Linshang Chemical
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4-Chloro-1-Methyl-Benzene
Linshang Chemical
|
HS Code |
965568 |
| Chemical Formula | C7H7Cl |
| Molar Mass | 126.583 g/mol |
| Appearance | Colorless to light - yellow liquid |
| Odor | Aromatic odor |
| Density | 1.069 g/cm³ at 20 °C |
| Boiling Point | 162 - 163 °C |
| Melting Point | -35 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in most organic solvents like ethanol, ether |
| Flash Point | 47 °C |
| Vapor Pressure | 0.42 kPa at 25 °C |
| Refractive Index | 1.522 at 20 °C |
As an accredited 4-Chloro-1-Methyl-Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500 - gram bottles containing 4 - chloro - 1 - methyl - benzene, well - sealed for safety. |
| Storage | 4 - chloro - 1 - methyl - benzene, also known as p - chlorotoluene, should be stored in a cool, well - ventilated area. Keep it away from heat, sparks, and open flames as it is flammable. Store in tightly closed containers to prevent vapor release. Separate from oxidizing agents and incompatible materials to avoid potential reactions. Label storage areas clearly for easy identification and safety. |
| Shipping | 4 - chloro - 1 - methyl - benzene is shipped in tightly sealed, corrosion - resistant containers. It's transported under regulated conditions, following safety protocols due to its chemical nature, ensuring secure transit to the destination. |
Competitive 4-Chloro-1-Methyl-Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 4-chloro-1-methyl-benzene?
4-Chloro-1-methyl-benzene, that is, p-chlorotoluene, is a kind of organic compound. Its physical and chemical properties are unique, and it has important uses in many fields.
This compound is colorless to light yellow liquid and has an aromatic odor. Its boiling point is about 162 ° C, its melting point is 7.5 ° C. Its density is slightly higher than that of water, and it is difficult to dissolve in water, but it is easily soluble in organic solvents such as ethanol and ether.
In terms of chemical properties, the 4-chloro-1-methyl-benzene ring is connected to chlorine atoms and methyl groups, so it exhibits various reactivity. The electron cloud density of the benzene ring increases due to the electron-giving effect of methyl groups, making the benzene ring more prone to electrophilic substitution reactions. For example, under appropriate conditions, it can nitrate with mixed acids of nitric acid and sulfuric acid to generate products such as 4-chloro-2-nitro-1-methyl-benzene and 4-chloro-4-nitro-1-methyl-benzene.
In addition, chlorine atoms can participate in nucleophilic substitution reactions. Under specific conditions such as strong bases or high temperatures, chlorine atoms can be replaced by nucleophiles such as hydroxyl and amino groups to generate corresponding substitution products. For example, when heated in an alcohol solution of sodium hydroxide, the chlorine atom may be replaced by a hydroxyl group to form p-methylphenol.
At the same time, the methyl group in 4-chloro-1-methyl-benzene can also react. Under the condition of light or the presence of an initiator, the hydrogen atom on the methyl group can be replaced by a halogen atom to undergo a free radical substitution reaction. For example, when reacted with chlorine under light, products such as 4-chloro-1- (chloromethyl) -benzene can be formed. With these chemical properties, 4-chloro-1-methyl-benzene is widely used as an important intermediate in the fields of medicine, pesticides, dyes, and other industries to synthesize various organic compounds with specific functions.
This compound is colorless to light yellow liquid and has an aromatic odor. Its boiling point is about 162 ° C, its melting point is 7.5 ° C. Its density is slightly higher than that of water, and it is difficult to dissolve in water, but it is easily soluble in organic solvents such as ethanol and ether.
In terms of chemical properties, the 4-chloro-1-methyl-benzene ring is connected to chlorine atoms and methyl groups, so it exhibits various reactivity. The electron cloud density of the benzene ring increases due to the electron-giving effect of methyl groups, making the benzene ring more prone to electrophilic substitution reactions. For example, under appropriate conditions, it can nitrate with mixed acids of nitric acid and sulfuric acid to generate products such as 4-chloro-2-nitro-1-methyl-benzene and 4-chloro-4-nitro-1-methyl-benzene.
