Linshang Chemical
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4-Chloro-2-Fluorobenzeneboronic Acid 98%
Linshang Chemical
|
HS Code |
750856 |
| Name | 4-Chloro-2-Fluorobenzeneboronic Acid 98% |
| Chemical Formula | C6H5BClFO2 |
| Molar Mass | 174.37 g/mol |
| Appearance | White to off - white solid |
| Purity | 98% |
| Solubility In Water | Slightly soluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, dichloromethane |
| Melting Point | 145 - 149 °C |
| Boiling Point | Decomposes before boiling |
| Hazard Class | Irritant (can cause skin, eye and respiratory irritation) |
As an accredited 4-Chloro-2-Fluorobenzeneboronic Acid 98% factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 98% 4 - chloro - 2 - fluorobenzeneboronic acid in sealed chemical - grade packaging. |
| Storage | 4 - Chloro - 2 - fluorobenzeneboronic Acid (98%) should be stored in a cool, dry place away from heat and ignition sources. Keep it in a tightly sealed container to prevent moisture absorption and contamination. Store it separately from incompatible substances, like strong oxidizing agents. This helps maintain its chemical integrity and safety during storage. |
| Shipping | 4 - chloro - 2 - fluorobenzeneboronic Acid (98%) is shipped in well - sealed, corrosion - resistant containers. They are carefully packed to prevent breakage during transit and handled in accordance with chemical shipping safety regulations. |
Competitive 4-Chloro-2-Fluorobenzeneboronic Acid 98% prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4-Chloro-2-Fluorobenzeneboronic Acid 98% in China?
As a trusted 4-Chloro-2-Fluorobenzeneboronic Acid 98% manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-Chloro-2-Fluorobenzeneboronic Acid 98% supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
4-chloro-2-fluorobenzeneboronic Acid 98% of the main application fields
4-Chloro-2-fluorophenylboronic acid, with a content of 98%, has a wide range of uses and has applications in various fields.
In the field of pharmaceutical synthesis, its role is significant. It can be used as a key intermediate to help create new drugs. Due to the unique structure of phenylboronic acid, it can interact with specific biomolecules. With rational design, 4-chloro-2-fluorophenylboronic acid can be introduced into drug molecules to optimize their pharmacological activity, bioavailability and targeting. For example, in the development of anti-cancer drugs, ingenious modification can make it act precisely on cancer cell targets, improve the therapeutic effect and reduce the damage to normal cells.
is also indispensable in the field of materials science. It is often used in the preparation of functional materials, such as organic optoelectronic materials. In the field of organic Light Emitting Diode (OLED), with its structural properties, the electronic transport and luminescence properties of materials can be improved, and the luminous efficiency, stability and service life of OLED devices can be improved. In addition, in the preparation of sensor materials, it can specifically identify and respond to specific substances, thus constructing highly sensitive and highly selective sensors for the detection of environmental pollutants, biomarkers, etc.
In the synthesis of pesticides, 4-chloro-2-fluorophenylboronic acid also has important uses. It can be used as a raw material for the synthesis of new pesticides. Through rational molecular design, pesticides are endowed with unique insecticidal, bactericidal or herbicidal activities, and can reduce the harm to the environment, meeting the needs of modern green agriculture for high-efficiency and low-toxicity pesticides.
In the field of organic synthetic chemistry, it is an extremely important synthetic building block. It can participate in a variety of organic reactions, such as Suzuki-Miyaura coupling reaction, etc., to construct complex organic molecular structures, providing organic synthetic chemists with rich synthesis strategies and means, which greatly promotes the development of organic synthetic chemistry.
In the field of pharmaceutical synthesis, its role is significant. It can be used as a key intermediate to help create new drugs. Due to the unique structure of phenylboronic acid, it can interact with specific biomolecules. With rational design, 4-chloro-2-fluorophenylboronic acid can be introduced into drug molecules to optimize their pharmacological activity, bioavailability and targeting. For example, in the development of anti-cancer drugs, ingenious modification can make it act precisely on cancer cell targets, improve the therapeutic effect and reduce the damage to normal cells.
is also indispensable in the field of materials science. It is often used in the preparation of functional materials, such as organic optoelectronic materials. In the field of organic Light Emitting Diode (OLED), with its structural properties, the electronic transport and luminescence properties of materials can be improved, and the luminous efficiency, stability and service life of OLED devices can be improved. In addition, in the preparation of sensor materials, it can specifically identify and respond to specific substances, thus constructing highly sensitive and highly selective sensors for the detection of environmental pollutants, biomarkers, etc.
