Linshang Chemical
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4-Chloro-2-Fluoro-1-Methoxybenzene
Linshang Chemical
|
HS Code |
895330 |
| Chemical Formula | C7H6ClFO |
| Molecular Weight | 160.57 |
| Appearance | Liquid (usually) |
| Boiling Point | Approx. 175 - 180 °C |
| Density | Approx. 1.28 - 1.30 g/cm³ |
| Solubility In Water | Low, insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | Approx. 65 - 70 °C |
| Vapor Pressure | Low at room temperature |
As an accredited 4-Chloro-2-Fluoro-1-Methoxybenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 mL of 4 - chloro - 2 - fluoro - 1 - methoxybenzene in a sealed, labeled glass bottle. |
| Storage | 4 - chloro - 2 - fluoro - 1 - methoxybenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store it in a tightly - sealed container, preferably made of corrosion - resistant materials like glass or certain plastics. Label the storage container clearly to prevent misidentification. |
| Shipping | 4 - chloro - 2 - fluoro - 1 - methoxybenzene should be shipped in tightly sealed, corrosion - resistant containers. It must be labeled clearly. Follow all hazardous chemical shipping regulations to ensure safe transport. |
Competitive 4-Chloro-2-Fluoro-1-Methoxybenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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As a leading 4-Chloro-2-Fluoro-1-Methoxybenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 4-chloro-2-fluoro-1-methoxybenzene?
4-Chloro-2-fluoro-1-methoxybenzene is one of the organic compounds. Its chemical properties can be discussed from the polyend.
First, the presence of the benzene ring gives it aromaticity. The benzene ring has a conjugated system, which makes the compound relatively stable, less prone to addition reaction, and more prone to electrophilic substitution reaction.
As far as the substituent is concerned, both the chlorine atom and the fluorine atom are halogen atoms, which have an electron-absorbing induction effect, which can reduce the electron cloud density of the benzene ring, so that the electrophilic substitution reaction activity is slightly lower than that of benzene, and the halogen atom is an ortho-para-site group, and the electrophilic reagent is more likely to attack Methoxy groups have electron-giving conjugation effect and electron-withdrawing induction effect. Generally, the electron-giving conjugation effect is the main one, which can increase the electron cloud density of the benzene ring and improve the activity of electrophilic substitution reaction. Moreover, it is an ortho-para-localization group, so that the electrophilic substitution reaction mostly occurs in the ortho-position and para-position.
In the electrophilic substitution reaction, because the electron-giving ability of the methoxy group is stronger than that of the halogen atom, the reaction check point is mostly in the ortho-position and para-position of the methoxy group. For example, when a nitration reaction occurs, the nitro group or the methoxy group is mainly introduced into the ortho-position or para-position.
< br Under appropriate conditions, chlorine or fluorine atoms can be replaced by nucleophiles to form new compounds. For example, in strong bases and suitable solvents, chlorine atoms can be replaced by nucleophiles such as hydroxyl groups to obtain corresponding phenolic derivatives.
The chemical properties of this compound are of great significance in the field of organic synthesis, and various reactions can be designed by virtue of their properties to prepare various organic compounds with specific functions.
First, the presence of the benzene ring gives it aromaticity. The benzene ring has a conjugated system, which makes the compound relatively stable, less prone to addition reaction, and more prone to electrophilic substitution reaction.
As far as the substituent is concerned, both the chlorine atom and the fluorine atom are halogen atoms, which have an electron-absorbing induction effect, which can reduce the electron cloud density of the benzene ring, so that the electrophilic substitution reaction activity is slightly lower than that of benzene, and the halogen atom is an ortho-para-site group, and the electrophilic reagent is more likely to attack Methoxy groups have electron-giving conjugation effect and electron-withdrawing induction effect. Generally, the electron-giving conjugation effect is the main one, which can increase the electron cloud density of the benzene ring and improve the activity of electrophilic substitution reaction. Moreover, it is an ortho-para-localization group, so that the electrophilic substitution reaction mostly occurs in the ortho-position and para-position.
