Linshang Chemical
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4-Chloro-2-Fluoro Bromobenzene
Linshang Chemical
|
HS Code |
607859 |
| Chemical Formula | C6H3BrClF |
| Molar Mass | 225.44 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Approximately 195 - 197 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether, and dichloromethane |
| Vapor Pressure | Low vapor pressure at room temperature |
| Odor | Characteristic, pungent odor typical of halogenated aromatics |
As an accredited 4-Chloro-2-Fluoro Bromobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 - gram bottle of 4 - chloro - 2 - fluoro Bromobenzene, securely sealed. |
| Storage | 4 - chloro - 2 - fluorobromobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly sealed container to prevent leakage and vapor release. Store it separately from oxidizing agents, reactive chemicals, and substances that could cause decomposition or reaction, in a dedicated chemical storage cabinet. |
| Shipping | 4 - chloro - 2 - fluoro Bromobenzene is shipped in tightly sealed, corrosion - resistant containers. It's transported under conditions compliant with hazardous chemical regulations to prevent spills and ensure safety during transit. |
Competitive 4-Chloro-2-Fluoro Bromobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4-Chloro-2-Fluoro Bromobenzene in China?
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As a leading 4-Chloro-2-Fluoro Bromobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 4-chloro-2-fluoro Bromobenzene?
4-Chloro-2-fluorobromobenzene is a genus of organohalogenated aromatic hydrocarbons. In this compound, chlorine, fluorine and bromine atoms are all attached to the benzene ring, giving it unique chemical properties.
In terms of reactivity, the reactivity of the halogen atom on the benzene ring varies depending on the type of atom. Generally speaking, the halogen atom can undergo nucleophilic substitution reaction. Under the action of many nucleophiles, the halogen atom can be replaced. Among them, the fluorine atom is tightly bound to the benzene ring due to its small atomic radius and large electronegativity, which makes the nucleophilic substitution reaction relatively difficult and requires more harsh reaction conditions, such as high temperature, strong base, or the In contrast, the nucleophilic substitution activity of chlorine atom and bromine atom is slightly higher, and under appropriate reagents and conditions, it is easier to be replaced.
In addition, the benzene ring of 4-chloro-2-fluorobrobenzene can undergo electrophilic substitution. Because the halogen atom is an ortho-para-site locator, the electron cloud density of the benzene ring can increase in the ortho-para position, so the electrophilic reagents tend to attack the ortho-site and para-site of the halogen atom. In electrophilic substitution reactions such as nitrification, sulfonation, and halogenation, corresponding substituents can be introduced at specific positions in the benz
Because it contains multiple halogen atoms, under the action of metal reagents, metallization reactions can occur, and then participate in coupling reactions, such as cross-coupling reactions catalyzed by palladium, which are quite valuable in building carbon-carbon bonds and can be used to synthesize organic compounds with more complex structures.
In the field of organic synthesis, 4-chloro-2-fluorobromobenzene is often used as a key intermediate for the creation of various organic products such as medicines, pesticides, and materials. It plays an important role in organic chemistry research and industrial production.
In terms of reactivity, the reactivity of the halogen atom on the benzene ring varies depending on the type of atom. Generally speaking, the halogen atom can undergo nucleophilic substitution reaction. Under the action of many nucleophiles, the halogen atom can be replaced. Among them, the fluorine atom is tightly bound to the benzene ring due to its small atomic radius and large electronegativity, which makes the nucleophilic substitution reaction relatively difficult and requires more harsh reaction conditions, such as high temperature, strong base, or the In contrast, the nucleophilic substitution activity of chlorine atom and bromine atom is slightly higher, and under appropriate reagents and conditions, it is easier to be replaced.
In addition, the benzene ring of 4-chloro-2-fluorobrobenzene can undergo electrophilic substitution. Because the halogen atom is an ortho-para-site locator, the electron cloud density of the benzene ring can increase in the ortho-para position, so the electrophilic reagents tend to attack the ortho-site and para-site of the halogen atom. In electrophilic substitution reactions such as nitrification, sulfonation, and halogenation, corresponding substituents can be introduced at specific positions in the benz
Because it contains multiple halogen atoms, under the action of metal reagents, metallization reactions can occur, and then participate in coupling reactions, such as cross-coupling reactions catalyzed by palladium, which are quite valuable in building carbon-carbon bonds and can be used to synthesize organic compounds with more complex structures.
