Linshang Chemical
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4-Chloro-2-Iodo-1-Methylbenzene
Linshang Chemical
|
HS Code |
564850 |
| Chemical Formula | C7H6ClI |
| Molar Mass | 254.48 g/mol |
| Appearance | likely a colorless to pale - yellow liquid or solid |
| Solubility In Water | insoluble (due to non - polar nature of benzene ring) |
| Solubility In Organic Solvents | soluble in common organic solvents like ethanol, ether, etc. |
| Odor | likely has an aromatic odor characteristic of benzene derivatives |
| Reactivity | can undergo substitution reactions due to the presence of halogen atoms |
As an accredited 4-Chloro-2-Iodo-1-Methylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chloro - 2 - iodo - 1 - methylbenzene packaged in a sealed glass bottle. |
| Storage | 4 - chloro - 2 - iodo - 1 - methylbenzene should be stored in a cool, dry, well - ventilated area, away from sources of heat, ignition, and direct sunlight. It should be stored in a tightly - sealed container, preferably made of a material resistant to corrosion. Keep it separated from oxidizing agents and incompatible substances to prevent reactions. Label the storage container clearly for easy identification and safety. |
| Shipping | 4 - chloro - 2 - iodo - 1 - methylbenzene is shipped in well - sealed, corrosion - resistant containers. It's transported by specialized chemical carriers following strict safety regulations to prevent leakage and ensure safe delivery. |
Competitive 4-Chloro-2-Iodo-1-Methylbenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What is the chemical structure of 4-chloro-2-iodo-1-methylbenzene?
4-Chloro-2-iodine-1-methylbenzene is also an organic compound. Looking at its name, we can know the approximate molecular structure. "Benzene" is a hexavalent cyclic aromatic hydrocarbon group with unique stability and chemical properties. There are three substituents on its ring, namely "chlorine", "iodine" and "methyl".
"4-chlorine", that is, the fourth carbon atom on the benzene ring is connected to a chlorine atom. This chlorine atom is connected to the benzene ring carbon by a covalent bond. The chlorine atom has a certain electronegativity, which can affect the electron cloud distribution of the benzene ring, and then affect the reactivity of the compound.
"2-Iodine" means that there is an iodine atom attached to the second carbon atom of the benzene ring. The iodine atom is relatively large, and its electron cloud distribution is different from that of the chlorine atom. It also plays an important role in the electron cloud state of the benzene ring and the spatial structure of the whole molecule.
"1-methyl" means that the first carbon atom of the benzene ring is connected to a methyl group (-CH 🥰). The methyl group is the power supply group, which interacts with the electron-absorbing chlorine and iodine atoms to change the electron cloud density of the benzene ring, which affects the activity and positional selectivity of reactions such as electrophilic sub
The structure of this compound is based on the benzene ring as the core, the chlorine atom occupies the fourth position of the ring, the iodine atom is in the second position, and the A is based on the first position. The spatial arrangement of each substituent shows a specific spatial relationship due to the planar structure of the benzene ring, which affects its physical and chemical properties. It may have potential uses in organic synthesis, medicinal chemistry and other fields.
"4-chlorine", that is, the fourth carbon atom on the benzene ring is connected to a chlorine atom. This chlorine atom is connected to the benzene ring carbon by a covalent bond. The chlorine atom has a certain electronegativity, which can affect the electron cloud distribution of the benzene ring, and then affect the reactivity of the compound.
"2-Iodine" means that there is an iodine atom attached to the second carbon atom of the benzene ring. The iodine atom is relatively large, and its electron cloud distribution is different from that of the chlorine atom. It also plays an important role in the electron cloud state of the benzene ring and the spatial structure of the whole molecule.
"1-methyl" means that the first carbon atom of the benzene ring is connected to a methyl group (-CH 🥰). The methyl group is the power supply group, which interacts with the electron-absorbing chlorine and iodine atoms to change the electron cloud density of the benzene ring, which affects the activity and positional selectivity of reactions such as electrophilic sub
The structure of this compound is based on the benzene ring as the core, the chlorine atom occupies the fourth position of the ring, the iodine atom is in the second position, and the A is based on the first position. The spatial arrangement of each substituent shows a specific spatial relationship due to the planar structure of the benzene ring, which affects its physical and chemical properties. It may have potential uses in organic synthesis, medicinal chemistry and other fields.
What are the physical properties of 4-chloro-2-iodo-1-methylbenzene?
4-Chloro-2-iodine-1-methylbenzene is one of the organic compounds. It has several physical properties, and let me tell you one by one.
Looking at its properties, under normal temperature and pressure, this substance may be in a liquid state, but it also varies depending on the specific conditions. Its color may be colorless to light yellow, and it is clear and clear without variegation.