In the electrophilic substitution reaction, because the electron-giving ability of the methoxy group is stronger than that of the halogen atom, the reaction check point is mostly in the ortho-position and para-position of the methoxy group. For example, when a nitration reaction occurs, the nitro group or the methoxy group is mainly introduced into the ortho-position or para-position.
< br Under appropriate conditions, chlorine or fluorine atoms can be replaced by nucleophiles to form new compounds. For example, in strong bases and suitable solvents, chlorine atoms can be replaced by nucleophiles such as hydroxyl groups to obtain corresponding phenolic derivatives.
The chemical properties of this compound are of great significance in the field of organic synthesis, and various reactions can be designed by virtue of their properties to prepare various organic compounds with specific functions.
What are the common uses of 4-chloro-2-fluoro-1-methoxybenzene?
4-Chloro-2-fluoro-1-methoxybenzene, an organic compound, is widely used in the field of organic synthesis. Its common preparation methods include the following:
First, halogenated benzene is used as the starting material. Appropriate halogenated benzene can be taken first to interact with fluorinated reagents to introduce fluorine atoms. In the fluorination reaction, potassium fluoride and other reagents are commonly used. Under specific solvents and reaction conditions, halogen atoms are substituted with fluorine atoms to obtain fluorinated halogenated benzene. Subsequently, it is reacted with chlorinated reagents to introduce chlorine atoms. In the chlorination process, a suitable chlorination agent can be selected to precisely locate the substitution position of chlorine atoms under the action of a specific catalyst. Finally, it is reacted with methoxylating reagents, such as sodium methoxide, to achieve the introduction of methoxy groups, thereby obtaining 4-chloro-2-fluoro-1-methoxylbenzene.
Second, phenolic compounds are used as starting materials. First, the phenolic hydroxyl group is methoxylated to protect, and appropriate methylating reagents such as dimethyl sulfate are used to react under basic conditions to generate methoxylphenol. After that, the fluorination and chlorination reactions are carried out in sequence. The reagents and conditions used are similar to the process of using halogenated benzene as raw materials, and the target product is obtained through a series of reactions.
Third, through an aromatic nucleophilic substitution reaction. Select suitable aromatic substrates, containing good leaving groups that can be substituted, such as sulfonate groups, etc. Under strong alkaline conditions, react with nucleophiles such as fluoride ions, chloride ions and methoxy negative ions in sequence to gradually build the target molecular structure and realize the synthesis of 4-chloro-2-fluoro-1-methoxylbenzene.
This compound has important applications in the fields of medicine, pesticides and materials. In the field of medicine, or as an intermediate, it can participate in the synthesis of specific biologically active drugs; in the field of pesticides, or lay the foundation for the preparation of new and efficient pesticides; in the field of materials, or because of its special structure, it provides key raw materials for the research and development of new functional materials.
First, halogenated benzene is used as the starting material. Appropriate halogenated benzene can be taken first to interact with fluorinated reagents to introduce fluorine atoms. In the fluorination reaction, potassium fluoride and other reagents are commonly used. Under specific solvents and reaction conditions, halogen atoms are substituted with fluorine atoms to obtain fluorinated halogenated benzene. Subsequently, it is reacted with chlorinated reagents to introduce chlorine atoms. In the chlorination process, a suitable chlorination agent can be selected to precisely locate the substitution position of chlorine atoms under the action of a specific catalyst. Finally, it is reacted with methoxylating reagents, such as sodium methoxide, to achieve the introduction of methoxy groups, thereby obtaining 4-chloro-2-fluoro-1-methoxylbenzene.
Second, phenolic compounds are used as starting materials. First, the phenolic hydroxyl group is methoxylated to protect, and appropriate methylating reagents such as dimethyl sulfate are used to react under basic conditions to generate methoxylphenol. After that, the fluorination and chlorination reactions are carried out in sequence. The reagents and conditions used are similar to the process of using halogenated benzene as raw materials, and the target product is obtained through a series of reactions.
