Linshang Chemical
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4-Chloro-1-Methoxy-2-Nitrobenzene
Linshang Chemical
|
HS Code |
709633 |
| Chemical Formula | C7H6ClNO3 |
| Molar Mass | 187.58 g/mol |
| Appearance | Yellow solid (usually) |
| Melting Point | 55 - 57 °C |
| Boiling Point | 293.5 °C at 760 mmHg |
| Density | 1.39 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | 131.3 °C |
| Odor | Typical aromatic nitro - compound odor |
| Stability | Stable under normal conditions, but may react with strong oxidizing agents |
As an accredited 4-Chloro-1-Methoxy-2-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chloro - 1 - methoxy - 2 - nitrobenzene packaged in a sealed, labeled bottle. |
| Storage | 4 - chloro - 1 - methoxy - 2 - nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent leakage and exposure to air and moisture. Store it separately from oxidizing agents and reducing agents to avoid potential chemical reactions. |
| Shipping | 4 - chloro - 1 - methoxy - 2 - nitrobenzene should be shipped in well - sealed, corrosion - resistant containers. Label packages clearly with hazard warnings. Transport via approved carriers following strict chemical shipping regulations to ensure safety. |
Competitive 4-Chloro-1-Methoxy-2-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4-Chloro-1-Methoxy-2-Nitrobenzene in China?
As a trusted 4-Chloro-1-Methoxy-2-Nitrobenzene manufacturer, we deliver:
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-Chloro-1-Methoxy-2-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 4-chloro-1-methoxy-2-nitrobenzene?
4-Chloro-1-methoxy-2-nitrobenzene has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. Due to the activity of chlorine, methoxy and nitro in its structure, it can participate in a variety of chemical reactions to produce various organic compounds.
First, in the synthesis of medicine, specific functional groups can be introduced through a series of reactions, and then the molecular structure with biological activity can be constructed for the creation of new drugs. Second, in the field of materials science, it can be integrated into the polymer material system through polymerization reaction or modification process to endow the material with unique electrical, optical or thermal properties, such as the preparation of conductive materials with special functions, optical display materials, etc.
Furthermore, in the field of pesticide chemistry, using this as a starting material, through rational design and reaction, can synthesize pesticide products with high insecticidal, bactericidal or herbicidal properties. Because its structure can be precisely regulated, it can optimize the activity and selectivity of pesticides to target organisms and reduce the impact on non-target organisms.
In addition, in dye chemistry, it can be used to participate in dye synthesis, because different substituents can affect the electron cloud distribution and conjugation system of dye molecules, thereby adjusting the color, fastness and other properties of dyes, and can be used to prepare dyes with rich colors and excellent properties. From this perspective, 4-chloro-1-methoxy-2-nitrobenzene plays an important role in many fields of chemical industry, providing an important basis for the preparation of many fine chemicals.
First, in the synthesis of medicine, specific functional groups can be introduced through a series of reactions, and then the molecular structure with biological activity can be constructed for the creation of new drugs. Second, in the field of materials science, it can be integrated into the polymer material system through polymerization reaction or modification process to endow the material with unique electrical, optical or thermal properties, such as the preparation of conductive materials with special functions, optical display materials, etc.
Furthermore, in the field of pesticide chemistry, using this as a starting material, through rational design and reaction, can synthesize pesticide products with high insecticidal, bactericidal or herbicidal properties. Because its structure can be precisely regulated, it can optimize the activity and selectivity of pesticides to target organisms and reduce the impact on non-target organisms.
In addition, in dye chemistry, it can be used to participate in dye synthesis, because different substituents can affect the electron cloud distribution and conjugation system of dye molecules, thereby adjusting the color, fastness and other properties of dyes, and can be used to prepare dyes with rich colors and excellent properties. From this perspective, 4-chloro-1-methoxy-2-nitrobenzene plays an important role in many fields of chemical industry, providing an important basis for the preparation of many fine chemicals.
What are the physical properties of 4-chloro-1-methoxy-2-nitrobenzene?
4-Chloro-1-methoxy-2-nitrobenzene is one of the organic compounds. Its physical properties are quite important, let me tell you one by one.
