Linshang Chemical
PRODUCTS
4-Chloro-2-Fluoronitrobenzene
Linshang Chemical
|
HS Code |
972792 |
| Chemical Formula | C6H3ClFNO2 |
| Molecular Weight | 177.545 g/mol |
| Appearance | Yellow - brown liquid or solid |
| Boiling Point | 230 - 232 °C |
| Melting Point | 15 - 18 °C |
| Density | 1.488 g/cm³ (at 20 °C) |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in many organic solvents like ethanol, ether |
| Flash Point | 102 °C |
| Vapor Pressure | Low vapor pressure |
As an accredited 4-Chloro-2-Fluoronitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chloro - 2 - fluoronitrobenzene packaged in a sealed, corrosion - resistant container. |
| Storage | 4 - chloro - 2 - fluoronitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat, sparks, and open flames. Keep it in a tightly sealed container to prevent leakage. Store it separately from oxidizing agents, reducing agents, and other reactive substances. Avoid storage near food, beverages, and animal feed to prevent contamination. |
| Shipping | 4 - chloro - 2 - fluoronitrobenzene is shipped in tightly sealed, corrosion - resistant containers. It's transported under regulated conditions, following strict safety protocols due to its chemical nature, ensuring secure delivery. |
Competitive 4-Chloro-2-Fluoronitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4-Chloro-2-Fluoronitrobenzene in China?
As a trusted 4-Chloro-2-Fluoronitrobenzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-Chloro-2-Fluoronitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 4-chloro-2-fluoronitrobenzene?
4-Chloro-2-fluoronitrobenzene is an important agent in organic synthesis. It has a wide range of uses and is important in the fields of medicine, pesticides, dyes, etc.
In the field of medicine, it is often the key intermediate for the synthesis of special drugs. Due to the characteristics of chlorine, fluorine and nitro groups in its molecular structure, it is endowed with specific chemical activity and reactivity. It can introduce the required functional groups through various chemical reactions, and then build complex drug molecular structures to prepare drugs with specific pharmacological activities.
In pesticides, 4-chloro-2-fluoronitrobenzene also plays an important role. It can be used as a starting material to synthesize highly efficient pesticide varieties through a series of transformations. The presence of fluorine and chlorine atoms may enhance the toxicity, stability and environmental adaptability of pesticides to pests, while nitro groups can change the electron cloud distribution of compounds, affect their interaction with targets in organisms, and improve the insecticidal, bactericidal or herbicidal effectiveness of pesticides.
In the dye industry, this compound is also indispensable. It can be connected to the molecular structure of the dye through an appropriate reaction path, giving the dye a special color, fastness and application performance. Because its structure can be designed and modified to meet the needs of different dyes, such as acid dyes, reactive dyes, etc., it can help to produce dye products with rich colors and excellent performance. In conclusion, 4-chloro-2-fluoronitrobenzene plays a key role in many industrial fields due to its unique molecular structure and chemical properties, providing an important material basis for the development of related industries.
In the field of medicine, it is often the key intermediate for the synthesis of special drugs. Due to the characteristics of chlorine, fluorine and nitro groups in its molecular structure, it is endowed with specific chemical activity and reactivity. It can introduce the required functional groups through various chemical reactions, and then build complex drug molecular structures to prepare drugs with specific pharmacological activities.
In pesticides, 4-chloro-2-fluoronitrobenzene also plays an important role. It can be used as a starting material to synthesize highly efficient pesticide varieties through a series of transformations. The presence of fluorine and chlorine atoms may enhance the toxicity, stability and environmental adaptability of pesticides to pests, while nitro groups can change the electron cloud distribution of compounds, affect their interaction with targets in organisms, and improve the insecticidal, bactericidal or herbicidal effectiveness of pesticides.
In the dye industry, this compound is also indispensable. It can be connected to the molecular structure of the dye through an appropriate reaction path, giving the dye a special color, fastness and application performance. Because its structure can be designed and modified to meet the needs of different dyes, such as acid dyes, reactive dyes, etc., it can help to produce dye products with rich colors and excellent performance. In conclusion, 4-chloro-2-fluoronitrobenzene plays a key role in many industrial fields due to its unique molecular structure and chemical properties, providing an important material basis for the development of related industries.
What are the physical properties of 4-chloro-2-fluoronitrobenzene?