Third, through an aromatic nucleophilic substitution reaction. Select suitable aromatic substrates, containing good leaving groups that can be substituted, such as sulfonate groups, etc. Under strong alkaline conditions, react with nucleophiles such as fluoride ions, chloride ions and methoxy negative ions in sequence to gradually build the target molecular structure and realize the synthesis of 4-chloro-2-fluoro-1-methoxylbenzene.
This compound has important applications in the fields of medicine, pesticides and materials. In the field of medicine, or as an intermediate, it can participate in the synthesis of specific biologically active drugs; in the field of pesticides, or lay the foundation for the preparation of new and efficient pesticides; in the field of materials, or because of its special structure, it provides key raw materials for the research and development of new functional materials.
What are 4-chloro-2-fluoro-1-methoxybenzene synthesis methods?
The synthesis method of 4-chloro-2-fluoro-1-methoxybenzene is very particular and has a variety of paths. The following is your detailed description.
First, it can be started from halogenated aromatics. First, take a suitable halogenated benzene, such as 4-chloro-2-fluorobenzene, and introduce the methoxy group through methoxylation. This reaction requires a suitable base, such as potassium carbonate, in a polar solvent, such as N, N-dimethylformamide (DMF), and co-heat with methylating reagents such as iodomethane or dimethyl sulfate. Potassium carbonate can remove the active hydrogen of halogenated benzene to form phenoxy anions, and then react with methylation reagents to obtain the target product 4-chloro-2-fluoro-1-methoxybenzene.
Second, phenolic compounds are used as starting materials. 4-chloro-2-fluorophenol is first prepared, and then its phenolic hydroxyl group is methylated. The methylation reagent can be dimethyl sulfate and reacted under alkaline conditions. Sodium hydroxide solution can convert phenolic hydroxyl groups into sodium phenol. Sodium phenol has strong nucleophilicity and is easy to undergo nucleophilic substitution with dimethyl sulfate to generate 4-chloro-2-fluoro-1-methoxylbenzene.
Third, through the Fu-gram reaction. Using 1-chloro-3-fluorobenzene as the substrate, under the catalysis of anhydrous aluminum trichloride and other Lewis acids, the Fu-gram alkylation reaction occurs with chloromethyl ether. Lewis acid activates chloromethyl ether to generate carbocation ions, which attack the benzene ring and obtain the target product after a series of reactions. After the reaction is completed, the reaction system needs to be handled carefully to remove the catalyst and by-products.
Fourth, the coupling reaction catalyzed by palladium can also be used. For example, 4-chloro-2-fluoroiodobenzene and methoxyborate are coupled in a suitable base and solvent under the action of a palladium catalyst, such as tetra (triphenylphosphine) palladium (0). The base can stabilize the reaction intermediate, and the solvent needs to have good solubility to the reactants and catalysts to promote the smooth progress of the reaction, and finally 4-chloro-2-fluoro-1-methoxybenzene is obtained.
All synthetic methods have their own advantages and disadvantages. In actual operation, factors such as the availability of raw materials, cost, difficulty of reaction conditions, and product purity requirements must be carefully weighed and carefully selected.
First, it can be started from halogenated aromatics. First, take a suitable halogenated benzene, such as 4-chloro-2-fluorobenzene, and introduce the methoxy group through methoxylation. This reaction requires a suitable base, such as potassium carbonate, in a polar solvent, such as N, N-dimethylformamide (DMF), and co-heat with methylating reagents such as iodomethane or dimethyl sulfate. Potassium carbonate can remove the active hydrogen of halogenated benzene to form phenoxy anions, and then react with methylation reagents to obtain the target product 4-chloro-2-fluoro-1-methoxybenzene.
