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4-Chloro-2-Fluorobenzene-1-Sulfonyl Chloride
Linshang Chemical
|
HS Code |
165545 |
| Name | 4-Chloro-2-Fluorobenzene-1-Sulfonyl Chloride |
| Chemical Formula | C6H3Cl2FO2S |
| Molar Mass | 231.055 g/mol |
| Appearance | Typically a colorless to light - yellow liquid |
| Boiling Point | Around 265 - 267 °C |
| Density | Data may vary, but around 1.6 g/cm³ |
| Solubility | Soluble in many organic solvents, insoluble in water |
| Pungency | Has a pungent odor |
| Reactivity | Reactive towards nucleophiles due to the presence of sulfonyl chloride group |
| Hazard Class | Corrosive, causes burns to skin and eyes |
As an accredited 4-Chloro-2-Fluorobenzene-1-Sulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1 kg of 4 - chloro - 2 - fluorobenzene - 1 - sulfonyl chloride in a sealed chemical - resistant drum. |
| Storage | 4 - chloro - 2 - fluorobenzene - 1 - sulfonyl chloride should be stored in a cool, dry, well - ventilated area. Keep it away from heat, ignition sources, and moisture as it may react exothermically with water. Store in a tightly - sealed container, preferably made of corrosion - resistant materials, to prevent leakage and contact with air or other reactive substances. |
| Shipping | 4 - chloro - 2 - fluorobenzene - 1 - sulfonyl chloride is a chemical. It should be shipped in sealed, corrosion - resistant containers, following strict hazardous materials regulations, ensuring proper labeling and handling to prevent leaks and ensure safety during transit. |
Competitive 4-Chloro-2-Fluorobenzene-1-Sulfonyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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As a leading 4-Chloro-2-Fluorobenzene-1-Sulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 4-chloro-2-fluorobenzene-1-sulfonyl Chloride?
4-Chloro-2-fluorobenzene-1-sulfonyl chloride, which has a wide range of uses. In the field of organic synthesis, its position is pivotal.
First, it is often used as a key intermediate to prepare various organic compounds containing sulfur, chlorine and fluorine. Due to the unique electronic effects and physiological activities of fluorine atoms, the introduction of fluorine atoms can significantly change the physical, chemical properties and biological activities of organic molecules. Therefore, with the help of 4-chloro-2-fluorobenzene-1-sulfonyl chloride, fluorine, chlorine and sulfonyl groups can be introduced into target molecules, expanding the structural diversity of compounds, and laying the foundation for the creation of new drugs, pesticides and functional materials.
In terms of drug synthesis, it can construct molecular structures with specific pharmacological activities. For example, in the synthesis of some antibacterial and anti-tumor drugs, 4-chloro-2-fluorobenzene-1-sulfonyl chloride is involved, and through a series of reactions, compounds containing specific functional groups are generated, which are expected to become effective drugs for the treatment of diseases.
In the field of pesticides, fluorinated chlorinated pesticides prepared from this raw material often have the characteristics of high efficiency, low toxicity and environmental friendliness. Due to its special structure, it can enhance the effect of pesticides on target organisms, while reducing the impact on non-target organisms, and improving the comprehensive performance of pesticides.
In addition, in the field of materials science, 4-chloro-2-fluorobenzene-1-sulfonyl chloride is also useful. It can be used to synthesize polymer materials with special functions, such as fluorosulfonated polymers, which may have excellent thermal stability, chemical stability and electrical properties, and have potential applications in high-end fields such as aerospace and electronics. In conclusion, 4-chloro-2-fluorobenzene-1-sulfonyl chloride, with its unique structure and reactivity, plays an important role in many fields such as organic synthesis, pharmaceuticals, pesticides, and materials science, promoting the sustainable development and innovation of related fields.
First, it is often used as a key intermediate to prepare various organic compounds containing sulfur, chlorine and fluorine. Due to the unique electronic effects and physiological activities of fluorine atoms, the introduction of fluorine atoms can significantly change the physical, chemical properties and biological activities of organic molecules. Therefore, with the help of 4-chloro-2-fluorobenzene-1-sulfonyl chloride, fluorine, chlorine and sulfonyl groups can be introduced into target molecules, expanding the structural diversity of compounds, and laying the foundation for the creation of new drugs, pesticides and functional materials.
