Linshang Chemical
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4-Chloro-2-Fluoro-1-Isocyanatobenzene
Linshang Chemical
|
HS Code |
763881 |
| Chemical Formula | C7H3ClFNO |
| Molecular Weight | 171.556 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Around 198 - 200 °C |
| Density | Data may vary, but around 1.3 - 1.4 g/cm³ |
| Solubility | Soluble in organic solvents like dichloromethane, toluene |
| Vapor Pressure | Low vapor pressure at room temperature |
| Stability | Stable under normal conditions, but reactive with water and amines |
As an accredited 4-Chloro-2-Fluoro-1-Isocyanatobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chloro - 2 - fluoro - 1 - isocyanatobenzene packaged in a sealed, corrosion - resistant drum. |
| Storage | 4 - chloro - 2 - fluoro - 1 - isocyanatobenzene should be stored in a cool, dry, well - ventilated area, away from sources of heat, ignition, and moisture. It should be stored in a tightly - sealed container to prevent leakage. Keep it separate from incompatible substances like acids, bases, and reactive metals to avoid potential reactions. Store at a recommended temperature range to maintain its stability. |
| Shipping | 4 - chloro - 2 - fluoro - 1 - isocyanatobenzene is a chemical. Ship it in well - sealed, corrosion - resistant containers. Follow strict hazardous material shipping regulations, ensuring proper labeling and documentation for safe transportation. |
Competitive 4-Chloro-2-Fluoro-1-Isocyanatobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4-Chloro-2-Fluoro-1-Isocyanatobenzene in China?
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-Chloro-2-Fluoro-1-Isocyanatobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 4-chloro-2-fluoro-1-isocyanatobenzene?
4-Chloro-2-fluoro-1-isocyanate benzene, this compound has a wide range of uses and is a crucial intermediate in the field of organic synthesis.
First, in the process of pesticide creation, it can participate in the synthesis of pesticide ingredients with high-efficiency insecticidal, bactericidal or herbicidal activities. By reacting with many compounds of specific structures, a novel and unique pesticide molecular structure can be constructed. With its special chemical structure, it enhances the effectiveness of target organisms, enhances the selectivity and effectiveness of pesticides, and thus achieves the purpose of precise prevention and control of pests, escorting agricultural harvests.
Second, it also plays a key role in the development of medicine. It can be used as a key building block for the synthesis of specific drug molecules, and can be introduced into the active structure of the drug through clever reaction design. Or it can improve the physical and chemical properties of the drug, such as improving fat solubility to promote drug absorption, or adjusting the spatial conformation of the molecule, optimizing the interaction with biological targets, thereby improving the efficacy of the drug, and contributing to human health and well-being.
Third, in the field of materials science, it can participate in the preparation of polymer materials with special properties. Polymerization with monomers containing functional groups such as active hydrogen introduces structural units containing fluorine, chlorine and isocyanate groups into the polymer main chain or side chain, giving the material unique properties such as excellent chemical resistance, weather resistance, and low surface energy. These materials have potential applications in aerospace, automotive manufacturing, electronic devices, and other fields, assisting in the technological upgrading of related industries.
First, in the process of pesticide creation, it can participate in the synthesis of pesticide ingredients with high-efficiency insecticidal, bactericidal or herbicidal activities. By reacting with many compounds of specific structures, a novel and unique pesticide molecular structure can be constructed. With its special chemical structure, it enhances the effectiveness of target organisms, enhances the selectivity and effectiveness of pesticides, and thus achieves the purpose of precise prevention and control of pests, escorting agricultural harvests.
Second, it also plays a key role in the development of medicine. It can be used as a key building block for the synthesis of specific drug molecules, and can be introduced into the active structure of the drug through clever reaction design. Or it can improve the physical and chemical properties of the drug, such as improving fat solubility to promote drug absorption, or adjusting the spatial conformation of the molecule, optimizing the interaction with biological targets, thereby improving the efficacy of the drug, and contributing to human health and well-being.
Third, in the field of materials science, it can participate in the preparation of polymer materials with special properties. Polymerization with monomers containing functional groups such as active hydrogen introduces structural units containing fluorine, chlorine and isocyanate groups into the polymer main chain or side chain, giving the material unique properties such as excellent chemical resistance, weather resistance, and low surface energy. These materials have potential applications in aerospace, automotive manufacturing, electronic devices, and other fields, assisting in the technological upgrading of related industries.
