Linshang Chemical
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4-Chloro-2-Fluoro-1-Methylbenzene
Linshang Chemical
|
HS Code |
683647 |
| Chemical Formula | C7H6ClF |
| Molecular Weight | 144.57 |
| Appearance | Liquid (usually) |
| Boiling Point | Around 155 - 157 °C |
| Density | Approx. 1.18 - 1.22 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether, etc. |
| Odor | Aromatic, characteristic benzene - like odor |
| Flash Point | Around 46 - 48 °C |
As an accredited 4-Chloro-2-Fluoro-1-Methylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500 mL of 4 - chloro - 2 - fluoro - 1 - methylbenzene in a tightly - sealed glass bottle. |
| Storage | 4 - chloro - 2 - fluoro - 1 - methylbenzene should be stored in a cool, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and reactive chemicals. Use corrosion - resistant storage materials due to its potentially reactive nature. Ensure the storage area has proper spill - containment measures. |
| Shipping | 4 - chloro - 2 - fluoro - 1 - methylbenzene is shipped in tightly sealed, corrosion - resistant containers. It must be transported in accordance with hazardous chemical regulations, ensuring proper labeling and secure handling during transit. |
Competitive 4-Chloro-2-Fluoro-1-Methylbenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 4-Chloro-2-Fluoro-1-Methylbenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 4-chloro-2-fluoro-1-methylbenzene?
4-Chloro-2-fluoro-1-methylbenzene is a family of organic compounds. Its chemical properties are unique and of great research value.
The first part of its substitution reaction is its substitution reaction. Because of its benzene ring, chlorine, fluorine and methyl are in their respective positions, making the electron cloud density of the benzene ring different. Chlorine and fluorine are electron-withdrawing groups, while methyl is the power-supplying sub-group. In this way, the electron effects are superimposed, and the electron cloud density of the adjacent and para-site of the benzene ring is relatively high. In the electrophilic substitution reaction, electrophilic reagents such as bromine or chlorine are more likely to attack these two positions. In case of halogenation reaction, electrophilic reagents such as bromine or chlorine will mostly introduce new groups in the adjacent and
Let's talk about its reaction with metal reagents. The chlorine atom in 4-chloro-2-fluoro-1-methylbenzene has high activity and can react with metals such as magnesium in anhydrous ether and other solvents to form Grignard reagents. This Grignard reagent is extremely active and can undergo nucleophilic addition reactions with many carbonyl compounds, such as aldons and ketones, thereby increasing the carbon chain and synthesizing more complex organic compounds.
Furthermore, although its fluorine atom is not as active as the chlorine atom, it can also participate in the reaction under certain conditions. For example, under the action of some fluorine-containing reagents, the substitution reaction of fluorine atoms can occur to introduce other functional groups to enrich the structure and properties of the compound. Due to its unique substituents and rich chemical properties, 4-chloro-2-fluoro-1-methylbenzene provides many possibilities for the construction of various complex organic molecules in the field of organic synthesis. It is an important basic compound for organic chemistry research.
The first part of its substitution reaction is its substitution reaction. Because of its benzene ring, chlorine, fluorine and methyl are in their respective positions, making the electron cloud density of the benzene ring different. Chlorine and fluorine are electron-withdrawing groups, while methyl is the power-supplying sub-group. In this way, the electron effects are superimposed, and the electron cloud density of the adjacent and para-site of the benzene ring is relatively high. In the electrophilic substitution reaction, electrophilic reagents such as bromine or chlorine are more likely to attack these two positions. In case of halogenation reaction, electrophilic reagents such as bromine or chlorine will mostly introduce new groups in the adjacent and
Let's talk about its reaction with metal reagents. The chlorine atom in 4-chloro-2-fluoro-1-methylbenzene has high activity and can react with metals such as magnesium in anhydrous ether and other solvents to form Grignard reagents. This Grignard reagent is extremely active and can undergo nucleophilic addition reactions with many carbonyl compounds, such as aldons and ketones, thereby increasing the carbon chain and synthesizing more complex organic compounds.
Furthermore, although its fluorine atom is not as active as the chlorine atom, it can also participate in the reaction under certain conditions. For example, under the action of some fluorine-containing reagents, the substitution reaction of fluorine atoms can occur to introduce other functional groups to enrich the structure and properties of the compound. Due to its unique substituents and rich chemical properties, 4-chloro-2-fluoro-1-methylbenzene provides many possibilities for the construction of various complex organic molecules in the field of organic synthesis. It is an important basic compound for organic chemistry research.
