Linshang Chemical
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4-Chloro-2-Fluoroiodobenzene
Linshang Chemical
|
HS Code |
136718 |
| Chemical Formula | C6H3ClFI |
| Appearance | Liquid (usually) |
| Boiling Point | Data may vary, typically in the range relevant to similar halo - benzenes |
| Solubility In Water | Low solubility, as it is an organic halogen - containing aromatic compound |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Vapor Pressure | Low vapor pressure due to its relatively high molecular weight and non - volatile nature |
As an accredited 4-Chloro-2-Fluoroiodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - chloro - 2 - fluoroiodobenzene packaged in a sealed glass bottle. |
| Storage | 4 - chloro - 2 - fluoroiodobenzene should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials. Due to its potential reactivity and toxicity, store it separately from oxidizing agents, reducing agents, and other incompatible chemicals. Label the storage clearly for easy identification and safety. |
| Shipping | 4 - chloro - 2 - fluoroiodobenzene is shipped in sealed, corrosion - resistant containers. It's handled as a hazardous chemical, following strict regulations. Shipment ensures proper insulation and secure packaging to prevent leakage during transit. |
Competitive 4-Chloro-2-Fluoroiodobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
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What is the chemistry of 4-chloro-2-fluoroiodobenzene?
4-Chloro-2-fluoroiodobenzene is one of the organic compounds. Its chemical properties are quite interesting and have attracted the attention of many chemistry learners.
When it comes to reactivity, the halogen atom is on the benzene ring, each showing its own characteristics. The iodine atom is relatively active. In the nucleophilic substitution reaction, it is easy to be attacked by the nucleophilic reagent and leave to cause the formation of new bonds. In case of a strong nucleophilic body, the iodine ion can leave quickly, and the benzene ring is combined with the nucleophilic reagent to form a different compound. This is because the atomic radius of iodine is relatively large, and the C-I bond energy is relatively small, which is easier to break.
Although chlorine atoms and fluorine atoms are also active, they are slightly less active than iodine. Fluorine atoms have a great impact on the benzene ring electron cloud due to their extremely high electronegativity, which reduces the density of the benzene ring electron cloud and makes it difficult for electrophilic substitution reactions to occur. And chlorine atoms, although electronegativity is not low, have a slightly slower effect on the benzene ring electron cloud than fluorine.
In the aromatic electrophilic substitution reaction, the reaction check point is biased due to the positioning effect of fluorine and chlorine. Both are ortho-para-sites, but the positioning effect of fluorine atoms is stronger, so electrophilic reagents are more inclined to attack the positions adjacent to or opposite fluorine atoms on the benzene ring.
Its physical properties are also related to chemical properties. Due to the presence of halogen atoms in the molecule, it has a certain polarity and can be soluble in organic solvents. The melting boiling point varies depending on the intermolecular forces. The number of halogen atoms increases, the intermolecular forces increase, and the melting boiling point also increases accordingly.
4-chloro-2-fluoroiodobenzene has a wide range of uses in the field of organic synthesis due to its unique chemical properties. Various reaction paths can be used to obtain various valuable organic compounds.
When it comes to reactivity, the halogen atom is on the benzene ring, each showing its own characteristics. The iodine atom is relatively active. In the nucleophilic substitution reaction, it is easy to be attacked by the nucleophilic reagent and leave to cause the formation of new bonds. In case of a strong nucleophilic body, the iodine ion can leave quickly, and the benzene ring is combined with the nucleophilic reagent to form a different compound. This is because the atomic radius of iodine is relatively large, and the C-I bond energy is relatively small, which is easier to break.
Although chlorine atoms and fluorine atoms are also active, they are slightly less active than iodine. Fluorine atoms have a great impact on the benzene ring electron cloud due to their extremely high electronegativity, which reduces the density of the benzene ring electron cloud and makes it difficult for electrophilic substitution reactions to occur. And chlorine atoms, although electronegativity is not low, have a slightly slower effect on the benzene ring electron cloud than fluorine.
In the aromatic electrophilic substitution reaction, the reaction check point is biased due to the positioning effect of fluorine and chlorine. Both are ortho-para-sites, but the positioning effect of fluorine atoms is stronger, so electrophilic reagents are more inclined to attack the positions adjacent to or opposite fluorine atoms on the benzene ring.
