Linshang Chemical
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4-Chloro-2-Fluoro-1-Iodobenzene
Linshang Chemical
|
HS Code |
750604 |
| Name | 4-Chloro-2-Fluoro-1-Iodobenzene |
| Molecular Formula | C6H3ClFI |
| Molecular Weight | 256.44 |
| Appearance | Liquid (usually) |
| Boiling Point | Approximately 205 - 207 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform, etc. |
| Purity Usually Available | Typically >95% in commercial products |
As an accredited 4-Chloro-2-Fluoro-1-Iodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - chloro - 2 - fluoro - 1 - iodobenzene packaged in a sealed glass bottle. |
| Storage | 4 - chloro - 2 - fluoro - 1 - iodobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container to prevent leakage and exposure to air and moisture, which could potentially lead to decomposition or reaction. Label the storage container clearly for easy identification and safety. |
| Shipping | 4 - chloro - 2 - fluoro - 1 - iodobenzene is a chemical. For shipping, it must be in a properly sealed, corrosion - resistant container. Label it clearly with relevant hazard warnings, and ship via methods compliant with chemical transportation regulations. |
Competitive 4-Chloro-2-Fluoro-1-Iodobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 4-Chloro-2-Fluoro-1-Iodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemistry of 4-chloro-2-fluoro-1-iodobenzene?
4-Chloro-2-fluoro-1-iodobenzene is one of the organic compounds. Among its molecules, there are chlorine, fluorine and iodine atoms attached to the benzene ring. This compound has special chemical properties and is active due to the presence of halogen atoms.
First of all, its physical properties. At room temperature, 4-chloro-2-fluoro-1-iodobenzene is often liquid or solid, depending on the specific environment. Its melting point and boiling point are controlled by intermolecular forces. Halogen atoms change the polarity of the molecule, which in turn affects the melting boiling point. Usually, due to the introduction of halogen atoms, the melting boiling point is higher than that of benzene.
As for chemical properties, the electronic effect of halogen atoms changes the electron cloud density distribution of benzene ring. Chlorine, fluorine and iodine atoms have electron-sucking induction effects, which reduce the electron cloud density of benzene ring, and the electrophilic substitution reaction activity is lower than that of benzene. However, under certain conditions, such reactions can still occur.
In nucleophilic substitution reactions, halogen atoms can be replaced by nucleophilic reagents. Iodine atoms have high activity in nucleophilic substitution reactions due to their large atomic radius and relatively small C-I bond energy. Although chlorine and fluorine atoms are slightly less active, they can also participate in the reaction under appropriate conditions.
4-chloro-2-fluoro-1-iodobenzene can participate in metal-catalyzed coupling reactions. Under the action of metal catalysts such as palladium and nickel, its halogen atoms can be coupled with carbon-containing nucleophiles to form carbon-carbon bonds. It is widely used in the field of organic synthesis and can be used to create complex organic molecules.
In addition, it can also participate in reduction reactions, and halogen atoms may be reduced to remove or converted into other functional groups. In oxidation reactions, benzene rings or side chains may also oxidize under the action of specific oxidants.
In conclusion, 4-chloro-2-fluoro-1-iodobenzene is composed of unique atoms, rich in chemical properties, and has important value in many fields such as organic synthesis. It is an important raw material for chemists to create novel compounds.
First of all, its physical properties. At room temperature, 4-chloro-2-fluoro-1-iodobenzene is often liquid or solid, depending on the specific environment. Its melting point and boiling point are controlled by intermolecular forces. Halogen atoms change the polarity of the molecule, which in turn affects the melting boiling point. Usually, due to the introduction of halogen atoms, the melting boiling point is higher than that of benzene.
As for chemical properties, the electronic effect of halogen atoms changes the electron cloud density distribution of benzene ring. Chlorine, fluorine and iodine atoms have electron-sucking induction effects, which reduce the electron cloud density of benzene ring, and the electrophilic substitution reaction activity is lower than that of benzene. However, under certain conditions, such reactions can still occur.
In nucleophilic substitution reactions, halogen atoms can be replaced by nucleophilic reagents. Iodine atoms have high activity in nucleophilic substitution reactions due to their large atomic radius and relatively small C-I bond energy. Although chlorine and fluorine atoms are slightly less active, they can also participate in the reaction under appropriate conditions.
