4-Chloro-2,5-Difluoronitrobenzene

Linshang Chemical

Specifications

HS Code

140064

Chemical Formula C6H2ClF2NO2
Molar Mass 193.535 g/mol
Appearance Solid (likely white to off - white powder)
Solubility In Water Low solubility, due to non - polar nature of benzene ring and presence of nitro group
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform, etc., based on its non - polar structure
Vapor Pressure Low vapor pressure as it is a solid at room temperature

As an accredited 4-Chloro-2,5-Difluoronitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 4 - chloro - 2,5 - difluoronitrobenzene packaged in a sealed, corrosion - resistant bottle.
Storage 4 - chloro - 2,5 - difluoronitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be stored in tightly - sealed containers to prevent leakage and vapor release. Keep it separate from oxidizing agents, reducing agents, and bases to avoid potential chemical reactions. Store at a temperature range suitable to maintain its stability.
Shipping 4 - chloro - 2,5 - difluoronitrobenzene is shipped in well - sealed containers, following strict hazardous chemical regulations. It's transported by specialized carriers, ensuring safety during transit to prevent spills and environmental or safety risks.
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4-Chloro-2,5-Difluoronitrobenzene 4-Chloro-2,5-Difluoronitrobenzene
General Information
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Frequently Asked Questions

As a leading 4-Chloro-2,5-Difluoronitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 4-chloro-2,5-difluoronitrobenzene?
The main users of 4-deuterium-2,5-diethylbenzyl are related to many fields.
In the field of medicinal chemistry, it is often an important intermediate. With exquisite chemical synthesis techniques, compounds with unique pharmacological activities can be constructed based on this. Due to the special isotope effect of deuterium atoms, the physical and chemical properties of compounds such as metabolic stability and fat solubility can be changed, so that the absorption, distribution, metabolism and excretion processes of the resulting drugs in the body are different, which may optimize the efficacy of drugs and reduce adverse reactions.
In the field of materials science, 4-deuterium-2,5-diethylbenzyl is also useful. When preparing special polymer materials, it is introduced into the polymer structure to adjust the properties of the material. For example, it can improve the thermal stability of the material, so that it can still maintain good physical and mechanical properties in high temperature environments; or adjust the optical properties of the material, showing unique advantages in optoelectronic devices and other aspects, contributing to the research and development of new optoelectronic materials.
Furthermore, in the process of organic synthesis chemistry, this compound is often used as a key synthetic building block. Organic chemists use their unique structures and reactivity to build complex organic molecular structures through various organic reactions, such as nucleophilic substitution, electrophilic addition, coupling reactions, etc., to expand the boundaries of organic synthesis, providing possibilities for the creation of novel organic compounds, and promoting the continuous development of organic chemistry.
From this perspective, 4-deuterium-2,5-diethylbenzyl plays an important role in many fields such as medicine, materials, and organic synthesis, and is an indispensable chemical substance.
What are the synthesis methods of 4-chloro-2,5-difluoronitrobenzene?
To prepare 4-bromo-2,5-diethoxybenzyl, the following methods can be used:
First, 2,5-diethoxybenzene is used as the starting material, and bromine atoms are introduced by bromination. First, dissolve 2,5-diethoxybenzene into an appropriate amount of inert solvent, such as dichloromethane, and cool to a suitable temperature, usually about 0 ° C. Slow down the mixture of bromine and an appropriate amount of catalyst, such as iron powder or iron tribromide. This process requires strict temperature control to prevent the formation of polybrominates. After the reaction is completed, 4-bromo-2,5-diethoxybenzene is obtained by washing with water, drying, and distillation. Subsequently, it is reacted with chloromethyl ether in the presence of a base, which can be selected from potassium carbonate, etc., and reacted by heating in a suitable organic solvent such as N, N-dimethylformamide. After separation and purification, the target product 4-bromo-2,5-diethoxybenzyl can be obtained.
Second, 2,5-diethoxybenzoic acid is used as the starting material. It is first reduced to 2,5-diethoxybenzyl alcohol, and a common reducing agent such as lithium aluminum hydride is reacted in a solvent such as anhydrous ethyl ether or tetrahydrofuran. Then, 2,5-diethoxybenzyl alcohol is brominated, and reagents such as phosphorus tribromide or hydrobromic acid can be selected to react under suitable conditions to obtain 2,5-diethoxybenzyl bromide. Then 2,5-diethoxybenzyl bromide is reacted with alcohol salts such as sodium ethanol to introduce ethoxy groups. After subsequent separation and purification operations, 4-bromo-2,5-diethoxybenzyl can also be obtained.
Third, the Grignard reagent method is used. Taking 2,5-diethoxybromobenzene as the starting material, it is reacted with magnesium chips in anhydrous ethyl ether or tetrahydrofuran to prepare Grignard reagent. After that, it is reacted with formaldehyde or paraformaldehyde to produce 2,5-diethoxybenzyl alcohol. After bromination and ethoxylation steps, the target product can be obtained by the same method as above. These methods have advantages and disadvantages, and should be carefully selected according to the actual situation, such as raw material availability, cost, yield and other factors.
What are the physical properties of 4-chloro-2,5-difluoronitrobenzene?
4-Cyanogen-2,5-diethoxybenzyl compounds have unique physical and chemical properties. Its physical properties are as follows:
In terms of appearance properties, it is mostly white to light yellow crystalline powder under normal conditions, with fine texture. This feature is easy to observe and distinguish in different scenarios. In drug development or chemical production, its purity and state can be intuitively judged.
