Linshang Chemical
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4-Chloro-2-Fluorobenzeneboronic Acid
Linshang Chemical
|
HS Code |
776968 |
| Chemical Formula | C6H5BClFO2 |
| Molecular Weight | 175.36 |
| Appearance | White to off - white solid |
| Purity | Typically high - purity, e.g., 97%+ |
| Melting Point | 135 - 140 °C |
| Solubility | Soluble in some organic solvents like dichloromethane, less soluble in water |
| Cas Number | 1218790 - 42 - 6 |
| Boiling Point | Decomposes before boiling under normal conditions |
As an accredited 4-Chloro-2-Fluorobenzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 5 - gram vial of 4 - chloro - 2 - fluorobenzeneboronic acid, well - sealed for protection. |
| Storage | 4 - chloro - 2 - fluorobenzeneboronic acid should be stored in a cool, dry, well - ventilated area, away from heat sources and direct sunlight. Keep it in a tightly sealed container to prevent moisture absorption and reaction with air components. Store separately from incompatible substances like strong oxidizing agents, bases, and reactive metals to avoid potential chemical reactions. |
| Shipping | 4 - chloro - 2 - fluorobenzeneboronic acid is shipped in well - sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, ensuring safe transportation to prevent any leakage or reaction during transit. |
Competitive 4-Chloro-2-Fluorobenzeneboronic Acid prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4-Chloro-2-Fluorobenzeneboronic Acid in China?
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As a leading 4-Chloro-2-Fluorobenzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 4-chloro-2-fluorobenzeneboronic Acid?
4-Chloro-2-fluorophenylboronic acid is an important reagent in organic synthesis. Its chemical properties are unique, with three atomic properties of boron, chlorine and fluorine.
As far as its boric acid fraction is concerned, it has the chemical activity of typical boric acid. In case of alkali, it can form borate, which is often used in the catalytic process of organic reactions. The boric acid fraction can react with compounds containing hydroxyl groups to form borate esters. This reaction is crucial in the construction of complex organic structures. By forming borate esters, molecules can be modified and linked to assist in the synthesis of organic compounds with specific structures. The presence of chlorine atoms gives the compound specific reactivity. Chlorine atoms are relatively active. In nucleophilic substitution reactions, chlorine atoms are easily replaced by various nucleophilic reagents, thereby introducing different functional groups to expand the structural diversity of compounds. For example, when reacting with nucleophilic reagents such as alcohols and amines, ether or amine derivatives can be formed, providing a variety of pathways for organic synthesis.
Fluorine atoms also have a profound impact on the properties of compounds. Fluorine atoms are extremely electronegative, which changes the distribution of molecular electron clouds, which in turn affects their physical and chemical properties. Fluorine-containing compounds often have unique biological activities and have attracted much attention in the field of medicinal chemistry. The presence of fluorine atoms in 4-chloro-2-fluorophenylboronic acid may give its derivatives a special advantage in biological activity research and drug development. At the same time, fluorine atoms affect molecular polarity and stability, which is of great significance in the field of organic synthesis and materials science.
In addition, the benzene ring structure of 4-chloro-2-fluorophenylboronic acid is a planar conjugated system, which endows the molecule with certain stability and electron delocalization characteristics. The benzene ring can undergo electrophilic substitution reactions, which cooperate with boric acid, chlorine, and fluorine atoms to further enrich its chemical reactivity and play a key role in the construction of complex aromatic compounds.
As far as its boric acid fraction is concerned, it has the chemical activity of typical boric acid. In case of alkali, it can form borate, which is often used in the catalytic process of organic reactions. The boric acid fraction can react with compounds containing hydroxyl groups to form borate esters. This reaction is crucial in the construction of complex organic structures. By forming borate esters, molecules can be modified and linked to assist in the synthesis of organic compounds with specific structures. The presence of chlorine atoms gives the compound specific reactivity. Chlorine atoms are relatively active. In nucleophilic substitution reactions, chlorine atoms are easily replaced by various nucleophilic reagents, thereby introducing different functional groups to expand the structural diversity of compounds. For example, when reacting with nucleophilic reagents such as alcohols and amines, ether or amine derivatives can be formed, providing a variety of pathways for organic synthesis.
