Linshang Chemical
PRODUCTS
4-Chloro-1-Iodo-2-Methoxybenzene
Linshang Chemical
|
HS Code |
401633 |
| Chemical Formula | C7H6ClIO |
| Molecular Weight | 254.48 |
| Appearance | Solid (usually) |
| Boiling Point | Approximately 260 - 270 °C (estimated) |
| Melting Point | 38 - 42 °C |
| Density | Around 1.85 g/cm³ (estimated) |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | Approximately 115 °C (estimated) |
| Stability | Stable under normal conditions, but may react with strong oxidizing agents |
As an accredited 4-Chloro-1-Iodo-2-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - chloro - 1 - iodo - 2 - methoxybenzene packaged in a sealed glass bottle. |
| Storage | 4 - chloro - 1 - iodo - 2 - methoxybenzene should be stored in a cool, dry, well - ventilated area away from sources of heat, ignition, and direct sunlight. Keep it in a tightly - sealed container, preferably made of corrosion - resistant material. Store it separately from oxidizing agents, reducing agents, and reactive chemicals to prevent potential chemical reactions. |
| Shipping | 4 - chloro - 1 - iodo - 2 - methoxybenzene is shipped in well - sealed, corrosion - resistant containers. It's transported with strict adherence to chemical safety regulations, ensuring proper handling to prevent spills and exposure during transit. |
Competitive 4-Chloro-1-Iodo-2-Methoxybenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 4-Chloro-1-Iodo-2-Methoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemistry of 4-chloro-1-iodo-2-methoxybenzene?
4-Chloro-1-iodine-2-methoxybenzene is one of the organic compounds. Its chemical properties are well researched.
As far as nucleophilic substitution is concerned, the chlorine atom and the iodine atom on the benzene ring are different in activity due to the influence of the benzene ring and the methoxy group. Iodine atoms are more likely to leave than chlorine atoms because of their larger atomic radius and relatively small C-I bond energy. Therefore, under the action of nucleophiles, the position of iodine atoms is more prone to nucleophilic substitution. If the nucleophilic reagent contains active nucleophilic check points, such as alkoxides, amines, etc., it can attack the carbon site of the iodine atom on the benzene ring, so that the iodine ion leaves and the corresponding substituted product is formed.
In the redox reaction, this compound also has unique performance. The benzene ring can be oxidized by a specific strong oxidant, resulting in a change in the structure of the benzene ring, or the side chain methoxy group may also be oxidized. However, the specific degree of oxidation and the product depend on the type of oxidant, the reaction conditions such as temperature, pH, etc. In the reduction reaction, when an appropriate reducing agent such as a metal hydride is present, the halogen atom on the benzene ring can be reduced to a hydrogen atom, causing the compound
In addition, the electron cloud density of the benzene ring can be increased due to the methoxy group as the power supply, especially in the adjacent and para-site effects. This property affects the electron cloud distribution of the compound, which in turn affects its reactivity and selectivity. In the electrophilic substitution reaction, the electrophilic reagents tend to attack the adjacent and para-site of the methoxy group. However, due to the presence of chlorine atoms and iodine atoms, the reactivity and localization effects are also adjusted, which makes the reaction situation more complicated. The regulation of reaction conditions, such as the choice of catalyst and the proportion of reactants, has a significant impact on the reaction process and product distribution. In conclusion, the chemical properties of 4-chloro-1-iodine-2-methoxybenzene are complex and diverse due to the interaction of various groups in the molecular structure, and have important research and application value in the fields of organic synthesis.
As far as nucleophilic substitution is concerned, the chlorine atom and the iodine atom on the benzene ring are different in activity due to the influence of the benzene ring and the methoxy group. Iodine atoms are more likely to leave than chlorine atoms because of their larger atomic radius and relatively small C-I bond energy. Therefore, under the action of nucleophiles, the position of iodine atoms is more prone to nucleophilic substitution. If the nucleophilic reagent contains active nucleophilic check points, such as alkoxides, amines, etc., it can attack the carbon site of the iodine atom on the benzene ring, so that the iodine ion leaves and the corresponding substituted product is formed.
