Linshang Chemical
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4-Chloro-1-Nitro-2-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
143491 |
| Chemical Formula | C7H3ClF3NO2 |
| Molar Mass | 225.55 g/mol |
| Appearance | Colorless to light yellow liquid or solid |
| Boiling Point | 227 - 228 °C |
| Melting Point | 42 - 44 °C |
| Density | 1.554 g/cm³ |
| Solubility | Insoluble in water, soluble in organic solvents like ethanol, ether |
| Flash Point | 102 °C |
| Refractive Index | 1.492 (20 °C) |
| Vapor Pressure | Low at room temperature |
As an accredited 4-Chloro-1-Nitro-2-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chloro - 1 - nitro - 2 - (trifluoromethyl)benzene in sealed chemical - grade container. |
| Storage | 4 - chloro - 1 - nitro - 2 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container to prevent vapor leakage. Due to its potential hazards, it should be stored separately from incompatible substances, and the storage area should be clearly labeled. |
| Shipping | 4 - chloro - 1 - nitro - 2 - (trifluoromethyl)benzene is shipped in specialized, well - sealed containers compliant with chemical transportation regulations. Care is taken to prevent leakage during transit due to its potentially hazardous nature. |
Competitive 4-Chloro-1-Nitro-2-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the chemical properties of 4-chloro-1-nitro-2- (trifluoromethyl) benzene
4-Chloro-1-nitro-2- (trifluoromethyl) benzene, this is an organic compound. Its chemical properties are unique and quite critical.
First of all, its halogenated aromatics, chlorine atoms are connected to benzene rings, and have halogenated hydrocarbon characteristics. The activity of chlorine atoms is not low, and nucleophilic substitution reactions can occur. Under suitable conditions, such as the presence of strong bases and heating, chlorine atoms are easily replaced by nucleophilic reagents, such as by hydroxyl (-OH) to produce phenolic derivatives, or by amino (-NH2O) to obtain compounds containing amino groups.
The presence of nitro groups is also extremely important. Nitro is a strong electron-absorbing group, which decreases the electron cloud density of the benzene ring and decreases the activity of the electrophilic substitution reaction of the benzene ring. However, it can undergo reduction reaction, and under the action of suitable reducing agents, the nitro group can be gradually reduced to amino group, which is an important path for the preparation of amino-containing aromatic compounds.
Trifluoromethyl also has a significant effect. Trifluoromethyl has strong electron absorption and high stability, which greatly changes the electron cloud distribution of the benzene ring and affects the physical and chemical properties of the compound. Because of its strong electron absorption, the electron cloud density of the adjacent and para-site on the benzene ring decreases even more, which makes the electrophilic substitution reaction more likely to occur in the meta-site. And the existence of trifluoromethyl enhances the lipid solubility of the compound and has a great
In addition, the compound contains a variety of functional groups, and the functional groups interact with each other. For example, the electron-withdrawing action of nitro and trifluoromethyl makes chlorine atoms easier to leave and enhances their nucleophilic substitution activity. These chemical properties are of great significance in the field of organic synthesis, and can be used to prepare a variety of organic intermediates, and then synthesize many organic compounds such as drugs, pesticides, and materials.
First of all, its halogenated aromatics, chlorine atoms are connected to benzene rings, and have halogenated hydrocarbon characteristics. The activity of chlorine atoms is not low, and nucleophilic substitution reactions can occur. Under suitable conditions, such as the presence of strong bases and heating, chlorine atoms are easily replaced by nucleophilic reagents, such as by hydroxyl (-OH) to produce phenolic derivatives, or by amino (-NH2O) to obtain compounds containing amino groups.
The presence of nitro groups is also extremely important. Nitro is a strong electron-absorbing group, which decreases the electron cloud density of the benzene ring and decreases the activity of the electrophilic substitution reaction of the benzene ring. However, it can undergo reduction reaction, and under the action of suitable reducing agents, the nitro group can be gradually reduced to amino group, which is an important path for the preparation of amino-containing aromatic compounds.