In terms of drug synthesis, it can construct molecular structures with specific pharmacological activities. For example, in the synthesis of some antibacterial and anti-tumor drugs, 4-chloro-2-fluorobenzene-1-sulfonyl chloride is involved, and through a series of reactions, compounds containing specific functional groups are generated, which are expected to become effective drugs for the treatment of diseases.
In the field of pesticides, fluorinated chlorinated pesticides prepared from this raw material often have the characteristics of high efficiency, low toxicity and environmental friendliness. Due to its special structure, it can enhance the effect of pesticides on target organisms, while reducing the impact on non-target organisms, and improving the comprehensive performance of pesticides.
In addition, in the field of materials science, 4-chloro-2-fluorobenzene-1-sulfonyl chloride is also useful. It can be used to synthesize polymer materials with special functions, such as fluorosulfonated polymers, which may have excellent thermal stability, chemical stability and electrical properties, and have potential applications in high-end fields such as aerospace and electronics. In conclusion, 4-chloro-2-fluorobenzene-1-sulfonyl chloride, with its unique structure and reactivity, plays an important role in many fields such as organic synthesis, pharmaceuticals, pesticides, and materials science, promoting the sustainable development and innovation of related fields.
What are the physical properties of 4-chloro-2-fluorobenzene-1-sulfonyl Chloride?
4-Chloro-2-fluorobenzene-1-sulfonyl chloride is an important compound in organic chemistry. Its physical properties are quite unique, and I would like to tell you one by one.
Looking at its shape, under room temperature and pressure, 4-chloro-2-fluorobenzene-1-sulfonyl chloride is often colorless to light yellow liquid, and the texture is relatively dense. It can be regarded as a substance with a special appearance. This shape is easy to observe and initially distinguish.
As for its smell, it emits a stimulating smell, which is quite strong and easy to attract attention. This pungent odor not only affects the surrounding environment, but also suggests that its chemical activity is high. Because of its obvious stimulation to the olfactory nerve, extreme caution must be used when handling this substance to prevent harm to the human body.
Furthermore, when talking about the boiling point. The boiling point of 4-chloro-2-fluorobenzene-1-sulfonyl chloride is in a specific range, about [specific boiling point value] ℃. The boiling point is the key temperature point at which a substance changes from liquid to gas state. This boiling point characteristic determines its physical state under different temperature conditions. Knowing the boiling point helps to accurately control the temperature in experimental operations such as distillation and separation or industrial production processes, so as to achieve the purpose of separating and purifying the substance.
In terms of melting point, the compound also has its specific melting point value, which is about [specific melting point value] ° C. The melting point is the temperature limit for a substance to change from a solid state to a liquid state. The determination of the melting point helps to identify the purity of the compound. If the purity of the substance is high, the melting point range is usually narrow; conversely, when there are many impurities, the melting point will be reduced and the melting point range will be wider.
Solubility is also one of its important physical properties. 4-Chloro-2-fluorobenzene-1-sulfonyl chloride exhibits good solubility in organic solvents, such as common ether and dichloromethane. This property allows these organic solvents to be used as reaction media in organic synthesis reactions, promoting the reaction to proceed more smoothly. However, its solubility in water is poor, which is mainly due to the influence of hydrophobic groups in the molecular structure of the compound, and the force between water molecules is weak, so it is difficult to dissolve in water.
In addition, the density of 4-chloro-2-fluorobenzene-1-sulfonyl chloride is greater than that of water, which is about [specific density value] g/cm ³. This density property makes it sink to the bottom when mixed with water. When it involves operations such as liquid-liquid separation, it can be separated according to this property.
In summary, the physical properties of 4-chloro-2-fluorobenzene-1-sulfonyl chloride, such as morphology, odor, melting and boiling point, solubility and density, are of great significance in the research, experimental operation and industrial production of organic chemistry, laying the foundation for in-depth understanding and rational use of this compound.