What are the physical properties of 4-chloro-2-fluoro-1-isocyanatobenzene?
4-Chloro-2-fluoro-1-isocyanate benzene is one of the organic compounds. It has specific physical properties and is involved in many fields such as chemical industry.
In terms of its properties, it is mostly liquid under normal conditions, but it may also change due to environmental factors. Looking at its color, it is often colorless to slightly yellow and clear. Smell it, it has a pungent smell, which is caused by its active groups such as isocyanate.
In terms of boiling point, it is about a certain temperature range, and the specific value will vary with the change of external pressure. Generally speaking, under standard pressure, the boiling point allows it to change from liquid to gas under specific conditions.
Melting point is also a key physical property. Its melting point determines the temperature at which this substance can be melted from solid to liquid. In a specific temperature range, phase transition occurs.
In terms of solubility, 4-chloro-2-fluoro-1-isocyanate benzene has good solubility in organic solvents, such as common aromatic hydrocarbons and halogenated hydrocarbon solvents. However, in water, the solubility is poor, due to the hydrophobic groups in the molecular structure.
Density is also an important physical property. Its density is different from that of water. In practical operation and application, this characteristic is related to the layering and mixing of substances.
The vapor pressure of this compound has a corresponding value at a specific temperature. The vapor pressure reflects the difficulty of volatilization. Higher vapor pressure means that it is more volatile to the gas phase, which requires special attention during storage and use.
In summary, the physical properties of 4-chloro-2-fluoro-1-isocyanate benzene are complex and diverse, and each property is interrelated, which has a profound impact on its application fields such as chemical synthesis and material preparation. In practical application, it is necessary to carefully investigate its various physical properties in order to achieve the best use effect and ensure the safety and efficiency of operation.
In terms of its properties, it is mostly liquid under normal conditions, but it may also change due to environmental factors. Looking at its color, it is often colorless to slightly yellow and clear. Smell it, it has a pungent smell, which is caused by its active groups such as isocyanate.
In terms of boiling point, it is about a certain temperature range, and the specific value will vary with the change of external pressure. Generally speaking, under standard pressure, the boiling point allows it to change from liquid to gas under specific conditions.
Melting point is also a key physical property. Its melting point determines the temperature at which this substance can be melted from solid to liquid. In a specific temperature range, phase transition occurs.
In terms of solubility, 4-chloro-2-fluoro-1-isocyanate benzene has good solubility in organic solvents, such as common aromatic hydrocarbons and halogenated hydrocarbon solvents. However, in water, the solubility is poor, due to the hydrophobic groups in the molecular structure.
Density is also an important physical property. Its density is different from that of water. In practical operation and application, this characteristic is related to the layering and mixing of substances.
The vapor pressure of this compound has a corresponding value at a specific temperature. The vapor pressure reflects the difficulty of volatilization. Higher vapor pressure means that it is more volatile to the gas phase, which requires special attention during storage and use.
In summary, the physical properties of 4-chloro-2-fluoro-1-isocyanate benzene are complex and diverse, and each property is interrelated, which has a profound impact on its application fields such as chemical synthesis and material preparation. In practical application, it is necessary to carefully investigate its various physical properties in order to achieve the best use effect and ensure the safety and efficiency of operation.
What is the chemistry of 4-chloro-2-fluoro-1-isocyanatobenzene?
4-Chloro-2-fluoro-1-isocyanate benzene is an organic compound. It has unique chemical properties and plays a key role in many chemical reactions and industrial processes.
Let's talk about its reactivity first. Isocyanate (-NCO) is active and easily reacts with active compounds containing hydrogen. In case of alcohols, it can form carbamate; in case of amines, it can form urea. This reactivity makes it widely used in the synthesis of polymer materials, such as the preparation of polyurethane. In the production of polyurethane, 4-chloro-2-fluoro-1-isocyanate benzene reacts with polyols, and gradually polymerizes to create polyurethane materials with excellent properties. The materials are widely used in coatings, adhesives, foam plastics and other industries.
Furthermore, the presence of chlorine atoms and fluorine atoms also has an important impact on their properties. The high electronegativity of fluorine atoms changes the distribution of molecular electron clouds, enhances molecular polarity, and affects the physical properties of compounds, such as boiling point and solubility. At the same time, the introduction of fluorine atoms can improve the stability and chemical inertness of compounds, and in some cases can enhance their corrosion resistance and weather resistance. Chlorine atoms also affect the molecular electron cloud, and can participate in nucleophilic substitution reactions. When suitable nucleophilic reagents exist, chlorine atoms can be replaced to achieve molecular structure modification, providing various possibilities for organic synthesis.