Trifluoromethyl also has a significant effect. Trifluoromethyl has strong electron absorption and high stability, which greatly changes the electron cloud distribution of the benzene ring and affects the physical and chemical properties of the compound. Because of its strong electron absorption, the electron cloud density of the adjacent and para-site on the benzene ring decreases even more, which makes the electrophilic substitution reaction more likely to occur in the meta-site. And the existence of trifluoromethyl enhances the lipid solubility of the compound and has a great
In addition, the compound contains a variety of functional groups, and the functional groups interact with each other. For example, the electron-withdrawing action of nitro and trifluoromethyl makes chlorine atoms easier to leave and enhances their nucleophilic substitution activity. These chemical properties are of great significance in the field of organic synthesis, and can be used to prepare a variety of organic intermediates, and then synthesize many organic compounds such as drugs, pesticides, and materials.
What is the main use of 4-chloro-1-nitro-2- (trifluoromethyl) benzene?
4-Chloro-1-nitro-2- (trifluoromethyl) benzene, which is a crucial raw material in the field of organic synthesis, can be seen in the preparation of many chemical products.
In the synthesis of medicine, it can be used as a key intermediate to help create a variety of specific drugs. For example, the synthesis of some antibacterial drugs requires this material as the starting material and goes through a series of delicate chemical reactions to construct a molecular structure with specific pharmacological activities, so as to achieve the effect of fighting pathogens and treating diseases.
In the field of pesticide manufacturing, it also plays a pivotal role. Many high-efficiency and low-toxicity pesticide varieties are based on 4-chloro-1-nitro-2 - (trifluoromethyl) benzene. Through carefully designed synthesis routes, pesticides are endowed with excellent insecticidal, bactericidal, weeding and other properties, protecting the robust growth of crops and ensuring a bumper grain harvest.
Furthermore, in the field of materials science, this compound can be used as an important component in the synthesis of special functional materials. With its unique chemical structure and properties, new materials with excellent thermal stability, chemical stability or optical properties can be prepared, which are widely used in cutting-edge technology fields such as electronics and optics, and promote the vigorous development of related industries.
From this perspective, although 4-chloro-1-nitro-2- (trifluoromethyl) benzene is an organic compound, its application in many key fields such as medicine, pesticides, and materials is of great significance and has made tremendous contributions to the progress and development of human society.
In the synthesis of medicine, it can be used as a key intermediate to help create a variety of specific drugs. For example, the synthesis of some antibacterial drugs requires this material as the starting material and goes through a series of delicate chemical reactions to construct a molecular structure with specific pharmacological activities, so as to achieve the effect of fighting pathogens and treating diseases.
In the field of pesticide manufacturing, it also plays a pivotal role. Many high-efficiency and low-toxicity pesticide varieties are based on 4-chloro-1-nitro-2 - (trifluoromethyl) benzene. Through carefully designed synthesis routes, pesticides are endowed with excellent insecticidal, bactericidal, weeding and other properties, protecting the robust growth of crops and ensuring a bumper grain harvest.
Furthermore, in the field of materials science, this compound can be used as an important component in the synthesis of special functional materials. With its unique chemical structure and properties, new materials with excellent thermal stability, chemical stability or optical properties can be prepared, which are widely used in cutting-edge technology fields such as electronics and optics, and promote the vigorous development of related industries.
From this perspective, although 4-chloro-1-nitro-2- (trifluoromethyl) benzene is an organic compound, its application in many key fields such as medicine, pesticides, and materials is of great significance and has made tremendous contributions to the progress and development of human society.
What are the synthesis methods of 4-chloro-1-nitro-2- (trifluoromethyl) benzene
4-Chloro-1-nitro-2- (trifluoromethyl) benzene can be synthesized by the following methods.
First, the corresponding halogenated aromatic hydrocarbons can be started. First, take the appropriate halogenated benzene derivative and introduce the nitro group under specific reaction conditions. This process requires attention to the reaction temperature, the type and dosage of the nitrifying reagent used. Commonly used nitrifying reagents, such as mixed acid (a mixture of nitric acid and sulfuric acid), are carefully controlled at moderate temperatures to precisely replace the nitro group at a specific position in the benzene ring. Subsequently, try to introduce trifluoromethyl. A reagent containing trifluoromethyl can be selected, and with the help of a suitable catalyst, the trifluoromethyl can be connected through a specific reaction mechanism to obtain the target product.