In addition, chlorine atoms can participate in nucleophilic substitution reactions. Under specific conditions such as strong bases or high temperatures, chlorine atoms can be replaced by nucleophiles such as hydroxyl and amino groups to generate corresponding substitution products. For example, when heated in an alcohol solution of sodium hydroxide, the chlorine atom may be replaced by a hydroxyl group to form p-methylphenol.
At the same time, the methyl group in 4-chloro-1-methyl-benzene can also react. Under the condition of light or the presence of an initiator, the hydrogen atom on the methyl group can be replaced by a halogen atom to undergo a free radical substitution reaction. For example, when reacted with chlorine under light, products such as 4-chloro-1- (chloromethyl) -benzene can be formed. With these chemical properties, 4-chloro-1-methyl-benzene is widely used as an important intermediate in the fields of medicine, pesticides, dyes, and other industries to synthesize various organic compounds with specific functions.
What are the physical properties of 4-chloro-1-methyl-benzene?
4-Chloro-1-methyl-benzene, also known as p-chlorotoluene, has the following physical properties:
This substance is a colorless to light yellow liquid at room temperature, resembling a clear oil. It can be seen that its texture is pure, and there are no obvious impurities mixed in it. p-chlorotoluene has a unique smell, and the smell is pungent. If you inhale it accidentally, you will feel uncomfortable.
Its boiling point is about 162-163 ° C. When the temperature rises to this range, p-chlorotoluene will change from liquid to gaseous state and rise in a closed space. The melting point is about 7.5 ° C. When the temperature drops to this point and below, the liquid that originally flowed will gradually solidify and turn into a solid state.
The density of p-chlorotoluene is about 1.07 (g/cm ³), which is heavier than water. If it is placed in a container with water, p-chlorotoluene will settle at the bottom, and the layers with water are clear, and the two are difficult to dissolve.
In addition, p-chlorotoluene is insoluble in water, but easily soluble in organic solvents such as ethanol, ether, and chloroform. In case of ethanol, the two can quickly blend to form a uniform and stable mixed system.
Its vapor is heavier than air. In poorly ventilated places, the steam is easy to spread close to the ground and accumulate in low-lying places. In case of open flames and hot topics, there is a risk of combustion and explosion. When using, be extremely cautious to prevent accidents.
This substance is a colorless to light yellow liquid at room temperature, resembling a clear oil. It can be seen that its texture is pure, and there are no obvious impurities mixed in it. p-chlorotoluene has a unique smell, and the smell is pungent. If you inhale it accidentally, you will feel uncomfortable.
Its boiling point is about 162-163 ° C. When the temperature rises to this range, p-chlorotoluene will change from liquid to gaseous state and rise in a closed space. The melting point is about 7.5 ° C. When the temperature drops to this point and below, the liquid that originally flowed will gradually solidify and turn into a solid state.
The density of p-chlorotoluene is about 1.07 (g/cm ³), which is heavier than water. If it is placed in a container with water, p-chlorotoluene will settle at the bottom, and the layers with water are clear, and the two are difficult to dissolve.
In addition, p-chlorotoluene is insoluble in water, but easily soluble in organic solvents such as ethanol, ether, and chloroform. In case of ethanol, the two can quickly blend to form a uniform and stable mixed system.
Its vapor is heavier than air. In poorly ventilated places, the steam is easy to spread close to the ground and accumulate in low-lying places. In case of open flames and hot topics, there is a risk of combustion and explosion. When using, be extremely cautious to prevent accidents.
What are the main uses of 4-chloro-1-methyl-benzene?
4-Chloro-1-methyl-benzene, also known as p-chlorotoluene, has a wide range of uses.
In the field of chemical synthesis, it is an important organic raw material. A variety of compounds can be prepared through many reactions. For example, through oxidation reaction, p-chlorobenzoic acid can be prepared, which is an intermediate of medicine, pesticides and dyes. In the manufacture of pesticides, p-chlorobenzoic acid can further derive high-efficiency pesticides, which can be used for crop pest control and ensure crop yield and quality. After halogenation, nitrification and other reactions, compounds containing different functional groups such as chlorine and nitro can be synthesized, which are indispensable in the synthesis of medicines and fragrances.