Its physical properties are also related to chemical properties. Due to the presence of halogen atoms in the molecule, it has a certain polarity and can be soluble in organic solvents. The melting boiling point varies depending on the intermolecular forces. The number of halogen atoms increases, the intermolecular forces increase, and the melting boiling point also increases accordingly.
4-chloro-2-fluoroiodobenzene has a wide range of uses in the field of organic synthesis due to its unique chemical properties. Various reaction paths can be used to obtain various valuable organic compounds.
What are 4-chloro-2-fluoroiodobenzene synthesis methods?
The synthesis method of 4-chloro-2-fluoroiodobenzene has been explored by chemists throughout the ages. The methods vary and each has its own strengths.
First, the method of using halogenated aromatic hydrocarbons as starting materials. First take a suitable halogenated benzene, such as 4-chloro-2-fluorobenzene, so that the substitution reaction occurs with the iodine source. Common iodine sources, such as potassium iodide, iodine elemental substance, etc. During the reaction, a catalyst is often added to promote the smooth progress of the reaction. For example, a copper salt catalyst, such as cuprous iodide, can be used with an appropriate ligand, such as 1,10-phenanthroline. In a suitable solvent, such as N, N-dimethylformamide (DMF), control the reaction temperature and time, so that the chlorine atom is replaced by the iodine atom, resulting in 4-chloro-2-fluoroiodobenzene. This solvent has good polarity and can dissolve many reactants, which is conducive to the collision between reaction molecules and improves the reaction efficiency. Temperature control is very critical, and it is generally carried out under heating and reflux conditions. The time depends on the reaction process, and it often takes several hours to ten hours.
Second, it is converted by aryl borate esters. First, 4-chloro-2-fluorophenylborate was prepared, which can be prepared by the reaction of 4-chloro-2-fluorobromobenzene with borate ester reagent under palladium catalysis. Subsequently, the borate ester is reacted with an iodine reagent. The iodine reagent can be selected as N-iodosuccinimide (NIS). Under basic conditions, it can be reacted in a suitable organic solvent such as tetrahydrofuran (THF). The alkaline environment can help the borate to be converted into an active intermediate and react smoothly with the iodine reagent. As a common organic solvent, tetrahydrofuran has stable properties and has little impact on the reaction system. It can make the reaction occur smoothly, and the final product is 4-chloro-2-fluoroiodobenzene.
Third, the reaction of diazonium salts is used. First, 4-chloro-2-fluoroaniline is converted into diazonium salts through diazotization reaction. Sodium nitrite and hydrochloric acid are used as reagents to perform diazotization at low temperature to form a stable diazonium salt solution. After that, potassium iodide solution is added, and the diazonium group is replaced by iodine atoms to obtain 4-chloro-2-fluoroiodobenzene. Low temperature conditions can prevent the decomposition of diazonium salts and ensure that the
The above synthesis methods are selected by chemists according to factors such as the availability of raw materials, the difficulty of reaction conditions, and the high or low yield, in order to efficiently prepare 4-chloro-2-fluoroiodobenzene.
First, the method of using halogenated aromatic hydrocarbons as starting materials. First take a suitable halogenated benzene, such as 4-chloro-2-fluorobenzene, so that the substitution reaction occurs with the iodine source. Common iodine sources, such as potassium iodide, iodine elemental substance, etc. During the reaction, a catalyst is often added to promote the smooth progress of the reaction. For example, a copper salt catalyst, such as cuprous iodide, can be used with an appropriate ligand, such as 1,10-phenanthroline. In a suitable solvent, such as N, N-dimethylformamide (DMF), control the reaction temperature and time, so that the chlorine atom is replaced by the iodine atom, resulting in 4-chloro-2-fluoroiodobenzene. This solvent has good polarity and can dissolve many reactants, which is conducive to the collision between reaction molecules and improves the reaction efficiency. Temperature control is very critical, and it is generally carried out under heating and reflux conditions. The time depends on the reaction process, and it often takes several hours to ten hours.