In the field of organic synthesis, 4-chloro-2-fluorobromobenzene is often used as a key intermediate for the creation of various organic products such as medicines, pesticides, and materials. It plays an important role in organic chemistry research and industrial production.
What are the main uses of 4-chloro-2-fluoro Bromobenzene?
4-Chloro-2-fluorobromobenzene is an organic compound with a wide range of uses. In the field of pharmaceutical synthesis, it is often a key intermediate. Due to the characteristics of halogen atoms, various chemical reactions can introduce other functional groups to build complex drug molecules. For example, in the synthesis of antimicrobial drugs with specific physiological activities, 4-chloro-2-fluorobromobenzene can be used as a starting material, and a series of steps such as halogenation reaction and nucleophilic substitution reaction can accurately build the skeleton structure required for drugs.
In the field of materials science, it also has its uses. It can participate in the preparation of polymer materials with excellent performance. Due to the chlorine, fluorine, and bromine atoms in the molecule, the compounds are endowed with unique electronic properties and spatial structures. Polymer materials synthesized from this raw material may have good thermal stability, chemical stability, or even special optical properties. For example, it is used in the field of organic optoelectronic materials to help fabricate devices such as Light Emitting Diodes and solar cells with better performance.
In the synthesis of pesticides, 4-chloro-2-fluorobromobenzene is also indispensable. Through proper chemical conversion, efficient and low-toxic pesticides can be prepared. Halogen atoms can enhance the interaction between pesticides and specific receptors in target organisms, improve the biological activity and selectivity of pesticides, make them act more accurately on pests, and reduce the adverse effects on the environment and non-target organisms. In short, 4-chloro-2-fluorobromobenzene has important value in many fields and has made great contributions to the development of related industries.
In the field of materials science, it also has its uses. It can participate in the preparation of polymer materials with excellent performance. Due to the chlorine, fluorine, and bromine atoms in the molecule, the compounds are endowed with unique electronic properties and spatial structures. Polymer materials synthesized from this raw material may have good thermal stability, chemical stability, or even special optical properties. For example, it is used in the field of organic optoelectronic materials to help fabricate devices such as Light Emitting Diodes and solar cells with better performance.
In the synthesis of pesticides, 4-chloro-2-fluorobromobenzene is also indispensable. Through proper chemical conversion, efficient and low-toxic pesticides can be prepared. Halogen atoms can enhance the interaction between pesticides and specific receptors in target organisms, improve the biological activity and selectivity of pesticides, make them act more accurately on pests, and reduce the adverse effects on the environment and non-target organisms. In short, 4-chloro-2-fluorobromobenzene has important value in many fields and has made great contributions to the development of related industries.
What are the synthesis methods of 4-chloro-2-fluoro Bromobenzene?
There are several methods for the synthesis of 4-chloro-2-fluorobromobenzene:
First, the halogenated aromatic hydrocarbon coupling method. The aromatic hydrocarbons containing chlorine and fluorine are used as starting materials and the bromine atom is introduced into the benzene ring at a specific position through halogenation. This process requires the selection of appropriate halogenating reagents, such as N-bromosuccinimide (NBS), and the peroxide or light as the initiation conditions to precisely control the substitution of bromine atoms. If the chlorine and fluorine are positioned at a specific position in the benzene ring with a specific catalyst and reaction conditions, and then the bromination reaction is carried out, the target product can be obtained. This method requires strict control of the reaction conditions, such as temperature, reaction time, and reagent dosage, in order to improve the purity and yield of the product.
Second, the synthesis method involving metal-organic reagents. Carbon-halogen bonds can be constructed by organolithium or Grignard reagents. First, an aryl lithium or aryl Grignard reagent containing chlorine and fluorine is prepared, and a specific halogenated hydrocarbon is reacted with it. For example, a halobenzene containing chlorine is reacted with metal lithium to form an aryl lithium reagent, and then reacted with a brominated reagent to connect the bromine atom to the benzene ring. This path requires a high reaction environment and needs to be operated under anhydrous and oxygen-free conditions to avoid side reactions between metal-organic reagents and water or oxygen, which affect the formation of the product
Third, the diazonium salt conversion method. The aromatic amine containing chlorine and fluorine is first prepared, and then it reacts with nitrous acid to form a diazonium salt. Diazonium salts have high activity and can react with reagents such as copper bromide to achieve the replacement of diazonium groups by bromine atoms to obtain 4-chloro-2-fluorobromobenzene. However, the stability of diazonium salts is not good, the reaction needs to be carried out quickly at low temperatures, and the preparation process of diazonium salts needs to be handled with caution to prevent danger.