In the dye industry, dyes made from 4-chloro-1-methyl-benzene through a series of reactions have bright colors and good stability. They are widely used in the textile printing and dyeing industry to give fabrics rich colors.
In terms of solvents, 4-chloro-1-methyl-benzene is used as an organic solvent in the coatings and ink industries due to its own dissolution properties. In coatings, it can dissolve resins and other components, making coatings have good construction performance and film-forming effect; in inks, the drying speed and printability of inks can be adjusted to ensure printing quality.
In the field of electronics industry, with the development of electronic technology, the demand for high-purity organic compounds is increasing. After being purified and refined, 4-chloro-1-methyl-benzene can be used to make electronic chemicals, such as photoresist solvents, etc., which play a key role in semiconductor manufacturing and other processes to assist in the precision manufacturing of electronic components.
In the field of chemical synthesis, it is an important organic raw material. A variety of compounds can be prepared through many reactions. For example, through oxidation reaction, p-chlorobenzoic acid can be prepared, which is an intermediate of medicine, pesticides and dyes. In the manufacture of pesticides, p-chlorobenzoic acid can further derive high-efficiency pesticides, which can be used for crop pest control and ensure crop yield and quality. After halogenation, nitrification and other reactions, compounds containing different functional groups such as chlorine and nitro can be synthesized, which are indispensable in the synthesis of medicines and fragrances.
In the dye industry, dyes made from 4-chloro-1-methyl-benzene through a series of reactions have bright colors and good stability. They are widely used in the textile printing and dyeing industry to give fabrics rich colors.
In terms of solvents, 4-chloro-1-methyl-benzene is used as an organic solvent in the coatings and ink industries due to its own dissolution properties. In coatings, it can dissolve resins and other components, making coatings have good construction performance and film-forming effect; in inks, the drying speed and printability of inks can be adjusted to ensure printing quality.
In the field of electronics industry, with the development of electronic technology, the demand for high-purity organic compounds is increasing. After being purified and refined, 4-chloro-1-methyl-benzene can be used to make electronic chemicals, such as photoresist solvents, etc., which play a key role in semiconductor manufacturing and other processes to assist in the precision manufacturing of electronic components.
4-chloro-1-methyl-benzene What are the precautions during the synthesis process?
4-Chloro-1-methylbenzene, that is, p-chlorotoluene, requires attention to many matters during synthesis.
First and foremost, the purity of the raw material is crucial. If the raw material contains impurities, the reaction product will be impure, or it will affect the process of the reaction. If the raw material contains other halogenated aromatics, it may generate miscellaneous by-products in the reaction, which will increase the difficulty for subsequent separation and purification. Therefore, before taking the raw material, it is necessary to carefully test its purity. If it does not meet the standard, it needs to be purified first.
The control of the reaction conditions should not be taken lightly. In terms of temperature, the reaction in which p-chlorotoluene participates, the temperature often has a significant impact on the reaction rate and product selectivity. Taking the nucleophilic substitution reaction as an example, if the temperature is too low, the reaction is slow, and the yield is difficult to be high; if the temperature is too high, it is easy to cause frequent side reactions and generate unnecessary by-products. The same is true for pressure, and some reactions can be carried out efficiently under a specific pressure. For example, in some catalytic hydrogenation reactions, the appropriate pressure can improve the solubility of hydrogen in the reaction system and promote the reaction to the right. In addition, the reaction time needs to be precisely controlled. If it is too short, the reaction will not be completed, and if it is too long, there may be a risk of overreaction.
Furthermore, the choice and use of catalysts are extremely critical. The catalytic effect of different catalysts on the reaction varies significantly. For example, in some functional group conversion reactions of p-chlorotoluene, the selection of suitable metal catalysts can greatly improve the reaction activity and selectivity. However, the amount of catalyst also needs to be carefully considered, too much may increase the cost, and may lead to unnecessary side reactions; too little will lead to poor catalytic effect and slow reaction rate.