In the synthesis of pesticides, 4-chloro-2-fluorophenylboronic acid also has important uses. It can be used as a raw material for the synthesis of new pesticides. Through rational molecular design, pesticides are endowed with unique insecticidal, bactericidal or herbicidal activities, and can reduce the harm to the environment, meeting the needs of modern green agriculture for high-efficiency and low-toxicity pesticides.
In the field of organic synthetic chemistry, it is an extremely important synthetic building block. It can participate in a variety of organic reactions, such as Suzuki-Miyaura coupling reaction, etc., to construct complex organic molecular structures, providing organic synthetic chemists with rich synthesis strategies and means, which greatly promotes the development of organic synthetic chemistry.
4-chloro-2-fluorobenzeneboronic 98% of the market price of Acid
4-Chloro-2-fluorophenylboronic acid, with a purity of 98%, the market size varies depending on the situation, and also varies depending on the supply and demand, the location, and the amount of trade. In the past, this product is in the market, and the price may be wavy.
Generally speaking, if the batch is low in the field of business, the larger the quantity is, the cheaper it will be. However, the market is not prosperous, and the market will be determined. In the past, for example, if you want to use a small amount of oil per gram, the price will often be the highest. If you need a large number of molds, the amount will be huge, and you can get good results. In addition, different suppliers also have equal differences, or there are differences in the method of providing and the calculation of costs.
The feeling of the market, such as the flow of water, requires a lot of business conditions, and it is better to compare the market. Therefore, if you want to know the market, you must use the same suppliers as the next one, and you can only get it if you observe the situation.
Generally speaking, if the batch is low in the field of business, the larger the quantity is, the cheaper it will be. However, the market is not prosperous, and the market will be determined. In the past, for example, if you want to use a small amount of oil per gram, the price will often be the highest. If you need a large number of molds, the amount will be huge, and you can get good results. In addition, different suppliers also have equal differences, or there are differences in the method of providing and the calculation of costs.
The feeling of the market, such as the flow of water, requires a lot of business conditions, and it is better to compare the market. Therefore, if you want to know the market, you must use the same suppliers as the next one, and you can only get it if you observe the situation.
4-chloro-2-fluorobenzeneboronic Acid 98% What are the precautions during storage and transportation
4-Chloro-2-fluorophenylboronic acid, with a content of 98%, is an important raw material for fine chemicals. During storage and transportation, many matters must be paid attention to.
First talk about storage, this substance should be placed in a cool, dry and well-ventilated place. Because of its certain chemical activity, if the storage environment humidity is high, it is prone to moisture deterioration, resulting in a decrease in its purity and affecting the subsequent use efficiency. Therefore, it is necessary to keep away from water sources and moisture, and it can be stored in a sealed container to prevent moisture from dissolving. Furthermore, temperature is also critical. High temperature or chemical reactions can change the properties of the substance. Therefore, high temperature environments should be avoided and should be controlled in a suitable low temperature range.
As for transportation, the first thing to ensure is that the packaging is intact. Packaging materials must have good protective properties, can resist vibration, collisions, and prevent material leakage caused by container damage. During transportation, they should be separated from oxidizing agents, acids, alkalis and other chemicals, because of their active chemical properties, contact with these substances or react violently, endangering transportation safety. And transport vehicles should be selected with good ventilation conditions to prevent the accumulation of harmful gases in the transportation space. Transport personnel must also be professionally trained to be familiar with the characteristics of this substance and emergency treatment methods. In case of emergencies, they can respond quickly and effectively to ensure transportation safety.
First talk about storage, this substance should be placed in a cool, dry and well-ventilated place. Because of its certain chemical activity, if the storage environment humidity is high, it is prone to moisture deterioration, resulting in a decrease in its purity and affecting the subsequent use efficiency. Therefore, it is necessary to keep away from water sources and moisture, and it can be stored in a sealed container to prevent moisture from dissolving. Furthermore, temperature is also critical. High temperature or chemical reactions can change the properties of the substance. Therefore, high temperature environments should be avoided and should be controlled in a suitable low temperature range.