Looking at its shape, under room temperature and pressure, 4-chloro-2-fluorobenzene-1-sulfonyl chloride is often colorless to light yellow liquid, and the texture is relatively dense. It can be regarded as a substance with a special appearance. This shape is easy to observe and initially distinguish.
As for its smell, it emits a stimulating smell, which is quite strong and easy to attract attention. This pungent odor not only affects the surrounding environment, but also suggests that its chemical activity is high. Because of its obvious stimulation to the olfactory nerve, extreme caution must be used when handling this substance to prevent harm to the human body.
Furthermore, when talking about the boiling point. The boiling point of 4-chloro-2-fluorobenzene-1-sulfonyl chloride is in a specific range, about [specific boiling point value] ℃. The boiling point is the key temperature point at which a substance changes from liquid to gas state. This boiling point characteristic determines its physical state under different temperature conditions. Knowing the boiling point helps to accurately control the temperature in experimental operations such as distillation and separation or industrial production processes, so as to achieve the purpose of separating and purifying the substance.
In terms of melting point, the compound also has its specific melting point value, which is about [specific melting point value] ° C. The melting point is the temperature limit for a substance to change from a solid state to a liquid state. The determination of the melting point helps to identify the purity of the compound. If the purity of the substance is high, the melting point range is usually narrow; conversely, when there are many impurities, the melting point will be reduced and the melting point range will be wider.
Solubility is also one of its important physical properties. 4-Chloro-2-fluorobenzene-1-sulfonyl chloride exhibits good solubility in organic solvents, such as common ether and dichloromethane. This property allows these organic solvents to be used as reaction media in organic synthesis reactions, promoting the reaction to proceed more smoothly. However, its solubility in water is poor, which is mainly due to the influence of hydrophobic groups in the molecular structure of the compound, and the force between water molecules is weak, so it is difficult to dissolve in water.
In addition, the density of 4-chloro-2-fluorobenzene-1-sulfonyl chloride is greater than that of water, which is about [specific density value] g/cm ³. This density property makes it sink to the bottom when mixed with water. When it involves operations such as liquid-liquid separation, it can be separated according to this property.
In summary, the physical properties of 4-chloro-2-fluorobenzene-1-sulfonyl chloride, such as morphology, odor, melting and boiling point, solubility and density, are of great significance in the research, experimental operation and industrial production of organic chemistry, laying the foundation for in-depth understanding and rational use of this compound.
4-chloro-2-fluorobenzene-1-sulfonyl the chemistry of Chloride
4-Chloro-2-fluorobenzene-1-sulfonyl chloride, this material is strong and highly reactive. Its color is often colorless to slightly yellow, like a liquid, prone to smoke in the air, and has a pungent smell.
Its chemical activity is very strong, and the sulfonyl chloride group (-SO 2O Cl) is very active. In contact with water, it reacts rapidly, releasing hydrogen chloride gas and generating corresponding sulfonic acids. This reaction is violent and often accompanied by heat.
When it encounters alcohols, an alcoholysis reaction occurs to form sulfonates. In this process, the chlorine atom of the sulfonyl chloride group is replaced by the alkoxy group of the alcohol, which is an important way to prepare sulfonate compounds.
When exposed to amines, it can react rapidly. The chlorine atom is substituted with an amino group to obtain sulfonamide products. Such reactions are widely used in organic synthesis, and the preparation of many drugs and functional materials often depends on this.
Because of its fluorine and chlorine atoms, this molecule has unique electronic effects and spatial effects. Fluorine atoms have high electronegativity, which can affect the distribution of molecular electron clouds, enhance their chemical stability and some special properties. And chlorine atoms also contribute to the reactivity and physical properties of molecules, such as changing their polarity and solubility.
4-chloro-2-fluorobenzene-1-sulfonyl chloride is a key intermediate in the field of organic synthesis due to its active chemical properties. It can be used to construct rich organic compounds through various reactions. However, due to its high reactivity and corrosiveness, strict precautions are required when using and strict operating procedures are followed.