Looking at its appearance, under room temperature and pressure, it often takes a light yellow to brown crystalline powder shape. The shape of this color state can be one of the aids in identifying this substance.
As for the melting point, it is about 57-61 ° C. The melting point is the temperature limit at which the substance changes from solid to liquid. This specific melting point range is quite practical in identifying and purifying the compound.
In terms of boiling point, it is about 277.9 ° C. Boiling point, the temperature at which the saturated vapor pressure of a liquid is equal to the external atmospheric pressure. Knowing the boiling point of this substance can be an important reference in separation operations such as distillation.
Its density is about 1.382g/cm ³. Density is the mass per unit volume of a substance. This value is helpful in converting its mass and volume in experimental operations, and in studying its distribution in different media.
Furthermore, this substance is slightly soluble in water. Water is the source of all things, and many substances interact with it differently. 4-Chloro-1-methoxy-2-nitrobenzene is slightly soluble in water, indicating that the interaction between it and water molecules is weak, but it can be soluble in organic solvents such as ethanol, ether, acetone, etc. Organic solvents are widely used in organic synthesis and other fields. The solubility of this compound makes it a basis for the selection of media for related chemical reactions.
In summary, the physical properties of 4-chloro-1-methoxy-2-nitrobenzene, such as appearance, melting point, boiling point, density, and solubility, are all indispensable information for the study and application of this substance, and can provide an important theoretical basis for practical operation in many fields such as chemical industry and medicine.
Looking at its appearance, under room temperature and pressure, it often takes a light yellow to brown crystalline powder shape. The shape of this color state can be one of the aids in identifying this substance.
As for the melting point, it is about 57-61 ° C. The melting point is the temperature limit at which the substance changes from solid to liquid. This specific melting point range is quite practical in identifying and purifying the compound.
In terms of boiling point, it is about 277.9 ° C. Boiling point, the temperature at which the saturated vapor pressure of a liquid is equal to the external atmospheric pressure. Knowing the boiling point of this substance can be an important reference in separation operations such as distillation.
Its density is about 1.382g/cm ³. Density is the mass per unit volume of a substance. This value is helpful in converting its mass and volume in experimental operations, and in studying its distribution in different media.
Furthermore, this substance is slightly soluble in water. Water is the source of all things, and many substances interact with it differently. 4-Chloro-1-methoxy-2-nitrobenzene is slightly soluble in water, indicating that the interaction between it and water molecules is weak, but it can be soluble in organic solvents such as ethanol, ether, acetone, etc. Organic solvents are widely used in organic synthesis and other fields. The solubility of this compound makes it a basis for the selection of media for related chemical reactions.
In summary, the physical properties of 4-chloro-1-methoxy-2-nitrobenzene, such as appearance, melting point, boiling point, density, and solubility, are all indispensable information for the study and application of this substance, and can provide an important theoretical basis for practical operation in many fields such as chemical industry and medicine.
What are the chemical properties of 4-chloro-1-methoxy-2-nitrobenzene?
4-Chloro-1-methoxy-2-nitrobenzene is one of the organic compounds. It has unique chemical properties and has attracted much attention in many chemical fields.
In terms of reactivity, the chlorine atoms in this compound are active due to the electronic effect of the benzene ring. Chlorine atoms can participate in nucleophilic substitution reactions, because nitro and methoxy groups on the benzene ring have an impact on the distribution of its electron cloud. Nitro has strong electron absorption, which decreases the electron cloud density of the benzene ring, especially the electron cloud density of the chlorine atom in the adjacent para-position, which makes the chlorine atom more easily replaced by nucleophilic reagents. For example, when treated with an aqueous solution of sodium hydroxide, the hydroxyl group or a substituted chlorine atom generates 4-methoxy-2-nitrophenol.
Methoxy group belongs to the donator group on the benzene ring, which can increase the electron cloud density of the benzene ring ortho-para, and has a certain activation effect on the electrophilic substitution reaction of the benzene ring. However, due to the dominant strong electron-absorbing effect of nitro group, the overall electron cloud density of the benzene ring is still low, and the electrophilic substitution reaction activity is slightly lower than that of the general benzene ring. However, under specific conditions and suitable electrophilic reagents, electrophilic substitution can still occur, substituting the check point or tending to the methoxy ortho-site (where the steric resistance is relatively small).