Separation and purification steps should not be ignored. After the reaction, the product mixture often contains impurities such as unreacted raw materials, by-products and catalysts. Appropriate separation methods should be selected according to the physical and chemical properties of the products and impurities. For example, using the difference in boiling point, separate substances with different boiling points by distillation; according to the difference in solubility, purify the product by extraction, recrystallization and other means. During this process, the operation must be fine to prevent product loss or the introduction of new impurities.
Safety issues are always important in chemical synthesis. P-chlorotoluene is toxic and flammable, and safety procedures must be strictly followed during operation. Such as reacting in a well-ventilated place to avoid its vapor accumulation; properly disposing of waste to prevent environmental pollution; operators should wear protective clothing, protective gloves and goggles to prevent contact injuries. All of these are key points that should be paid close attention to during the synthesis of 4-chloro-1-methylbenzene.
First and foremost, the purity of the raw material is crucial. If the raw material contains impurities, the reaction product will be impure, or it will affect the process of the reaction. If the raw material contains other halogenated aromatics, it may generate miscellaneous by-products in the reaction, which will increase the difficulty for subsequent separation and purification. Therefore, before taking the raw material, it is necessary to carefully test its purity. If it does not meet the standard, it needs to be purified first.
The control of the reaction conditions should not be taken lightly. In terms of temperature, the reaction in which p-chlorotoluene participates, the temperature often has a significant impact on the reaction rate and product selectivity. Taking the nucleophilic substitution reaction as an example, if the temperature is too low, the reaction is slow, and the yield is difficult to be high; if the temperature is too high, it is easy to cause frequent side reactions and generate unnecessary by-products. The same is true for pressure, and some reactions can be carried out efficiently under a specific pressure. For example, in some catalytic hydrogenation reactions, the appropriate pressure can improve the solubility of hydrogen in the reaction system and promote the reaction to the right. In addition, the reaction time needs to be precisely controlled. If it is too short, the reaction will not be completed, and if it is too long, there may be a risk of overreaction.
Furthermore, the choice and use of catalysts are extremely critical. The catalytic effect of different catalysts on the reaction varies significantly. For example, in some functional group conversion reactions of p-chlorotoluene, the selection of suitable metal catalysts can greatly improve the reaction activity and selectivity. However, the amount of catalyst also needs to be carefully considered, too much may increase the cost, and may lead to unnecessary side reactions; too little will lead to poor catalytic effect and slow reaction rate.
Separation and purification steps should not be ignored. After the reaction, the product mixture often contains impurities such as unreacted raw materials, by-products and catalysts. Appropriate separation methods should be selected according to the physical and chemical properties of the products and impurities. For example, using the difference in boiling point, separate substances with different boiling points by distillation; according to the difference in solubility, purify the product by extraction, recrystallization and other means. During this process, the operation must be fine to prevent product loss or the introduction of new impurities.
Safety issues are always important in chemical synthesis. P-chlorotoluene is toxic and flammable, and safety procedures must be strictly followed during operation. Such as reacting in a well-ventilated place to avoid its vapor accumulation; properly disposing of waste to prevent environmental pollution; operators should wear protective clothing, protective gloves and goggles to prevent contact injuries. All of these are key points that should be paid close attention to during the synthesis of 4-chloro-1-methylbenzene.
What impact does 4-chloro-1-methyl-benzene have on the environment?
4-Chloro-1-methyl-benzene, also known as p-chlorotoluene, has a significant impact on the environment.
This substance has a certain volatility. If it escapes into the atmosphere, it may cause air quality to decline. Its odor is pungent, people smell it, or feel uncomfortable, and even damage the respiratory tract. And it may affect the photochemical reaction of the atmosphere, or involve the formation of secondary pollutants, such as ozone, which enhances the oxidation of the atmosphere and affects the regional climate and air quality.
In the water environment, 4-chloro-1-methyl-benzene is insoluble, but it can enter the water body through surface runoff, industrial wastewater discharge, etc. It may accumulate in aquatic organisms, pass through the food chain, amplify, and threaten the survival and reproduction of aquatic organisms. At high concentrations, it may cause acute poisoning of aquatic organisms, inhibit their growth and reproduction, and destroy the aquatic ecological balance.