Its chemical activity is very strong, and the sulfonyl chloride group (-SO 2O Cl) is very active. In contact with water, it reacts rapidly, releasing hydrogen chloride gas and generating corresponding sulfonic acids. This reaction is violent and often accompanied by heat.
When it encounters alcohols, an alcoholysis reaction occurs to form sulfonates. In this process, the chlorine atom of the sulfonyl chloride group is replaced by the alkoxy group of the alcohol, which is an important way to prepare sulfonate compounds.
When exposed to amines, it can react rapidly. The chlorine atom is substituted with an amino group to obtain sulfonamide products. Such reactions are widely used in organic synthesis, and the preparation of many drugs and functional materials often depends on this.
Because of its fluorine and chlorine atoms, this molecule has unique electronic effects and spatial effects. Fluorine atoms have high electronegativity, which can affect the distribution of molecular electron clouds, enhance their chemical stability and some special properties. And chlorine atoms also contribute to the reactivity and physical properties of molecules, such as changing their polarity and solubility.
4-chloro-2-fluorobenzene-1-sulfonyl chloride is a key intermediate in the field of organic synthesis due to its active chemical properties. It can be used to construct rich organic compounds through various reactions. However, due to its high reactivity and corrosiveness, strict precautions are required when using and strict operating procedures are followed.
What are the synthesis methods of 4-chloro-2-fluorobenzene-1-sulfonyl Chloride?
The synthesis of 4-chloro-2-fluorobenzene-1-sulfonyl chloride is an important topic in organic synthetic chemistry. Its synthesis pathways are diverse, and the common methods are described in detail below.
First, 4-chloro-2-fluorobenzene is used as the starting material. First, 4-chloro-2-fluorobenzene is sulfonated with fuming sulfuric acid at an appropriate temperature and reaction time. In this process, fuming sulfuric acid is used as a sulfonation reagent to introduce sulfonic acid groups into the benzene ring. The reaction conditions need to be carefully regulated. If the temperature is too high or the time is too long, it is easy to cause side reactions such as polysulfonation, which affects the purity and yield of the product. Generally speaking, the temperature is often controlled within a specific range, such as between tens of degrees Celsius, and the reaction time depends on the specific reaction process monitoring. After the sulfonated product is separated and purified, it can be reacted with chlorinated reagents such as sulfoxide chloride to obtain 4-chloro-2-fluorobenzene-1-sulfonyl chloride. In this step of the reaction, the sulfoxide chloride reacts with the sulfonic acid group to form the target product, and at the same time escapes sulfur dioxide and hydrogen chloride gas. The reaction is usually carried out in suitable solvents, such as some halogenated hydrocarbon solvents, to promote the smooth progress of the reaction.
Second, benzene derivatives containing appropriate substituents are also used as starting materials. After multiple steps of reaction, the target molecular structure is gradually constructed. For example, chlorine atoms and fluorine atoms can be introduced at specific positions in the benzene ring through reactions such as nucleophilic substitution, and then the sulfonylation reaction can be carried out. Although this method is slightly complicated, the reaction path can be flexibly selected according to different raw materials and reaction conditions, and the reaction selectivity and yield can be improved in some cases.
Or other special synthesis strategies can be used. For example, the reaction catalyzed by transition metals can precisely control the reaction check point and selectivity. Although this method has high technical requirements, it is widely used in modern organic synthesis, and it is expected to provide a more efficient and green way for the synthesis of 4-chloro-2-fluorobenzene-1-sulfonyl chloride.
There are many methods for synthesizing 4-chloro-2-fluorobenzene-1-sulfonyl chloride, each with its own advantages and disadvantages. In actual synthesis, the appropriate synthesis method should be carefully selected according to the comprehensive consideration of raw material availability, cost, reaction conditions, target product purity and yield.