All synthesis methods have advantages and disadvantages. In practice, it is necessary to consider the availability of raw materials, the difficulty of controlling reaction conditions, product purity and yield, and carefully select an appropriate synthesis path to efficiently synthesize 4-chloro-2-fluorobromobenzene.
First, the halogenated aromatic hydrocarbon coupling method. The aromatic hydrocarbons containing chlorine and fluorine are used as starting materials and the bromine atom is introduced into the benzene ring at a specific position through halogenation. This process requires the selection of appropriate halogenating reagents, such as N-bromosuccinimide (NBS), and the peroxide or light as the initiation conditions to precisely control the substitution of bromine atoms. If the chlorine and fluorine are positioned at a specific position in the benzene ring with a specific catalyst and reaction conditions, and then the bromination reaction is carried out, the target product can be obtained. This method requires strict control of the reaction conditions, such as temperature, reaction time, and reagent dosage, in order to improve the purity and yield of the product.
Second, the synthesis method involving metal-organic reagents. Carbon-halogen bonds can be constructed by organolithium or Grignard reagents. First, an aryl lithium or aryl Grignard reagent containing chlorine and fluorine is prepared, and a specific halogenated hydrocarbon is reacted with it. For example, a halobenzene containing chlorine is reacted with metal lithium to form an aryl lithium reagent, and then reacted with a brominated reagent to connect the bromine atom to the benzene ring. This path requires a high reaction environment and needs to be operated under anhydrous and oxygen-free conditions to avoid side reactions between metal-organic reagents and water or oxygen, which affect the formation of the product
Third, the diazonium salt conversion method. The aromatic amine containing chlorine and fluorine is first prepared, and then it reacts with nitrous acid to form a diazonium salt. Diazonium salts have high activity and can react with reagents such as copper bromide to achieve the replacement of diazonium groups by bromine atoms to obtain 4-chloro-2-fluorobromobenzene. However, the stability of diazonium salts is not good, the reaction needs to be carried out quickly at low temperatures, and the preparation process of diazonium salts needs to be handled with caution to prevent danger.
All synthesis methods have advantages and disadvantages. In practice, it is necessary to consider the availability of raw materials, the difficulty of controlling reaction conditions, product purity and yield, and carefully select an appropriate synthesis path to efficiently synthesize 4-chloro-2-fluorobromobenzene.
What are the precautions for 4-chloro-2-fluoro Bromobenzene in storage and transportation?
4-Chloro-2-fluorobromobenzene is an important compound in organic chemistry. During storage and transportation, many precautions are required to ensure safety and avoid loss.
First storage environment. Find a cool, dry and well-ventilated place. This compound is very sensitive to temperature and humidity, and high temperature or humid environment can easily cause it to chemically react, which affects the quality. If placed in a high temperature place, it may cause it to evaporate and even cause decomposition; while a humid environment may cause it to react with water vapor, resulting in deterioration.
Second, storage containers should not be ignored. Use corrosion-resistant materials, such as glass or specific plastic containers. Because 4-chloro-2-fluorobromobenzene is corrosive to a certain extent, ordinary metal containers may be corroded, resulting in damage to the container and leakage of compounds. Glass containers are chemically stable and can effectively avoid such situations.
Furthermore, when transporting, be sure to take protective measures. It is necessary to ensure that the packaging is tight to prevent leakage due to vibration and collision. And it should be transported separately from oxidants, acids, alkalis and other substances, because they may react violently with these substances and cause safety accidents.
In addition, relevant regulations and standards must be strictly followed regardless of storage or transportation. Operators should be professionally trained and familiar with their characteristics and emergency treatment methods. In the event of an accident such as a leak, it can be responded to quickly and properly to minimize the harm.
In summary, the storage and transportation of 4-chloro-2-fluorobromobenzene requires attention to the environment, containers, protection and personnel, so as to ensure its safety and quality.
