Linshang Chemical
PRODUCTS
4-Chloro-2-Ethoxy-1-Fluorobenzene
Linshang Chemical
|
HS Code |
670018 |
| Chemical Formula | C8H8ClFO |
| Molecular Weight | 174.6 |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Around 190 - 195 °C |
| Density | Approx. 1.2 g/cm³ |
| Solubility In Water | Poorly soluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | Around 70 - 80 °C |
| Vapor Pressure | Low at room temperature |
| Odor | Characteristic aromatic odor |
| Stability | Stable under normal conditions |
As an accredited 4-Chloro-2-Ethoxy-1-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chloro - 2 - ethoxy - 1 - fluorobenzene packaged in a sealed, chemical - resistant bottle. |
| Storage | 4 - chloro - 2 - ethoxy - 1 - fluorobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and reactive chemicals to avoid potential reactions. Use appropriate storage cabinets dedicated to hazardous chemicals for safety. |
| Shipping | 4 - chloro - 2 - ethoxy - 1 - fluorobenzene is shipped in accordance with chemical regulations. Packed in suitable containers to prevent leakage, it's transported by approved carriers ensuring proper handling and safety during transit. |
Competitive 4-Chloro-2-Ethoxy-1-Fluorobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4-Chloro-2-Ethoxy-1-Fluorobenzene in China?
As a trusted 4-Chloro-2-Ethoxy-1-Fluorobenzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-Chloro-2-Ethoxy-1-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the physical properties of 4-chloro-2-ethoxy-1-fluorobenzene?
4-Bromo-2-ethyloxy-1-bromobenzene is one of the organic compounds. Its physical properties are quite specific, and I will tell you in detail today.
Looking at its appearance, under room temperature and pressure, it is mostly colorless to pale yellow liquid, clear and with a specific luster, like a clear spring. Under the light, there may be a faint light flickering, which makes people curious.
Smelling its smell is often irritating. Although it is not foul and unpleasant, it can also feel its unique smell when you get close to it. This smell is particularly obvious in a confined space or when the concentration is slightly higher, which can make people feel slightly uncomfortable at the nose end.
When it comes to density, it is heavier than water. If it is placed in the same place as water, it will slowly settle to the bottom of the water, just like a pearl sinking in the abyss. This property makes it possible to distinguish between water and water according to density differences during separation and mixing operations.
Its boiling point is also fixed. Under a certain pressure, it will boil and transform into a gaseous state when it reaches a certain temperature. The value of the boiling point varies slightly due to changes in ambient pressure, but it is roughly within a certain range. This temperature allows molecules to obtain enough energy to break free from each other and transition from the liquid phase to the gas phase.
In terms of solubility, in organic solvents, such as ethanol, ether, etc., there are many good solubility, and they can be miscible with other organic solvents, just like water emulsion, forming a uniform system; while in water, its solubility is poor. After mixing the two, it is easy to appear stratified, just like oil floating on water, with clear boundaries.
The physical properties of this compound are of great significance in many fields such as organic synthesis and chemical production. They are the basis for related operations and reactions, and are also a key factor that researchers cannot ignore.
Looking at its appearance, under room temperature and pressure, it is mostly colorless to pale yellow liquid, clear and with a specific luster, like a clear spring. Under the light, there may be a faint light flickering, which makes people curious.
Smelling its smell is often irritating. Although it is not foul and unpleasant, it can also feel its unique smell when you get close to it. This smell is particularly obvious in a confined space or when the concentration is slightly higher, which can make people feel slightly uncomfortable at the nose end.
When it comes to density, it is heavier than water. If it is placed in the same place as water, it will slowly settle to the bottom of the water, just like a pearl sinking in the abyss. This property makes it possible to distinguish between water and water according to density differences during separation and mixing operations.
Its boiling point is also fixed. Under a certain pressure, it will boil and transform into a gaseous state when it reaches a certain temperature. The value of the boiling point varies slightly due to changes in ambient pressure, but it is roughly within a certain range. This temperature allows molecules to obtain enough energy to break free from each other and transition from the liquid phase to the gas phase.
In terms of solubility, in organic solvents, such as ethanol, ether, etc., there are many good solubility, and they can be miscible with other organic solvents, just like water emulsion, forming a uniform system; while in water, its solubility is poor. After mixing the two, it is easy to appear stratified, just like oil floating on water, with clear boundaries.
The physical properties of this compound are of great significance in many fields such as organic synthesis and chemical production. They are the basis for related operations and reactions, and are also a key factor that researchers cannot ignore.
What are the chemical properties of 4-chloro-2-ethoxy-1-fluorobenzene?
4-Bromo-2-ethoxy-1-bromobenzene has the properties of halogenated aromatics, and the attachment of bromine and ethoxy to the benzene ring makes the physical properties different.