In soil, 4-chloro-1-methyl-benzene degrades slowly, and will accumulate residues. Can affect soil microbial activity and community structure, inhibit material transformation and circulation in soil. If plant roots come into contact, it may affect the absorption of nutrients and water, hinder growth and development, and reduce crop yield and quality.
4-chloro-1-methyl-benzene has relatively stable chemical properties, takes a long time to degrade in the natural environment, or exists in the environment for a long time, which continues to endanger the ecology. And because of its fat solubility, it is easy to accumulate in biological adipose tissue, resulting in chronic health problems. Therefore, its production, use and discharge should be strictly controlled to reduce its harm to the environment and protect the ecological environment and human health.
This substance has a certain volatility. If it escapes into the atmosphere, it may cause air quality to decline. Its odor is pungent, people smell it, or feel uncomfortable, and even damage the respiratory tract. And it may affect the photochemical reaction of the atmosphere, or involve the formation of secondary pollutants, such as ozone, which enhances the oxidation of the atmosphere and affects the regional climate and air quality.
In the water environment, 4-chloro-1-methyl-benzene is insoluble, but it can enter the water body through surface runoff, industrial wastewater discharge, etc. It may accumulate in aquatic organisms, pass through the food chain, amplify, and threaten the survival and reproduction of aquatic organisms. At high concentrations, it may cause acute poisoning of aquatic organisms, inhibit their growth and reproduction, and destroy the aquatic ecological balance.
In soil, 4-chloro-1-methyl-benzene degrades slowly, and will accumulate residues. Can affect soil microbial activity and community structure, inhibit material transformation and circulation in soil. If plant roots come into contact, it may affect the absorption of nutrients and water, hinder growth and development, and reduce crop yield and quality.
4-chloro-1-methyl-benzene has relatively stable chemical properties, takes a long time to degrade in the natural environment, or exists in the environment for a long time, which continues to endanger the ecology. And because of its fat solubility, it is easy to accumulate in biological adipose tissue, resulting in chronic health problems. Therefore, its production, use and discharge should be strictly controlled to reduce its harm to the environment and protect the ecological environment and human health.
What is the Chinese name of 4-chloro-1-methyl-benzene?
The Chinese name for 4-chloro-1-methyl-benzene is chlorotoluene. This name is derived from the naming of the compound. The naming of a compound is intended to be given in a clear and clear manner according to its characteristics, so that it can be communicated by the author and the author.
In the naming system of benzene, benzene is an important parent. If there is a substituent on benzene, it can be named according to its phase position. In this compound, the methyl chloride atom is divided into benzene, and the position of the benzene phase is different, so chlorotoluene. The word "" indicates that the substituent is at the 1,4-position on benzene, that is, the position of each other. Chlorine is the first substituent, followed by methyl, which is the name. This nomenclature is not only suitable for naming, but also can clearly reflect its molecular identity, so that the name can be used to know its significance in terms of chemical research, engineering, education, etc., which is universal in the world.
In the naming system of benzene, benzene is an important parent. If there is a substituent on benzene, it can be named according to its phase position. In this compound, the methyl chloride atom is divided into benzene, and the position of the benzene phase is different, so chlorotoluene. The word "" indicates that the substituent is at the 1,4-position on benzene, that is, the position of each other. Chlorine is the first substituent, followed by methyl, which is the name. This nomenclature is not only suitable for naming, but also can clearly reflect its molecular identity, so that the name can be used to know its significance in terms of chemical research, engineering, education, etc., which is universal in the world.
What are the main uses of 4-chloro-1-methyl-benzene?
4-Chloro-1-methyl-benzene, also known as p-chlorotoluene, has a wide range of uses. In the industrial field, it is a key raw material for organic synthesis. Through a series of chemical reactions, many important compounds can be prepared. For example, in pesticide synthesis, it can be converted into pesticide components with specific structures, contributing to the control of crops and pests, so as to ensure that crops are abundant and crops are protected from insect infestation.
In the field of medicinal chemistry, it is also an important starting material for the synthesis of many drugs. Through subtle chemical modification and reaction steps, molecules with specific pharmacological activities can be obtained, providing help for human beings to fight diseases and improve health.