4-chloro-2-fluoro-1-iodobenzene can participate in metal-catalyzed coupling reactions. Under the action of metal catalysts such as palladium and nickel, its halogen atoms can be coupled with carbon-containing nucleophiles to form carbon-carbon bonds. It is widely used in the field of organic synthesis and can be used to create complex organic molecules.
In addition, it can also participate in reduction reactions, and halogen atoms may be reduced to remove or converted into other functional groups. In oxidation reactions, benzene rings or side chains may also oxidize under the action of specific oxidants.
In conclusion, 4-chloro-2-fluoro-1-iodobenzene is composed of unique atoms, rich in chemical properties, and has important value in many fields such as organic synthesis. It is an important raw material for chemists to create novel compounds.
What are the main uses of 4-chloro-2-fluoro-1-iodobenzene?
4-Chloro-2-fluoro-1-iodobenzene is one of the organic compounds and has important uses in many fields such as chemical industry and medicine.
In the chemical industry, it is often a key intermediate in organic synthesis. Due to the unique reactivity of chlorine, fluorine and iodine atoms in its molecules, it can interact with many reagents through various chemical reactions, such as nucleophilic substitution, coupling reaction, etc., to construct complex organic molecules. Taking nucleophilic substitution as an example, halogen atoms can be replaced by other functional groups, opening up a path for the creation of new compounds, which can be used to synthesize materials with special properties, such as organic semiconductor materials with unique optoelectronic properties, etc., making extraordinary contributions to the field of electronics.
In the field of medicine, 4-chloro-2-fluoro-1-iodobenzene is also important. Because its structure can be modified to fit specific biological targets, in the process of many drug development, this is used as a starting material, and chemical modification and optimization are used to obtain compounds with specific pharmacological activities. Or it can be used to synthesize antibacterial drugs, which can interfere with the normal physiological activities of bacteria by combining their special structures with targets in bacteria to achieve antibacterial effect; or in the development of anti-tumor drugs, the structure is modified to enable them to accurately act on tumor cell targets and inhibit tumor cell growth and proliferation.
In addition, in the field of pesticides, pesticides developed on the basis of this compound may have an efficient control effect on specific pests or weeds due to their unique chemical structure, and the presence of halogen atoms in the structure may endow the pesticide with certain environmental stability and effectiveness. However, it is also necessary to pay attention to its potential impact on the environment. In short, 4-chloro-2-fluoro-1-iodobenzene is widely used in chemical, pharmaceutical, pesticide and other industries, and plays an important role in promoting the development of various fields.
In the chemical industry, it is often a key intermediate in organic synthesis. Due to the unique reactivity of chlorine, fluorine and iodine atoms in its molecules, it can interact with many reagents through various chemical reactions, such as nucleophilic substitution, coupling reaction, etc., to construct complex organic molecules. Taking nucleophilic substitution as an example, halogen atoms can be replaced by other functional groups, opening up a path for the creation of new compounds, which can be used to synthesize materials with special properties, such as organic semiconductor materials with unique optoelectronic properties, etc., making extraordinary contributions to the field of electronics.
In the field of medicine, 4-chloro-2-fluoro-1-iodobenzene is also important. Because its structure can be modified to fit specific biological targets, in the process of many drug development, this is used as a starting material, and chemical modification and optimization are used to obtain compounds with specific pharmacological activities. Or it can be used to synthesize antibacterial drugs, which can interfere with the normal physiological activities of bacteria by combining their special structures with targets in bacteria to achieve antibacterial effect; or in the development of anti-tumor drugs, the structure is modified to enable them to accurately act on tumor cell targets and inhibit tumor cell growth and proliferation.
In addition, in the field of pesticides, pesticides developed on the basis of this compound may have an efficient control effect on specific pests or weeds due to their unique chemical structure, and the presence of halogen atoms in the structure may endow the pesticide with certain environmental stability and effectiveness. However, it is also necessary to pay attention to its potential impact on the environment. In short, 4-chloro-2-fluoro-1-iodobenzene is widely used in chemical, pharmaceutical, pesticide and other industries, and plays an important role in promoting the development of various fields.
What are 4-chloro-2-fluoro-1-iodobenzene synthesis methods?
The synthesis of 4-chloro-2-fluoro-1-iodobenzene has been studied by chemists through the ages.
