Linshang Chemical
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4-Chloro-2-Fluoro-1-Nitrobenzene
Linshang Chemical
|
HS Code |
708364 |
| Chemical Formula | C6H3ClFNO2 |
| Molecular Weight | 177.545 g/mol |
| Appearance | Yellow - to - orange liquid |
| Boiling Point | 208 - 210 °C |
| Melting Point | 19 - 21 °C |
| Density | 1.486 g/cm³ |
| Flash Point | 87 °C |
| Solubility In Water | Insoluble |
| Vapor Pressure | Low |
| Stability | Stable under normal conditions |
As an accredited 4-Chloro-2-Fluoro-1-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chloro - 2 - fluoro - 1 - nitrobenzene packaged in a sealed, corrosion - resistant bottle. |
| Storage | 4 - chloro - 2 - fluoro - 1 - nitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, reducing agents, and substances that may react with it. Adhere to proper labeling for easy identification and safety. |
| Shipping | 4 - chloro - 2 - fluoro - 1 - nitrobenzene is shipped in tightly sealed, corrosion - resistant containers. It must be transported in accordance with hazardous chemical regulations, ensuring proper handling to prevent leakage and environmental or safety risks. |
Competitive 4-Chloro-2-Fluoro-1-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4-Chloro-2-Fluoro-1-Nitrobenzene in China?
As a trusted 4-Chloro-2-Fluoro-1-Nitrobenzene manufacturer, we deliver:
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-Chloro-2-Fluoro-1-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 4-chloro-2-fluoro-1-nitrobenzene?
4-Chloro-2-fluoro-1-nitrobenzene has a wide range of uses. In the field of organic synthesis, it can be called a key raw material. First, it can be used as an intermediary for pharmaceutical synthesis. Due to its special structure, it can participate in a series of reactions and help the construction of pharmaceutical molecules. For example, in the preparation of certain antibacterial drugs, 4-chloro-2-fluoro-1-nitrobenzene can be converted into a core part of pharmaceutical activity and contribute a lot to human health.
Second, it also has extraordinary performance in the field of pesticides. Using it as a starting material and undergoing subtle chemical changes, efficient pesticides can be prepared. Such pesticides have strong lethality to pests, and have good selectivity, do not disturb beneficial insects, and greatly contribute to agricultural harvests.
Furthermore, it also has a role in materials science. It can be introduced into the structure of polymer materials through specific reactions to improve material properties. For example, to improve the heat resistance and chemical stability of materials, so that materials can play a stable role in extreme environments, and are used in high-end fields such as aerospace and electronic equipment.
In short, 4-chloro-2-fluoro-1-nitrobenzene plays an important role in many branches of chemical industry, and plays a significant role in promoting the progress of related industries.
Second, it also has extraordinary performance in the field of pesticides. Using it as a starting material and undergoing subtle chemical changes, efficient pesticides can be prepared. Such pesticides have strong lethality to pests, and have good selectivity, do not disturb beneficial insects, and greatly contribute to agricultural harvests.
Furthermore, it also has a role in materials science. It can be introduced into the structure of polymer materials through specific reactions to improve material properties. For example, to improve the heat resistance and chemical stability of materials, so that materials can play a stable role in extreme environments, and are used in high-end fields such as aerospace and electronic equipment.
In short, 4-chloro-2-fluoro-1-nitrobenzene plays an important role in many branches of chemical industry, and plays a significant role in promoting the progress of related industries.
What are the physical properties of 4-chloro-2-fluoro-1-nitrobenzene?
4-Chloro-2-fluoro-1-nitrobenzene is one of the organic compounds. Its unique physical properties are described below.
First of all, under normal temperature and pressure, 4-chloro-2-fluoro-1-nitrobenzene is often a light yellow to brown liquid, with a clear appearance and can be seen as an oily fluid, which is quite shiny.
As for the melting point, it is about -12 ° C. At this temperature, the compound gradually solidifies from a liquid state to a solid state. The boiling point is around 234 ° C. When the temperature rises to the boiling point, the compound is violently vaporized from a liquid state and converted into a gas state.