What are the physical properties of 4-chloro-2-fluoro-1-methylbenzene?
4-Chloro-2-fluoro-1-methylbenzene is also an organic compound. Its physical properties are quite critical and it is useful in various fields of chemistry.
First of all, its appearance, under room temperature and pressure, is mostly colorless to light yellow transparent liquid. The view is clear, and there is no significant impurity variegation. This is a visually recognizable state.
Second, its boiling point is about 150-160 ° C. The boiling point is also the critical temperature at which a substance changes from liquid to gaseous. At this temperature, the molecule of 4-chloro-2-fluoro-1-methylbenzene is energized enough to break free from the liquid phase and escape into the gas phase. The boiling point characteristic is of great significance in chemical operations such as separation and purification. The compound can be precipitated from the mixture by distillation according to the difference in boiling points.
Furthermore, its melting point is about -40 ° C. The melting point is the temperature limit at which a substance melts from solid to liquid. When the ambient temperature is higher than the melting point, 4-chloro-2-fluoro-1-methylbenzene is converted from solid to liquid. The melting point data is of great reference value for the setting of storage and transportation conditions, in case the temperature is too low to cause it to solidify and affect the use.
The density of 4-chloro-2-fluoro-1-methylbenzene is about 1.18-1.22 g/cm ³. The density is also the mass of the substance per unit volume. This value is slightly larger than that of water, so if mixed with water, it will sink underwater. Density characteristics are important parameters in the measurement of materials in chemical production, mixing ratio control, etc.
Its solubility is also an important property. Slightly soluble in water, it can be miscible with most organic solvents such as ethanol, ether, acetone, etc. This solubility characteristic is crucial in the organic synthesis reaction. With the solubility of organic solvents, the reactants can be fully contacted to improve the reaction rate and yield.
In addition, 4-chloro-2-fluoro-1-methyl benzene is volatile to a certain extent and can evaporate slowly in the air. Volatility should be paid attention to during storage and should be sealed to prevent it from escaping into the environment and causing material loss. Volatile substances may have potential effects on the environment and human health.
In summary, the physical properties of 4-chloro-2-fluoro-1-methylbenzene, such as appearance, boiling point, melting point, density, solubility, and volatility, are indispensable factors for chemical production, scientific research experiments, and many other aspects. It is essential for its rational use and proper disposal.
First of all, its appearance, under room temperature and pressure, is mostly colorless to light yellow transparent liquid. The view is clear, and there is no significant impurity variegation. This is a visually recognizable state.
Second, its boiling point is about 150-160 ° C. The boiling point is also the critical temperature at which a substance changes from liquid to gaseous. At this temperature, the molecule of 4-chloro-2-fluoro-1-methylbenzene is energized enough to break free from the liquid phase and escape into the gas phase. The boiling point characteristic is of great significance in chemical operations such as separation and purification. The compound can be precipitated from the mixture by distillation according to the difference in boiling points.
Furthermore, its melting point is about -40 ° C. The melting point is the temperature limit at which a substance melts from solid to liquid. When the ambient temperature is higher than the melting point, 4-chloro-2-fluoro-1-methylbenzene is converted from solid to liquid. The melting point data is of great reference value for the setting of storage and transportation conditions, in case the temperature is too low to cause it to solidify and affect the use.
The density of 4-chloro-2-fluoro-1-methylbenzene is about 1.18-1.22 g/cm ³. The density is also the mass of the substance per unit volume. This value is slightly larger than that of water, so if mixed with water, it will sink underwater. Density characteristics are important parameters in the measurement of materials in chemical production, mixing ratio control, etc.
Its solubility is also an important property. Slightly soluble in water, it can be miscible with most organic solvents such as ethanol, ether, acetone, etc. This solubility characteristic is crucial in the organic synthesis reaction. With the solubility of organic solvents, the reactants can be fully contacted to improve the reaction rate and yield.
In addition, 4-chloro-2-fluoro-1-methyl benzene is volatile to a certain extent and can evaporate slowly in the air. Volatility should be paid attention to during storage and should be sealed to prevent it from escaping into the environment and causing material loss. Volatile substances may have potential effects on the environment and human health.
In summary, the physical properties of 4-chloro-2-fluoro-1-methylbenzene, such as appearance, boiling point, melting point, density, solubility, and volatility, are indispensable factors for chemical production, scientific research experiments, and many other aspects. It is essential for its rational use and proper disposal.
What are the main uses of 4-chloro-2-fluoro-1-methylbenzene?