As for its smell, it is a halogenated aromatic hydrocarbon or has a special aromatic smell, and slightly contains the unique smell given by halogen elements. However, the intensity of this smell is also related to the environment and the concentration of the substance.
The melting point and boiling point are affected by the presence of chlorine, iodine and methyl groups in the molecular structure. Chlorine and iodine atoms are heavier and have a certain polarity, which enhances the intermolecular force and increases the boiling point; the introduction of methyl groups modifies their physical properties. Generally speaking, when the boiling point is within a certain temperature range, the exact value needs to be accurately determined according to experiments.
In terms of solubility, this substance is insoluble in water. Because water is a polar solvent, and this compound is non-polar or weakly polar, according to the principle of "similar compatibility", the two are incompatible. However, it is soluble in common organic solvents, such as ethanol, ether, benzene, etc. This property is quite useful in organic synthesis and related experimental operations, according to which suitable solvents can be selected for reaction or separation and purification.
Above the density, the density of chlorine and iodine atoms is greater than that of water due to their relatively large atomic masses. If it is co-placed with water, it can be seen that it sinks to the bottom of the water. This property is also an important basis for identification and separation operations.
The physical properties of 4-chloro-2-iodine-1-methylbenzene are of great significance in the research, synthesis and application of organic chemistry, and can provide many key references for the development of related work.
Looking at its properties, under normal temperature and pressure, this substance may be in a liquid state, but it also varies depending on the specific conditions. Its color may be colorless to light yellow, and it is clear and clear without variegation.
As for its smell, it is a halogenated aromatic hydrocarbon or has a special aromatic smell, and slightly contains the unique smell given by halogen elements. However, the intensity of this smell is also related to the environment and the concentration of the substance.
The melting point and boiling point are affected by the presence of chlorine, iodine and methyl groups in the molecular structure. Chlorine and iodine atoms are heavier and have a certain polarity, which enhances the intermolecular force and increases the boiling point; the introduction of methyl groups modifies their physical properties. Generally speaking, when the boiling point is within a certain temperature range, the exact value needs to be accurately determined according to experiments.
In terms of solubility, this substance is insoluble in water. Because water is a polar solvent, and this compound is non-polar or weakly polar, according to the principle of "similar compatibility", the two are incompatible. However, it is soluble in common organic solvents, such as ethanol, ether, benzene, etc. This property is quite useful in organic synthesis and related experimental operations, according to which suitable solvents can be selected for reaction or separation and purification.
Above the density, the density of chlorine and iodine atoms is greater than that of water due to their relatively large atomic masses. If it is co-placed with water, it can be seen that it sinks to the bottom of the water. This property is also an important basis for identification and separation operations.
The physical properties of 4-chloro-2-iodine-1-methylbenzene are of great significance in the research, synthesis and application of organic chemistry, and can provide many key references for the development of related work.
What are the common synthetic methods of 4-chloro-2-iodo-1-methylbenzene?
4-Chloro-2-iodine-1-methylbenzene is also an organic compound. There are several common synthesis methods as follows.
First, the halogenation reaction method. Using 1-methylbenzene as the starting material, chlorine atoms can be introduced into the benzene ring through the chlorination reaction. Because methyl is an ortho-para-position group, under suitable conditions, chlorine atoms can be mainly introduced into the ortho-position or para-position of methyl. Then the iodization reaction is carried out. Under specific reagents and conditions, iodine atoms can be introduced to the target position, and then 4-chloro-2-iodine-1-methylbenzene can be obtained. In this process, a suitable chlorination agent, such as chlorine, needs to be selected during chlorination, and the reaction is carried out in the presence of light or catalyst. During iodization, the commonly used iodizing reagents, such as iodine elemental substances, cooperate with appropriate oxidizing agents to promote the smooth integration of iodine atoms into the benzene ring.
Second, the method of coupling reaction. Aromatic halide intermediates containing chlorine and iodine can be prepared separately, and the two need to have suitable substituents and reaction check points. Then, the coupling reaction catalyzed by transition metals, such as the coupling reaction catalyzed by palladium. In the presence of palladium catalyst, ligand and suitable base, the two intermediates are coupled, and then the carbon-carbon bond of the target compound is formed to achieve the synthesis of 4-chloro-2-iodine-1-methylbenzene. This method requires strict control of the reaction conditions, including temperature, reaction time, ratio of reagents, etc., in order to improve the yield and selectivity of the reaction.