In the field of materials science, p-chlorotoluene can become a component of some high-performance materials after reaction. For example, it is used to prepare engineering plastics with special properties, so that plastic products have better physical and chemical properties, and are used in various equipment and equipment to play their unique functions.
In the dye industry, it also has a place. It can be used as the basic raw material for synthetic dyes, and it can be processed through a series of processes to produce colorful and stable dyes, which can be used in fabric dyeing and other fields to make fabrics show colorful colors.
In short, 4-chloro-1-methyl-benzene plays an important role in many chemical-related industries and is indispensable for promoting the development of various industries.
In the field of medicinal chemistry, it is also an important starting material for the synthesis of many drugs. Through subtle chemical modification and reaction steps, molecules with specific pharmacological activities can be obtained, providing help for human beings to fight diseases and improve health.
In the field of materials science, p-chlorotoluene can become a component of some high-performance materials after reaction. For example, it is used to prepare engineering plastics with special properties, so that plastic products have better physical and chemical properties, and are used in various equipment and equipment to play their unique functions.
In the dye industry, it also has a place. It can be used as the basic raw material for synthetic dyes, and it can be processed through a series of processes to produce colorful and stable dyes, which can be used in fabric dyeing and other fields to make fabrics show colorful colors.
In short, 4-chloro-1-methyl-benzene plays an important role in many chemical-related industries and is indispensable for promoting the development of various industries.
What are the physical properties of 4-chloro-1-methyl-benzene?
4-Chloro-1-methyl-benzene, also known as p-chlorotoluene, is an important compound in organic chemistry. Its physical properties are as follows:
Looking at it, this is a colorless to light yellow transparent liquid with a clear appearance and is quite eye-catching. Smell it, it has a special aromatic smell. Although it is fragrant, it should not be ignored because it has a certain irritation.
When it comes to the melting point, it is about 7.5 ° C. When the temperature drops to this point, it is like a slumber, gradually solidifying from a flowing state. The boiling point is around 162 ° C. When the temperature rises, it sublimates from a liquid state to a gaseous state like a butterfly.
Its density is about 1.07g/cm ³, which is heavier than water. If the two meet, it will sink to the bottom of the water. And slightly soluble in water, as if it is naturally separated from water, it is difficult to blend intimately. However, in organic solvents such as ethanol, ether, and chloroform, it can be easily dissolved in it like a duck to water.
Not only that, it is also flammable. In case of open flames and hot topics, it is like dry wood in case of fire, and it is very easy to burn. Its steam mixes with air, which is like a hidden danger, and can form an explosive mixture. In case of fire, it will burst like thunder, and its power is amazing.
4-chloro-1-methyl-benzene has unique physical properties and is widely used in the chemical industry. However, when it is used, it is necessary to always be vigilant of its potential dangers.
Looking at it, this is a colorless to light yellow transparent liquid with a clear appearance and is quite eye-catching. Smell it, it has a special aromatic smell. Although it is fragrant, it should not be ignored because it has a certain irritation.
When it comes to the melting point, it is about 7.5 ° C. When the temperature drops to this point, it is like a slumber, gradually solidifying from a flowing state. The boiling point is around 162 ° C. When the temperature rises, it sublimates from a liquid state to a gaseous state like a butterfly.
Its density is about 1.07g/cm ³, which is heavier than water. If the two meet, it will sink to the bottom of the water. And slightly soluble in water, as if it is naturally separated from water, it is difficult to blend intimately. However, in organic solvents such as ethanol, ether, and chloroform, it can be easily dissolved in it like a duck to water.
Not only that, it is also flammable. In case of open flames and hot topics, it is like dry wood in case of fire, and it is very easy to burn. Its steam mixes with air, which is like a hidden danger, and can form an explosive mixture. In case of fire, it will burst like thunder, and its power is amazing.
4-chloro-1-methyl-benzene has unique physical properties and is widely used in the chemical industry. However, when it is used, it is necessary to always be vigilant of its potential dangers.
What are the chemical properties of 4-chloro-1-methyl-benzene?