First, halogenated aromatic hydrocarbons are used as starting materials. First, take a suitable halogenated benzene with a specific substituent on the benzene ring. Through a halogen atom exchange reaction, this reaction requires precise control of the reaction conditions, such as temperature, pressure and catalyst dosage. Catalyzed by a specific metal catalyst, in a suitable solvent, chlorine atoms, fluorine atoms and iodine atoms are introduced into the predetermined position of the benzene ring in sequence. The reaction process must be carefully monitored to prevent side reactions from occurring and causing the product to be impure.
Second, through the conversion of aromatic diazonium salts. First, aromatic amines containing chlorine and fluorine are prepared, which are converted into diazonium salts with appropriate reagents. The diazonium salts are active, and then react with iodizing reagents. After a series of complex reaction processes, the diazonium groups are replaced by iodine atoms, and then the target product is 4-chloro-2-fluoro-1-iodobenzene. This process requires strict reaction environment, unstable diazonium salts, easy decomposition, and needs to be operated at low temperature and appropriate pH.
Third, transition metal catalytic coupling reaction is used. The halogenated aromatics containing chlorine and fluorine and iodine reagents are used as raw materials, and the coupling reaction occurs in the presence of ligands with the help of transition metal catalysts such as palladium and nickel. The ligand can adjust the metal activity and selectivity, and the reaction conditions are mild, but it is crucial for the selection of catalysts and ligands, and different combinations affect the reaction efficiency and product yield.
There are many methods for synthesizing 4-chloro-2-fluoro-1-iodobenzene, each with its own advantages and disadvantages. The optimal synthesis path should be selected according to the actual situation, considering factors such as raw material availability, cost, reaction conditions and product purity.
First, halogenated aromatic hydrocarbons are used as starting materials. First, take a suitable halogenated benzene with a specific substituent on the benzene ring. Through a halogen atom exchange reaction, this reaction requires precise control of the reaction conditions, such as temperature, pressure and catalyst dosage. Catalyzed by a specific metal catalyst, in a suitable solvent, chlorine atoms, fluorine atoms and iodine atoms are introduced into the predetermined position of the benzene ring in sequence. The reaction process must be carefully monitored to prevent side reactions from occurring and causing the product to be impure.
Second, through the conversion of aromatic diazonium salts. First, aromatic amines containing chlorine and fluorine are prepared, which are converted into diazonium salts with appropriate reagents. The diazonium salts are active, and then react with iodizing reagents. After a series of complex reaction processes, the diazonium groups are replaced by iodine atoms, and then the target product is 4-chloro-2-fluoro-1-iodobenzene. This process requires strict reaction environment, unstable diazonium salts, easy decomposition, and needs to be operated at low temperature and appropriate pH.
Third, transition metal catalytic coupling reaction is used. The halogenated aromatics containing chlorine and fluorine and iodine reagents are used as raw materials, and the coupling reaction occurs in the presence of ligands with the help of transition metal catalysts such as palladium and nickel. The ligand can adjust the metal activity and selectivity, and the reaction conditions are mild, but it is crucial for the selection of catalysts and ligands, and different combinations affect the reaction efficiency and product yield.
There are many methods for synthesizing 4-chloro-2-fluoro-1-iodobenzene, each with its own advantages and disadvantages. The optimal synthesis path should be selected according to the actual situation, considering factors such as raw material availability, cost, reaction conditions and product purity.
4-chloro-2-fluoro-1-iodobenzene What are the precautions during storage and transportation?
4-Chloro-2-fluoro-1-iodobenzene is an organic compound. When storing and transporting, many matters must be paid attention to.
First words storage. This compound is quite sensitive to environmental factors and should be placed in a cool, dry and well-ventilated place. If it is placed in a high temperature environment, it may increase its volatilization, or even cause chemical reactions and cause it to deteriorate. Humidity must also be strictly controlled. Reactions such as moisture or hydrolysis will damage the purity and quality of the compound. Store away from fire and heat sources to prevent fire. Furthermore, this compound should be stored separately from oxidizing agents, acids, alkalis, etc. Due to contact with it, violent chemical reactions are prone to occur, resulting in danger.