Third, the method of diazonium salt conversion. With the corresponding amino compound as the starting material, the diazonium salt is first prepared. After diazotization, the amino group is converted into a diazonium group. Then, using the special reactivity of diazonium salts, chlorine atoms and iodine atoms are introduced respectively. If a suitable chlorination reagent is reacted with the diazonium salt, the diazonium group can be replaced with a chlorine atom; then an iodide can be reacted with it, and an iodine atom can be introduced to produce 4-chloro-2-iodine-1-methylbenzene. This process requires high conditions for the diazotization reaction, and requires low temperature and precise control of the reaction process to prevent side reactions such as decomposition of the diazonium salt from occurring.
First, the halogenation reaction method. Using 1-methylbenzene as the starting material, chlorine atoms can be introduced into the benzene ring through the chlorination reaction. Because methyl is an ortho-para-position group, under suitable conditions, chlorine atoms can be mainly introduced into the ortho-position or para-position of methyl. Then the iodization reaction is carried out. Under specific reagents and conditions, iodine atoms can be introduced to the target position, and then 4-chloro-2-iodine-1-methylbenzene can be obtained. In this process, a suitable chlorination agent, such as chlorine, needs to be selected during chlorination, and the reaction is carried out in the presence of light or catalyst. During iodization, the commonly used iodizing reagents, such as iodine elemental substances, cooperate with appropriate oxidizing agents to promote the smooth integration of iodine atoms into the benzene ring.
Second, the method of coupling reaction. Aromatic halide intermediates containing chlorine and iodine can be prepared separately, and the two need to have suitable substituents and reaction check points. Then, the coupling reaction catalyzed by transition metals, such as the coupling reaction catalyzed by palladium. In the presence of palladium catalyst, ligand and suitable base, the two intermediates are coupled, and then the carbon-carbon bond of the target compound is formed to achieve the synthesis of 4-chloro-2-iodine-1-methylbenzene. This method requires strict control of the reaction conditions, including temperature, reaction time, ratio of reagents, etc., in order to improve the yield and selectivity of the reaction.
Third, the method of diazonium salt conversion. With the corresponding amino compound as the starting material, the diazonium salt is first prepared. After diazotization, the amino group is converted into a diazonium group. Then, using the special reactivity of diazonium salts, chlorine atoms and iodine atoms are introduced respectively. If a suitable chlorination reagent is reacted with the diazonium salt, the diazonium group can be replaced with a chlorine atom; then an iodide can be reacted with it, and an iodine atom can be introduced to produce 4-chloro-2-iodine-1-methylbenzene. This process requires high conditions for the diazotization reaction, and requires low temperature and precise control of the reaction process to prevent side reactions such as decomposition of the diazonium salt from occurring.
4-chloro-2-iodo-1-methylbenzene in what areas?
4-Chloro-2-iodine-1-methylbenzene, which is used in many fields.
In the field of pharmaceutical synthesis, it is often a key intermediate. The presence of halogen atoms and methyl groups gives molecules unique reactivity. Chemists can build complex drug molecules with 4-chloro-2-iodine-1-methylbenzene as starting materials through nucleophilic substitution, coupling and other reactions. For example, chlorine or iodine atoms can be replaced by groups with specific biological activities, so as to develop new drugs for specific diseases and contribute to human health.
In the field of materials science, it also has its own influence. Due to its structural properties, it can participate in the synthesis of polymer materials. By ingeniously designing reactions and introducing them into the main or side chains of polymers, the properties of materials, such as thermal stability, mechanical properties, and optical properties, can be improved. Materials synthesized on this basis may be applied to electronic devices, optical instruments, and other fields to promote the progress of related technologies.
In the field of organic synthetic chemistry, it is an extremely important building block. Researchers take advantage of the differences in the activity of halogen atoms at different positions to carry out selective reactions to synthesize organic compounds with special structures and functions. This helps to explore the relationship between the structure and properties of new organic molecules, and contributes to the development of organic chemistry theory.
In the fine chemical industry, 4-chloro-2-iodine-1-methylbenzene can be used to prepare high-end pigments, fragrances and other fine chemicals. Through subsequent chemical reactions, the product is endowed with unique color, aroma and other characteristics to meet the market demand for high-quality fine chemicals.
In the field of pharmaceutical synthesis, it is often a key intermediate. The presence of halogen atoms and methyl groups gives molecules unique reactivity. Chemists can build complex drug molecules with 4-chloro-2-iodine-1-methylbenzene as starting materials through nucleophilic substitution, coupling and other reactions. For example, chlorine or iodine atoms can be replaced by groups with specific biological activities, so as to develop new drugs for specific diseases and contribute to human health.
In the field of materials science, it also has its own influence. Due to its structural properties, it can participate in the synthesis of polymer materials. By ingeniously designing reactions and introducing them into the main or side chains of polymers, the properties of materials, such as thermal stability, mechanical properties, and optical properties, can be improved. Materials synthesized on this basis may be applied to electronic devices, optical instruments, and other fields to promote the progress of related technologies.