Second, phenolic compounds are used as starting materials. 4-chloro-2-fluorophenol is first prepared, and then its phenolic hydroxyl group is methylated. The methylation reagent can be dimethyl sulfate and reacted under alkaline conditions. Sodium hydroxide solution can convert phenolic hydroxyl groups into sodium phenol. Sodium phenol has strong nucleophilicity and is easy to undergo nucleophilic substitution with dimethyl sulfate to generate 4-chloro-2-fluoro-1-methoxylbenzene.
Third, through the Fu-gram reaction. Using 1-chloro-3-fluorobenzene as the substrate, under the catalysis of anhydrous aluminum trichloride and other Lewis acids, the Fu-gram alkylation reaction occurs with chloromethyl ether. Lewis acid activates chloromethyl ether to generate carbocation ions, which attack the benzene ring and obtain the target product after a series of reactions. After the reaction is completed, the reaction system needs to be handled carefully to remove the catalyst and by-products.
Fourth, the coupling reaction catalyzed by palladium can also be used. For example, 4-chloro-2-fluoroiodobenzene and methoxyborate are coupled in a suitable base and solvent under the action of a palladium catalyst, such as tetra (triphenylphosphine) palladium (0). The base can stabilize the reaction intermediate, and the solvent needs to have good solubility to the reactants and catalysts to promote the smooth progress of the reaction, and finally 4-chloro-2-fluoro-1-methoxybenzene is obtained.
All synthetic methods have their own advantages and disadvantages. In actual operation, factors such as the availability of raw materials, cost, difficulty of reaction conditions, and product purity requirements must be carefully weighed and carefully selected.
4-chloro-2-fluoro-1-methoxybenzene what are the precautions during storage and transportation?
4-Chloro-2-fluoro-1-methoxybenzene is also an organic compound. All matters must be handled with caution during storage and transportation.
Bear the brunt, and the storage place must be cool and dry. This compound is active or active, and high temperature and humidity can easily cause it to deteriorate, or cause chemical reactions to occur for no reason. If placed in a hot sun or a place with heavy moisture, it may damage its chemical structure and lose its inherent nature.
Furthermore, the place of storage must be well ventilated. 4-Chloro-2-fluoro-1-methoxybenzene may be volatile. If its vapor accumulates in a confined space, it will damage the storage container, and if it encounters an open flame or hot topic, it may cause the risk of explosion. Good ventilation can disperse its vapor and ensure the safety of the environment.
When transporting, the packaging must be solid and reliable. When in a suitable container, prevent its leakage. If this compound leaks outside, or pollutes the environment, and is harmful to human and animal health. Outside the packaging, it should be clearly marked to indicate that it is a chemical, indicating its characteristics and hazards, so that both transporters and contacts can be cautious.
At the same time, during transportation, temperature and vibration should also be paid attention to. Violent vibration or damage to the container, and changes in temperature, if it exceeds the appropriate range, will also affect its stability. Therefore, the transportation equipment should have the ability of temperature control and shock absorption to ensure its safe delivery.
Also, whether it is stored or transported, it must be kept away from fire sources, heat sources and oxidants. 4-chloro-2-fluoro-1-methoxylbenzene is easy to burn in case of fire or hot topic; contact with oxidants, or react violently, causing unexpected disasters.
All of these, in the storage and transportation of 4-chloro-2-fluoro-1-methoxybenzene, are the key, do not be slack, and must follow the regulations to ensure safety.
Bear the brunt, and the storage place must be cool and dry. This compound is active or active, and high temperature and humidity can easily cause it to deteriorate, or cause chemical reactions to occur for no reason. If placed in a hot sun or a place with heavy moisture, it may damage its chemical structure and lose its inherent nature.
Furthermore, the place of storage must be well ventilated. 4-Chloro-2-fluoro-1-methoxybenzene may be volatile. If its vapor accumulates in a confined space, it will damage the storage container, and if it encounters an open flame or hot topic, it may cause the risk of explosion. Good ventilation can disperse its vapor and ensure the safety of the environment.
