Linshang Chemical
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4-Chloro-1-Fluoro-2-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
204641 |
| Chemical Formula | C7H3ClF4 |
| Molar Mass | 198.54 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Around 138 - 140 °C |
| Density | Approx. 1.44 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | Approx. 40 °C |
| Odor | Characteristic aromatic odor |
| Stability | Stable under normal conditions, but reactive with strong oxidizing agents |
As an accredited 4-Chloro-1-Fluoro-2-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram bottle packaging for 4 - chloro - 1 - fluoro - 2 - (trifluoromethyl)benzene. |
| Storage | 4 - chloro - 1 - fluoro - 2 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents, reducing agents, and reactive chemicals to avoid potential reactions. |
| Shipping | 4 - chloro - 1 - fluoro - 2 - (trifluoromethyl)benzene is shipped in well - sealed, corrosion - resistant containers. It adheres to strict chemical shipping regulations, ensuring secure transport to prevent leakage and environmental or safety risks. |
Competitive 4-Chloro-1-Fluoro-2-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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As a leading 4-Chloro-1-Fluoro-2-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 4-chloro-1-fluoro-2- (trifluoromethyl) benzene
4-Chloro-1-fluoro-2- (trifluoromethyl) benzene, this is an organic compound with unique chemical properties and important uses in many fields.
When it comes to physical properties, it is usually a colorless to light yellow liquid at room temperature and pressure, with a certain volatility, audible and special odor. Its physical constants such as boiling point and melting point vary according to specific experimental conditions. Generally speaking, due to the presence of halogen atoms and trifluoromethyl in the molecule, its boiling point is relatively high, and the intermolecular force is enhanced.
In terms of chemical properties, chlorine atoms, fluorine atoms and trifluoromethyl atoms in this compound give it unique reactivity. Chlorine atoms have nucleophilic substitution reaction activity. When encountering nucleophilic reagents, such as hydroxyl anions, amino anions, etc., chlorine atoms can be replaced to form corresponding alcohol and amine derivatives. This reaction mechanism is often that nucleophilic reagents attack the carbon atoms connected to chlorine on the benzene ring, and the chlorine atoms leave with a pair of electrons.
The presence of fluorine atoms enhances the stability of molecules. Because of its high electronegativity, it can attract electron clouds and reduce the density of electron clouds in the benzene ring. This property not only affects the reactivity of other substituents on the benzene ring, but also changes the stability of the whole molecule to oxidation, reduction and other reactions.
Trifluoromethyl is a strong electron-absorbing group, which greatly affects the electron cloud distribution of the benzene ring and reduces the electrophilic substitution reaction activity on the benzene ring. However, under specific conditions, electrophilic substitution reactions can still occur, such as nitrification, sulfonation, etc. The reaction check point is mostly at the position where the electron cloud density is relatively high. Due to the electron-absorbing action of trifluoromethyl, the reaction often occurs at the position of the benzene ring far from the trifluoromethyl.
In addition, 4-chloro-1-fluoro-2 - (trifluoromethyl) benzene can also participate in metal-catalyzed coupling reactions, such as Suzuki coupling reaction with organoboronic acid under palladium catalysis, forming carbon-carbon bonds, synthesizing organic compounds with more complex structures, which is of great significance in the fields of drug synthesis and materials science.
To sum up, 4-chloro-1-fluoro-2 - (trifluoromethyl) benzene has rich and diverse chemical properties due to its special substituents, providing an important intermediate and research object for organic synthesis chemistry.
When it comes to physical properties, it is usually a colorless to light yellow liquid at room temperature and pressure, with a certain volatility, audible and special odor. Its physical constants such as boiling point and melting point vary according to specific experimental conditions. Generally speaking, due to the presence of halogen atoms and trifluoromethyl in the molecule, its boiling point is relatively high, and the intermolecular force is enhanced.
In terms of chemical properties, chlorine atoms, fluorine atoms and trifluoromethyl atoms in this compound give it unique reactivity. Chlorine atoms have nucleophilic substitution reaction activity. When encountering nucleophilic reagents, such as hydroxyl anions, amino anions, etc., chlorine atoms can be replaced to form corresponding alcohol and amine derivatives. This reaction mechanism is often that nucleophilic reagents attack the carbon atoms connected to chlorine on the benzene ring, and the chlorine atoms leave with a pair of electrons.
The presence of fluorine atoms enhances the stability of molecules. Because of its high electronegativity, it can attract electron clouds and reduce the density of electron clouds in the benzene ring. This property not only affects the reactivity of other substituents on the benzene ring, but also changes the stability of the whole molecule to oxidation, reduction and other reactions.