As for transportation, the first thing to ensure is that the packaging is intact. Packaging materials must have good protective properties, can resist vibration, collisions, and prevent material leakage caused by container damage. During transportation, they should be separated from oxidizing agents, acids, alkalis and other chemicals, because of their active chemical properties, contact with these substances or react violently, endangering transportation safety. And transport vehicles should be selected with good ventilation conditions to prevent the accumulation of harmful gases in the transportation space. Transport personnel must also be professionally trained to be familiar with the characteristics of this substance and emergency treatment methods. In case of emergencies, they can respond quickly and effectively to ensure transportation safety.
What are the 98% synthesis methods of 4-chloro-2-fluorobenzeneboronic Acid?
4-Chloro-2-fluorophenylboronic acid, the content is 98%. There are probably several ways to synthesize it.
First, halogenated aromatics are used as starting materials. Take 4-chloro-2-fluorobromobenzene first, place it and magnesium chips in anhydrous ether, and stir it carefully in a low temperature environment to make it slowly react to form a format reagent. This process needs to pay attention to the anhydrous and oxygen-free environment to prevent side reactions from breeding. When the format reagent is complete, slowly drop it into a borate ester, such as trimethyl borate. When adding dropwise, control the rate to prevent the reaction from being too violent. After adding dropwise, heat up and reflux to make the reaction fully proceed. Then, through the step of hydrolysis, the reaction solution is treated with dilute acid to obtain 4-chloro-2-fluorophenylboronic acid crude product. Then purified by recrystallization and other means to improve the purity of the product.
Second, the coupling reaction catalyzed by palladium. Take 4-chloro-2-fluorohalobenzene, mix it with diphenyl alcohol borate, add a palladium catalyst, such as tetra (triphenylphosphine) palladium, and an appropriate amount of ligand, in a suitable organic solvent, such as toluene. At the same time, add an appropriate amount of base, such as potassium carbonate, to create a suitable reaction environment. Under nitrogen protection, heat the reflux reaction. This reaction requires precise control of temperature, catalyst dosage and other conditions to make the reaction proceed efficiently. After the reaction is completed, the pure 4-chloro-2-fluorophenylboronic acid is obtained through extraction, column chromatography and other separation operations.
Third, the phenylboronic acid derivative is used as the starting material. If there is a suitable phenylboronic acid derivative with modifiable groups, it will be halogenated to introduce chlorine and fluorine atoms. This process requires the selection of suitable halogenating reagents, such as chlorine and fluorine-containing halogenating agents. The reaction conditions also need to be carefully regulated, because the selectivity of the halogenation reaction is very important. After the reaction, the target product 4-chloro-2-fluorophenylboronic acid can be obtained through a series of post-treatment, such as separation and purification.
First, halogenated aromatics are used as starting materials. Take 4-chloro-2-fluorobromobenzene first, place it and magnesium chips in anhydrous ether, and stir it carefully in a low temperature environment to make it slowly react to form a format reagent. This process needs to pay attention to the anhydrous and oxygen-free environment to prevent side reactions from breeding. When the format reagent is complete, slowly drop it into a borate ester, such as trimethyl borate. When adding dropwise, control the rate to prevent the reaction from being too violent. After adding dropwise, heat up and reflux to make the reaction fully proceed. Then, through the step of hydrolysis, the reaction solution is treated with dilute acid to obtain 4-chloro-2-fluorophenylboronic acid crude product. Then purified by recrystallization and other means to improve the purity of the product.
Second, the coupling reaction catalyzed by palladium. Take 4-chloro-2-fluorohalobenzene, mix it with diphenyl alcohol borate, add a palladium catalyst, such as tetra (triphenylphosphine) palladium, and an appropriate amount of ligand, in a suitable organic solvent, such as toluene. At the same time, add an appropriate amount of base, such as potassium carbonate, to create a suitable reaction environment. Under nitrogen protection, heat the reflux reaction. This reaction requires precise control of temperature, catalyst dosage and other conditions to make the reaction proceed efficiently. After the reaction is completed, the pure 4-chloro-2-fluorophenylboronic acid is obtained through extraction, column chromatography and other separation operations.