The density of 4-chloro-2-fluoro-1-nitrobenzene is about 1.54 g/cm ³, which is heavier than water. If it is placed in one place with water, it will sink to the bottom.
In terms of solubility, it is difficult to dissolve in water. Due to the large difference between the molecular polarity of the compound and the polarity of the water molecule, it is difficult to interact with water and dissolve. However, in organic solvents, such as ethanol, ether, acetone, etc., it has good solubility. Because the force between organic solvents and 4-chloro-2-fluoro-1-nitrobenzene is similar, it conforms to the principle of "similar miscibility".
In terms of volatility, the compound has a certain degree of volatility and can evaporate slowly in the air, but its volatility is not very strong.
In addition, 4-chloro-2-fluoro-1-nitrobenzene has a special odor, which is pungent, and this odor can be used as one of the aids in identifying the compound.
In summary, 4-chloro-2-fluoro-1-nitrobenzene has unique physical properties in terms of appearance, melting point, density, solubility, volatility and odor, which are of great significance in its identification, application and treatment.
First of all, under normal temperature and pressure, 4-chloro-2-fluoro-1-nitrobenzene is often a light yellow to brown liquid, with a clear appearance and can be seen as an oily fluid, which is quite shiny.
As for the melting point, it is about -12 ° C. At this temperature, the compound gradually solidifies from a liquid state to a solid state. The boiling point is around 234 ° C. When the temperature rises to the boiling point, the compound is violently vaporized from a liquid state and converted into a gas state.
The density of 4-chloro-2-fluoro-1-nitrobenzene is about 1.54 g/cm ³, which is heavier than water. If it is placed in one place with water, it will sink to the bottom.
In terms of solubility, it is difficult to dissolve in water. Due to the large difference between the molecular polarity of the compound and the polarity of the water molecule, it is difficult to interact with water and dissolve. However, in organic solvents, such as ethanol, ether, acetone, etc., it has good solubility. Because the force between organic solvents and 4-chloro-2-fluoro-1-nitrobenzene is similar, it conforms to the principle of "similar miscibility".
In terms of volatility, the compound has a certain degree of volatility and can evaporate slowly in the air, but its volatility is not very strong.
In addition, 4-chloro-2-fluoro-1-nitrobenzene has a special odor, which is pungent, and this odor can be used as one of the aids in identifying the compound.
In summary, 4-chloro-2-fluoro-1-nitrobenzene has unique physical properties in terms of appearance, melting point, density, solubility, volatility and odor, which are of great significance in its identification, application and treatment.
Is 4-chloro-2-fluoro-1-nitrobenzene chemically stable?
The chemical properties of 4-chloro-2-fluoro-1-nitrobenzene are stable under normal conditions. This compound contains chlorine, fluorine, nitro and other groups, and each group affects its properties.
Nitro has strong electron absorption, which reduces the electron cloud density of the benzene ring, making the benzene ring more susceptible to attack by nucleophiles. However, under most common conditions, it is not easy to react spontaneously without extreme conditions such as strong nucleophiles, high temperatures, and strong bases.
Although chlorine and fluorine are halogen atoms and have certain activity, in the benzene ring system, their activity is also inhibited due to the conjugation effect. In the normal environment, if there is no specific catalyst or suitable reaction conditions, the halogen atom is not easy to break away from the benzene ring and undergo substitution and other reactions.
However, in case of high temperature and strong nucleophilic reagents, 4-chloro-2-fluoro-1-nitrobenzene can undergo nucleophilic substitution reaction, and the halogen atom can be replaced by nucleophilic reagents. In case of strong reducing agents, the nitro group may also be reduced.
In summary, under general experimental operation and storage conditions, if there is no special chemical environment stimulation, the chemical properties of 4-chloro-2-fluoro-1-nitrobenzene are relatively stable, but under specific chemical reaction conditions, its groups can exhibit corresponding activities and participate in the reaction.
Nitro has strong electron absorption, which reduces the electron cloud density of the benzene ring, making the benzene ring more susceptible to attack by nucleophiles. However, under most common conditions, it is not easy to react spontaneously without extreme conditions such as strong nucleophiles, high temperatures, and strong bases.