In the redox reaction, this compound also has unique performance. The benzene ring can be oxidized by a specific strong oxidant, resulting in a change in the structure of the benzene ring, or the side chain methoxy group may also be oxidized. However, the specific degree of oxidation and the product depend on the type of oxidant, the reaction conditions such as temperature, pH, etc. In the reduction reaction, when an appropriate reducing agent such as a metal hydride is present, the halogen atom on the benzene ring can be reduced to a hydrogen atom, causing the compound
In addition, the electron cloud density of the benzene ring can be increased due to the methoxy group as the power supply, especially in the adjacent and para-site effects. This property affects the electron cloud distribution of the compound, which in turn affects its reactivity and selectivity. In the electrophilic substitution reaction, the electrophilic reagents tend to attack the adjacent and para-site of the methoxy group. However, due to the presence of chlorine atoms and iodine atoms, the reactivity and localization effects are also adjusted, which makes the reaction situation more complicated. The regulation of reaction conditions, such as the choice of catalyst and the proportion of reactants, has a significant impact on the reaction process and product distribution. In conclusion, the chemical properties of 4-chloro-1-iodine-2-methoxybenzene are complex and diverse due to the interaction of various groups in the molecular structure, and have important research and application value in the fields of organic synthesis.
What are the common uses of 4-chloro-1-iodo-2-methoxybenzene?
4-Chloro-1-iodine-2-methoxybenzene is also an organic compound. It has a wide range of common uses and is related to many chemical fields.
First, it is often used as a key intermediate in organic synthesis. Because of its molecular structure, chlorine, iodine and methoxy groups have their own characteristics, which can trigger a variety of chemical reactions. For example, chlorine atoms are highly active and can introduce various functional groups into the benzene ring through nucleophilic substitution reactions. Chemists can use this to react with nucleophilic reagents such as alcohols and amines to generate new compounds, expand the structural diversity of organic molecules, and pave the way for the creation of complex organic compounds.
Second, it also has a place in the field of medicinal chemistry. The structure of this compound may be the basis for the design of new drug molecules. The introduction of iodine atoms is relatively large, which can change the spatial configuration of molecules and the distribution of electron clouds, affecting the interaction between drugs and targets. Methoxy can enhance the lipid solubility of molecules, which is conducive to the passage of drugs through biofilms and improve bioavailability. Therefore, drug developers may use this as a starting material to create drugs with specific pharmacological activities through multi-step reactions.
Third, it also shows potential value in the field of materials science. Its structure endows certain electrical and optical properties, or it can be applied to organic optoelectronic materials. For example, in the development of organic Light Emitting Diode (OLED) or organic solar cell materials, through structural modification and optimization, the energy level structure and charge transport performance of the material can be adjusted to improve the performance and efficiency of the device.
In summary, 4-chloro-1-iodine-2-methoxybenzene, with its unique molecular structure, is an important chemical substance in the fields of organic synthesis, pharmaceutical chemistry and materials science, with rich uses and far-reaching significance.
First, it is often used as a key intermediate in organic synthesis. Because of its molecular structure, chlorine, iodine and methoxy groups have their own characteristics, which can trigger a variety of chemical reactions. For example, chlorine atoms are highly active and can introduce various functional groups into the benzene ring through nucleophilic substitution reactions. Chemists can use this to react with nucleophilic reagents such as alcohols and amines to generate new compounds, expand the structural diversity of organic molecules, and pave the way for the creation of complex organic compounds.
Second, it also has a place in the field of medicinal chemistry. The structure of this compound may be the basis for the design of new drug molecules. The introduction of iodine atoms is relatively large, which can change the spatial configuration of molecules and the distribution of electron clouds, affecting the interaction between drugs and targets. Methoxy can enhance the lipid solubility of molecules, which is conducive to the passage of drugs through biofilms and improve bioavailability. Therefore, drug developers may use this as a starting material to create drugs with specific pharmacological activities through multi-step reactions.
Third, it also shows potential value in the field of materials science. Its structure endows certain electrical and optical properties, or it can be applied to organic optoelectronic materials. For example, in the development of organic Light Emitting Diode (OLED) or organic solar cell materials, through structural modification and optimization, the energy level structure and charge transport performance of the material can be adjusted to improve the performance and efficiency of the device.
In summary, 4-chloro-1-iodine-2-methoxybenzene, with its unique molecular structure, is an important chemical substance in the fields of organic synthesis, pharmaceutical chemistry and materials science, with rich uses and far-reaching significance.
What are 4-chloro-1-iodo-2-methoxybenzene synthesis methods?
The synthesis of 4-chloro-1-iodine-2-methoxybenzene is an important topic in the field of organic synthesis. There are several common synthesis routes.
First, it can be started from the corresponding phenols. First, phenol and halomethane are reacted under alkaline conditions to achieve methoxylation of phenolic hydroxyl groups. This step requires a suitable base agent, such as potassium carbonate, etc., to be carried out in a suitable solvent, such as acetone, so that methoxylation products can be obtained. Later, chlorine and iodine atoms are introduced at specific positions in the benzene ring. The introduction of chlorine atoms can be achieved by electrophilic substitution reaction, and a suitable chlorinated reagent, such as thionyl chloride or phosphorus oxychloride, can be achieved under the catalysis of a suitable catalyst, such as aluminum trichloride. The introduction of iodine atoms usually uses iodizing reagents, such as potassium iodide in combination with appropriate oxidizing agents, or directly uses iodine-containing electrophilic reagents. Under mild reaction conditions, the iodine atoms are selectively connected to the predetermined position of the benzene ring, and then the target product 4-chloro-1-iodine-2-methoxybenzene is synthesized.