4-Chloro-2-fluoronitrobenzene is one of the organic compounds. Its physical properties are unique and it is of great importance in the chemical industry.
First of all, its appearance is usually a light yellow to light brown crystalline solid. Looking at it, it is quite textured and has a unique color, which is the characteristic of its appearance.
The melting point is about 35-38 ° C. When the ambient temperature gradually rises, the substance slowly melts from the solid state to the liquid state. The characteristics of the melting point are crucial in the separation, purification and identification of substances.
As for the boiling point, it is probably at 240-242 ° C. At this temperature, 4-chloro-2-fluoronitrobenzene converts from liquid to gaseous state, which is related to its distillation and fractionation operations in chemical processes.
Its density is about 1.52 g/cm ³, which is heavier than water. When placed in water, this substance will sink to the bottom of the water. This density characteristic is indispensable when involving processes such as liquid-liquid separation.
In terms of solubility, 4-chloro-2-fluoronitrobenzene is insoluble in water, but soluble in organic solvents such as ethanol, ether, and acetone. Such differences in solubility have a significant impact on the extraction of substances and the selection of reaction media.
In addition, 4-chloro-2-fluoronitrobenzene has a certain volatility and can evaporate slowly in the air. This is also one end of its physical properties. During storage and use, attention should be paid.
In summary, the physical properties of 4-chloro-2-fluoronitrobenzene are diverse, and each property is interrelated, which together determine its application and treatment in chemical production, scientific research experiments and many other fields.
First of all, its appearance is usually a light yellow to light brown crystalline solid. Looking at it, it is quite textured and has a unique color, which is the characteristic of its appearance.
The melting point is about 35-38 ° C. When the ambient temperature gradually rises, the substance slowly melts from the solid state to the liquid state. The characteristics of the melting point are crucial in the separation, purification and identification of substances.
As for the boiling point, it is probably at 240-242 ° C. At this temperature, 4-chloro-2-fluoronitrobenzene converts from liquid to gaseous state, which is related to its distillation and fractionation operations in chemical processes.
Its density is about 1.52 g/cm ³, which is heavier than water. When placed in water, this substance will sink to the bottom of the water. This density characteristic is indispensable when involving processes such as liquid-liquid separation.
In terms of solubility, 4-chloro-2-fluoronitrobenzene is insoluble in water, but soluble in organic solvents such as ethanol, ether, and acetone. Such differences in solubility have a significant impact on the extraction of substances and the selection of reaction media.
In addition, 4-chloro-2-fluoronitrobenzene has a certain volatility and can evaporate slowly in the air. This is also one end of its physical properties. During storage and use, attention should be paid.
In summary, the physical properties of 4-chloro-2-fluoronitrobenzene are diverse, and each property is interrelated, which together determine its application and treatment in chemical production, scientific research experiments and many other fields.
What is the chemistry of 4-chloro-2-fluoronitrobenzene?
4-Chloro-2-fluoronitrobenzene is also an organic compound. It has unique chemical properties. In this substance, the presence of chlorine, fluorine and nitro groups significantly affects its reactivity and characteristics.
In terms of reactivity, the nitro group is a strong electron-absorbing group, which can reduce the electron cloud density of the benzene ring and cause the activity of the electrophilic substitution of the benzene ring to decrease. However, it can enhance the positive electricity of the carbon atoms in the o-and para-position of the benzene ring, making it easier for nucleophiles to attack this position. In this compound, although the chlorine and fluorine atoms are also electron-absorbing groups, their electron-absorbing ability is weaker than that of the nitro group.
Chlorine atoms can make benzene ring ortho and para-sites more vulnerable to nucleophilic reagents due to their electronic effects. In nucleophilic substitution reactions, chlorine atoms can be replaced by a variety of nucleophilic reagents, such as hydroxyl groups, amino groups, etc. Fluorine atoms have a small radius and large electronegativity, and their existence also affects the electron cloud distribution and spatial structure of molecules. Fluorine substituents can enhance the stability of molecules and have an impact on reaction selectivity.
4-chloro-2-fluoronitrobenzene has a wide range of uses in the field of organic synthesis. It is often used as an intermediate in the preparation of various drugs, pesticides and functional materials. During the reaction, the reaction conditions and reagents should be carefully selected according to their chemical properties to achieve the expected reaction effect and product purity. In short, its chemical properties are complex and have important application value, and it plays an important role in the research and practical production of organic chemistry.