Although chlorine and fluorine are halogen atoms and have certain activity, in the benzene ring system, their activity is also inhibited due to the conjugation effect. In the normal environment, if there is no specific catalyst or suitable reaction conditions, the halogen atom is not easy to break away from the benzene ring and undergo substitution and other reactions.
However, in case of high temperature and strong nucleophilic reagents, 4-chloro-2-fluoro-1-nitrobenzene can undergo nucleophilic substitution reaction, and the halogen atom can be replaced by nucleophilic reagents. In case of strong reducing agents, the nitro group may also be reduced.
In summary, under general experimental operation and storage conditions, if there is no special chemical environment stimulation, the chemical properties of 4-chloro-2-fluoro-1-nitrobenzene are relatively stable, but under specific chemical reaction conditions, its groups can exhibit corresponding activities and participate in the reaction.
What are the preparation methods of 4-chloro-2-fluoro-1-nitrobenzene?
There are probably several ways to prepare 4-chloro-2-fluoro-1-nitrobenzene.
First, 4-chloro-2-fluoroaniline is used as the starting material. 4-chloro-2-fluoroaniline is first reacted by diazotization, usually with sodium nitrite and inorganic acids (such as hydrochloric acid or sulfuric acid) at low temperature (usually 0-5 ° C) to form diazonium salts. Then, using the activity of the diazonium salt, it is reacted with nitrite or other suitable reagents to convert the diazonium group into nitro group to obtain 4-chloro-2-fluoro-1-nitrobenzene. This method requires precise control of the reaction temperature and the amount of reagents to prevent the decomposition of the diazonium salt or side reactions.
Second, start from 2-fluoro-4-chlorophenol. First, 2-fluoro-4-chlorophenol is nitrified with a suitable nitrifying reagent, such as mixed acid (a mixture of concentrated sulfuric acid and concentrated nitric acid). Concentrated sulfuric acid is used here as a catalyst and dehydrating agent to promote the electrophilic substitution of nitro-p-phenyl ring. The reaction conditions need to be carefully controlled, and factors such as temperature and acid mixing ratio have a great influence on the selectivity and yield of the reaction. 4-Chloro-2-fluoro-1-nitrobenzene can be obtained by nitration reaction, but other nitrification products may be formed in this process, which needs to be purified by subsequent separation methods.
Third, 2-fluoro-4-chlorobenzoic acid is used as raw material. It is first decarboxylated, and the carboxyl group can be removed in the form of carbon dioxide by heating and using a suitable catalyst (such as copper salt, etc.) to obtain the corresponding aromatic hydrocarbon. After that, the aromatic hydrocarbon is nitrified, and the nitro group is introduced by mixed acid or other nitrifying reagents to finally obtain 4-chloro-2-fluoro-1-nitrobenzene. This path has a little more steps, and each step of the reaction needs to pay attention to the control of conditions and the purification of intermediate products in order to obtain higher purity target products.
These several preparation methods have their own advantages and disadvantages, and the appropriate method should be selected according to the actual situation, such as the availability of raw materials, cost, product purity requirements and other factors.
First, 4-chloro-2-fluoroaniline is used as the starting material. 4-chloro-2-fluoroaniline is first reacted by diazotization, usually with sodium nitrite and inorganic acids (such as hydrochloric acid or sulfuric acid) at low temperature (usually 0-5 ° C) to form diazonium salts. Then, using the activity of the diazonium salt, it is reacted with nitrite or other suitable reagents to convert the diazonium group into nitro group to obtain 4-chloro-2-fluoro-1-nitrobenzene. This method requires precise control of the reaction temperature and the amount of reagents to prevent the decomposition of the diazonium salt or side reactions.
Second, start from 2-fluoro-4-chlorophenol. First, 2-fluoro-4-chlorophenol is nitrified with a suitable nitrifying reagent, such as mixed acid (a mixture of concentrated sulfuric acid and concentrated nitric acid). Concentrated sulfuric acid is used here as a catalyst and dehydrating agent to promote the electrophilic substitution of nitro-p-phenyl ring. The reaction conditions need to be carefully controlled, and factors such as temperature and acid mixing ratio have a great influence on the selectivity and yield of the reaction. 4-Chloro-2-fluoro-1-nitrobenzene can be obtained by nitration reaction, but other nitrification products may be formed in this process, which needs to be purified by subsequent separation methods.