4-Chloro-2-fluoro-1-methylbenzene, this substance has a wide range of uses. In the field of chemical synthesis, it is a key organic intermediate. In terms of fragrance synthesis, with its unique chemical structure, it can undergo a series of reactions to derive unique fragrance components, giving unique fragrance to many high-end perfumes and aromatherapy products.
In the field of medicinal chemistry, it also has important value. It can be used as a starting material to build a specific drug molecular skeleton through multi-step reactions. During the development of many new antibacterial and anti-inflammatory drugs, it is often used to introduce specific functional groups to optimize the activity, solubility and bioavailability of drugs and many other key properties.
In the field of materials science, it has also made its mark. For example, in the synthesis of new polymer materials, 4-chloro-2-fluoro-1-methylbenzene can participate in the polymerization reaction, giving the material special properties, such as enhancing the stability and chemical resistance of the material, or improving the electrical and optical properties of the material, so as to meet the strict requirements for high-performance materials in the fields of electronic devices, aerospace and so on.
In addition, in pesticide chemistry, it can also be used as an important intermediate for the synthesis of new pesticides. Through rational molecular design and reaction transformation, high-efficiency, low-toxicity and environmentally friendly pesticide products can be prepared, which can help to effectively control pests and diseases in agricultural production and improve crop yield and quality. Overall, 4-chloro-2-fluoro-1-methylbenzene plays an indispensable role in many chemical-related industries, and is of great significance for promoting technological progress and industrial development in various fields.
In the field of medicinal chemistry, it also has important value. It can be used as a starting material to build a specific drug molecular skeleton through multi-step reactions. During the development of many new antibacterial and anti-inflammatory drugs, it is often used to introduce specific functional groups to optimize the activity, solubility and bioavailability of drugs and many other key properties.
In the field of materials science, it has also made its mark. For example, in the synthesis of new polymer materials, 4-chloro-2-fluoro-1-methylbenzene can participate in the polymerization reaction, giving the material special properties, such as enhancing the stability and chemical resistance of the material, or improving the electrical and optical properties of the material, so as to meet the strict requirements for high-performance materials in the fields of electronic devices, aerospace and so on.
In addition, in pesticide chemistry, it can also be used as an important intermediate for the synthesis of new pesticides. Through rational molecular design and reaction transformation, high-efficiency, low-toxicity and environmentally friendly pesticide products can be prepared, which can help to effectively control pests and diseases in agricultural production and improve crop yield and quality. Overall, 4-chloro-2-fluoro-1-methylbenzene plays an indispensable role in many chemical-related industries, and is of great significance for promoting technological progress and industrial development in various fields.
What is 4-chloro-2-fluoro-1-methylbenzene synthesis method?
4-Chloro-2-fluoro-1-methylbenzene is also an organic compound. Its synthesis method is studied by chemists.
To synthesize this substance, one method can be initiated by the halogenation reaction of aromatic hydrocarbons. First take an appropriate methyl benzene derivative and add an appropriate amount of halogenating reagent in a specific reaction vessel. If you want to introduce chlorine atoms, you can choose chlorinated reagents, such as chlorine gas or chlorine-containing compounds. With the help of light or catalyst, chlorine atoms can replace hydrogen atoms at specific positions on the benzene ring. The choice of its position is related to the positioning effect of the original groups on the benzene ring. Methyl is an ortho-para-localization group. Under this reaction condition, the chlorine atom may fall in the ortho or para-position of methyl.
After the chlorine-containing methyl benzene derivative is obtained, a special fluorination method can be used to introduce a fluorine atom. Fluorophilic reagents, such as nucleophilic fluorination reagents, are often used to interact with the previous product in suitable solvents and reaction conditions. Nucleophilic fluorination reagents can attack a specific carbon atom on the benzene ring and replace an atom on it with a fluorine atom (such as a substituted group such as a halogen atom) to obtain 4-chloro-2-fluoro-1-methylbenzene.
In the reaction, many factors must be carefully considered. The reaction temperature, reaction time, and the proportion of reagents are all related to the yield and purity of the product. If the temperature is too high, or side reactions will occur, and the product will be complex; if the temperature is too low, the reaction rate will be slow and take a long time. The proportion of reagents is not appropriate, or the reaction may not be fully carried out, and the raw materials will remain or unwanted by-products will be formed.
And the solvent used in the reaction is also critical. It must be compatible with the reactants and reagents, and it will affect the activity and selectivity of the reaction. Appropriate solvents can promote the progress of the reaction and improve the quality of the product.