4-Chloro-1-methyl-benzene, also known as p-chlorotoluene, has unique chemical properties and is widely used in many fields.
p-chlorotoluene has typical properties of aromatic hydrocarbons and can undergo a variety of reactions. One is the substitution reaction, because the electron cloud density of the benzene ring is affected by methyl and chlorine atoms, and the electron cloud density of the ortho and para-position is relatively high, which is prone to electrophilic substitution. Taking the nitrification reaction as an example, the reaction with concentrated nitric acid catalyzed by sulfuric acid will preferentially replace the o-and para-hydrogen atoms of the benzene ring to form products such as 2-nitro-4-chlorotoluene and 4-chloro-3-nitrotoluene. The same is true for halogenation reactions. Under the action of light or catalyst, chlorine atoms can replace hydrogen atoms on methyl groups to form benzyl chloride derivatives. For example, when reacted with chlorine light, 4-chlorobenzyl chloride, 4-chlorobenzyl chloride, etc. are gradually generated.
The second is an oxidation reaction, and methyl groups become active and highly reducing under the influence of benzene rings. In case of strong oxidants such as acidic potassium permanganate solution, methyl groups will be oxidized to carboxyl groups to form 4-chlorobenzoic acid. This reaction is an important method for the preparation of chlorobenzoic acid compounds.
The third is a reduction reaction, and p-chlorotoluene rings can be reduced under specific conditions. For example, in the presence of catalysts and hydrogen suppliers, the benzene ring can be partially hydrogenated to form cyclohexene derivatives, or completely hydrogenated to form corresponding saturated hydrocarbons. This is of great significance in the preparation of alicyclic compounds with specific structures in organic synthesis.
The fourth is a metal-organic reaction. The chlorine atom in p-chlorotoluene has a certain activity and can react with metal reagents to form metal-organic compounds. The reagent 4-chlorobenzyl magnesium chloride can be prepared by reacting with magnesium in anhydrous ether. This reagent has a wide range of uses in organic synthesis. It can react with carbonyl compounds to form carbon-carbon bonds and realize the synthesis of complex organic molecules.
p-chlorotoluene has diverse chemical properties and is an important intermediate in organic synthesis, providing a basis for the synthesis of medicines, pesticides, dyes and fragrances.
p-chlorotoluene has typical properties of aromatic hydrocarbons and can undergo a variety of reactions. One is the substitution reaction, because the electron cloud density of the benzene ring is affected by methyl and chlorine atoms, and the electron cloud density of the ortho and para-position is relatively high, which is prone to electrophilic substitution. Taking the nitrification reaction as an example, the reaction with concentrated nitric acid catalyzed by sulfuric acid will preferentially replace the o-and para-hydrogen atoms of the benzene ring to form products such as 2-nitro-4-chlorotoluene and 4-chloro-3-nitrotoluene. The same is true for halogenation reactions. Under the action of light or catalyst, chlorine atoms can replace hydrogen atoms on methyl groups to form benzyl chloride derivatives. For example, when reacted with chlorine light, 4-chlorobenzyl chloride, 4-chlorobenzyl chloride, etc. are gradually generated.
The second is an oxidation reaction, and methyl groups become active and highly reducing under the influence of benzene rings. In case of strong oxidants such as acidic potassium permanganate solution, methyl groups will be oxidized to carboxyl groups to form 4-chlorobenzoic acid. This reaction is an important method for the preparation of chlorobenzoic acid compounds.
The third is a reduction reaction, and p-chlorotoluene rings can be reduced under specific conditions. For example, in the presence of catalysts and hydrogen suppliers, the benzene ring can be partially hydrogenated to form cyclohexene derivatives, or completely hydrogenated to form corresponding saturated hydrocarbons. This is of great significance in the preparation of alicyclic compounds with specific structures in organic synthesis.
The fourth is a metal-organic reaction. The chlorine atom in p-chlorotoluene has a certain activity and can react with metal reagents to form metal-organic compounds. The reagent 4-chlorobenzyl magnesium chloride can be prepared by reacting with magnesium in anhydrous ether. This reagent has a wide range of uses in organic synthesis. It can react with carbonyl compounds to form carbon-carbon bonds and realize the synthesis of complex organic molecules.
p-chlorotoluene has diverse chemical properties and is an important intermediate in organic synthesis, providing a basis for the synthesis of medicines, pesticides, dyes and fragrances.