In the field of organic synthetic chemistry, it is an extremely important building block. Researchers take advantage of the differences in the activity of halogen atoms at different positions to carry out selective reactions to synthesize organic compounds with special structures and functions. This helps to explore the relationship between the structure and properties of new organic molecules, and contributes to the development of organic chemistry theory.
In the fine chemical industry, 4-chloro-2-iodine-1-methylbenzene can be used to prepare high-end pigments, fragrances and other fine chemicals. Through subsequent chemical reactions, the product is endowed with unique color, aroma and other characteristics to meet the market demand for high-quality fine chemicals.
What are the chemical properties of 4-chloro-2-iodo-1-methylbenzene?
4-Chloro-2-iodine-1-methylbenzene, an organic compound with rich chemical properties, is described in detail today.
The first part of its substitution reaction. Because the benzene ring is rich in electron clouds, it has a tendency to electrophilic substitution reaction. Although chlorine and iodine are electron-withdrawing groups, the electron cloud density of the neighboring and para-position of the benzene ring is still relatively high. Therefore, electrophilic reagents are prone to attack the benzene ring, causing the occurrence of substitution reactions. In case of bromine elemental catalyzed by iron bromide, bromine atoms or hydrogen atoms on the neighboring and para-position of the benzene ring are substituted to form new halogenated aromatics. This is because the electrophilic reagent is easily attracted by the benzene ring electron cloud, while the density of the adjacent and para-potential electron clouds is relatively high, which is more conducive to the reaction.
The reaction of the halogen atom is secondary. Both chlorine and iodine atoms can undergo substitution reactions. Iodine atoms have high activity because of their large atomic radius and relatively small C-I bond energy. Under the action of appropriate nucleophiles such as sodium alcohol, iodine atoms can be replaced by alkoxy groups to form corresponding ether compounds. The activity of chlorine atoms is slightly inferior to that of iodine atoms. To replace chlorine atoms, more violent reaction conditions are often required, such as higher temperatures and stronger nucleophiles.
Furthermore, methyl groups also have an impact on the properties of the compound. The electron cloud density of the benzene ring can be increased by methyl group as the power supply group, especially in the ortho and para-position. This not only affects the activity and positional selectivity of the electrophilic substitution reaction of the benzene ring, but also some specialized reactions can occur in methyl group. For example, under light or high temperature conditions, the hydrogen atom on the methyl group can be replaced by halogen free radicals to form halogenated methyl benzene derivatives.
This compound is widely used in the field of organic synthesis and can be used as a key intermediate for the synthesis of many complex organic molecules. By ingeniously designing the reaction route and taking advantage of the reactivity of its groups, rich and diverse organic structures can be constructed.
The first part of its substitution reaction. Because the benzene ring is rich in electron clouds, it has a tendency to electrophilic substitution reaction. Although chlorine and iodine are electron-withdrawing groups, the electron cloud density of the neighboring and para-position of the benzene ring is still relatively high. Therefore, electrophilic reagents are prone to attack the benzene ring, causing the occurrence of substitution reactions. In case of bromine elemental catalyzed by iron bromide, bromine atoms or hydrogen atoms on the neighboring and para-position of the benzene ring are substituted to form new halogenated aromatics. This is because the electrophilic reagent is easily attracted by the benzene ring electron cloud, while the density of the adjacent and para-potential electron clouds is relatively high, which is more conducive to the reaction.
The reaction of the halogen atom is secondary. Both chlorine and iodine atoms can undergo substitution reactions. Iodine atoms have high activity because of their large atomic radius and relatively small C-I bond energy. Under the action of appropriate nucleophiles such as sodium alcohol, iodine atoms can be replaced by alkoxy groups to form corresponding ether compounds. The activity of chlorine atoms is slightly inferior to that of iodine atoms. To replace chlorine atoms, more violent reaction conditions are often required, such as higher temperatures and stronger nucleophiles.
Furthermore, methyl groups also have an impact on the properties of the compound. The electron cloud density of the benzene ring can be increased by methyl group as the power supply group, especially in the ortho and para-position. This not only affects the activity and positional selectivity of the electrophilic substitution reaction of the benzene ring, but also some specialized reactions can occur in methyl group. For example, under light or high temperature conditions, the hydrogen atom on the methyl group can be replaced by halogen free radicals to form halogenated methyl benzene derivatives.
This compound is widely used in the field of organic synthesis and can be used as a key intermediate for the synthesis of many complex organic molecules. By ingeniously designing the reaction route and taking advantage of the reactivity of its groups, rich and diverse organic structures can be constructed.
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