Second talk about transportation. During transportation, the packaging must be solid and reliable to prevent damage and leakage. Packaging materials should be able to withstand certain external impact and chemical corrosion. Transportation vehicles should be selected with good ventilation equipment, and should be kept away from fire and heat sources. Transportation personnel must be professionally trained to be familiar with the properties of this compound and emergency treatment methods. During driving, drive slowly and steadily to avoid violent actions such as sudden braking and sharp turns to prevent damage to the packaging. If there is a leak during transportation, do not panic, and evacuate the surrounding people immediately. It is strictly forbidden for fire to approach. Emergency responders must wear protective clothing and gas masks to properly collect spills to prevent them from spreading into the environment and causing greater harm.
First words storage. This compound is quite sensitive to environmental factors and should be placed in a cool, dry and well-ventilated place. If it is placed in a high temperature environment, it may increase its volatilization, or even cause chemical reactions and cause it to deteriorate. Humidity must also be strictly controlled. Reactions such as moisture or hydrolysis will damage the purity and quality of the compound. Store away from fire and heat sources to prevent fire. Furthermore, this compound should be stored separately from oxidizing agents, acids, alkalis, etc. Due to contact with it, violent chemical reactions are prone to occur, resulting in danger.
Second talk about transportation. During transportation, the packaging must be solid and reliable to prevent damage and leakage. Packaging materials should be able to withstand certain external impact and chemical corrosion. Transportation vehicles should be selected with good ventilation equipment, and should be kept away from fire and heat sources. Transportation personnel must be professionally trained to be familiar with the properties of this compound and emergency treatment methods. During driving, drive slowly and steadily to avoid violent actions such as sudden braking and sharp turns to prevent damage to the packaging. If there is a leak during transportation, do not panic, and evacuate the surrounding people immediately. It is strictly forbidden for fire to approach. Emergency responders must wear protective clothing and gas masks to properly collect spills to prevent them from spreading into the environment and causing greater harm.
4-chloro-2-fluoro-1-iodobenzene impact on the environment and human health
4-Chloro-2-fluoro-1-iodobenzene is one of the organohalogenated aromatic hydrocarbons. The impact of this substance on the environment and human health cannot be underestimated.
As far as the environment is concerned, it has certain stability and is not easy to rapidly degrade in the natural environment. If released into the soil, it may be adsorbed on soil particles, affecting the physical and chemical properties of the soil, hindering the uptake of nutrients and moisture by plant roots, and then affecting plant growth and development. Inflow into water bodies will cause water pollution and threaten the survival of aquatic organisms. Because it is fat-soluble, it is easy to accumulate in aquatic organisms, pass through the food chain and amplify, or be toxic to high-rise organisms.
As for human health, 4-chloro-2-fluoro-1-iodobenzene may cause damage to multiple organ systems after entering the human body through respiratory, digestive tract or skin contact. It may interfere with the human endocrine system, affect the synthesis, secretion and metabolism of hormones, and cause endocrine disorders. It may also have adverse effects on the nervous system, causing symptoms such as headache, vertigo, fatigue, memory loss, etc. Long-term exposure may increase the risk of cancer, due to the structure of halogenated aromatics, during metabolism in the body, or generate carcinogenic intermediates.
To sum up, 4-chloro-2-fluoro-1-iodobenzene poses potential hazards to the environment and human health. During its production, use and disposal, it needs to be treated with caution and strictly controlled to reduce its adverse effects on the ecological environment and people.
As far as the environment is concerned, it has certain stability and is not easy to rapidly degrade in the natural environment. If released into the soil, it may be adsorbed on soil particles, affecting the physical and chemical properties of the soil, hindering the uptake of nutrients and moisture by plant roots, and then affecting plant growth and development. Inflow into water bodies will cause water pollution and threaten the survival of aquatic organisms. Because it is fat-soluble, it is easy to accumulate in aquatic organisms, pass through the food chain and amplify, or be toxic to high-rise organisms.
As for human health, 4-chloro-2-fluoro-1-iodobenzene may cause damage to multiple organ systems after entering the human body through respiratory, digestive tract or skin contact. It may interfere with the human endocrine system, affect the synthesis, secretion and metabolism of hormones, and cause endocrine disorders. It may also have adverse effects on the nervous system, causing symptoms such as headache, vertigo, fatigue, memory loss, etc. Long-term exposure may increase the risk of cancer, due to the structure of halogenated aromatics, during metabolism in the body, or generate carcinogenic intermediates.
To sum up, 4-chloro-2-fluoro-1-iodobenzene poses potential hazards to the environment and human health. During its production, use and disposal, it needs to be treated with caution and strictly controlled to reduce its adverse effects on the ecological environment and people.
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