Trifluoromethyl is a strong electron-absorbing group, which greatly affects the electron cloud distribution of the benzene ring and reduces the electrophilic substitution reaction activity on the benzene ring. However, under specific conditions, electrophilic substitution reactions can still occur, such as nitrification, sulfonation, etc. The reaction check point is mostly at the position where the electron cloud density is relatively high. Due to the electron-absorbing action of trifluoromethyl, the reaction often occurs at the position of the benzene ring far from the trifluoromethyl.
In addition, 4-chloro-1-fluoro-2 - (trifluoromethyl) benzene can also participate in metal-catalyzed coupling reactions, such as Suzuki coupling reaction with organoboronic acid under palladium catalysis, forming carbon-carbon bonds, synthesizing organic compounds with more complex structures, which is of great significance in the fields of drug synthesis and materials science.
To sum up, 4-chloro-1-fluoro-2 - (trifluoromethyl) benzene has rich and diverse chemical properties due to its special substituents, providing an important intermediate and research object for organic synthesis chemistry.
What are the common uses of 4-chloro-1-fluoro-2- (trifluoromethyl) benzene
4-Chloro-1-fluoro-2- (trifluoromethyl) benzene, this is an organic compound with a wide range of common uses.
First, in the field of pharmaceutical synthesis, it is often a key intermediate. Due to the special structure of fluorine and chlorine atoms, it endows the molecule with unique physical and chemical properties and biological activities. Through chemical reactions, it can be converted into compounds with specific pharmacological activities for the development of new drugs. For example, in the development of anti-cancer drugs and anti-infective drugs, this compound may participate in the construction of the core structure of the drug through a series of reactions, helping to optimize the efficacy and safety of the drug.
Second, it also plays an important role in the creation of pesticides. Due to its structural characteristics, it can be used as a raw material for the synthesis of high-efficiency and low-toxicity pesticides. Through modification and transformation, pesticide varieties with high selectivity to pests and environmental friendliness are prepared. For example, the synthesis of new insecticides, through its special structure, interact with the target in the pest body, inhibit the normal physiological function of pests, achieve the purpose of pest control, and reduce the harm to non-target organisms and the environment.
Third, in the field of materials science, 4-chloro-1-fluoro-2 - (trifluoromethyl) benzene can be used to synthesize special polymer materials. Because of its fluorine-containing groups, it can improve the chemical resistance, weather resistance and low surface energy of materials. For example, synthetic high-performance coatings, engineering plastics, etc. are used in aerospace, electronics and other fields to meet the strict requirements of material properties in special environments.
Fourth, as a building block for organic synthesis, it provides organic chemists with the basic structure for constructing complex organic molecules. With its various chemical reaction activity check points, it can combine with various reagents through nucleophilic substitution, electrophilic substitution, metal catalytic coupling and other reactions to build different carbon-carbon and carbon-heteroatom bonds, expand the structural diversity of organic molecules, and lay the foundation for the creation of new compounds and the study of organic synthesis methodologies.
First, in the field of pharmaceutical synthesis, it is often a key intermediate. Due to the special structure of fluorine and chlorine atoms, it endows the molecule with unique physical and chemical properties and biological activities. Through chemical reactions, it can be converted into compounds with specific pharmacological activities for the development of new drugs. For example, in the development of anti-cancer drugs and anti-infective drugs, this compound may participate in the construction of the core structure of the drug through a series of reactions, helping to optimize the efficacy and safety of the drug.
Second, it also plays an important role in the creation of pesticides. Due to its structural characteristics, it can be used as a raw material for the synthesis of high-efficiency and low-toxicity pesticides. Through modification and transformation, pesticide varieties with high selectivity to pests and environmental friendliness are prepared. For example, the synthesis of new insecticides, through its special structure, interact with the target in the pest body, inhibit the normal physiological function of pests, achieve the purpose of pest control, and reduce the harm to non-target organisms and the environment.
Third, in the field of materials science, 4-chloro-1-fluoro-2 - (trifluoromethyl) benzene can be used to synthesize special polymer materials. Because of its fluorine-containing groups, it can improve the chemical resistance, weather resistance and low surface energy of materials. For example, synthetic high-performance coatings, engineering plastics, etc. are used in aerospace, electronics and other fields to meet the strict requirements of material properties in special environments.
Fourth, as a building block for organic synthesis, it provides organic chemists with the basic structure for constructing complex organic molecules. With its various chemical reaction activity check points, it can combine with various reagents through nucleophilic substitution, electrophilic substitution, metal catalytic coupling and other reactions to build different carbon-carbon and carbon-heteroatom bonds, expand the structural diversity of organic molecules, and lay the foundation for the creation of new compounds and the study of organic synthesis methodologies.
What is the synthesis method of 4-chloro-1-fluoro-2- (trifluoromethyl) benzene
The synthesis of 4-chloro-1-fluoro-2 - (trifluoromethyl) benzene is an important topic in the field of organic synthetic chemistry. This compound has critical uses in many fields such as medicine, pesticides and materials science, so it is of great significance to explore efficient synthesis paths.