Fluorine atoms also have a profound impact on the properties of compounds. Fluorine atoms are extremely electronegative, which changes the distribution of molecular electron clouds, which in turn affects their physical and chemical properties. Fluorine-containing compounds often have unique biological activities and have attracted much attention in the field of medicinal chemistry. The presence of fluorine atoms in 4-chloro-2-fluorophenylboronic acid may give its derivatives a special advantage in biological activity research and drug development. At the same time, fluorine atoms affect molecular polarity and stability, which is of great significance in the field of organic synthesis and materials science.
In addition, the benzene ring structure of 4-chloro-2-fluorophenylboronic acid is a planar conjugated system, which endows the molecule with certain stability and electron delocalization characteristics. The benzene ring can undergo electrophilic substitution reactions, which cooperate with boric acid, chlorine, and fluorine atoms to further enrich its chemical reactivity and play a key role in the construction of complex aromatic compounds.
What are the common synthesis methods of 4-chloro-2-fluorobenzeneboronic Acid?
The common synthesis methods of 4-chloro-2-fluorophenylboronic acid are as follows.
First, the halogenated aromatics are used as the starting material and prepared by metallization reaction. Take 4-chloro-2-fluorobromobenzene first and dissolve it in anhydrous ether or tetrahydrofuran and other organic solvents. At low temperature, n-butyl lithium is slowly added dropwise to the system. This process requires strict temperature control. Because the metallization reaction activity is quite high, the temperature is slightly worse, which is easy to cause a cluster of side reactions. The lithium-halogen exchange reaction occurs between n-butyl lithium and halogenated aromatics to form 4-chloro-2-fluorophenyl lithium intermediates. Subsequently, borate esters, such as trimethyl borate or triisopropyl borate, are added, and after hydrolysis, 4-chloro-2-fluorophenylboronic acid is obtained.
Second, a palladium-catalyzed cross-coupling reaction. Using 4-chloro-2-fluorobrombenzene and pinacol borate as raw materials, in an organic solvent such as dioxane or toluene, a palladium catalyst such as tetrakis (triphenylphosphine) palladium (0) is added, and a base such as potassium carbonate or sodium carbonate is added. Under appropriate temperature, heating and stirring, the palladium catalyst promotes the coupling reaction of halogenated aromatics and borate esters to generate 4-chloro-2-fluorophenylboronic acid pinacol ester, which can be obtained by acidic hydrolysis. 4-chloro-2-fluorophenylboronic acid. This method has good selectivity and high yield, but the cost of palladium catalysts is relatively high. In industrial production, cost factors may need to be considered.
Third, the Grignard reagent method is used. Using 4-chloro-2-fluorobromobenzene and magnesium chips as raw materials, in anhydrous ether or tetrahydrofuran, the Grignard reaction is initiated to generate 4-chloro-2-fluorophenyl magnesium bromide Grignard reagent. Then, after reacting with borate esters and hydrolyzing, 4-chloro-2-fluorophenylboronic acid can also be obtained. The Grignard reagent method is relatively convenient to operate, but it requires strict reaction conditions and requires an absolutely anhydrous environment, otherwise the Grignard reagent is easily decomposed and affects the yield.
All methods of synthesis have their own advantages and disadvantages. In practical applications, the appropriate method should be carefully selected according to specific requirements, such as product purity, cost, yield and other factors.
First, the halogenated aromatics are used as the starting material and prepared by metallization reaction. Take 4-chloro-2-fluorobromobenzene first and dissolve it in anhydrous ether or tetrahydrofuran and other organic solvents. At low temperature, n-butyl lithium is slowly added dropwise to the system. This process requires strict temperature control. Because the metallization reaction activity is quite high, the temperature is slightly worse, which is easy to cause a cluster of side reactions. The lithium-halogen exchange reaction occurs between n-butyl lithium and halogenated aromatics to form 4-chloro-2-fluorophenyl lithium intermediates. Subsequently, borate esters, such as trimethyl borate or triisopropyl borate, are added, and after hydrolysis, 4-chloro-2-fluorophenylboronic acid is obtained.
Second, a palladium-catalyzed cross-coupling reaction. Using 4-chloro-2-fluorobrombenzene and pinacol borate as raw materials, in an organic solvent such as dioxane or toluene, a palladium catalyst such as tetrakis (triphenylphosphine) palladium (0) is added, and a base such as potassium carbonate or sodium carbonate is added. Under appropriate temperature, heating and stirring, the palladium catalyst promotes the coupling reaction of halogenated aromatics and borate esters to generate 4-chloro-2-fluorophenylboronic acid pinacol ester, which can be obtained by acidic hydrolysis. 4-chloro-2-fluorophenylboronic acid. This method has good selectivity and high yield, but the cost of palladium catalysts is relatively high. In industrial production, cost factors may need to be considered.