In terms of reactivity, the nitro group is a strong electron-absorbing group, which can reduce the electron cloud density of the benzene ring and cause the activity of the electrophilic substitution of the benzene ring to decrease. However, it can enhance the positive electricity of the carbon atoms in the o-and para-position of the benzene ring, making it easier for nucleophiles to attack this position. In this compound, although the chlorine and fluorine atoms are also electron-absorbing groups, their electron-absorbing ability is weaker than that of the nitro group.
Chlorine atoms can make benzene ring ortho and para-sites more vulnerable to nucleophilic reagents due to their electronic effects. In nucleophilic substitution reactions, chlorine atoms can be replaced by a variety of nucleophilic reagents, such as hydroxyl groups, amino groups, etc. Fluorine atoms have a small radius and large electronegativity, and their existence also affects the electron cloud distribution and spatial structure of molecules. Fluorine substituents can enhance the stability of molecules and have an impact on reaction selectivity.
4-chloro-2-fluoronitrobenzene has a wide range of uses in the field of organic synthesis. It is often used as an intermediate in the preparation of various drugs, pesticides and functional materials. During the reaction, the reaction conditions and reagents should be carefully selected according to their chemical properties to achieve the expected reaction effect and product purity. In short, its chemical properties are complex and have important application value, and it plays an important role in the research and practical production of organic chemistry.
What is 4-chloro-2-fluoronitrobenzene production method?
4-Chloro-2-fluoronitrobenzene is also an important intermediate in organic synthesis. There are several common methods for its preparation.
First, 4-chloro-2-fluoroaniline is used as the starting material. First, it is co-diazotized with sodium nitrite and hydrochloric acid. This process needs to be in a low temperature environment, about 0-5 ° C, so diazonium salts can be obtained. After that, the diazonium salt is co-heated with sodium nitrite and copper powder, and the diazo group is replaced by a nitro group through a Sandmeyer reaction, thereby 4-chloro-2-fluoronitrobenzene is prepared. Although this method is more classical, the steps are slightly complicated, and the diazotization reaction needs to be handled with caution to ensure safety and yield.
Second, starting from 2-fluoro-4-chlorobenzoic acid. First, it is converted into an acid chloride, which is often obtained by the action of thionyl chloride. Then, the acid chloride is reacted with ammonia to form an amide. The amide is then treated with a Hofmann degradation reaction. Under basic conditions, the amide group is converted into an amino group and decarboxylated to form 4-chloro-2-fluoroaniline. After that, as in the first method, the nitro group is introduced through diazotization and Sandmeier reaction to obtain the target product. There are many steps in this path, but the raw materials are relatively easy to obtain, and the reaction conditions for each step are relatively mature.
Third, 2,4-dichlorofluorobenzene is used as the raw material. By using nitrification reaction, under the action of suitable nitrifying reagents, such as mixed acid (mixture of concentrated sulfuric acid and concentrated nitric acid), at a suitable temperature of about 50-70 ° C, nitro groups are selectively introduced into the benzene ring to obtain 4-chloro-2-fluoronitrobenzene. This method is relatively simple and the reaction conditions are not harsh. However, attention should be paid to the selectivity of the reaction. Because the original chlorine and fluorine atoms on the benzene ring may affect the position of nitro introduction, by controlling the reaction conditions and the proportion of reagents, the yield of the target product can be improved.
All kinds of production methods have advantages and disadvantages. In actual production, we should comprehensively weigh the availability of raw materials, cost, yield and product purity, and choose the best one.
First, 4-chloro-2-fluoroaniline is used as the starting material. First, it is co-diazotized with sodium nitrite and hydrochloric acid. This process needs to be in a low temperature environment, about 0-5 ° C, so diazonium salts can be obtained. After that, the diazonium salt is co-heated with sodium nitrite and copper powder, and the diazo group is replaced by a nitro group through a Sandmeyer reaction, thereby 4-chloro-2-fluoronitrobenzene is prepared. Although this method is more classical, the steps are slightly complicated, and the diazotization reaction needs to be handled with caution to ensure safety and yield.