Second, it is converted by aryl borate esters. First, 4-chloro-2-fluorophenylborate was prepared, which can be prepared by the reaction of 4-chloro-2-fluorobromobenzene with borate ester reagent under palladium catalysis. Subsequently, the borate ester is reacted with an iodine reagent. The iodine reagent can be selected as N-iodosuccinimide (NIS). Under basic conditions, it can be reacted in a suitable organic solvent such as tetrahydrofuran (THF). The alkaline environment can help the borate to be converted into an active intermediate and react smoothly with the iodine reagent. As a common organic solvent, tetrahydrofuran has stable properties and has little impact on the reaction system. It can make the reaction occur smoothly, and the final product is 4-chloro-2-fluoroiodobenzene.
Third, the reaction of diazonium salts is used. First, 4-chloro-2-fluoroaniline is converted into diazonium salts through diazotization reaction. Sodium nitrite and hydrochloric acid are used as reagents to perform diazotization at low temperature to form a stable diazonium salt solution. After that, potassium iodide solution is added, and the diazonium group is replaced by iodine atoms to obtain 4-chloro-2-fluoroiodobenzene. Low temperature conditions can prevent the decomposition of diazonium salts and ensure that the
The above synthesis methods are selected by chemists according to factors such as the availability of raw materials, the difficulty of reaction conditions, and the high or low yield, in order to efficiently prepare 4-chloro-2-fluoroiodobenzene.
4-chloro-2-fluoroiodobenzene in what areas?
4-Chloro-2-fluoroiodobenzene is useful in many fields.
In the field of medicinal chemistry, it can be an important intermediate in organic synthesis. Physicians want to make special drugs, often rely on this compound. With its unique structure, various functional groups can be introduced through delicate chemical reactions, and then molecules with specific pharmacological activities can be constructed. For example, to make antibacterial agents, 4-chloro-2-fluoroiodobenzene can be used to start, and after several steps of reaction, substances with antibacterial activity can be obtained to help heal diseases.
In the field of material science, it also has its own extraordinary. In today's world, the search for special performance materials is increasingly important. 4-Chloro-2-fluoroiodobenzene can be used to synthesize materials with special optical and electrical properties. For example, in the preparation of organic optoelectronic materials, it can be integrated into the material structure, or the electronic transport characteristics of the material can be changed, making it suitable for organic Light Emitting Diode (OLED), solar cells and other devices to improve the efficiency of the device.
In the field of pesticide chemistry, this compound is also promising. To make high-efficiency and low-toxicity pesticides, 4-chloro-2-fluoroiodobenzene can be used as a starting material. After chemical modification, pesticides with insecticidal, weeding and other effects can be obtained, which can help agriculture, ensure the growth of crops, and reduce the infestation of diseases and pests.
In addition, in the field of fine chemicals, it can be used to synthesize special dyes, fragrances, etc. The production of dyes, adding this compound, may make dyes have better color, light resistance and other characteristics; the production of fragrances, using it to participate in the reaction, or to obtain a unique aroma of fragrances, pleasing to the sense of smell. In short, 4-chloro-2-fluoroiodobenzene is an indispensable substance in many industries and has important application value.
In the field of medicinal chemistry, it can be an important intermediate in organic synthesis. Physicians want to make special drugs, often rely on this compound. With its unique structure, various functional groups can be introduced through delicate chemical reactions, and then molecules with specific pharmacological activities can be constructed. For example, to make antibacterial agents, 4-chloro-2-fluoroiodobenzene can be used to start, and after several steps of reaction, substances with antibacterial activity can be obtained to help heal diseases.
In the field of material science, it also has its own extraordinary. In today's world, the search for special performance materials is increasingly important. 4-Chloro-2-fluoroiodobenzene can be used to synthesize materials with special optical and electrical properties. For example, in the preparation of organic optoelectronic materials, it can be integrated into the material structure, or the electronic transport characteristics of the material can be changed, making it suitable for organic Light Emitting Diode (OLED), solar cells and other devices to improve the efficiency of the device.
In the field of pesticide chemistry, this compound is also promising. To make high-efficiency and low-toxicity pesticides, 4-chloro-2-fluoroiodobenzene can be used as a starting material. After chemical modification, pesticides with insecticidal, weeding and other effects can be obtained, which can help agriculture, ensure the growth of crops, and reduce the infestation of diseases and pests.