Third, the phenylboronic acid derivative is used as the starting material. If there is a suitable phenylboronic acid derivative with modifiable groups, it will be halogenated to introduce chlorine and fluorine atoms. This process requires the selection of suitable halogenating reagents, such as chlorine and fluorine-containing halogenating agents. The reaction conditions also need to be carefully regulated, because the selectivity of the halogenation reaction is very important. After the reaction, the target product 4-chloro-2-fluorophenylboronic acid can be obtained through a series of post-treatment, such as separation and purification.
4-chloro-2-fluorobenzeneboronic Acid 98% Quality Standard
4-Chloro-2-fluorophenylboronic acid, with a content of 98%, has the following Quality Standards:
First of all, in terms of appearance, it should appear as white to off-white crystalline powder. The characterization of this color and morphology is an important basis for preliminary judgment of its quality. Pure products often have a uniform appearance and conform to their inherent characteristics.
Regarding purity, it is clearly stipulated that 98% or more is required. This purity index is crucial and is related to the effect of the chemical in various reactions and applications. Insufficient purity, impurities may interfere with the reaction process and affect the quality of the product. To accurately determine purity, analytical methods such as high-performance liquid chromatography (HPLC) are often used. Through HPLC detection, the purity can be accurately calculated according to parameters such as peak area.
When talking about the melting point again, 4-chloro-2-fluorophenylboronic acid has its specific melting point range. Accurate determination of the melting point can provide strong support for judging its purity and material characteristics. The method of determining the melting point is commonly used with a capillary melting point tester. During operation, conditions such as the heating rate must be strictly controlled to obtain accurate melting point data.
In addition, there are strict restrictions on the moisture content. Excessive moisture may affect its stability or interfere with some water-sensitive reactions. To determine moisture, classic methods such as the Karl Fischer method are often used to ensure that the moisture content is within the specified range.
And for heavy metal content, the same needs to be controlled. Heavy metal impurities may have toxic effects on subsequent reaction catalysts, or cause safety and quality problems in some application scenarios. To detect heavy metals, atomic absorption spectroscopy (AAS) and other technologies are often used to ensure that their content meets the standard requirements.
In summary, those with 98% content of 4-chloro-2-fluorophenylboronic acid have clear and strict Quality Standards in terms of appearance, purity, melting point, moisture and heavy metal content to ensure their reliable application in chemical, pharmaceutical and other fields.
First of all, in terms of appearance, it should appear as white to off-white crystalline powder. The characterization of this color and morphology is an important basis for preliminary judgment of its quality. Pure products often have a uniform appearance and conform to their inherent characteristics.
Regarding purity, it is clearly stipulated that 98% or more is required. This purity index is crucial and is related to the effect of the chemical in various reactions and applications. Insufficient purity, impurities may interfere with the reaction process and affect the quality of the product. To accurately determine purity, analytical methods such as high-performance liquid chromatography (HPLC) are often used. Through HPLC detection, the purity can be accurately calculated according to parameters such as peak area.
When talking about the melting point again, 4-chloro-2-fluorophenylboronic acid has its specific melting point range. Accurate determination of the melting point can provide strong support for judging its purity and material characteristics. The method of determining the melting point is commonly used with a capillary melting point tester. During operation, conditions such as the heating rate must be strictly controlled to obtain accurate melting point data.
In addition, there are strict restrictions on the moisture content. Excessive moisture may affect its stability or interfere with some water-sensitive reactions. To determine moisture, classic methods such as the Karl Fischer method are often used to ensure that the moisture content is within the specified range.
And for heavy metal content, the same needs to be controlled. Heavy metal impurities may have toxic effects on subsequent reaction catalysts, or cause safety and quality problems in some application scenarios. To detect heavy metals, atomic absorption spectroscopy (AAS) and other technologies are often used to ensure that their content meets the standard requirements.
In summary, those with 98% content of 4-chloro-2-fluorophenylboronic acid have clear and strict Quality Standards in terms of appearance, purity, melting point, moisture and heavy metal content to ensure their reliable application in chemical, pharmaceutical and other fields.
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