Linshang Chemical
PRODUCTS
4-Chloro-2-Fluoro-1-(Trifluoromethyl)Benzene
Linshang Chemical
|
HS Code |
743052 |
| Chemical Formula | C7H3ClF4 |
| Molar Mass | 198.545 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 115 - 117 °C |
| Melting Point | N/A |
| Density | 1.439 g/cm³ |
| Solubility In Water | Insoluble |
| Vapor Pressure | N/A |
| Flash Point | 22 °C |
| Refractive Index | 1.429 |
As an accredited 4-Chloro-2-Fluoro-1-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500 mL bottle of 4 - chloro - 2 - fluoro - 1 - (trifluoromethyl)benzene, well - sealed. |
| Storage | 4 - chloro - 2 - fluoro - 1 - (trifluoromethyl)benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents and incompatible substances to avoid potential chemical reactions. Ensure proper labeling for easy identification. |
| Shipping | 4 - chloro - 2 - fluoro - 1 - (trifluoromethyl)benzene is shipped in sealed, corrosion - resistant containers. Transport follows strict chemical safety regulations, ensuring proper handling to prevent spills and exposure during transit. |
Competitive 4-Chloro-2-Fluoro-1-(Trifluoromethyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4-Chloro-2-Fluoro-1-(Trifluoromethyl)Benzene in China?
As a trusted 4-Chloro-2-Fluoro-1-(Trifluoromethyl)Benzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-Chloro-2-Fluoro-1-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 4-chloro-2-fluoro-1- (trifluoromethyl) benzene
4-Chloro-2-fluoro-1- (trifluoromethyl) benzene is a kind of organic compound. Its chemical properties are unique and have many characteristics of halogenated aromatics.
The substitution of chlorine, fluorine and trifluoromethyl has a great influence on the distribution of electron clouds in the benzene ring. Chlorine and fluorine atoms have electron-absorbing induction effects, while trifluoromethyl has stronger electron-absorbing ability, resulting in a decrease in the electron cloud density of the benzene ring, making the electrophilic substitution reaction more difficult to occur than benzene.
In the electrophilic substitution reaction, due to the localization effect of the substituent, such substituents are meta-localizers. Therefore, the electrophilic reagent mostly attacks the interposition of benzene ring, which is different from the electrophilic substitution check point of benzene.
Furthermore, the carbon-halogen bond in this compound has a certain activity. The stability of the carbon-chlorine bond and the carbon-fluorine bond is different due to the difference in the electronegativity of the halogen atom. Under specific conditions, such as high temperature, strong base or the presence of catalyst, the carbon-halogen bond can be broken and participate in the substitution, elimination and other reactions.
Its fluorine-containing group gives the compound certain special physical properties, such as high fat solubility and good solubility in organic solvents. This property may affect its behavior in chemical reactions, and has potential applications in materials science, medicinal chemistry and other fields.
And because it contains multiple halogen atoms, it may have a certain impact on the environment or organisms. In the environment, the degradation of such compounds may require specific microorganisms or conditions, and their bioaccumulation and toxicity need to be further investigated.
The substitution of chlorine, fluorine and trifluoromethyl has a great influence on the distribution of electron clouds in the benzene ring. Chlorine and fluorine atoms have electron-absorbing induction effects, while trifluoromethyl has stronger electron-absorbing ability, resulting in a decrease in the electron cloud density of the benzene ring, making the electrophilic substitution reaction more difficult to occur than benzene.
In the electrophilic substitution reaction, due to the localization effect of the substituent, such substituents are meta-localizers. Therefore, the electrophilic reagent mostly attacks the interposition of benzene ring, which is different from the electrophilic substitution check point of benzene.
Furthermore, the carbon-halogen bond in this compound has a certain activity. The stability of the carbon-chlorine bond and the carbon-fluorine bond is different due to the difference in the electronegativity of the halogen atom. Under specific conditions, such as high temperature, strong base or the presence of catalyst, the carbon-halogen bond can be broken and participate in the substitution, elimination and other reactions.
Its fluorine-containing group gives the compound certain special physical properties, such as high fat solubility and good solubility in organic solvents. This property may affect its behavior in chemical reactions, and has potential applications in materials science, medicinal chemistry and other fields.
And because it contains multiple halogen atoms, it may have a certain impact on the environment or organisms. In the environment, the degradation of such compounds may require specific microorganisms or conditions, and their bioaccumulation and toxicity need to be further investigated.
What are the main uses of 4-chloro-2-fluoro-1- (trifluoromethyl) benzene
4-Chloro-2-fluoro-1- (trifluoromethyl) benzene is one of the organic compounds, which has a wide range of uses and has its presence in many fields.