The process of synthesis is a delicate one, and every detail must be carefully handled to obtain pure 4-chloro-2-fluoro-1-methylbenzene.
To synthesize this substance, one method can be initiated by the halogenation reaction of aromatic hydrocarbons. First take an appropriate methyl benzene derivative and add an appropriate amount of halogenating reagent in a specific reaction vessel. If you want to introduce chlorine atoms, you can choose chlorinated reagents, such as chlorine gas or chlorine-containing compounds. With the help of light or catalyst, chlorine atoms can replace hydrogen atoms at specific positions on the benzene ring. The choice of its position is related to the positioning effect of the original groups on the benzene ring. Methyl is an ortho-para-localization group. Under this reaction condition, the chlorine atom may fall in the ortho or para-position of methyl.
After the chlorine-containing methyl benzene derivative is obtained, a special fluorination method can be used to introduce a fluorine atom. Fluorophilic reagents, such as nucleophilic fluorination reagents, are often used to interact with the previous product in suitable solvents and reaction conditions. Nucleophilic fluorination reagents can attack a specific carbon atom on the benzene ring and replace an atom on it with a fluorine atom (such as a substituted group such as a halogen atom) to obtain 4-chloro-2-fluoro-1-methylbenzene.
In the reaction, many factors must be carefully considered. The reaction temperature, reaction time, and the proportion of reagents are all related to the yield and purity of the product. If the temperature is too high, or side reactions will occur, and the product will be complex; if the temperature is too low, the reaction rate will be slow and take a long time. The proportion of reagents is not appropriate, or the reaction may not be fully carried out, and the raw materials will remain or unwanted by-products will be formed.
And the solvent used in the reaction is also critical. It must be compatible with the reactants and reagents, and it will affect the activity and selectivity of the reaction. Appropriate solvents can promote the progress of the reaction and improve the quality of the product.
The process of synthesis is a delicate one, and every detail must be carefully handled to obtain pure 4-chloro-2-fluoro-1-methylbenzene.
4-chloro-2-fluoro-1-methylbenzene what are the precautions in storage and transportation?
4-Chloro-2-fluoro-1-methylbenzene, when storing and transporting, be sure to pay attention to many matters.
This is an organic compound with specific chemical properties. When storing, first choose a cool, dry and well-ventilated place. Because it may be sensitive to heat, under high temperatures, it may cause chemical changes or even cause dangerous reactions, so it should be protected from direct sunlight and heat sources.
Furthermore, the choice of storage containers is crucial. When using corrosion-resistant materials, they contain chlorine, fluorine and other elements, or react chemically with certain materials, causing damage to the container and material leakage. And the container must be well sealed to prevent volatilization, pollution of the environment, and to prevent reactions with air components.
During transportation, do not slack off. It is necessary to use suitable transportation tools in accordance with relevant regulations. When handling, be careful to avoid collisions and vibrations, and avoid package damage. Transport personnel should be familiar with the characteristics of this compound and emergency treatment methods. If there are emergencies such as leakage, they can deal with it in a timely and appropriate manner.
In addition, because of its toxicity and irritation, storage and transportation areas should be clearly marked with warning signs, and non-professionals should not enter. At the same time, the surrounding area should be equipped with corresponding emergency rescue equipment and materials, such as adsorbents, neutralizers, etc., so that in the event of an accident, rapid measures can be taken to reduce hazards.
This is an organic compound with specific chemical properties. When storing, first choose a cool, dry and well-ventilated place. Because it may be sensitive to heat, under high temperatures, it may cause chemical changes or even cause dangerous reactions, so it should be protected from direct sunlight and heat sources.
Furthermore, the choice of storage containers is crucial. When using corrosion-resistant materials, they contain chlorine, fluorine and other elements, or react chemically with certain materials, causing damage to the container and material leakage. And the container must be well sealed to prevent volatilization, pollution of the environment, and to prevent reactions with air components.
During transportation, do not slack off. It is necessary to use suitable transportation tools in accordance with relevant regulations. When handling, be careful to avoid collisions and vibrations, and avoid package damage. Transport personnel should be familiar with the characteristics of this compound and emergency treatment methods. If there are emergencies such as leakage, they can deal with it in a timely and appropriate manner.
In addition, because of its toxicity and irritation, storage and transportation areas should be clearly marked with warning signs, and non-professionals should not enter. At the same time, the surrounding area should be equipped with corresponding emergency rescue equipment and materials, such as adsorbents, neutralizers, etc., so that in the event of an accident, rapid measures can be taken to reduce hazards.
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