In the past, 4-chloro-1-fluoro-2 - (trifluoromethyl) benzene was synthesized, often with benzene derivatives as starting materials. One method uses 2-chloro-5-fluorobenzoic acid as the initial material, first converts the carboxyl group into a easily leaving group, such as the corresponding ester through esterification reaction. Subsequently, trifluoromethyl is introduced after treatment with suitable nucleophiles. In this step, trifluoromethylation reagents may be used, such as trifluoromethyl magnesium halide or trifluoromethyl copper reagent. Careful control of reaction conditions, such as temperature, solvent and reaction time, is required to ensure reaction selectivity and yield.
Another synthetic strategy starts from 2-chloro-5-fluorotoluene. The methyl group is first selectively oxidized to obtain the corresponding benzoic acid derivative. After that, the carboxyl group is converted and introduced into the trifluoromethyl group through similar steps as above, and the target product 4-chloro-1-fluoro-2 - (trifluoromethyl) benzene is obtained.
There are also studies trying to synthesize chlorofluoroaromatics with reagents containing trifluoromethyl through transition metal catalytic coupling reaction. This method often uses transition metals such as palladium and nickel as catalysts, and ligands cooperate to couple chlorofluoroaromatics with trifluoromethylation reagents. This approach requires careful selection of catalysts and ligands, and optimization of reaction conditions to achieve efficient synthesis.
There are many methods for synthesizing 4-chloro-1-fluoro-2 - (trifluoromethyl) benzene, and each method has its advantages and disadvantages. In practical application, it is necessary to choose the most suitable synthetic method according to the comprehensive consideration of many factors such as the availability of raw materials, the difficulty of controlling the reaction conditions, and the purity and yield of the target product.
In the past, 4-chloro-1-fluoro-2 - (trifluoromethyl) benzene was synthesized, often with benzene derivatives as starting materials. One method uses 2-chloro-5-fluorobenzoic acid as the initial material, first converts the carboxyl group into a easily leaving group, such as the corresponding ester through esterification reaction. Subsequently, trifluoromethyl is introduced after treatment with suitable nucleophiles. In this step, trifluoromethylation reagents may be used, such as trifluoromethyl magnesium halide or trifluoromethyl copper reagent. Careful control of reaction conditions, such as temperature, solvent and reaction time, is required to ensure reaction selectivity and yield.
Another synthetic strategy starts from 2-chloro-5-fluorotoluene. The methyl group is first selectively oxidized to obtain the corresponding benzoic acid derivative. After that, the carboxyl group is converted and introduced into the trifluoromethyl group through similar steps as above, and the target product 4-chloro-1-fluoro-2 - (trifluoromethyl) benzene is obtained.
There are also studies trying to synthesize chlorofluoroaromatics with reagents containing trifluoromethyl through transition metal catalytic coupling reaction. This method often uses transition metals such as palladium and nickel as catalysts, and ligands cooperate to couple chlorofluoroaromatics with trifluoromethylation reagents. This approach requires careful selection of catalysts and ligands, and optimization of reaction conditions to achieve efficient synthesis.
There are many methods for synthesizing 4-chloro-1-fluoro-2 - (trifluoromethyl) benzene, and each method has its advantages and disadvantages. In practical application, it is necessary to choose the most suitable synthetic method according to the comprehensive consideration of many factors such as the availability of raw materials, the difficulty of controlling the reaction conditions, and the purity and yield of the target product.
4-chloro-1-fluoro-2- (trifluoromethyl) benzene in storage and transportation
4-Chloro-1-fluoro-2- (trifluoromethyl) benzene is an organic chemical substance. During storage and transportation, many important items must be observed.
First talk about storage. This substance should be placed in a cool, dry and well-ventilated place. Because of its volatility, if it is in a warm and humid place, it may increase volatilization, or even trigger chemical reactions due to environmental factors. And it should be kept away from fires and heat sources. Because it may be flammable, it may cause fire or even explosion in case of open flame, hot topic, or danger. Be sure to store it separately from oxidants, acids, bases, etc., and cannot be mixed. Due to these substances or chemical reactions with 4-chloro-1-fluoro-2 - (trifluoromethyl) benzene, causing deterioration and increasing safety risks. Storage places should have suitable materials to contain leaks in case of leakage, which can be properly handled in a timely manner.
As for transportation. Before transportation, containers and packaging must be carefully inspected to ensure that they are intact and free from leakage. Packaging should be tight, with corresponding warning labels, indicating its characteristics and dangers, so that transporters and related personnel can be clear. During transportation, the speed should not be too fast, nor should it be braked abruptly to prevent packaging damage due to bumps and collisions, and material leakage. Transportation vehicles should be equipped with the appropriate variety and quantity of fire fighting equipment and leakage emergency treatment equipment. If a leak occurs during transportation, drivers and passengers must take immediate emergency measures to evacuate the crowd, isolate the scene, and report to the relevant departments in a timely manner.