Second, halogenated benzene derivatives can also be used as starting materials. The methoxy group is introduced on the benzene ring first, which can be achieved by nucleophilic substitution reaction. Halogenated benzene is reacted with methoxylating reagents such as halogenated benzene and sodium methoxide under appropriate solvent and reaction temperature to generate methoxy-substituted halogenated benzene. Subsequently, according to the positioning rules, chlorine and iodine atoms In this process, it is necessary to precisely control the reaction conditions, such as reaction temperature, reagent dosage and reaction time, to ensure that the chlorine and iodine atoms are substituted according to the expected position, so as to successfully synthesize 4-chloro-1-iodine-2-methoxybenzene.
When synthesizing this compound, all reaction conditions need to be carefully regulated. If the temperature is too high or too low, it may affect the reaction rate and product selectivity; if the reagent dosage ratio is improper, it may cause side reactions to occur and reduce the yield of the target product. In addition, the choice of reaction solvent is also crucial, and its effect on the solubility of reactants and products and on the reactivity needs to be considered. 4-Chloro-1-iodine-2-methoxybenzene can be synthesized efficiently and with high purity only by properly controlling each link.
First, it can be started from the corresponding phenols. First, phenol and halomethane are reacted under alkaline conditions to achieve methoxylation of phenolic hydroxyl groups. This step requires a suitable base agent, such as potassium carbonate, etc., to be carried out in a suitable solvent, such as acetone, so that methoxylation products can be obtained. Later, chlorine and iodine atoms are introduced at specific positions in the benzene ring. The introduction of chlorine atoms can be achieved by electrophilic substitution reaction, and a suitable chlorinated reagent, such as thionyl chloride or phosphorus oxychloride, can be achieved under the catalysis of a suitable catalyst, such as aluminum trichloride. The introduction of iodine atoms usually uses iodizing reagents, such as potassium iodide in combination with appropriate oxidizing agents, or directly uses iodine-containing electrophilic reagents. Under mild reaction conditions, the iodine atoms are selectively connected to the predetermined position of the benzene ring, and then the target product 4-chloro-1-iodine-2-methoxybenzene is synthesized.
Second, halogenated benzene derivatives can also be used as starting materials. The methoxy group is introduced on the benzene ring first, which can be achieved by nucleophilic substitution reaction. Halogenated benzene is reacted with methoxylating reagents such as halogenated benzene and sodium methoxide under appropriate solvent and reaction temperature to generate methoxy-substituted halogenated benzene. Subsequently, according to the positioning rules, chlorine and iodine atoms In this process, it is necessary to precisely control the reaction conditions, such as reaction temperature, reagent dosage and reaction time, to ensure that the chlorine and iodine atoms are substituted according to the expected position, so as to successfully synthesize 4-chloro-1-iodine-2-methoxybenzene.
When synthesizing this compound, all reaction conditions need to be carefully regulated. If the temperature is too high or too low, it may affect the reaction rate and product selectivity; if the reagent dosage ratio is improper, it may cause side reactions to occur and reduce the yield of the target product. In addition, the choice of reaction solvent is also crucial, and its effect on the solubility of reactants and products and on the reactivity needs to be considered. 4-Chloro-1-iodine-2-methoxybenzene can be synthesized efficiently and with high purity only by properly controlling each link.
4-chloro-1-iodo-2-methoxybenzene What are the precautions during storage and transportation?
For 4-chloro-1-iodine-2-methoxybenzene, many matters must be paid attention to during storage and transportation.
Its nature may be more active, and it is afraid of light and heat. Therefore, when storing, it should be placed in a cool, dry and dark place. The warehouse temperature should not be too high to prevent changes in material properties. And it is necessary to stay away from fire and heat sources, and avoid co-storage and mixing with oxidants, acids, etc., because it may react with it chemically, causing danger.
During transportation, the packaging must be tight to ensure that there is no risk of leakage. The means of transportation used should also be clean and dry, and no substances that can react with them should be left. When loading and unloading, the operation should be gentle, do not drop, heavy pressure, so as not to damage the packaging.