In addition, in the field of fine chemicals, it can be used to synthesize special dyes, fragrances, etc. The production of dyes, adding this compound, may make dyes have better color, light resistance and other characteristics; the production of fragrances, using it to participate in the reaction, or to obtain a unique aroma of fragrances, pleasing to the sense of smell. In short, 4-chloro-2-fluoroiodobenzene is an indispensable substance in many industries and has important application value.
What is the market outlook for 4-chloro-2-fluoroiodobenzene?
4-Chloro-2-fluoroiodobenzene is a key intermediate in the field of organic synthesis. Looking at its market prospects, many factors are intertwined and have a huge impact.
From the perspective of pharmaceutical and chemical industry, pharmaceutical research and development is changing with each passing day, and the demand for fine chemicals with specific functional groups is increasing. 4-chloro-2-fluoroiodobenzene has chlorine, fluorine, iodine and other atoms, which can play a unique role in constructing complex drug molecular structures. Other groups can be precisely introduced through various chemical reactions to form compounds with specific physiological activities. Therefore, with the advancement of innovative drug research and development, the demand for them may be on the rise.
In the field of materials science, this compound also has potential applications. With the vigorous development of electronic materials, optical materials and other fields, the demand for organic materials with special structures and properties has increased. 4-Chloro-2-fluoroiodobenzene may be used as a raw material to prepare materials with special photoelectric properties through a specific synthesis path, such as materials used in organic Light Emitting Diode (OLED), solar cells and other fields, which also opens up a broad market space for it.
However, it is also necessary to consider the challenges it faces. The process of synthesizing 4-chloro-2-fluoroiodobenzene involves complex reaction steps and strict reaction conditions, and cost control becomes a problem. If the production cost cannot be effectively reduced, its promotion and application may be hindered in the market competition. And new methods and new materials in the field of chemical synthesis continue to emerge. If more convenient, efficient and economical alternatives appear, the market share of 4-chloro-2-fluoroiodobenzene may be eroded.
Overall, 4-chloro-2-fluoroiodobenzene has potential opportunities in the fields of medicine, chemical industry and materials science, and the prospects are relatively promising. To fully seize this opportunity, it is necessary to overcome challenges such as cost control and competition in order to occupy a place in the market and seek long-term development.
From the perspective of pharmaceutical and chemical industry, pharmaceutical research and development is changing with each passing day, and the demand for fine chemicals with specific functional groups is increasing. 4-chloro-2-fluoroiodobenzene has chlorine, fluorine, iodine and other atoms, which can play a unique role in constructing complex drug molecular structures. Other groups can be precisely introduced through various chemical reactions to form compounds with specific physiological activities. Therefore, with the advancement of innovative drug research and development, the demand for them may be on the rise.
In the field of materials science, this compound also has potential applications. With the vigorous development of electronic materials, optical materials and other fields, the demand for organic materials with special structures and properties has increased. 4-Chloro-2-fluoroiodobenzene may be used as a raw material to prepare materials with special photoelectric properties through a specific synthesis path, such as materials used in organic Light Emitting Diode (OLED), solar cells and other fields, which also opens up a broad market space for it.
However, it is also necessary to consider the challenges it faces. The process of synthesizing 4-chloro-2-fluoroiodobenzene involves complex reaction steps and strict reaction conditions, and cost control becomes a problem. If the production cost cannot be effectively reduced, its promotion and application may be hindered in the market competition. And new methods and new materials in the field of chemical synthesis continue to emerge. If more convenient, efficient and economical alternatives appear, the market share of 4-chloro-2-fluoroiodobenzene may be eroded.
Overall, 4-chloro-2-fluoroiodobenzene has potential opportunities in the fields of medicine, chemical industry and materials science, and the prospects are relatively promising. To fully seize this opportunity, it is necessary to overcome challenges such as cost control and competition in order to occupy a place in the market and seek long-term development.
What are the precautions in the preparation of 4-chloro-2-fluoroiodobenzene?
When preparing 4-chloro-2-fluoroiodobenzene, many matters need careful attention.