In the field of pharmaceutical chemistry, this compound is often used as a key intermediate. Due to its unique chemical structure, it can participate in a variety of chemical reactions and help pharmaceutical developers build complex molecular structures. Through appropriate chemical transformation, it can be integrated into drug molecules, giving drugs specific biological activities and pharmacological properties, which is very helpful for the creation of new drugs, such as antibacterial, antiviral, and anti-tumor drugs.
In the field of materials science, it also has important uses. It can be used as a starting material for the synthesis of special functional materials. Due to its fluorine atom, it can impart properties such as excellent chemical resistance, low surface energy and good thermal stability to the material. For example, when synthesizing high-performance polymer materials, the introduction of this compound structural unit can improve the properties of the polymer, making it suitable for high-end fields such as aerospace and electronics.
In the field of pesticide chemistry, 4-chloro-2-fluoro-1- (trifluoromethyl) benzene is also indispensable. It can be chemically modified to prepare high-efficiency, low-toxicity and environmentally friendly pesticides. Its structural properties help to enhance the interaction between pesticides and target organisms, improve the insecticidal, bactericidal or weeding effects of pesticides, and make great contributions to agricultural pest control and crop protection.
In addition, in the study of organic synthetic chemistry, this compound provides chemists with a unique structural module. Through various organic reactions, such as nucleophilic substitution, electrophilic substitution and other reactions, many organic compounds with novel structures can be derived, promoting the development of organic synthetic chemistry, expanding the structural diversity of organic compounds, and laying the foundation for the creation and research of new substances.
In conclusion, 4-chloro-2-fluoro-1- (trifluoromethyl) benzene has shown important application value in many fields such as medicine, materials, pesticides and organic synthesis due to its unique chemical structure, which is of great significance to the development of related industries and the progress of scientific research.
In the field of pharmaceutical chemistry, this compound is often used as a key intermediate. Due to its unique chemical structure, it can participate in a variety of chemical reactions and help pharmaceutical developers build complex molecular structures. Through appropriate chemical transformation, it can be integrated into drug molecules, giving drugs specific biological activities and pharmacological properties, which is very helpful for the creation of new drugs, such as antibacterial, antiviral, and anti-tumor drugs.
In the field of materials science, it also has important uses. It can be used as a starting material for the synthesis of special functional materials. Due to its fluorine atom, it can impart properties such as excellent chemical resistance, low surface energy and good thermal stability to the material. For example, when synthesizing high-performance polymer materials, the introduction of this compound structural unit can improve the properties of the polymer, making it suitable for high-end fields such as aerospace and electronics.
In the field of pesticide chemistry, 4-chloro-2-fluoro-1- (trifluoromethyl) benzene is also indispensable. It can be chemically modified to prepare high-efficiency, low-toxicity and environmentally friendly pesticides. Its structural properties help to enhance the interaction between pesticides and target organisms, improve the insecticidal, bactericidal or weeding effects of pesticides, and make great contributions to agricultural pest control and crop protection.
In addition, in the study of organic synthetic chemistry, this compound provides chemists with a unique structural module. Through various organic reactions, such as nucleophilic substitution, electrophilic substitution and other reactions, many organic compounds with novel structures can be derived, promoting the development of organic synthetic chemistry, expanding the structural diversity of organic compounds, and laying the foundation for the creation and research of new substances.
In conclusion, 4-chloro-2-fluoro-1- (trifluoromethyl) benzene has shown important application value in many fields such as medicine, materials, pesticides and organic synthesis due to its unique chemical structure, which is of great significance to the development of related industries and the progress of scientific research.
What are the synthesis methods of 4-chloro-2-fluoro-1- (trifluoromethyl) benzene
The synthesis method of 4-chloro-2-fluoro-1- (trifluoromethyl) benzene has been explored by many parties in the past. There are many methods, and the selection is described in brief.
First, the method of using halogenated aromatics as starting materials. Appropriate halogenated benzene derivatives are often taken, and chlorine and fluorine atoms are introduced at specific positions first. This process requires the selection of suitable halogenated reagents and reaction conditions. For example, chlorinated reagents such as phosphorus trichloride, phosphorus pentachloride, etc. can be used to introduce chlorine atoms into the benzene ring under appropriate catalyst and temperature conditions; when introducing fluorine atoms, nucleophilic substitution reactions are mostly used, and fluorine sources such as potassium fluoride are selected. In polar aprotic solvents, with the assistance of phase transfer catalysts, the substitution of fluorine atoms to specific halogen atoms is realized. Subsequently, trifluoromethyl is introduced into the benzene ring through a suitable reaction. Trifluoromethylation reagents, such as trifluoromethyl magnesium halide, trifluoromethyl copper reagents, etc., can be used to react with halogenated benzene derivatives to achieve the access of trifluoromethyl, and then synthesize the target product.