Third, 2-fluoro-4-chlorobenzoic acid is used as raw material. It is first decarboxylated, and the carboxyl group can be removed in the form of carbon dioxide by heating and using a suitable catalyst (such as copper salt, etc.) to obtain the corresponding aromatic hydrocarbon. After that, the aromatic hydrocarbon is nitrified, and the nitro group is introduced by mixed acid or other nitrifying reagents to finally obtain 4-chloro-2-fluoro-1-nitrobenzene. This path has a little more steps, and each step of the reaction needs to pay attention to the control of conditions and the purification of intermediate products in order to obtain higher purity target products.
These several preparation methods have their own advantages and disadvantages, and the appropriate method should be selected according to the actual situation, such as the availability of raw materials, cost, product purity requirements and other factors.
4-chloro-2-fluoro-1-nitrobenzene What are the precautions during storage and transportation?
4-Chloro-2-fluoro-1-nitrobenzene is also an organic compound. During storage and transportation, many precautions should not be ignored.
When storing, the first environment. It should be placed in a cool and ventilated warehouse. This compound is prone to danger due to heat, and a cool place can reduce the risk of decomposition and volatilization. If it is well ventilated, it can avoid the accumulation of its gases to prevent explosion and poisoning.
Furthermore, it should be stored in isolation from oxidants, reducing agents, alkalis, etc. 4-Chloro-2-fluoro-1-nitrobenzene encounters oxidizing agents, or reacts violently, even causing combustion and explosion; in case of reducing agents, or causes chemical reactions to go out of control. Alkali contact with it, or cause adverse chemical changes, damage its quality and increase safety risks.
Packaging must be tight. This compound is toxic and volatile. If the packaging is not strict, it will pollute the environment and endanger humans and animals after leakage. Choose suitable packaging materials, such as corrosion-resistant containers, to ensure its stability during storage.
During transportation, there are also many points. Transportation vehicles must comply with the specifications for the transportation of hazardous chemicals. Vehicles should be equipped with corresponding fire equipment and leakage emergency treatment equipment. In the event of a leak or fire, it can be responded to in time to reduce the damage.
The escort personnel must be professionally trained and familiar with the properties, hazards and emergency treatment methods of 4-chloro-2-fluoro-1-nitrobenzene. During transportation, be careful loading and unloading to prevent package damage. During the journey, avoid high temperature and open flame areas, drive at a steady speed, and avoid bumps and collisions to ensure safe transportation.
When storing, the first environment. It should be placed in a cool and ventilated warehouse. This compound is prone to danger due to heat, and a cool place can reduce the risk of decomposition and volatilization. If it is well ventilated, it can avoid the accumulation of its gases to prevent explosion and poisoning.
Furthermore, it should be stored in isolation from oxidants, reducing agents, alkalis, etc. 4-Chloro-2-fluoro-1-nitrobenzene encounters oxidizing agents, or reacts violently, even causing combustion and explosion; in case of reducing agents, or causes chemical reactions to go out of control. Alkali contact with it, or cause adverse chemical changes, damage its quality and increase safety risks.
Packaging must be tight. This compound is toxic and volatile. If the packaging is not strict, it will pollute the environment and endanger humans and animals after leakage. Choose suitable packaging materials, such as corrosion-resistant containers, to ensure its stability during storage.
During transportation, there are also many points. Transportation vehicles must comply with the specifications for the transportation of hazardous chemicals. Vehicles should be equipped with corresponding fire equipment and leakage emergency treatment equipment. In the event of a leak or fire, it can be responded to in time to reduce the damage.
The escort personnel must be professionally trained and familiar with the properties, hazards and emergency treatment methods of 4-chloro-2-fluoro-1-nitrobenzene. During transportation, be careful loading and unloading to prevent package damage. During the journey, avoid high temperature and open flame areas, drive at a steady speed, and avoid bumps and collisions to ensure safe transportation.
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