Third, the Grignard reagent method is used. Using 4-chloro-2-fluorobromobenzene and magnesium chips as raw materials, in anhydrous ether or tetrahydrofuran, the Grignard reaction is initiated to generate 4-chloro-2-fluorophenyl magnesium bromide Grignard reagent. Then, after reacting with borate esters and hydrolyzing, 4-chloro-2-fluorophenylboronic acid can also be obtained. The Grignard reagent method is relatively convenient to operate, but it requires strict reaction conditions and requires an absolutely anhydrous environment, otherwise the Grignard reagent is easily decomposed and affects the yield.
All methods of synthesis have their own advantages and disadvantages. In practical applications, the appropriate method should be carefully selected according to specific requirements, such as product purity, cost, yield and other factors.
What are the main applications of 4-chloro-2-fluorobenzeneboronic Acid?
4-Chloro-2-fluorophenylboronic acid is useful in various fields. In the field of medicinal chemistry, it is often a key intermediate, assisting the industry of organic synthesis. With it, organic molecules with special structures can be constructed, which is of great significance for the creation of new drugs. Cover drug development, often rely on unique structural molecules, 4-chloro-2-fluorophenylboronic acid can just react with its boron group and other groups in the synthesis step to shape a framework that meets pharmacological needs, or may play an important role in targeted drugs or anti-infective drugs.
It can also be seen in the field of materials science. It can participate in the preparation of special materials, such as optoelectronic materials. In the field of organic optoelectronics, the structure and properties of organic molecules are closely related. 4-chloro-2-fluorophenylboronic acid can impart specific optoelectronic properties to materials due to its unique atomic arrangement. Or it can adjust the conductivity and fluorescence of materials, etc., to provide assistance for the preparation of high-efficiency organic Light Emitting Diodes, organic solar cell materials, etc.
Furthermore, in the field of organic synthetic chemistry, it is a commonly used reagent. In many reactions, such as the Suzuki-Miyaura coupling reaction, this reaction is an important means to construct carbon-carbon bonds. 4-Chloro-2-fluorophenylboronic acid can react with halogenated aromatic hydrocarbons and other substrates under suitable catalyst, base and other conditions to generate biphenyl compounds with specific structures, which greatly enriches the strategy of organic synthesis and provides an effective path for the synthesis of complex organic molecules. It also has important value in the synthesis of fine chemicals.
It can also be seen in the field of materials science. It can participate in the preparation of special materials, such as optoelectronic materials. In the field of organic optoelectronics, the structure and properties of organic molecules are closely related. 4-chloro-2-fluorophenylboronic acid can impart specific optoelectronic properties to materials due to its unique atomic arrangement. Or it can adjust the conductivity and fluorescence of materials, etc., to provide assistance for the preparation of high-efficiency organic Light Emitting Diodes, organic solar cell materials, etc.
Furthermore, in the field of organic synthetic chemistry, it is a commonly used reagent. In many reactions, such as the Suzuki-Miyaura coupling reaction, this reaction is an important means to construct carbon-carbon bonds. 4-Chloro-2-fluorophenylboronic acid can react with halogenated aromatic hydrocarbons and other substrates under suitable catalyst, base and other conditions to generate biphenyl compounds with specific structures, which greatly enriches the strategy of organic synthesis and provides an effective path for the synthesis of complex organic molecules. It also has important value in the synthesis of fine chemicals.
What is the market price of 4-chloro-2-fluorobenzeneboronic Acid?
The market price of 4-chloro-2-fluorophenylboronic acid is difficult to make a quick conclusion. Its price often fluctuates due to many factors, just like the changing situation, which is elusive.
First, the trend of market supply and demand is deeply affected. If there are many people who want it, the supply is scarce, and the price will rise; conversely, if the supply exceeds the demand, the price will drop. Second, the quality is good or bad, and the price is also affected. Those with high quality are often expensive; those with lower quality are slightly less expensive. Third, the manufacturing cost is the basis of the price. The price of raw materials, the simplicity of the process, and the amount of energy consumption are all related to the cost, which in turn affects the price. Fourth, the state of market competition should not be underestimated. Fierce competition in the same industry, the price often tends to be reasonable; on the contrary, if the trend of monopoly is established, the price may remain high.