Its bromine has a halogen atom and is quite active. It can react with nucleophiles. If it encounters sodium alcohol, ammonia, etc., bromine is easily replaced by bromine, resulting in new compounds. If it interacts with sodium alcohol, bromine is replaced by alkoxy and forms a genus of ethers. This is the usual way of nucleophilic substitution, following the mechanism of SN2 or SN1, depending on environmental conditions.
and its ethoxy group, which has the effect of an electron conductor, can increase the electron cloud density of the phenyl ring. In the aromatic electrophilic substitution reaction, the ethoxy group is the localization group of the ortho and para-position, so that the electrophilic reagent tends to attach to the ortho and para-position of the benzene ring. Therefore, in case of halogenation, nitrification, and sulfonation reactions, the product is mostly the ortho and para-position substitutes.
4-Bromo-2-ethoxy-1-bromobenzene also has certain solubility. It is still soluble in organic solvents such as ethanol, ethyl ether, and dichloromethane, but it is insoluble in water. This is due to the non-polarity of its molecules.
and its chemical stability, due to the benzene ring conjugate system and increase, but the presence of bromine atoms, and the molecule has an active check point, can lead to all kinds of chemical reactions, in the field of organic synthesis, the use is also wide, can be used as an intermediate, to make other complex organic compounds.
Its bromine has a halogen atom and is quite active. It can react with nucleophiles. If it encounters sodium alcohol, ammonia, etc., bromine is easily replaced by bromine, resulting in new compounds. If it interacts with sodium alcohol, bromine is replaced by alkoxy and forms a genus of ethers. This is the usual way of nucleophilic substitution, following the mechanism of SN2 or SN1, depending on environmental conditions.
and its ethoxy group, which has the effect of an electron conductor, can increase the electron cloud density of the phenyl ring. In the aromatic electrophilic substitution reaction, the ethoxy group is the localization group of the ortho and para-position, so that the electrophilic reagent tends to attach to the ortho and para-position of the benzene ring. Therefore, in case of halogenation, nitrification, and sulfonation reactions, the product is mostly the ortho and para-position substitutes.
4-Bromo-2-ethoxy-1-bromobenzene also has certain solubility. It is still soluble in organic solvents such as ethanol, ethyl ether, and dichloromethane, but it is insoluble in water. This is due to the non-polarity of its molecules.
and its chemical stability, due to the benzene ring conjugate system and increase, but the presence of bromine atoms, and the molecule has an active check point, can lead to all kinds of chemical reactions, in the field of organic synthesis, the use is also wide, can be used as an intermediate, to make other complex organic compounds.
What fields are 4-chloro-2-ethoxy-1-fluorobenzene used in?
4-Bromo-2-ethoxy-1-fluorobenzene has a wide range of applications. In the field of medicine, this compound is often a key intermediate for the creation of new drugs. The introduction of atoms such as fluorine and bromine can significantly change the physical, chemical properties and biological activities of the compound. When developing antibacterial drugs, such compounds containing halogenated benzene structures can combine with targets in bacteria through specific mechanisms, or interfere with their metabolic processes, or hinder the synthesis of their cell walls, in order to achieve antibacterial effects.
In the field of pesticides, 4-bromo-2-ethoxy-1-fluorobenzene also has extraordinary performance. After rational design and modification, highly effective insecticides, fungicides, etc. can be derived. For example, some insecticides based on this structure can precisely act on the nervous system of pests, causing nerve conduction disorders and paralysis death, and the impact on the environment is relatively small, which is in line with the current concept of green environmental protection.
In the field of materials science, this compound can also play a unique role. In the synthesis of organic optoelectronic materials, because of its specific electron cloud distribution and conjugate structure, it can be used to prepare organic Light Emitting Diode (OLED) materials and organic solar cell materials with excellent performance. By adjusting its molecular structure, the photoelectric properties of materials can be optimized, and the luminous efficiency, stability and energy conversion efficiency of devices can be improved, which will contribute to the development of a new generation of optoelectronic materials.
In addition, in the preparation of fine chemical products, 4-bromo-2-ethoxy-1-fluorobenzene can be used as an important raw material for the synthesis of special fragrances, dyes, etc. Through chemical synthesis methods, perfumes can be given a more unique aroma, or dyes can have better dyeing properties and light fastness.
In the field of pesticides, 4-bromo-2-ethoxy-1-fluorobenzene also has extraordinary performance. After rational design and modification, highly effective insecticides, fungicides, etc. can be derived. For example, some insecticides based on this structure can precisely act on the nervous system of pests, causing nerve conduction disorders and paralysis death, and the impact on the environment is relatively small, which is in line with the current concept of green environmental protection.