Second, benzene derivatives containing trifluoromethyl can also be used as raw materials. First, it is halogenated to introduce chlorine atoms into the benzene ring. During the halogenation reaction, a suitable halogenating agent and reaction conditions should be selected according to the characteristics of the raw materials and reaction requirements to ensure that the substitution position of the chlorine atoms conforms to the structure of the target product. After that, the halogenated trifluoromethyl benzene derivative is nitrified. This step also strictly controls the reaction conditions, so that the nitro group is successfully introduced into the benzene ring, and the final product is 4-chloro-1-nitro-2- (trifluoromethyl) benzene.
Furthermore, a series of multi-step reactions can also be considered. For example, a benzene ring structure with a partial substituent is constructed through some reactions, and then it is gradually modified. First, a benzene ring intermediate with trifluoromethyl and other substituents is formed through a specific reaction with an appropriate starting material, and then chlorine atoms and nitro groups are introduced in sequence through selective reactions. By rationally designing the reaction sequence and conditions, the positions of each substituent are ensured to be accurate, and the synthesis of 4-chloro-1-nitro-2 - (trifluoromethyl) benzene is achieved. Each step of the reaction requires careful consideration of reaction conditions, reagent selection, product separation and purification, etc., to improve the yield and purity of the product.
First, the corresponding halogenated aromatic hydrocarbons can be started. First, take the appropriate halogenated benzene derivative and introduce the nitro group under specific reaction conditions. This process requires attention to the reaction temperature, the type and dosage of the nitrifying reagent used. Commonly used nitrifying reagents, such as mixed acid (a mixture of nitric acid and sulfuric acid), are carefully controlled at moderate temperatures to precisely replace the nitro group at a specific position in the benzene ring. Subsequently, try to introduce trifluoromethyl. A reagent containing trifluoromethyl can be selected, and with the help of a suitable catalyst, the trifluoromethyl can be connected through a specific reaction mechanism to obtain the target product.
Second, benzene derivatives containing trifluoromethyl can also be used as raw materials. First, it is halogenated to introduce chlorine atoms into the benzene ring. During the halogenation reaction, a suitable halogenating agent and reaction conditions should be selected according to the characteristics of the raw materials and reaction requirements to ensure that the substitution position of the chlorine atoms conforms to the structure of the target product. After that, the halogenated trifluoromethyl benzene derivative is nitrified. This step also strictly controls the reaction conditions, so that the nitro group is successfully introduced into the benzene ring, and the final product is 4-chloro-1-nitro-2- (trifluoromethyl) benzene.
Furthermore, a series of multi-step reactions can also be considered. For example, a benzene ring structure with a partial substituent is constructed through some reactions, and then it is gradually modified. First, a benzene ring intermediate with trifluoromethyl and other substituents is formed through a specific reaction with an appropriate starting material, and then chlorine atoms and nitro groups are introduced in sequence through selective reactions. By rationally designing the reaction sequence and conditions, the positions of each substituent are ensured to be accurate, and the synthesis of 4-chloro-1-nitro-2 - (trifluoromethyl) benzene is achieved. Each step of the reaction requires careful consideration of reaction conditions, reagent selection, product separation and purification, etc., to improve the yield and purity of the product.
What are the precautions for 4-chloro-1-nitro-2- (trifluoromethyl) benzene in storage and transportation?
4-Chloro-1-nitro-2- (trifluoromethyl) benzene should be stored and transported with caution. This is because of its specific chemical properties, which is related to safety.
First, store in a cool, dry and well-ventilated place. If this substance is exposed to high temperature, humidity, or chemical changes, it will damage its quality, and even cause safety risks. The temperature of the warehouse should be controlled within a suitable range to prevent it from decomposing or reacting due to heat. And it needs to be stored in isolation from oxidizing agents, reducing agents, alkalis, etc. Because it is mixed with them, it is prone to chemical reactions and triggers danger.
As for transportation, there are also many considerations. Transportation vehicles should be equipped with corresponding fire and emergency treatment equipment to prevent accidents. This substance should be stably loaded to prevent it from shaking and colliding during transportation, resulting in package damage. Packaging must be tight to ensure that there is no risk of leakage. When handling, operators must wear appropriate protective equipment, such as protective clothing, gloves, goggles, etc., to avoid contact with the human body and prevent it from causing harm to people. Transportation routes should also be carefully planned to avoid crowded and environmentally sensitive areas to reduce latent risks. In this way, 4-chloro-1-nitro-2 - (trifluoromethyl) benzene is safe for storage and transportation.