Second, starting from 2-fluoro-4-chlorobenzoic acid. First, it is converted into an acid chloride, which is often obtained by the action of thionyl chloride. Then, the acid chloride is reacted with ammonia to form an amide. The amide is then treated with a Hofmann degradation reaction. Under basic conditions, the amide group is converted into an amino group and decarboxylated to form 4-chloro-2-fluoroaniline. After that, as in the first method, the nitro group is introduced through diazotization and Sandmeier reaction to obtain the target product. There are many steps in this path, but the raw materials are relatively easy to obtain, and the reaction conditions for each step are relatively mature.
Third, 2,4-dichlorofluorobenzene is used as the raw material. By using nitrification reaction, under the action of suitable nitrifying reagents, such as mixed acid (mixture of concentrated sulfuric acid and concentrated nitric acid), at a suitable temperature of about 50-70 ° C, nitro groups are selectively introduced into the benzene ring to obtain 4-chloro-2-fluoronitrobenzene. This method is relatively simple and the reaction conditions are not harsh. However, attention should be paid to the selectivity of the reaction. Because the original chlorine and fluorine atoms on the benzene ring may affect the position of nitro introduction, by controlling the reaction conditions and the proportion of reagents, the yield of the target product can be improved.
All kinds of production methods have advantages and disadvantages. In actual production, we should comprehensively weigh the availability of raw materials, cost, yield and product purity, and choose the best one.
What are the precautions in storage and transportation of 4-chloro-2-fluoronitrobenzene?
4-Chloro-2-fluoronitrobenzene is an important intermediate in organic synthesis. When storing and transporting it, many key matters must be paid attention to.
When storing, choose the first environment. It should be placed in a cool, dry and well-ventilated place, away from fires and heat sources. This is because of its flammability and toxicity, high temperature or open flame is easily dangerous. The warehouse temperature should be controlled within an appropriate range to prevent changes in material properties.
Furthermore, ensure that the storage container is well sealed. If 4-chloro-2-fluoronitrobenzene comes into contact with air and moisture, or reacts chemically, it will affect the quality and even produce harmful products. The container material also needs to be adapted to prevent corrosion leakage.
In addition, the storage area should be stored separately from oxidants, acids, alkalis, etc., and must not be mixed. Due to its active chemical properties, contact with these substances or cause violent reactions, causing serious consequences such as explosion.
During transportation, the packaging must be tight and stable. Select appropriate packaging materials to ensure that it is not damaged and leaked during bumps and vibrations. Transportation vehicles must also meet safety standards and be equipped with corresponding fire and emergency equipment.
Transportation personnel need to be professionally trained and familiar with the dangerous characteristics of 4-chloro-2-fluoronitrobenzene and emergency treatment methods. During driving, be careful to avoid sudden braking, sharp turns, etc., to prevent damage to the packaging.
And the status of the goods should be monitored at any time during transportation. In case of leakage and other emergencies, emergency plans should be initiated immediately, the crowd should be evacuated, and effective leak plugging and cleaning measures should be taken to ensure the safety of personnel and the environment from pollution.
When storing, choose the first environment. It should be placed in a cool, dry and well-ventilated place, away from fires and heat sources. This is because of its flammability and toxicity, high temperature or open flame is easily dangerous. The warehouse temperature should be controlled within an appropriate range to prevent changes in material properties.
Furthermore, ensure that the storage container is well sealed. If 4-chloro-2-fluoronitrobenzene comes into contact with air and moisture, or reacts chemically, it will affect the quality and even produce harmful products. The container material also needs to be adapted to prevent corrosion leakage.
In addition, the storage area should be stored separately from oxidants, acids, alkalis, etc., and must not be mixed. Due to its active chemical properties, contact with these substances or cause violent reactions, causing serious consequences such as explosion.
During transportation, the packaging must be tight and stable. Select appropriate packaging materials to ensure that it is not damaged and leaked during bumps and vibrations. Transportation vehicles must also meet safety standards and be equipped with corresponding fire and emergency equipment.
Transportation personnel need to be professionally trained and familiar with the dangerous characteristics of 4-chloro-2-fluoronitrobenzene and emergency treatment methods. During driving, be careful to avoid sudden braking, sharp turns, etc., to prevent damage to the packaging.
And the status of the goods should be monitored at any time during transportation. In case of leakage and other emergencies, emergency plans should be initiated immediately, the crowd should be evacuated, and effective leak plugging and cleaning measures should be taken to ensure the safety of personnel and the environment from pollution.
Scan to WhatsApp