In the field of materials science, this compound can also play a unique role. In the synthesis of organic optoelectronic materials, because of its specific electron cloud distribution and conjugate structure, it can be used to prepare organic Light Emitting Diode (OLED) materials and organic solar cell materials with excellent performance. By adjusting its molecular structure, the photoelectric properties of materials can be optimized, and the luminous efficiency, stability and energy conversion efficiency of devices can be improved, which will contribute to the development of a new generation of optoelectronic materials.
In addition, in the preparation of fine chemical products, 4-bromo-2-ethoxy-1-fluorobenzene can be used as an important raw material for the synthesis of special fragrances, dyes, etc. Through chemical synthesis methods, perfumes can be given a more unique aroma, or dyes can have better dyeing properties and light fastness.
What are the synthesis methods of 4-chloro-2-ethoxy-1-fluorobenzene?
To prepare 4-bromo-2-ethoxy-1-fluorobenzene, the following methods can be used:
First, start with a fluorine-containing aromatic compound. First, the fluorobenzene is brominated, and bromine atoms are introduced into its benzene ring. This bromination method can be used to co-react bromine with fluorobenzene under the catalysis of Lewis acid such as iron tribromide to obtain a mixture of o-bromofluorobenzene and p-bromofluorobenzene, and the mixture can be separated and purified to obtain o-bromofluorobenzene. Then, o-bromofluorobenzene is reacted with sodium ethanol, which is a nucleophilic substitution reaction. The ethoxy negative ion in sodium ethanol attacks the carbon connected to the bromine atom of o-bromofluorobenzene, and the bromine ion leaves, and then the ethoxy group is introduced to obtain the target product 4-bromo-2-ethoxy-1-fluorobenzene.
Second, an aromatic compound containing ethoxy groups is used as the starting material. The phenyl ether can be reacted with bromine under appropriate conditions, and the reaction conditions can be controlled so that the bromine atom is mainly substituted in the ortho-position of the methoxy group to obtain o-bromoanisole. Subsequently, the o-bromoanisole is reacted with a fluorinating agent such as potassium fluoride in the presence of a phase transfer catalyst, and the fluoride ion replaces Finally, p-fluorobenzene is demethylated and ethoxy is introduced. The methoxy group is changed to a hydroxyl group by an appropriate reagent such as hydroiodic acid, and then the ethoxy group is introduced by a substitution reaction with ethanol catalyzed by acid to obtain 4-bromo-2-ethoxy-1-fluorobenzene.
Third, bromobenzene is used as the starting material. First, the bromobenzene is nitrified to obtain a mixture of o-nitrobromobenzene and p-nitrobromobenzene to separate o-nitrobromobenzene. The o-nitrobromobenzene is reduced to o-amino bromobenzene, and then the amino group is converted into a diazonium salt by diazotization reaction with sodium nitrite and hydrochloric acid, and then reacted with fluoroboronic acid to The next step is the same as the first method, that is, the ethoxy group is introduced by reacting with sodium ethanol to make 4-bromo-2-ethoxy-1-fluorobenzene.
First, start with a fluorine-containing aromatic compound. First, the fluorobenzene is brominated, and bromine atoms are introduced into its benzene ring. This bromination method can be used to co-react bromine with fluorobenzene under the catalysis of Lewis acid such as iron tribromide to obtain a mixture of o-bromofluorobenzene and p-bromofluorobenzene, and the mixture can be separated and purified to obtain o-bromofluorobenzene. Then, o-bromofluorobenzene is reacted with sodium ethanol, which is a nucleophilic substitution reaction. The ethoxy negative ion in sodium ethanol attacks the carbon connected to the bromine atom of o-bromofluorobenzene, and the bromine ion leaves, and then the ethoxy group is introduced to obtain the target product 4-bromo-2-ethoxy-1-fluorobenzene.
Second, an aromatic compound containing ethoxy groups is used as the starting material. The phenyl ether can be reacted with bromine under appropriate conditions, and the reaction conditions can be controlled so that the bromine atom is mainly substituted in the ortho-position of the methoxy group to obtain o-bromoanisole. Subsequently, the o-bromoanisole is reacted with a fluorinating agent such as potassium fluoride in the presence of a phase transfer catalyst, and the fluoride ion replaces Finally, p-fluorobenzene is demethylated and ethoxy is introduced. The methoxy group is changed to a hydroxyl group by an appropriate reagent such as hydroiodic acid, and then the ethoxy group is introduced by a substitution reaction with ethanol catalyzed by acid to obtain 4-bromo-2-ethoxy-1-fluorobenzene.
Third, bromobenzene is used as the starting material. First, the bromobenzene is nitrified to obtain a mixture of o-nitrobromobenzene and p-nitrobromobenzene to separate o-nitrobromobenzene. The o-nitrobromobenzene is reduced to o-amino bromobenzene, and then the amino group is converted into a diazonium salt by diazotization reaction with sodium nitrite and hydrochloric acid, and then reacted with fluoroboronic acid to The next step is the same as the first method, that is, the ethoxy group is introduced by reacting with sodium ethanol to make 4-bromo-2-ethoxy-1-fluorobenzene.