First, store in a cool, dry and well-ventilated place. If this substance is exposed to high temperature, humidity, or chemical changes, it will damage its quality, and even cause safety risks. The temperature of the warehouse should be controlled within a suitable range to prevent it from decomposing or reacting due to heat. And it needs to be stored in isolation from oxidizing agents, reducing agents, alkalis, etc. Because it is mixed with them, it is prone to chemical reactions and triggers danger.
As for transportation, there are also many considerations. Transportation vehicles should be equipped with corresponding fire and emergency treatment equipment to prevent accidents. This substance should be stably loaded to prevent it from shaking and colliding during transportation, resulting in package damage. Packaging must be tight to ensure that there is no risk of leakage. When handling, operators must wear appropriate protective equipment, such as protective clothing, gloves, goggles, etc., to avoid contact with the human body and prevent it from causing harm to people. Transportation routes should also be carefully planned to avoid crowded and environmentally sensitive areas to reduce latent risks. In this way, 4-chloro-1-nitro-2 - (trifluoromethyl) benzene is safe for storage and transportation.
What are the effects of 4-chloro-1-nitro-2- (trifluoromethyl) benzene on the environment and human health?
4-Chloro-1-nitro-2- (trifluoromethyl) benzene, an organic compound, is widely used in the chemical industry, but it has many effects on the environment and human health.
First talk about the impact on the environment. It has certain chemical stability, is difficult to degrade in the natural environment, and is easy to retain for a long time. If released into the soil, or cause soil pollution, it will affect soil microbial activity and soil fertility, and then affect plant growth. Once it enters the water body, it will pollute the water source and harm aquatic organisms. Because of its fat solubility, it is easy to accumulate in aquatic organisms, pass through the food chain and amplify, threatening higher organisms and even humans. And it volatilizes into the atmosphere, or participates in photochemical reactions, affecting air quality and causing damage to the atmospheric environment.
As for the impact on human health, it should not be underestimated. Inhalation through the respiratory tract, skin contact or accidental ingestion can enter the human body. It may irritate the respiratory tract, causing symptoms such as cough and asthma. Long-term exposure, or damage the nervous system, cause headache, dizziness, fatigue, memory loss, etc. It may also affect the function of the liver and kidneys. Because its metabolism in the body requires the liver and kidneys, long-term accumulation will increase the burden on the liver and kidneys, resulting in liver and kidney damage. In particularly serious cases, animal experiments have shown that it may be potentially carcinogenic, and long-term exposure to this substance environment may increase the risk of cancer in the human body.
In summary, 4-chloro-1-nitro-2- (trifluoromethyl) benzene is potentially harmful to the environment and human health. During production, use and treatment, it is necessary to strictly control and take effective protective and treatment measures to reduce its negative effects.
First talk about the impact on the environment. It has certain chemical stability, is difficult to degrade in the natural environment, and is easy to retain for a long time. If released into the soil, or cause soil pollution, it will affect soil microbial activity and soil fertility, and then affect plant growth. Once it enters the water body, it will pollute the water source and harm aquatic organisms. Because of its fat solubility, it is easy to accumulate in aquatic organisms, pass through the food chain and amplify, threatening higher organisms and even humans. And it volatilizes into the atmosphere, or participates in photochemical reactions, affecting air quality and causing damage to the atmospheric environment.
As for the impact on human health, it should not be underestimated. Inhalation through the respiratory tract, skin contact or accidental ingestion can enter the human body. It may irritate the respiratory tract, causing symptoms such as cough and asthma. Long-term exposure, or damage the nervous system, cause headache, dizziness, fatigue, memory loss, etc. It may also affect the function of the liver and kidneys. Because its metabolism in the body requires the liver and kidneys, long-term accumulation will increase the burden on the liver and kidneys, resulting in liver and kidney damage. In particularly serious cases, animal experiments have shown that it may be potentially carcinogenic, and long-term exposure to this substance environment may increase the risk of cancer in the human body.
In summary, 4-chloro-1-nitro-2- (trifluoromethyl) benzene is potentially harmful to the environment and human health. During production, use and treatment, it is necessary to strictly control and take effective protective and treatment measures to reduce its negative effects.
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