4-Chloro-1-Hydroxy-3,5-Dimethylbenzene
Linshang Chemical
HS Code |
438035 |
Chemical Formula | C8H9ClO |
Molar Mass | 156.61 g/mol |
Appearance | Solid (presumably, based on similar compounds) |
Physical State At Room Temp | Solid |
Solubility In Water | Low (due to non - polar aromatic nature and small polar group) |
Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
As an accredited 4-Chloro-1-Hydroxy-3,5-Dimethylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
Packing | 500g of 4 - chloro - 1 - hydroxy - 3,5 - dimethylbenzene in sealed plastic containers. |
Storage | 4 - chloro - 1 - hydroxy - 3,5 - dimethylbenzene should be stored in a cool, dry, well - ventilated area, away from direct sunlight. Keep it in a tightly sealed container to prevent moisture absorption and evaporation. Store it separately from oxidizing agents and incompatible substances to avoid potential chemical reactions. Ensure the storage location is clearly labeled for easy identification. |
Shipping | 4 - chloro - 1 - hydroxy - 3,5 - dimethylbenzene is shipped in well - sealed, corrosion - resistant containers. Shipment follows strict chemical transport regulations, ensuring proper handling to prevent spills and exposure during transit. |
Competitive 4-Chloro-1-Hydroxy-3,5-Dimethylbenzene prices that fit your budget—flexible terms and customized quotes for every order.
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Tel: +8615365006308
Email: info@alchemist-chem.com


As a leading 4-Chloro-1-Hydroxy-3,5-Dimethylbenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
Looking at its structure, there are chlorine atoms, hydroxyl groups and two methyl groups attached to the benzene ring. According to the naming rules, the positions and names of the substituents are listed first, and then the parent body is called. "4-chloro" indicates that the chlorine atom is located at the 4th position of the benzene ring; "1-hydroxy" refers to the hydroxyl group at the 1st position; "3,5-dimethyl" indicates that the two methyl groups are at the 3rd and 5th positions respectively.
In this way, this compound is accurately named 4-chloro-1-hydroxy-3,5-dimethylbenzene according to the existing rules. This designation can accurately reflect the structural characteristics of the compound, and is of great significance in chemical research, communication, and substance identification. It allows industry insiders to know its approximate structure and promotes the smooth development of academic research and industrial practice.
First, in the field of medicine, it can be used as a disinfectant. It has a good sterilization and disinfection effect and can kill many bacteria, fungi and viruses. In the past, disinfectants containing this ingredient were commonly used in medical clinics and wards to keep the environment clean and prevent the spread of germs. In household cleaning, some disinfectant water also contains this, which can disinfect furniture, floors, etc., to protect the health of the family.
Second, in the chemical industry, it is an important organic synthetic raw material. Through a series of chemical reactions, a variety of fine chemicals can be prepared, such as fragrances, pesticide intermediates, etc. With its special molecular structure, it imparts a unique aroma to the product when synthesizing fragrances; when making pesticide intermediates, it helps to improve the efficacy and stability of pesticides.
Third, it is also used in personal care products. Some high-end hand sanitizers, body washes, etc. add this substance to their antibacterial properties, remove bacteria on the surface of the skin, prevent infection, protect skin health, and make users feel refreshed and comfortable.
Fourth, it has a significant effect in the field of antiseptic. It can be added to coatings, adhesives and other products to prevent the growth of microorganisms, extend the shelf life of the product, and ensure the quality and performance of the product. If this is added to the coating, it can avoid the deterioration, discoloration and peeling of the coating due to microbial erosion.
When it comes to the melting point, it is about a specific range. This value is the inherent property of the substance and is the key basis for identifying this substance. When the temperature rises to the melting point, the solid 4-chloro-1-hydroxy-3,5-dimethylbenzene gradually melts into a liquid state, just like ice and snow meet the warm sun, quietly changing its form.
In addition to its solubility, it can be moderately dissolved in organic solvents, such as ethanol, ether, etc. Ethanol is like water and can be mixed with it, just like fish get water. Molecular interaction makes it evenly dispersed in ethanol. In water, its solubility is very small, just like oil and water, it is difficult to blend, which is due to the characteristics of molecular structure.
Its density is also one of the important physical properties. Compared with water, its density is slightly different. If it is placed in the same container as water, due to different densities, it either floats on water or sinks underwater, just like wood and stone, in their respective positions in water.
In addition, the volatility of this substance is weak, and it rarely evaporates into the air at room temperature. Even in a ventilated place, its molecular escape rate is slow, just like a stable person, and it is not easy to show signs. This property makes 4-chloro-1-hydroxy-3,5-dimethylbenzene less volatile during storage and use.
Chlorine atoms attached to the benzene ring have an electron-absorbing effect, but they can also change the electron cloud density distribution of the benzene ring due to the conjugation effect, which affects the reaction activity and check point. The methyl group on the benzene ring is the power supply group, which can increase the electron cloud density of the benzene ring, making the benzene ring more susceptible to attack by electrophilic reagents, and mainly makes the electrophilic substitution reaction occur in its adjacent and para-position.
Furthermore, 4-chloro-1-hydroxy-3,5-dimethylbenzene may have a certain acidity. Due to the strong electronegativity of the oxygen atom in the phenolic hydroxyl group and the large polarity of the hydrogen-oxygen bond, hydrogen is easier to dissociate in the form of protons, but its acidity is weaker than that of common inorganic acids and most carboxylic acids. In addition, the compound may exhibit certain physical properties due to the existence of benzene ring, hydroxyl group and methyl group, such as different solubility in specific organic solvents, and may have corresponding melting points, Due to its diverse chemical properties, it may have important uses and research value in fields such as organic synthesis and medicinal chemistry.
First, 3,5-dimethylphenol is prepared by chlorination with 3,5-dimethylphenol as the starting material. Place 3,5-dimethylphenol in a suitable reaction vessel, add an appropriate amount of solvent, such as dichloromethane, to help it dissolve and disperse. Then, under low temperature and stirring conditions, slowly introduce chlorine gas. In this process, chlorine gas undergoes a substitution reaction with 3,5-dimethylphenol, and the chlorine atom replaces the hydrogen atom at a specific position on the phenol ring to generate 4-chloro-3,5-dimethylphenol. Pay attention to the control of the reaction temperature. If the temperature is too high, it is easy to cause the formation of polychlorinated by-products, which affects the purity of the product. After the reaction is completed, a pure target product can be obtained after extraction, washing, distillation and other post-treatment steps.
Second, m-xylene is used as the starting material, and the phenylation reaction is first carried out, and then chlorination is carried out. M-xylene reacts with phenylation reagents, such as acrylonitrile and acidic catalysts, under specific temperature and pressure conditions to form 3,5-dimethylphenol intermediates Then, according to the above chlorination method using 3,5-dimethylphenol as raw material, 4-chloro-3,5-dimethylphenol is further reacted to obtain 4-chloro-3,5-dimethylphenol. This route step is slightly complicated, but the source of xylene raw materials is extensive, and the cost may be advantageous.
Third, the Grignard reagent method is adopted. The Grignard reagent is prepared by reacting an appropriate halogenated aromatic hydrocarbon with magnesium, and then reacting with the corresponding carbonyl compound. After hydrolysis and other steps, it is also expected to obtain 4-chloro-3,5-dimethylphenol. This method requires strict reaction conditions, requires an anhydrous and anaerobic environment, and the preparation and use of Grignard reagents need to be handled with caution to prevent However, in some specific situations, this method can provide a unique synthesis path, which helps to improve the selectivity and yield of the product.

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