First storage environment. Find a cool, dry and well-ventilated place. This compound is very sensitive to temperature and humidity, and high temperature or humid environment can easily cause it to chemically react, which affects the quality. If placed in a high temperature place, it may cause it to evaporate and even cause decomposition; while a humid environment may cause it to react with water vapor, resulting in deterioration.
Second, storage containers should not be ignored. Use corrosion-resistant materials, such as glass or specific plastic containers. Because 4-chloro-2-fluorobromobenzene is corrosive to a certain extent, ordinary metal containers may be corroded, resulting in damage to the container and leakage of compounds. Glass containers are chemically stable and can effectively avoid such situations.
Furthermore, when transporting, be sure to take protective measures. It is necessary to ensure that the packaging is tight to prevent leakage due to vibration and collision. And it should be transported separately from oxidants, acids, alkalis and other substances, because they may react violently with these substances and cause safety accidents.
In addition, relevant regulations and standards must be strictly followed regardless of storage or transportation. Operators should be professionally trained and familiar with their characteristics and emergency treatment methods. In the event of an accident such as a leak, it can be responded to quickly and properly to minimize the harm.
In summary, the storage and transportation of 4-chloro-2-fluorobromobenzene requires attention to the environment, containers, protection and personnel, so as to ensure its safety and quality.
What are the effects of 4-chloro-2-fluoro Bromobenzene on the environment and human health?
4-Chloro-2-fluorobromobenzene is one of the organic compounds. Its impact on the environment and human health cannot be ignored.
At one end of the environment, if this compound is released into nature, it may have multiple effects. First, its chemical structure is stable, it is difficult to degrade in the environment, and it is easy to accumulate for a long time. If it is scattered in the soil, it may cause soil pollution, hinder plant growth and reduce soil fertility. Second, it flows into the water body, which will be a sewage source and damage the habitat of aquatic organisms. Because of its toxicity, it may cause aquatic biological lesions and deaths, breaking the ecological balance and reducing biodiversity. Third, it volatilizes into the atmosphere, or participates in photochemical reactions, affecting air quality and damaging regional climate.
It is related to personal health, and 4-chloro-2-fluorobromobenzene is also at risk. If people ingest it through breathing, skin contact or diet, there may be adverse consequences. It enters the body through the respiratory tract, or irritates the mucosa of the respiratory tract, causing cough, asthma and other diseases, and long-term contact or increasing the risk of respiratory diseases. Contact with the skin may cause allergies, inflammation, and damage the skin barrier. If ingested by mistake, it may harm the digestive system, cause nausea, vomiting, abdominal pain, etc. What's more, it may invade the nervous system and endocrine system, affect nerve conduction, hormone secretion, and cause cognitive impairment, endocrine disorders and other diseases.
In summary, 4-chloro-2-fluorobromobenzene is potentially harmful to the environment and human health. When it is produced, used and disposed of, strict measures should be taken to reduce its threat to the environment and human body, so as to ensure ecological and human well-being.
At one end of the environment, if this compound is released into nature, it may have multiple effects. First, its chemical structure is stable, it is difficult to degrade in the environment, and it is easy to accumulate for a long time. If it is scattered in the soil, it may cause soil pollution, hinder plant growth and reduce soil fertility. Second, it flows into the water body, which will be a sewage source and damage the habitat of aquatic organisms. Because of its toxicity, it may cause aquatic biological lesions and deaths, breaking the ecological balance and reducing biodiversity. Third, it volatilizes into the atmosphere, or participates in photochemical reactions, affecting air quality and damaging regional climate.
It is related to personal health, and 4-chloro-2-fluorobromobenzene is also at risk. If people ingest it through breathing, skin contact or diet, there may be adverse consequences. It enters the body through the respiratory tract, or irritates the mucosa of the respiratory tract, causing cough, asthma and other diseases, and long-term contact or increasing the risk of respiratory diseases. Contact with the skin may cause allergies, inflammation, and damage the skin barrier. If ingested by mistake, it may harm the digestive system, cause nausea, vomiting, abdominal pain, etc. What's more, it may invade the nervous system and endocrine system, affect nerve conduction, hormone secretion, and cause cognitive impairment, endocrine disorders and other diseases.
In summary, 4-chloro-2-fluorobromobenzene is potentially harmful to the environment and human health. When it is produced, used and disposed of, strict measures should be taken to reduce its threat to the environment and human body, so as to ensure ecological and human well-being.
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