What are the market prospects for 4-chloro-2-ethoxy-1-fluorobenzene?
At present, 4-bromo-2-ethoxy-1-fluorobenzene is in the market, and the prospect is still good.
Its use in the field of medicine can be a key raw material for the creation of new drugs. Nowadays, pharmaceutical research and development is thirsty for innovation, and many pharmaceutical companies are making every effort to find new compounds with high efficiency and safety. 4-bromo-2-ethoxy-1-fluorobenzene has a unique structure and contains bromine, ethoxy, fluorine and other groups, which may be specifically combined with targets in organisms, paving the way for the development of new drugs. For example, when developing antiviral and anti-tumor drugs, this compound may be able to interfere with virus replication and tumor cell proliferation due to its characteristics, so the demand for it in the pharmaceutical industry is increasing.
In the field of materials, it has also emerged. With the development of electronic and optical materials, there is a growing demand for compounds with special properties. The introduction of 4-bromo-2-ethoxy-1-fluorobenzene fluorine atoms may endow materials with special electrical and optical properties, such as for the preparation of organic Light Emitting Diode (OLED) materials, or can improve luminous efficiency and stability; used for the synthesis of high-performance polymer materials, or to improve the chemical resistance and mechanical properties of materials, so the materials industry has paid more attention to it.
Look at the technology again. The process of synthesizing this compound is constantly improving. In the past, there may have been cumbersome steps and low yield. Today, developers are making unremitting explorations. New synthesis methods are coming out frequently, which increases the yield and reduces the cost. The production scale can be gradually expanded to meet the increasing needs of the market.
And the market demand is on the rise. With the development of the global economy, the expansion of the pharmaceutical and material industries, the demand for 4-bromo-2-ethoxy-1-fluorobenzene is rising. In the domestic market, relevant industrial policy support, and the enthusiasm of enterprises for R & D and production is high; in the international market, trade exchanges are frequent, and the export of this compound also has potential.
However, there are also challenges. The synthesis process may involve special reagents and conditions, and enterprises and researchers need to overcome technical problems to ensure efficient production and environmental protection; market competition is becoming increasingly fierce, and enterprises must improve product quality and reduce costs in order to gain a place.
In summary, although 4-bromo-2-ethoxy-1-fluorobenzene is facing challenges, it is in high demand in the fields of medicine and materials, supported by technological progress, and the prospect is quite promising.
Its use in the field of medicine can be a key raw material for the creation of new drugs. Nowadays, pharmaceutical research and development is thirsty for innovation, and many pharmaceutical companies are making every effort to find new compounds with high efficiency and safety. 4-bromo-2-ethoxy-1-fluorobenzene has a unique structure and contains bromine, ethoxy, fluorine and other groups, which may be specifically combined with targets in organisms, paving the way for the development of new drugs. For example, when developing antiviral and anti-tumor drugs, this compound may be able to interfere with virus replication and tumor cell proliferation due to its characteristics, so the demand for it in the pharmaceutical industry is increasing.
In the field of materials, it has also emerged. With the development of electronic and optical materials, there is a growing demand for compounds with special properties. The introduction of 4-bromo-2-ethoxy-1-fluorobenzene fluorine atoms may endow materials with special electrical and optical properties, such as for the preparation of organic Light Emitting Diode (OLED) materials, or can improve luminous efficiency and stability; used for the synthesis of high-performance polymer materials, or to improve the chemical resistance and mechanical properties of materials, so the materials industry has paid more attention to it.
Look at the technology again. The process of synthesizing this compound is constantly improving. In the past, there may have been cumbersome steps and low yield. Today, developers are making unremitting explorations. New synthesis methods are coming out frequently, which increases the yield and reduces the cost. The production scale can be gradually expanded to meet the increasing needs of the market.
And the market demand is on the rise. With the development of the global economy, the expansion of the pharmaceutical and material industries, the demand for 4-bromo-2-ethoxy-1-fluorobenzene is rising. In the domestic market, relevant industrial policy support, and the enthusiasm of enterprises for R & D and production is high; in the international market, trade exchanges are frequent, and the export of this compound also has potential.
However, there are also challenges. The synthesis process may involve special reagents and conditions, and enterprises and researchers need to overcome technical problems to ensure efficient production and environmental protection; market competition is becoming increasingly fierce, and enterprises must improve product quality and reduce costs in order to gain a place.
In summary, although 4-bromo-2-ethoxy-1-fluorobenzene is facing challenges, it is in high demand in the fields of medicine and materials, supported by technological progress, and the prospect is quite promising.
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