The nitro group Under the action of appropriate reducing agents such as iron and hydrochloric acid system, nitro groups can be gradually reduced to amino groups to generate 4-chloro-1-methoxy-2-aminobenzene. This product is often used as a key intermediate in the fields of dyes and pharmaceutical synthesis.
4-chloro-1-methoxy-2-nitrobenzene contains functional group characteristics, which show diverse chemical activities and are of great value in the field of organic synthesis. It provides basic raw materials and reaction starting points for the preparation of various fine chemicals.
In terms of reactivity, the chlorine atoms in this compound are active due to the electronic effect of the benzene ring. Chlorine atoms can participate in nucleophilic substitution reactions, because nitro and methoxy groups on the benzene ring have an impact on the distribution of its electron cloud. Nitro has strong electron absorption, which decreases the electron cloud density of the benzene ring, especially the electron cloud density of the chlorine atom in the adjacent para-position, which makes the chlorine atom more easily replaced by nucleophilic reagents. For example, when treated with an aqueous solution of sodium hydroxide, the hydroxyl group or a substituted chlorine atom generates 4-methoxy-2-nitrophenol.
Methoxy group belongs to the donator group on the benzene ring, which can increase the electron cloud density of the benzene ring ortho-para, and has a certain activation effect on the electrophilic substitution reaction of the benzene ring. However, due to the dominant strong electron-absorbing effect of nitro group, the overall electron cloud density of the benzene ring is still low, and the electrophilic substitution reaction activity is slightly lower than that of the general benzene ring. However, under specific conditions and suitable electrophilic reagents, electrophilic substitution can still occur, substituting the check point or tending to the methoxy ortho-site (where the steric resistance is relatively small).
The nitro group Under the action of appropriate reducing agents such as iron and hydrochloric acid system, nitro groups can be gradually reduced to amino groups to generate 4-chloro-1-methoxy-2-aminobenzene. This product is often used as a key intermediate in the fields of dyes and pharmaceutical synthesis.
4-chloro-1-methoxy-2-nitrobenzene contains functional group characteristics, which show diverse chemical activities and are of great value in the field of organic synthesis. It provides basic raw materials and reaction starting points for the preparation of various fine chemicals.
What are 4-chloro-1-methoxy-2-nitrobenzene synthesis methods?
To prepare 4-chloro-1-methoxy-2-nitrobenzene, there are two common methods. First, 1-methoxy-2-nitrobenzene is used as the starting material to react with chlorine-containing reagents. This is a method of electrophilic substitution. Usually, in the presence of suitable catalysts, such as anhydrous aluminum trichloride or iron filings, it interacts with chlorine gas or chlorinating agents such as sulfoxide chloride. During the reaction, chlorine atoms selectively replace hydrogen atoms at specific positions on the benzene ring. Because methoxy is an ortho-para-site group and nitro is an meta-site group, under the combined influence, chlorine atoms mainly enter the ortho-site of methoxy groups to form target products. The control of this reaction condition is extremely important, and the temperature, the proportion of reactants and the reaction time will all affect the yield and purity of the product.
Second, you can start from 4-chloro-1-methoxybenzene and make it react with nitrifying reagents. Generally, a mixed acid of concentrated nitric acid and concentrated sulfuric acid is used as a nitrifying agent. At an appropriate temperature, the benzene ring is nitrified. The positioning effect of the methoxy group guides the nitro group into its ortho-position, and then produces 4-chloro-1-methoxy-2-nitrobenzene. However, this process also needs to pay attention to the reaction conditions. The proportion of mixed acid and the temperature of the reaction are all related to the process of the reaction and the distribution of the product. If the temperature is too high, it may cause the formation of polynitro substitution by-products, reducing the yield of the target product.
Both are common ways to synthesize 4-chloro-1-methoxy-2-nitrobenzene. In practice, the best one should be selected according to the availability of raw materials, cost and ease of control of reaction conditions.