The choice of starting materials is crucial. The selected raw materials must not only be of good purity, but also have stable properties, so as to ensure the smooth progress of the reaction and reduce the growth of side reactions. For example, if halogenated benzene is used as the starting material, the activity and localization effect of the halogen atom have a significant impact on the check point and rate of the subsequent reaction.
The control of the reaction conditions cannot be ignored. If the temperature is too high, the reaction may go out of control and produce many by-products; if it is too low, the reaction rate will be slow and time-consuming. Taking nucleophilic substitution reactions as an example, a slight deviation in temperature will greatly affect the yield and purity of the product. The properties of the reaction solvents are also quite important. The choice of polar solvents or non-polar solvents will change the solubility and reactivity of the reactants. For example, in some reactions, polar aprotic solvents can effectively promote the activity of nucleophiles and improve the reaction efficiency. The use of
catalysts needs to be carefully considered. Different types of catalysts have significant differences in the catalytic effect of the reaction. Although some metal catalysts can speed up the reaction rate, the amount of dosage and catalytic activity are all related to the quality of the product. Excessive use of catalysts or excessive reaction can damage the purity of the product.
The monitoring of the reaction process is also of paramount importance. By means of thin-layer chromatography (TLC) and gas chromatography (GC), the reaction process can be observed in real time, and the reaction conditions can be adjusted in a timely manner. Once the reaction is found to deviate from expectations, such as the increase in the amount of by-products generated, timely measures can be taken, or the temperature can be changed, or the proportion of reactants can be adjusted, to ensure that the reaction proceeds in the direction of generating the target product.
Post-processing steps should not be underestimated. The separation and purification of the product is related to the purity of the final product. The rational selection of extraction, distillation, recrystallization and other methods depends on the nature of the product and impurities. During extraction, if the choice of extractant is not appropriate, or the impurities cannot be effectively separated; during distillation, the temperature and pressure are not properly controlled, or the product is lost.
All of these, when preparing 4-chloro-2-fluoroiodobenzene, the raw materials, reaction conditions, catalysts, reaction monitoring and post-processing all need to be carefully controlled, and a slight difference will affect the quality and yield of the product.
The choice of starting materials is crucial. The selected raw materials must not only be of good purity, but also have stable properties, so as to ensure the smooth progress of the reaction and reduce the growth of side reactions. For example, if halogenated benzene is used as the starting material, the activity and localization effect of the halogen atom have a significant impact on the check point and rate of the subsequent reaction.
The control of the reaction conditions cannot be ignored. If the temperature is too high, the reaction may go out of control and produce many by-products; if it is too low, the reaction rate will be slow and time-consuming. Taking nucleophilic substitution reactions as an example, a slight deviation in temperature will greatly affect the yield and purity of the product. The properties of the reaction solvents are also quite important. The choice of polar solvents or non-polar solvents will change the solubility and reactivity of the reactants. For example, in some reactions, polar aprotic solvents can effectively promote the activity of nucleophiles and improve the reaction efficiency. The use of
catalysts needs to be carefully considered. Different types of catalysts have significant differences in the catalytic effect of the reaction. Although some metal catalysts can speed up the reaction rate, the amount of dosage and catalytic activity are all related to the quality of the product. Excessive use of catalysts or excessive reaction can damage the purity of the product.
The monitoring of the reaction process is also of paramount importance. By means of thin-layer chromatography (TLC) and gas chromatography (GC), the reaction process can be observed in real time, and the reaction conditions can be adjusted in a timely manner. Once the reaction is found to deviate from expectations, such as the increase in the amount of by-products generated, timely measures can be taken, or the temperature can be changed, or the proportion of reactants can be adjusted, to ensure that the reaction proceeds in the direction of generating the target product.
Post-processing steps should not be underestimated. The separation and purification of the product is related to the purity of the final product. The rational selection of extraction, distillation, recrystallization and other methods depends on the nature of the product and impurities. During extraction, if the choice of extractant is not appropriate, or the impurities cannot be effectively separated; during distillation, the temperature and pressure are not properly controlled, or the product is lost.
All of these, when preparing 4-chloro-2-fluoroiodobenzene, the raw materials, reaction conditions, catalysts, reaction monitoring and post-processing all need to be carefully controlled, and a slight difference will affect the quality and yield of the product.
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