However, this compound also needs attention. Isocyanate has certain toxicity and irritation, and care should be taken during operation to ensure that it is carried out in a well-ventilated environment, and protective measures should be taken to avoid harm to the human body.
4-chloro-2-fluoro-1-isocyanate synbenzene has important value in the field of organic synthesis and materials science due to its unique chemical properties. However, it is also necessary to fully consider its latent risk when using it, and use it rationally to maximize its effectiveness.
Let's talk about its reactivity first. Isocyanate (-NCO) is active and easily reacts with active compounds containing hydrogen. In case of alcohols, it can form carbamate; in case of amines, it can form urea. This reactivity makes it widely used in the synthesis of polymer materials, such as the preparation of polyurethane. In the production of polyurethane, 4-chloro-2-fluoro-1-isocyanate benzene reacts with polyols, and gradually polymerizes to create polyurethane materials with excellent properties. The materials are widely used in coatings, adhesives, foam plastics and other industries.
Furthermore, the presence of chlorine atoms and fluorine atoms also has an important impact on their properties. The high electronegativity of fluorine atoms changes the distribution of molecular electron clouds, enhances molecular polarity, and affects the physical properties of compounds, such as boiling point and solubility. At the same time, the introduction of fluorine atoms can improve the stability and chemical inertness of compounds, and in some cases can enhance their corrosion resistance and weather resistance. Chlorine atoms also affect the molecular electron cloud, and can participate in nucleophilic substitution reactions. When suitable nucleophilic reagents exist, chlorine atoms can be replaced to achieve molecular structure modification, providing various possibilities for organic synthesis.
However, this compound also needs attention. Isocyanate has certain toxicity and irritation, and care should be taken during operation to ensure that it is carried out in a well-ventilated environment, and protective measures should be taken to avoid harm to the human body.
4-chloro-2-fluoro-1-isocyanate synbenzene has important value in the field of organic synthesis and materials science due to its unique chemical properties. However, it is also necessary to fully consider its latent risk when using it, and use it rationally to maximize its effectiveness.
What is 4-chloro-2-fluoro-1-isocyanatobenzene synthesis method?
The common method for preparing 4-chloro-2-fluoro-1-isocyanate benzene is as follows.
Starting with 4-chloro-2-fluoroaniline as raw material, this is the key starting material. First dissolve it in a suitable organic solvent, such as dichloromethane, chloroform, etc., which is the environment for subsequent reactions.
Then slowly add phosgene or its replacement reagent to this solution. Phosgene is the core reagent of the reaction and reacts with 4-chloro-2-fluoroaniline. When adding, it is necessary to pay attention to the temperature control, which is often maintained in the low temperature range, between about 0 ° C and 5 ° C. Because the reaction is exothermic, low temperature is conducive to the smooth progress of the reaction and the prevention of side reactions.
After the phosgene or alternative reagents are added, the reaction system is heated to room temperature and stirred for a period of time to make the reaction sufficient. During this process, the amino group of 4-chloro-2-fluoroaniline reacts chemically with the phosgene and gradually converts into isocyanate.
After the reaction is completed, the product is purified by vacuum distillation or column chromatography. Vacuum distillation can separate the target product by taking advantage of the difference in the boiling point of different substances; column chromatography can achieve the effect of separation according to the distribution coefficient of the substance between the stationary phase and the mobile phase.
In addition, phosgene is highly toxic, and the operation must be carried out in a well-ventilated environment, such as a fume hood, and the experimenter needs strict protection to ensure safety. There are also methods to replace phosgene with relatively safe reagents such as triphosgene. Although the reaction conditions may be different, the core is to convert amino groups into isocyanate. According to this principle, the reaction conditions and steps can be optimized according to the actual situation to obtain pure 4-chloro-2-fluoro-1-isocyanate benzene products.
Starting with 4-chloro-2-fluoroaniline as raw material, this is the key starting material. First dissolve it in a suitable organic solvent, such as dichloromethane, chloroform, etc., which is the environment for subsequent reactions.
Then slowly add phosgene or its replacement reagent to this solution. Phosgene is the core reagent of the reaction and reacts with 4-chloro-2-fluoroaniline. When adding, it is necessary to pay attention to the temperature control, which is often maintained in the low temperature range, between about 0 ° C and 5 ° C. Because the reaction is exothermic, low temperature is conducive to the smooth progress of the reaction and the prevention of side reactions.