Second, you can start from 4-chloro-1-methoxybenzene and make it react with nitrifying reagents. Generally, a mixed acid of concentrated nitric acid and concentrated sulfuric acid is used as a nitrifying agent. At an appropriate temperature, the benzene ring is nitrified. The positioning effect of the methoxy group guides the nitro group into its ortho-position, and then produces 4-chloro-1-methoxy-2-nitrobenzene. However, this process also needs to pay attention to the reaction conditions. The proportion of mixed acid and the temperature of the reaction are all related to the process of the reaction and the distribution of the product. If the temperature is too high, it may cause the formation of polynitro substitution by-products, reducing the yield of the target product.
Both are common ways to synthesize 4-chloro-1-methoxy-2-nitrobenzene. In practice, the best one should be selected according to the availability of raw materials, cost and ease of control of reaction conditions.
4-chloro-1-methoxy-2-nitrobenzene what are the precautions during use
For 4-chloro-1-methoxy-2-nitrobenzene, there are several ends that should be paid attention to when using it.
This substance is toxic and can cause harm to the body if it touches the skin, inhales its gas or takes it by mistake. Therefore, when taking it, it is necessary to wear appropriate protective equipment, such as gloves, masks, goggles, etc., to avoid contact with the skin, eyes and respiratory tract. After the operation, be sure to wash your hands with soap and any places that may be touched.
Its chemical properties are lively, and there is a risk of explosion in case of hot topics, open flames or strong oxidants. When storing, it should be placed in a cool and ventilated place, away from fire and heat sources, and stored separately from oxidants, reducing agents, alkalis, etc., and should not be mixed.
During use, it should be operated in a well-ventilated ring, preferably in a fume hood, to prevent the accumulation of volatile gas. If there is a leak, personnel from the contaminated area should be quickly evacuated to a safe place, and quarantined, strictly restricting access. Emergency personnel must wear self-contained positive pressure breathing apparatus, wear anti-toxic clothing, and do not let leaks come into contact with combustible substances. Small leaks can be sprinkled with soda ash on the ground, then rinsed with a large amount of water, diluted with washing water and discharged into the wastewater system; if there are large leaks, a dike should be built or dug for containment, and transferred to a tanker or a special collector by pump, recycled or transported to a waste treatment site for disposal.
Furthermore, when using 4-chloro-1-methoxy-2-nitrobenzene, the established operating procedures and experimental procedures should be followed, and no changes should be made. Experimental records should also be prepared in detail, including usage, reaction conditions, product conditions, etc., for future investigation. In this way, the safety of the use process can be ensured and accidents can be avoided.
This substance is toxic and can cause harm to the body if it touches the skin, inhales its gas or takes it by mistake. Therefore, when taking it, it is necessary to wear appropriate protective equipment, such as gloves, masks, goggles, etc., to avoid contact with the skin, eyes and respiratory tract. After the operation, be sure to wash your hands with soap and any places that may be touched.
Its chemical properties are lively, and there is a risk of explosion in case of hot topics, open flames or strong oxidants. When storing, it should be placed in a cool and ventilated place, away from fire and heat sources, and stored separately from oxidants, reducing agents, alkalis, etc., and should not be mixed.
During use, it should be operated in a well-ventilated ring, preferably in a fume hood, to prevent the accumulation of volatile gas. If there is a leak, personnel from the contaminated area should be quickly evacuated to a safe place, and quarantined, strictly restricting access. Emergency personnel must wear self-contained positive pressure breathing apparatus, wear anti-toxic clothing, and do not let leaks come into contact with combustible substances. Small leaks can be sprinkled with soda ash on the ground, then rinsed with a large amount of water, diluted with washing water and discharged into the wastewater system; if there are large leaks, a dike should be built or dug for containment, and transferred to a tanker or a special collector by pump, recycled or transported to a waste treatment site for disposal.
Furthermore, when using 4-chloro-1-methoxy-2-nitrobenzene, the established operating procedures and experimental procedures should be followed, and no changes should be made. Experimental records should also be prepared in detail, including usage, reaction conditions, product conditions, etc., for future investigation. In this way, the safety of the use process can be ensured and accidents can be avoided.
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