Second, through the path of aromatic Aromatic amines containing chlorine and fluorine are prepared first, and diazonium salts are formed by diazotization reaction. The diazotization reaction is usually carried out under low temperature and acidic conditions with sodium nitrite as the reagent. The resulting diazonium salt, and then reacted with a suitable trifluoromethylation reagent, can introduce trifluoromethyl into the benzene ring structure to obtain 4-chloro-2-fluoro-1 - (trifluoromethyl) benzene. In this process, the stability and reactivity of diazonium salts need to be carefully regulated to prevent side reactions.
Third, the coupling reaction catalyzed by transition metals is also a common method. Chlorine and fluorine-containing phenylboronic acid or its esters are selected, and trifluoromethyl halogenated hydrocarbons or trifluoromethylation reagents are used to realize the coupling of carbon-carbon bonds under the catalysis of transition metal catalysts such as palladium and nickel, and the structure of the target product is constructed. In the reaction, the activity of the catalyst, the selection of ligands, and the type of reaction solvent and base all have significant effects on the yield and selectivity of the reaction, which need to be carefully screened and optimized.
All synthesis methods have their own advantages and disadvantages. In practical application, the appropriate synthesis path should be weighed according to the availability of raw materials, the difficulty of the reaction, and the purity requirements of the product.
First, the method of using halogenated aromatics as starting materials. Appropriate halogenated benzene derivatives are often taken, and chlorine and fluorine atoms are introduced at specific positions first. This process requires the selection of suitable halogenated reagents and reaction conditions. For example, chlorinated reagents such as phosphorus trichloride, phosphorus pentachloride, etc. can be used to introduce chlorine atoms into the benzene ring under appropriate catalyst and temperature conditions; when introducing fluorine atoms, nucleophilic substitution reactions are mostly used, and fluorine sources such as potassium fluoride are selected. In polar aprotic solvents, with the assistance of phase transfer catalysts, the substitution of fluorine atoms to specific halogen atoms is realized. Subsequently, trifluoromethyl is introduced into the benzene ring through a suitable reaction. Trifluoromethylation reagents, such as trifluoromethyl magnesium halide, trifluoromethyl copper reagents, etc., can be used to react with halogenated benzene derivatives to achieve the access of trifluoromethyl, and then synthesize the target product.
Second, through the path of aromatic Aromatic amines containing chlorine and fluorine are prepared first, and diazonium salts are formed by diazotization reaction. The diazotization reaction is usually carried out under low temperature and acidic conditions with sodium nitrite as the reagent. The resulting diazonium salt, and then reacted with a suitable trifluoromethylation reagent, can introduce trifluoromethyl into the benzene ring structure to obtain 4-chloro-2-fluoro-1 - (trifluoromethyl) benzene. In this process, the stability and reactivity of diazonium salts need to be carefully regulated to prevent side reactions.
Third, the coupling reaction catalyzed by transition metals is also a common method. Chlorine and fluorine-containing phenylboronic acid or its esters are selected, and trifluoromethyl halogenated hydrocarbons or trifluoromethylation reagents are used to realize the coupling of carbon-carbon bonds under the catalysis of transition metal catalysts such as palladium and nickel, and the structure of the target product is constructed. In the reaction, the activity of the catalyst, the selection of ligands, and the type of reaction solvent and base all have significant effects on the yield and selectivity of the reaction, which need to be carefully screened and optimized.
All synthesis methods have their own advantages and disadvantages. In practical application, the appropriate synthesis path should be weighed according to the availability of raw materials, the difficulty of the reaction, and the purity requirements of the product.
What is the price range of 4-chloro-2-fluoro-1- (trifluoromethyl) benzene in the market?
It is difficult to determine the price range of 4-chloro-2-fluoro-1- (trifluoromethyl) benzene in the market. This is because the market is easy, the price changes with the wind, and there are many variables.
First, the supply and demand situation determines the price. If the buyer of this product is in high demand and the supply is scarce, the price will be high. On the contrary, if the supply exceeds the demand, the product volume will be like a mountain, and the price will decline.
Second, the production method and the cost are also the key. If the preparation method is complicated, the materials used are expensive, and the cost is high, the price will not be low. If you get a simple and good method, save labor and materials, and the cost will be reduced, the price may also be close to the people.