After the phosgene or alternative reagents are added, the reaction system is heated to room temperature and stirred for a period of time to make the reaction sufficient. During this process, the amino group of 4-chloro-2-fluoroaniline reacts chemically with the phosgene and gradually converts into isocyanate.
After the reaction is completed, the product is purified by vacuum distillation or column chromatography. Vacuum distillation can separate the target product by taking advantage of the difference in the boiling point of different substances; column chromatography can achieve the effect of separation according to the distribution coefficient of the substance between the stationary phase and the mobile phase.
In addition, phosgene is highly toxic, and the operation must be carried out in a well-ventilated environment, such as a fume hood, and the experimenter needs strict protection to ensure safety. There are also methods to replace phosgene with relatively safe reagents such as triphosgene. Although the reaction conditions may be different, the core is to convert amino groups into isocyanate. According to this principle, the reaction conditions and steps can be optimized according to the actual situation to obtain pure 4-chloro-2-fluoro-1-isocyanate benzene products.
4-chloro-2-fluoro-1-isocyanatobenzene what are the precautions during use
4-Chloro-2-fluoro-1-isocyanate benzene, there are many things to be careful about when using this product.
The first thing to pay attention to is its toxicity. This compound is toxic to a certain extent, and contact with the human body or inhalation of its volatile gas can cause health damage. Therefore, when operating, you must be fully armed, wearing protective clothing, protective gloves and gas masks to ensure your own safety.
The second time is about its chemical activity. Isocyanate is extremely active and easily reacts with compounds containing active hydrogen such as water, alcohols, and amines. During use, be sure to keep the environment dry and away from water vapor and the above active substances to prevent accidental reactions from occurring and causing danger.
Furthermore, the volatility of this substance cannot be ignored. Because of its certain volatility, escaping into the air can cause environmental pollution, and in areas with poor ventilation, it is easy to increase the concentration in the air and add danger. The operation should be carried out in a fume hood, and ensure that the laboratory ventilation system is working well to effectively discharge volatile gases.
In terms of storage, it should be placed in a cool, dry and well-ventilated place, away from fire and heat sources, and stored separately from oxidants, acids, alkalis, etc., and should not be stored in mixed storage. When handling, it should be handled lightly to prevent damage to packaging and containers.
Also note that if you accidentally come into contact with the skin or eyes, you should immediately rinse with a large amount of flowing water, and then seek medical treatment in time; if you inhale, you should quickly evacuate the scene to a fresh air place to keep the respiratory tract unobstructed, such as breathing difficulties, give oxygen, if breathing stops, immediately perform artificial respiration, and seek medical attention. The operation site should also be equipped with corresponding varieties and quantities of fire equipment and leakage emergency treatment equipment.
The first thing to pay attention to is its toxicity. This compound is toxic to a certain extent, and contact with the human body or inhalation of its volatile gas can cause health damage. Therefore, when operating, you must be fully armed, wearing protective clothing, protective gloves and gas masks to ensure your own safety.
The second time is about its chemical activity. Isocyanate is extremely active and easily reacts with compounds containing active hydrogen such as water, alcohols, and amines. During use, be sure to keep the environment dry and away from water vapor and the above active substances to prevent accidental reactions from occurring and causing danger.
Furthermore, the volatility of this substance cannot be ignored. Because of its certain volatility, escaping into the air can cause environmental pollution, and in areas with poor ventilation, it is easy to increase the concentration in the air and add danger. The operation should be carried out in a fume hood, and ensure that the laboratory ventilation system is working well to effectively discharge volatile gases.
In terms of storage, it should be placed in a cool, dry and well-ventilated place, away from fire and heat sources, and stored separately from oxidants, acids, alkalis, etc., and should not be stored in mixed storage. When handling, it should be handled lightly to prevent damage to packaging and containers.
Also note that if you accidentally come into contact with the skin or eyes, you should immediately rinse with a large amount of flowing water, and then seek medical treatment in time; if you inhale, you should quickly evacuate the scene to a fresh air place to keep the respiratory tract unobstructed, such as breathing difficulties, give oxygen, if breathing stops, immediately perform artificial respiration, and seek medical attention. The operation site should also be equipped with corresponding varieties and quantities of fire equipment and leakage emergency treatment equipment.
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