All of these are matters that should be paid attention to when storing and transporting 4-chloro-1-fluoro-2 - (trifluoromethyl) benzene, so as to ensure safety and avoid accidents.
First talk about storage. This substance should be placed in a cool, dry and well-ventilated place. Because of its volatility, if it is in a warm and humid place, it may increase volatilization, or even trigger chemical reactions due to environmental factors. And it should be kept away from fires and heat sources. Because it may be flammable, it may cause fire or even explosion in case of open flame, hot topic, or danger. Be sure to store it separately from oxidants, acids, bases, etc., and cannot be mixed. Due to these substances or chemical reactions with 4-chloro-1-fluoro-2 - (trifluoromethyl) benzene, causing deterioration and increasing safety risks. Storage places should have suitable materials to contain leaks in case of leakage, which can be properly handled in a timely manner.
As for transportation. Before transportation, containers and packaging must be carefully inspected to ensure that they are intact and free from leakage. Packaging should be tight, with corresponding warning labels, indicating its characteristics and dangers, so that transporters and related personnel can be clear. During transportation, the speed should not be too fast, nor should it be braked abruptly to prevent packaging damage due to bumps and collisions, and material leakage. Transportation vehicles should be equipped with the appropriate variety and quantity of fire fighting equipment and leakage emergency treatment equipment. If a leak occurs during transportation, drivers and passengers must take immediate emergency measures to evacuate the crowd, isolate the scene, and report to the relevant departments in a timely manner.
All of these are matters that should be paid attention to when storing and transporting 4-chloro-1-fluoro-2 - (trifluoromethyl) benzene, so as to ensure safety and avoid accidents.
What are the effects of 4-chloro-1-fluoro-2- (trifluoromethyl) benzene on the environment and human health?
4-Chloro-1-fluoro-2- (trifluoromethyl) benzene is of great concern to the world due to its impact on the environment and human health. This compound has certain chemical properties, and its effects are also multi-faceted.
At one end of the environment, its stability may cause it to persist in the natural environment for a long time. If released into the soil, or due to its own structure hindering microbial degradation, it will gradually accumulate, affecting soil ecology. Causes soil fertility to change, hindering plant growth. Entry into water bodies, due to its hydrophobicity, or adsorption to suspended particles, settle to the bottom, affecting aquatic ecosystems. Causes aquatic biological behavior, physiological abnormalities, or changes in community structure, threatening biodiversity. And this substance volatilizes into the atmosphere, or participates in photochemical reactions, affecting air quality, causing regional climate and environmental changes.
As for human health, it may be ingested into the human body through respiration, skin contact, or diet. In the body, or interact with biological macromolecules such as proteins and nucleic acids, interfering with normal physiological and biochemical processes. Long-term exposure may damage the function of organs such as the liver and kidneys, causing cell damage and lesions due to metabolism or toxic intermediates. It also has potential carcinogenic risks, or causes gene abnormalities, disrupts cell cycle regulation, and triggers tumors. In the nervous system, or affects neurotransmitter transmission, causing neurological symptoms such as headache, dizziness, fatigue, etc.
4-chloro-1-fluoro-2- (trifluoromethyl) benzene is potentially harmful to the environment and human health. It should be treated with caution, and monitoring and control should be strengthened to reduce its adverse effects and protect the environment and human safety.
At one end of the environment, its stability may cause it to persist in the natural environment for a long time. If released into the soil, or due to its own structure hindering microbial degradation, it will gradually accumulate, affecting soil ecology. Causes soil fertility to change, hindering plant growth. Entry into water bodies, due to its hydrophobicity, or adsorption to suspended particles, settle to the bottom, affecting aquatic ecosystems. Causes aquatic biological behavior, physiological abnormalities, or changes in community structure, threatening biodiversity. And this substance volatilizes into the atmosphere, or participates in photochemical reactions, affecting air quality, causing regional climate and environmental changes.
As for human health, it may be ingested into the human body through respiration, skin contact, or diet. In the body, or interact with biological macromolecules such as proteins and nucleic acids, interfering with normal physiological and biochemical processes. Long-term exposure may damage the function of organs such as the liver and kidneys, causing cell damage and lesions due to metabolism or toxic intermediates. It also has potential carcinogenic risks, or causes gene abnormalities, disrupts cell cycle regulation, and triggers tumors. In the nervous system, or affects neurotransmitter transmission, causing neurological symptoms such as headache, dizziness, fatigue, etc.
4-chloro-1-fluoro-2- (trifluoromethyl) benzene is potentially harmful to the environment and human health. It should be treated with caution, and monitoring and control should be strengthened to reduce its adverse effects and protect the environment and human safety.
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