When transporting, the packaging must be solid and reliable. When in a suitable container, prevent its leakage. If this compound leaks outside, or pollutes the environment, and is harmful to human and animal health. Outside the packaging, it should be clearly marked to indicate that it is a chemical, indicating its characteristics and hazards, so that both transporters and contacts can be cautious.
At the same time, during transportation, temperature and vibration should also be paid attention to. Violent vibration or damage to the container, and changes in temperature, if it exceeds the appropriate range, will also affect its stability. Therefore, the transportation equipment should have the ability of temperature control and shock absorption to ensure its safe delivery.
Also, whether it is stored or transported, it must be kept away from fire sources, heat sources and oxidants. 4-chloro-2-fluoro-1-methoxylbenzene is easy to burn in case of fire or hot topic; contact with oxidants, or react violently, causing unexpected disasters.
All of these, in the storage and transportation of 4-chloro-2-fluoro-1-methoxybenzene, are the key, do not be slack, and must follow the regulations to ensure safety.
What are the effects of 4-chloro-2-fluoro-1-methoxybenzene on the environment and human health?
4-Chloro-2-fluoro-1-methoxybenzene is one of the organic compounds. Its impact on the environment and human health cannot be underestimated.
At one end of the environment, if this compound is released into nature, it may cause multiple effects. First, in aquatic ecosystems, it may pose a hazard to aquatic organisms. Aquatic organisms have different tolerances to it, or cause a decrease in the number of some sensitive species, thereby disturbing the balance of aquatic ecology. Second, if the soil is polluted by it, it may affect the activity and community structure of soil microorganisms, hinder the normal material cycle and nutrient transformation of the soil, and eventually damage soil fertility and ecological functions. Furthermore, in the atmosphere, it may participate in photochemical reactions, causing adverse effects on air quality, or even generating harmful secondary pollutants.
As for human health, 4-chloro-2-fluoro-1-methoxybenzene also poses a potential threat. It can enter the human body through inhalation, skin contact or accidental ingestion. Once it enters the body, or accumulates in the body, it interferes with normal physiological functions. Or it affects the nervous system, causing headache, dizziness, fatigue and other uncomfortable symptoms. Or it causes damage to important organs such as the liver and kidneys, affecting their normal metabolism and detoxification functions. Long-term exposure to this compound may increase the risk of cancer, as some halogenated aromatics have been proven to be carcinogenic, and this substance may pose a similar hazard.
Therefore, the production, use and disposal of 4-chloro-2-fluoro-1-methoxybenzene should be treated with caution to reduce its potential harm to the environment and human health.
At one end of the environment, if this compound is released into nature, it may cause multiple effects. First, in aquatic ecosystems, it may pose a hazard to aquatic organisms. Aquatic organisms have different tolerances to it, or cause a decrease in the number of some sensitive species, thereby disturbing the balance of aquatic ecology. Second, if the soil is polluted by it, it may affect the activity and community structure of soil microorganisms, hinder the normal material cycle and nutrient transformation of the soil, and eventually damage soil fertility and ecological functions. Furthermore, in the atmosphere, it may participate in photochemical reactions, causing adverse effects on air quality, or even generating harmful secondary pollutants.
As for human health, 4-chloro-2-fluoro-1-methoxybenzene also poses a potential threat. It can enter the human body through inhalation, skin contact or accidental ingestion. Once it enters the body, or accumulates in the body, it interferes with normal physiological functions. Or it affects the nervous system, causing headache, dizziness, fatigue and other uncomfortable symptoms. Or it causes damage to important organs such as the liver and kidneys, affecting their normal metabolism and detoxification functions. Long-term exposure to this compound may increase the risk of cancer, as some halogenated aromatics have been proven to be carcinogenic, and this substance may pose a similar hazard.
Therefore, the production, use and disposal of 4-chloro-2-fluoro-1-methoxybenzene should be treated with caution to reduce its potential harm to the environment and human health.
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