In terms of melting point, it is usually in a specific temperature range, generally in the range of [X] ℃ - [X] ℃. The melting point characteristic is the key physical parameter for identifying this compound. Through melting point measurement experiments, the purity and authenticity of the compound can be accurately judged, which is of great significance to quality control. The solubility of
is quite special, slightly soluble in water, but easily soluble in common organic solvents, such as ethanol, ether, chloroform, etc. This property is based on the principle of "similar miscibility". Because its molecular structure contains hydrophobic groups, it is difficult to dissolve in water with strong polarity, and has good miscibility with organic solvents. This solubility is widely used in the separation, purification and preparation of compounds. For example, in the post-treatment of organic synthesis, the difference in solubility can be used to select a suitable solvent for extraction to achieve separation from impurities. The density of
is also a specific value, about [X] g/cm ³. Although the density data is slightly less important in some application scenarios, it is indispensable when it comes to accurate measurement and mixed system research. For example, when preparing composites with specific density requirements, or studying their behavior in fluids, density parameters are a key consideration.
In terms of stability, it is relatively stable under normal conditions, but in the case of strong acids, strong alkalis or high temperature environments, chemical reactions may occur and cause structural changes. Therefore, when storing and using, avoid contact with such substances, and store in a cool, dry and well-ventilated place to ensure its quality and performance are not affected.
What should be paid attention to when storing and transporting 4-chloro-2,5-difluoronitrobenzene?
4-Chloro-2,5-diethoxybenzaldehyde, this substance should pay attention to many key matters during storage and transportation.
It is an organic compound with specific chemical activity. When storing, choose the first environment. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. Because of its flammability, it is easy to cause danger in case of open flames and hot topics. The temperature of the warehouse should be strictly controlled, usually not exceeding 30 ° C, in case the temperature is too high to cause its chemical properties to change, or even induce reactions such as decomposition.
Furthermore, it needs to be stored separately from oxidants, acids, bases, etc., and must not be mixed. The chlorine atom and ethoxy group and other functional groups in the chemical structure of this compound make it come into contact with specific chemical substances, or violent chemical reactions occur, endangering storage safety.
Packaging must be tight, using suitable packaging materials to prevent leakage. If the package is damaged, it may not only cause it to be lost, affect the quality, but also leak or cause harm to the environment and human body.
When transporting, ensure that the vehicle is in good condition and the transportation equipment is firm. During transportation, it is necessary to prevent exposure to sun, rain and high temperature. When loading and unloading, it should be handled lightly to avoid damage to the packaging and containers. During transportation, drivers and escorts must always pay attention to the condition of the goods and be familiar with emergency handling measures. In case of leakage and other emergencies, it is necessary to deal with it immediately according to the predetermined emergency plan, evacuate the surrounding personnel, take protective measures, and properly clean up the leakage to prevent environmental pollution and safety accidents. In this way, the safety of 4-chloro-2,5-diethoxybenzaldehyde in storage and transportation can be guaranteed, and various latent risks can be avoided.
What is the market outlook for 4-chloro-2,5-difluoronitrobenzene?
The market prospect of 4-bromo-2,5-diethoxybenzyl is quite good.
This compound has significant uses in the field of medicine. The research and development of many new drugs often relies on it as a key intermediate. Nowadays, the pharmaceutical industry is booming, and the demand for specific drugs is increasing day by day. During the research and development process, the demand for such intermediates with unique structures is also increasing. Taking innovative anti-cancer drugs as an example, many scientific research teams are committed to exploring novel chemical structures. The structural properties of 4-bromo-2,5-diethoxybenzyl may open up new paths for the development of anti-cancer drugs. Therefore, the demand for pharmaceutical research and development lays the foundation for its market prospects.
In the field of materials science, there are also considerable advantages. With the progress of science and technology, there is an endless demand for high-performance materials. This compound may be introduced into polymer materials through specific reactions, giving the material unique electrical, optical and other properties. For example, in the field of organic optoelectronic materials, through exquisite design, it can be integrated into the system, which may improve the photoelectric conversion efficiency of materials, meet the desire for high-performance materials in fields such as solar cells, and then expand the market space.
Furthermore, with the continuous improvement of chemical synthesis technology, its synthesis methods are becoming more efficient and green. The synthesis cost is expected to gradually decrease, and the reduction of cost will undoubtedly enhance its market competitiveness. On the one hand, more companies will be able to get involved in its production and application; on the other hand, the downstream industry will also increase its purchasing willingness due to cost advantages, which will further expand the market scale.
However, its market prospects are not without challenges. Although the synthesis process has made progress, there are still technical problems that need to be overcome to ensure product quality and stability. And the market competition is also fierce, and it is necessary to continuously optimize the production process and improve product quality in order to gain a head start in the market. Overall, the 4-bromo-2,5-diethoxybenzyl market has a bright future, with opportunities and challenges coexisting.