Third, the quality level, the impact is not shallow. The excellent product is pure and high, has a wide range of uses and good efficiency, and the price is often the highest. The second is inferior in quality, and the price also drops accordingly.
Fourth, the competition in the city should not be underestimated. Compete for profits in the same industry, and use various means. Or there is a price reduction to attract customers, or there is a quality increase to increase the price.
And because of the changing times, the state of the economy, the rules of the government, and the cost of transportation can all fluctuate the price. In order to know the exact price of this item, you should carefully observe the current market conditions, consult various merchants, and compare their offers to obtain a more accurate price. In general, its price or due to various factors, fluctuations within a wide range, it is difficult to explain.
First, the supply and demand situation determines the price. If the buyer of this product is in high demand and the supply is scarce, the price will be high. On the contrary, if the supply exceeds the demand, the product volume will be like a mountain, and the price will decline.
Second, the production method and the cost are also the key. If the preparation method is complicated, the materials used are expensive, and the cost is high, the price will not be low. If you get a simple and good method, save labor and materials, and the cost will be reduced, the price may also be close to the people.
Third, the quality level, the impact is not shallow. The excellent product is pure and high, has a wide range of uses and good efficiency, and the price is often the highest. The second is inferior in quality, and the price also drops accordingly.
Fourth, the competition in the city should not be underestimated. Compete for profits in the same industry, and use various means. Or there is a price reduction to attract customers, or there is a quality increase to increase the price.
And because of the changing times, the state of the economy, the rules of the government, and the cost of transportation can all fluctuate the price. In order to know the exact price of this item, you should carefully observe the current market conditions, consult various merchants, and compare their offers to obtain a more accurate price. In general, its price or due to various factors, fluctuations within a wide range, it is difficult to explain.
What are the storage conditions for 4-chloro-2-fluoro-1- (trifluoromethyl) benzene?
4-Chloro-2-fluoro-1- (trifluoromethyl) benzene, this is an organic compound. Many conditions need to be observed for the preservation of this substance.
The drying of the first environment. Because of its exposure to water or moisture, it may cause chemical reactions and cause quality damage. Therefore, it should be stored in a dry place, away from water sources and moisture-filled places, such as humid basements, warehouses near water, etc. It is not advisable.
The second is temperature control. This compound is easily decomposed or volatilized by heat, so it should be avoided in high temperature environments. It should be stored in a cool place with a temperature not exceeding 30 ° C, such as an air-conditioned temperature-controlled warehouse, or a shady and ventilated storage room.
Furthermore, it is necessary to isolate the fire source and oxidant. Because of its flammability, in case of open flame, hot topic or oxidant, it is prone to violent reaction and even explosion. Therefore, fireworks are strictly prohibited in the storage place, and no co-storage with oxidants is allowed.
At the same time, the packaging must be tight. Use suitable packaging materials, such as glass bottles or special plastic containers, to ensure that they are well sealed to prevent leakage and volatilization, and avoid threats to the environment and personal safety.
In addition, the storage area should be clearly marked to warn everyone that this is a dangerous chemical, non-professional personnel are not allowed to enter, and appropriate emergency treatment equipment should be equipped, just in case. Only by strictly following these storage conditions can the quality and safety of 4-chloro-2-fluoro-1- (trifluoromethyl) benzene be ensured.
The drying of the first environment. Because of its exposure to water or moisture, it may cause chemical reactions and cause quality damage. Therefore, it should be stored in a dry place, away from water sources and moisture-filled places, such as humid basements, warehouses near water, etc. It is not advisable.
The second is temperature control. This compound is easily decomposed or volatilized by heat, so it should be avoided in high temperature environments. It should be stored in a cool place with a temperature not exceeding 30 ° C, such as an air-conditioned temperature-controlled warehouse, or a shady and ventilated storage room.
Furthermore, it is necessary to isolate the fire source and oxidant. Because of its flammability, in case of open flame, hot topic or oxidant, it is prone to violent reaction and even explosion. Therefore, fireworks are strictly prohibited in the storage place, and no co-storage with oxidants is allowed.
At the same time, the packaging must be tight. Use suitable packaging materials, such as glass bottles or special plastic containers, to ensure that they are well sealed to prevent leakage and volatilization, and avoid threats to the environment and personal safety.
In addition, the storage area should be clearly marked to warn everyone that this is a dangerous chemical, non-professional personnel are not allowed to enter, and appropriate emergency treatment equipment should be equipped, just in case. Only by strictly following these storage conditions can the quality and safety of 4-chloro-2-fluoro-1- (trifluoromethyl) benzene be ensured.
Scan to WhatsApp