This substance may be toxic and irritating, and contacts must wear appropriate protective equipment, such as protective clothing, gloves and goggles, to prevent it from touching the skin and eyes. If it is unfortunate to leak during transportation, quickly isolate the scene and evacuate the crowd. Small leaks can be absorbed by inert materials such as sand and vermiculite; large leaks need to be embanketed or dug for containment, and then properly disposed of.
In this way, in the process of storing and transporting 4-chloro-1-iodine-2-methoxybenzene, be careful and strictly abide by the norms to ensure safety.
Its nature may be more active, and it is afraid of light and heat. Therefore, when storing, it should be placed in a cool, dry and dark place. The warehouse temperature should not be too high to prevent changes in material properties. And it is necessary to stay away from fire and heat sources, and avoid co-storage and mixing with oxidants, acids, etc., because it may react with it chemically, causing danger.
During transportation, the packaging must be tight to ensure that there is no risk of leakage. The means of transportation used should also be clean and dry, and no substances that can react with them should be left. When loading and unloading, the operation should be gentle, do not drop, heavy pressure, so as not to damage the packaging.
This substance may be toxic and irritating, and contacts must wear appropriate protective equipment, such as protective clothing, gloves and goggles, to prevent it from touching the skin and eyes. If it is unfortunate to leak during transportation, quickly isolate the scene and evacuate the crowd. Small leaks can be absorbed by inert materials such as sand and vermiculite; large leaks need to be embanketed or dug for containment, and then properly disposed of.
In this way, in the process of storing and transporting 4-chloro-1-iodine-2-methoxybenzene, be careful and strictly abide by the norms to ensure safety.
4-chloro-1-iodo-2-methoxybenzene impact on the environment and human health
The effects of 4-chloro-1-iodine-2-methoxybenzene on the environment and human health should be discussed in detail.
This compound enters the environment or has many variables. In soil, its structure is stable to a certain extent, or it is difficult to be rapidly degraded by microorganisms, resulting in long-term residues. Its residues may affect the physical and chemical properties of the soil, disturb the balance of the soil ecosystem, and cause changes in the structure of the soil microbial community, which in turn affects the uptake and growth of nutrients by plant roots.
If it enters the water body, it has a certain fat solubility or is enriched by aquatic organisms. After ingesting small fish and shrimp, they are transmitted and amplified through the food chain, posing a threat to advanced aquatic organisms and even eaters of aquatic organisms. And it may affect the chemical balance of the water body, cause the deterioration of water quality, and endanger the diversity of aquatic ecosystems.
As for human health, 4-chloro-1-iodine-2-methoxybenzene is ingested into the human body through respiration, skin contact, and diet. Its chemical structure contains halogen atoms and methoxy groups, which may induce biochemical reactions in the body. Or interfere with the normal metabolic process of the human body, such as affecting the activity of enzymes, blocking the biochemical pathways in the body. Long-term exposure may damage the function of important organs such as the liver and kidneys, because it needs to be metabolized and excreted by the liver and kidneys. And may have potential genotoxicity and carcinogenicity, although there is no conclusive conclusion, halogenated aromatics have this risk and cannot be prevented.
In summary, 4-chloro-1-iodine-2-methoxybenzene has latent risks to the environment and human health, and needs to be treated with caution, and monitoring and control should be strengthened to reduce its harm.
This compound enters the environment or has many variables. In soil, its structure is stable to a certain extent, or it is difficult to be rapidly degraded by microorganisms, resulting in long-term residues. Its residues may affect the physical and chemical properties of the soil, disturb the balance of the soil ecosystem, and cause changes in the structure of the soil microbial community, which in turn affects the uptake and growth of nutrients by plant roots.
If it enters the water body, it has a certain fat solubility or is enriched by aquatic organisms. After ingesting small fish and shrimp, they are transmitted and amplified through the food chain, posing a threat to advanced aquatic organisms and even eaters of aquatic organisms. And it may affect the chemical balance of the water body, cause the deterioration of water quality, and endanger the diversity of aquatic ecosystems.
As for human health, 4-chloro-1-iodine-2-methoxybenzene is ingested into the human body through respiration, skin contact, and diet. Its chemical structure contains halogen atoms and methoxy groups, which may induce biochemical reactions in the body. Or interfere with the normal metabolic process of the human body, such as affecting the activity of enzymes, blocking the biochemical pathways in the body. Long-term exposure may damage the function of important organs such as the liver and kidneys, because it needs to be metabolized and excreted by the liver and kidneys. And may have potential genotoxicity and carcinogenicity, although there is no conclusive conclusion, halogenated aromatics have this risk and cannot be prevented.
In summary, 4-chloro-1-iodine-2-methoxybenzene has latent risks to the environment and human health, and needs to be treated with caution, and monitoring and control should be strengthened to reduce its harm.
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