First, 4-chloro-2-fluorobenzene is used as the starting material. First, 4-chloro-2-fluorobenzene is sulfonated with fuming sulfuric acid at an appropriate temperature and reaction time. In this process, fuming sulfuric acid is used as a sulfonation reagent to introduce sulfonic acid groups into the benzene ring. The reaction conditions need to be carefully regulated. If the temperature is too high or the time is too long, it is easy to cause side reactions such as polysulfonation, which affects the purity and yield of the product. Generally speaking, the temperature is often controlled within a specific range, such as between tens of degrees Celsius, and the reaction time depends on the specific reaction process monitoring. After the sulfonated product is separated and purified, it can be reacted with chlorinated reagents such as sulfoxide chloride to obtain 4-chloro-2-fluorobenzene-1-sulfonyl chloride. In this step of the reaction, the sulfoxide chloride reacts with the sulfonic acid group to form the target product, and at the same time escapes sulfur dioxide and hydrogen chloride gas. The reaction is usually carried out in suitable solvents, such as some halogenated hydrocarbon solvents, to promote the smooth progress of the reaction.
Second, benzene derivatives containing appropriate substituents are also used as starting materials. After multiple steps of reaction, the target molecular structure is gradually constructed. For example, chlorine atoms and fluorine atoms can be introduced at specific positions in the benzene ring through reactions such as nucleophilic substitution, and then the sulfonylation reaction can be carried out. Although this method is slightly complicated, the reaction path can be flexibly selected according to different raw materials and reaction conditions, and the reaction selectivity and yield can be improved in some cases.
Or other special synthesis strategies can be used. For example, the reaction catalyzed by transition metals can precisely control the reaction check point and selectivity. Although this method has high technical requirements, it is widely used in modern organic synthesis, and it is expected to provide a more efficient and green way for the synthesis of 4-chloro-2-fluorobenzene-1-sulfonyl chloride.
There are many methods for synthesizing 4-chloro-2-fluorobenzene-1-sulfonyl chloride, each with its own advantages and disadvantages. In actual synthesis, the appropriate synthesis method should be carefully selected according to the comprehensive consideration of raw material availability, cost, reaction conditions, target product purity and yield.
What are the precautions for 4-chloro-2-fluorobenzene-1-sulfonyl Chloride in storage and transportation?
4-Chloro-2-fluorobenzene-1-sulfonyl chloride. During storage and transportation, many matters need to be paid attention to.
It is active and corrosive. When storing, it must choose a dry, cool and well-ventilated place. It can be hydrolyzed due to humidity, which can damage its quality. The warehouse temperature should be strictly controlled and not too high to prevent it from decomposing or causing dangerous reactions. And it should be stored separately from alkalis, alcohols and other substances, because it is easy to react with them.
During transportation, the packaging must be solid and stable to prevent package damage due to collision and vibration. It needs to be packed in a specific corrosion-resistant container to ensure safe transportation. Transport vehicles should also be equipped with corresponding emergency treatment equipment and protective equipment in case of emergencies. Escorts must be familiar with the characteristics of this material and emergency response methods.
In addition, whether it is warehousing or transportation, relevant regulations and safety standards should be strictly followed. Daily inspection of storage and transportation equipment is also required to ensure that it is intact. If there is a leak, etc., it should be dealt with according to the established emergency plan to prevent the harm from expanding. In this way, the safety of 4-chloro-2-fluorobenzene-1-sulfonyl chloride during storage and transportation can be guaranteed.
It is active and corrosive. When storing, it must choose a dry, cool and well-ventilated place. It can be hydrolyzed due to humidity, which can damage its quality. The warehouse temperature should be strictly controlled and not too high to prevent it from decomposing or causing dangerous reactions. And it should be stored separately from alkalis, alcohols and other substances, because it is easy to react with them.
During transportation, the packaging must be solid and stable to prevent package damage due to collision and vibration. It needs to be packed in a specific corrosion-resistant container to ensure safe transportation. Transport vehicles should also be equipped with corresponding emergency treatment equipment and protective equipment in case of emergencies. Escorts must be familiar with the characteristics of this material and emergency response methods.
In addition, whether it is warehousing or transportation, relevant regulations and safety standards should be strictly followed. Daily inspection of storage and transportation equipment is also required to ensure that it is intact. If there is a leak, etc., it should be dealt with according to the established emergency plan to prevent the harm from expanding. In this way, the safety of 4-chloro-2-fluorobenzene-1-sulfonyl chloride during storage and transportation can be guaranteed.
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