What are 4-chloro-1-methyl-benzene synthesis methods?
4-Chloro-1-methyl-benzene, that is, p-chlorotoluene, has many synthesis methods, which are described in detail below.
First, toluene is used as the starting material and obtained by chlorination reaction. This reaction needs to be carried out under the presence of light or catalyst. When illuminated, chlorine radicals will selectively replace methyl ortho-para hydrogen atoms to form p-chlorotoluene, and some o-chlorotoluene will also be formed. When using catalysts, such as Lewis acids such as ferric chloride and aluminum trichloride, the selectivity of the reaction can be improved, and the proportion of p-chlorotoluene in the product can be increased. The general process of the reaction is that toluene and chlorine are mixed in the reactor, light is passed or a catalyst is added, and the reaction is reacted at a suitable temperature. After the reaction is completed, the product is separated and purified by distillation, extraction and other means.
Second, p-toluidine is used as a raw material and prepared by diazotization and Sandmeyer reaction. First, p-toluidine is reacted with hydrochloric acid and sodium nitrite at low temperature to form a diazonium salt. Subsequently, the diazonium salt is reacted with a halogenated cuprous salt such as cuprous chloride, and the diazonium group is replaced by a chlorine atom to form p-chlorotoluene. The advantage of this method is that the reaction selectivity is high, and high purity of p-chlorotoluene can be obtained. However, the steps are relatively complicated, and the raw material is more
Third, using p-cresol as raw material, it is prepared by chlorination and dehydroxylation reaction. The reaction of p-cresol with chlorination agent, the hydrogen atom of the hydroxyl group is replaced by the chlorine atom to form chloro-p-cresol. Then, through the dehydroxylation reaction, the hydroxyl group is removed and converted into p-chlorotoluene. Although this route has a little more steps, the raw material p-cresol has a wide range of sources, and the reaction conditions are relatively mild, which has certain application prospects in industrial production.
The above synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider many factors such as the availability of raw materials, cost, and product purity requirements, and carefully select the appropriate synthesis path.
First, toluene is used as the starting material and obtained by chlorination reaction. This reaction needs to be carried out under the presence of light or catalyst. When illuminated, chlorine radicals will selectively replace methyl ortho-para hydrogen atoms to form p-chlorotoluene, and some o-chlorotoluene will also be formed. When using catalysts, such as Lewis acids such as ferric chloride and aluminum trichloride, the selectivity of the reaction can be improved, and the proportion of p-chlorotoluene in the product can be increased. The general process of the reaction is that toluene and chlorine are mixed in the reactor, light is passed or a catalyst is added, and the reaction is reacted at a suitable temperature. After the reaction is completed, the product is separated and purified by distillation, extraction and other means.
Second, p-toluidine is used as a raw material and prepared by diazotization and Sandmeyer reaction. First, p-toluidine is reacted with hydrochloric acid and sodium nitrite at low temperature to form a diazonium salt. Subsequently, the diazonium salt is reacted with a halogenated cuprous salt such as cuprous chloride, and the diazonium group is replaced by a chlorine atom to form p-chlorotoluene. The advantage of this method is that the reaction selectivity is high, and high purity of p-chlorotoluene can be obtained. However, the steps are relatively complicated, and the raw material is more
Third, using p-cresol as raw material, it is prepared by chlorination and dehydroxylation reaction. The reaction of p-cresol with chlorination agent, the hydrogen atom of the hydroxyl group is replaced by the chlorine atom to form chloro-p-cresol. Then, through the dehydroxylation reaction, the hydroxyl group is removed and converted into p-chlorotoluene. Although this route has a little more steps, the raw material p-cresol has a wide range of sources, and the reaction conditions are relatively mild, which has certain application prospects in industrial production.
The above synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider many factors such as the availability of raw materials, cost, and product purity requirements, and carefully select the appropriate synthesis path.
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