According to past market traces, the price of this product fluctuates between a few yuan per gram and tens of yuan. However, this is only an approximate number, not an exact value. If you buy in bulk, you may get a discount due to large quantities, resulting in a decrease in unit price. Or due to sudden changes in the market, such as shortage of raw materials, policy adjustments, etc., the price deviates from the usual track. Therefore, in order to know the accurate market price, you must carefully observe the current market and negotiate carefully with suppliers before you can obtain the exact number.
First, the trend of market supply and demand is deeply affected. If there are many people who want it, the supply is scarce, and the price will rise; conversely, if the supply exceeds the demand, the price will drop. Second, the quality is good or bad, and the price is also affected. Those with high quality are often expensive; those with lower quality are slightly less expensive. Third, the manufacturing cost is the basis of the price. The price of raw materials, the simplicity of the process, and the amount of energy consumption are all related to the cost, which in turn affects the price. Fourth, the state of market competition should not be underestimated. Fierce competition in the same industry, the price often tends to be reasonable; on the contrary, if the trend of monopoly is established, the price may remain high.
According to past market traces, the price of this product fluctuates between a few yuan per gram and tens of yuan. However, this is only an approximate number, not an exact value. If you buy in bulk, you may get a discount due to large quantities, resulting in a decrease in unit price. Or due to sudden changes in the market, such as shortage of raw materials, policy adjustments, etc., the price deviates from the usual track. Therefore, in order to know the accurate market price, you must carefully observe the current market and negotiate carefully with suppliers before you can obtain the exact number.
What are the precautions for 4-chloro-2-fluorobenzeneboronic Acid during storage and transportation?
4-Chloro-2-fluorophenylboronic acid requires attention to many matters during storage and transportation.
Let's talk about storage first, which is the key point. Due to its nature, it should be placed in a dry place. If the environment is humid, water vapor is easy to interact with, or cause deterioration, affecting its quality and performance. And it should be stored in a cool place, where the temperature is too high, or cause chemical reactions, resulting in decomposition and other adverse conditions. In addition, it must be kept away from fire sources and oxidants. 4-chloro-2-fluorophenylboronic acid may react violently when exposed to an open flame or a strong oxidant, and there is a risk of combustion and explosion. Furthermore, it should be sealed and stored to prevent excessive contact with the air and avoid the reaction of oxygen, carbon dioxide and other components in the air with it.
As for transportation, it cannot be ignored. The transportation container must be well sealed to prevent leakage. Leakage will not only cause material damage, but also may cause harm to the environment and pollute soil, water sources, etc. The handling process should be careful to avoid severe vibration and collision, because the structure of the substance may change under the action of vibration or collision, which affects its quality. Transportation vehicles need to be equipped with corresponding fire protection equipment in case of accidents, which can be responded to in time and reduce losses. At the same time, transportation personnel must be familiar with the characteristics of 4-chloro-2-fluorophenylboronic acid and emergency treatment methods. In case of emergencies, they can be dealt with quickly and properly. Overall, the storage and transportation of 4-chloro-2-fluorophenylboronic acid involves every detail of safety and quality, and must not be taken lightly.
Let's talk about storage first, which is the key point. Due to its nature, it should be placed in a dry place. If the environment is humid, water vapor is easy to interact with, or cause deterioration, affecting its quality and performance. And it should be stored in a cool place, where the temperature is too high, or cause chemical reactions, resulting in decomposition and other adverse conditions. In addition, it must be kept away from fire sources and oxidants. 4-chloro-2-fluorophenylboronic acid may react violently when exposed to an open flame or a strong oxidant, and there is a risk of combustion and explosion. Furthermore, it should be sealed and stored to prevent excessive contact with the air and avoid the reaction of oxygen, carbon dioxide and other components in the air with it.
As for transportation, it cannot be ignored. The transportation container must be well sealed to prevent leakage. Leakage will not only cause material damage, but also may cause harm to the environment and pollute soil, water sources, etc. The handling process should be careful to avoid severe vibration and collision, because the structure of the substance may change under the action of vibration or collision, which affects its quality. Transportation vehicles need to be equipped with corresponding fire protection equipment in case of accidents, which can be responded to in time and reduce losses. At the same time, transportation personnel must be familiar with the characteristics of 4-chloro-2-fluorophenylboronic acid and emergency treatment methods. In case of emergencies, they can be dealt with quickly and properly. Overall, the storage and transportation of 4-chloro-2-fluorophenylboronic acid involves every detail of safety and quality, and must not be taken lightly.
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