it in suitable packaging materials to ensure that there is no damage and leakage during the journey. Transportation personnel should be familiar with its hazardous characteristics and prepare for emergency treatment.
In addition, this compound is a dangerous chemical, and transportation qualifications are essential. The carrier must have the corresponding permission to travel the transportation route according to the regulations, and cannot change it without authorization.
In short, the storage and transportation of 4-chloro-1-fluoro-2-nitrobenzene should be treated with caution. From the choice of storage environment, to the transportation packaging, personnel qualifications, etc., all are related to safety.
4-chloro-1-fluoro-2-nitrobenzene impact on the environment and human health
4-Chloro-1-fluoro-2-nitrobenzene is one of the organic compounds. Its impact on the environment and human health cannot be ignored.
In terms of the environment, if this substance is released in nature, it is difficult to degrade rapidly because of its certain chemical stability. Or it exists in soil and water bodies and is difficult to transfer. In soil, it can cause soil deterioration, affect the uptake of nutrients by plant roots, hinder plant growth, reduce crop production, and disrupt ecological balance. In water bodies, it can pollute water sources and endanger aquatic organisms. If fish, shellfish and other aquatic organisms are exposed to this, it may cause physiological disorders, decreased reproductive ability, and even death. And in the food chain, it can be enriched along the food chain, from aquatic organisms to animals that feed on it, and the scope of harm is gradually widening.
As for human health, 4-chloro-1-fluoro-2-nitrobenzene may enter the body through respiratory tract, skin contact, and accidental ingestion. Inhalation through the respiratory tract can irritate the mucosa of the respiratory tract, causing symptoms such as cough, asthma, and breathing difficulties. If exposed to the skin, it can cause skin allergies, itching, redness, and swelling. Those who eat it by mistake can damage the digestive system, causing nausea, vomiting, abdominal pain, diarrhea, etc. What's more, this substance may be potentially carcinogenic, teratogenic, and mutagenic. Long-term exposure to the environment containing this substance can damage human genetic material, increase the risk of cancer, have adverse effects on fetal development in pregnant women, and can cause serious consequences such as fetal malformation.
Therefore, the production, use and handling of 4-chloro-1-fluoro-2-nitrobenzene should be done with caution to reduce its harm to the environment and human health.
In terms of the environment, if this substance is released in nature, it is difficult to degrade rapidly because of its certain chemical stability. Or it exists in soil and water bodies and is difficult to transfer. In soil, it can cause soil deterioration, affect the uptake of nutrients by plant roots, hinder plant growth, reduce crop production, and disrupt ecological balance. In water bodies, it can pollute water sources and endanger aquatic organisms. If fish, shellfish and other aquatic organisms are exposed to this, it may cause physiological disorders, decreased reproductive ability, and even death. And in the food chain, it can be enriched along the food chain, from aquatic organisms to animals that feed on it, and the scope of harm is gradually widening.
As for human health, 4-chloro-1-fluoro-2-nitrobenzene may enter the body through respiratory tract, skin contact, and accidental ingestion. Inhalation through the respiratory tract can irritate the mucosa of the respiratory tract, causing symptoms such as cough, asthma, and breathing difficulties. If exposed to the skin, it can cause skin allergies, itching, redness, and swelling. Those who eat it by mistake can damage the digestive system, causing nausea, vomiting, abdominal pain, diarrhea, etc. What's more, this substance may be potentially carcinogenic, teratogenic, and mutagenic. Long-term exposure to the environment containing this substance can damage human genetic material, increase the risk of cancer, have adverse effects on fetal development in pregnant women, and can cause serious consequences such as fetal malformation.
Therefore, the production, use and handling of 4-chloro-1-fluoro-2-nitrobenzene should be done with caution to reduce its harm to the environment and human health.
Scan to WhatsApp
