Linshang Chemical
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4-Chloro-2-Methoxy-1-Methylbenzene
Linshang Chemical
|
HS Code |
539627 |
| Chemical Formula | C8H9ClO |
| Molar Mass | 156.609 g/mol |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | Around 202 - 204 °C |
| Density | Approximately 1.12 - 1.14 g/cm³ |
| Solubility | Slightly soluble in water, soluble in organic solvents like ethanol, ether |
| Odor | Aromatic odor |
| Flash Point | Around 83 - 85 °C |
| Vapor Pressure | Low vapor pressure at room temperature |
As an accredited 4-Chloro-2-Methoxy-1-Methylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chloro - 2 - methoxy - 1 - methylbenzene packaged in a sealed plastic bottle. |
| Storage | 4 - chloro - 2 - methoxy - 1 - methylbenzene should be stored in a cool, well - ventilated area, away from direct sunlight and heat sources. Keep it in a tightly closed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, strong acids, and bases to prevent potential reactions. Ensure the storage area has proper spill - containment measures. |
| Shipping | 4 - chloro - 2 - methoxy - 1 - methylbenzene should be shipped in tightly sealed, corrosion - resistant containers. It must be transported in accordance with hazardous chemical regulations, ensuring proper labeling and safe handling to prevent spills and exposure. |
Competitive 4-Chloro-2-Methoxy-1-Methylbenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 4-Chloro-2-Methoxy-1-Methylbenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemistry of 4-chloro-2-methoxy-1-methylbenzene?
4-Chloro-2-methoxy-1-methylbenzene, this is an organic compound. Its chemical properties are quite rich, and we will discuss them in detail today.
First of all, its structure, above the benzene ring, there are chlorine atoms, methoxy groups and methyl groups on each side. This unique structure makes its properties unique.
As far as its physical properties are concerned, it is mostly liquid at room temperature and has a special odor. Its boiling point, melting point and other properties are closely related to the intermolecular force. Due to the presence of chlorine atoms, methoxy groups and other functional groups in the molecule, the intermolecular force changes, and the boiling point and melting point also vary.
On its chemical properties, the electrophilic substitution reaction is firstly discussed. The benzene ring is rich in electron clouds and has a high electron density, which easily attracts electrophilic reagents. Although the chlorine atom has electron-absorbing induction effect, the methoxy group is a strong donator group, and its donator conjugation effect dominates, which makes the electron cloud density of the adjacent and para-sites of the benzene ring increase, and the electrophilic substitution reaction is more likely to occur in the adjacent and para-sites. For example, under appropriate conditions, it can be substituted with the bromine catalyzed by iron bromide to form bromogenic products.
Furthermore, the A gene is affected by the benzene ring, and its α-hydrogen has a certain activity. Under specific reagents and conditions, a substitution reaction can occur. For example, under light conditions with chlorine, α-hydrogen can be replaced by chlorine atoms.
Methoxy also exhibits unique chemical activity. The lone pair electrons on its oxygen atoms can participate in the reaction. For example, in some nucleophilic substitution reactions, the methoxy group can be used as a leaving group, or nucleophilic addition-elimination reactions occur with other reagents.
The chemical properties of 4-chloro-2-methoxy-1-methylbenzene are determined by its molecular structure. In the field of organic synthesis, its characteristics can be used to prepare many important organic compounds through ingenious design of reaction routes, which have important application value in chemical, pharmaceutical and other industries.
First of all, its structure, above the benzene ring, there are chlorine atoms, methoxy groups and methyl groups on each side. This unique structure makes its properties unique.
As far as its physical properties are concerned, it is mostly liquid at room temperature and has a special odor. Its boiling point, melting point and other properties are closely related to the intermolecular force. Due to the presence of chlorine atoms, methoxy groups and other functional groups in the molecule, the intermolecular force changes, and the boiling point and melting point also vary.
On its chemical properties, the electrophilic substitution reaction is firstly discussed. The benzene ring is rich in electron clouds and has a high electron density, which easily attracts electrophilic reagents. Although the chlorine atom has electron-absorbing induction effect, the methoxy group is a strong donator group, and its donator conjugation effect dominates, which makes the electron cloud density of the adjacent and para-sites of the benzene ring increase, and the electrophilic substitution reaction is more likely to occur in the adjacent and para-sites. For example, under appropriate conditions, it can be substituted with the bromine catalyzed by iron bromide to form bromogenic products.
Furthermore, the A gene is affected by the benzene ring, and its α-hydrogen has a certain activity. Under specific reagents and conditions, a substitution reaction can occur. For example, under light conditions with chlorine, α-hydrogen can be replaced by chlorine atoms.
Methoxy also exhibits unique chemical activity. The lone pair electrons on its oxygen atoms can participate in the reaction. For example, in some nucleophilic substitution reactions, the methoxy group can be used as a leaving group, or nucleophilic addition-elimination reactions occur with other reagents.
The chemical properties of 4-chloro-2-methoxy-1-methylbenzene are determined by its molecular structure. In the field of organic synthesis, its characteristics can be used to prepare many important organic compounds through ingenious design of reaction routes, which have important application value in chemical, pharmaceutical and other industries.
What are the physical properties of 4-chloro-2-methoxy-1-methylbenzene?
4-Chloro-2-methoxy-1-methylbenzene, this is an organic compound, and its physical properties are quite characteristic.
Looking at its properties, it is either a colorless to light yellow liquid or a solid under normal conditions, which varies depending on the specific environmental conditions. Its smell may have a special aromatic smell, but this smell is not acutely perceived by everyone and is easily disturbed by surrounding environmental factors.
When it comes to melting point and boiling point, the melting point is about a specific value, but it fluctuates slightly due to differences in impurities or measurement conditions. The boiling point also has a corresponding range. When the external pressure is standard atmospheric pressure, it will boil at a certain temperature, realizing the transformation from liquid to gas state.
As for solubility, in organic solvents, such as ethanol, ether, acetone, etc., it exhibits good solubility and can be miscible with it to form a uniform solution. However, in water, its solubility is poor. Due to the characteristics of the molecular structure of the compound, the force between it and water molecules is weak, so it is difficult to dissolve in water.
Its density is also one of the important physical properties, which may be different from that of water. In practical applications, this property is related to the distribution and stratification of substances in liquid systems.
In addition, the volatility of 4-chloro-2-methoxy-1-methylbenzene also needs attention. Under a certain temperature and environment, it will gradually evaporate into the air, and its volatilization rate is affected by factors such as temperature, surface area, and air circulation.
These physical properties are of great significance in the application of chemical industry, medicine, materials, and many other fields, and are related to the separation, purification, storage, and participation of the substance in chemical reactions. Conditions and processes.
Looking at its properties, it is either a colorless to light yellow liquid or a solid under normal conditions, which varies depending on the specific environmental conditions. Its smell may have a special aromatic smell, but this smell is not acutely perceived by everyone and is easily disturbed by surrounding environmental factors.
When it comes to melting point and boiling point, the melting point is about a specific value, but it fluctuates slightly due to differences in impurities or measurement conditions. The boiling point also has a corresponding range. When the external pressure is standard atmospheric pressure, it will boil at a certain temperature, realizing the transformation from liquid to gas state.
As for solubility, in organic solvents, such as ethanol, ether, acetone, etc., it exhibits good solubility and can be miscible with it to form a uniform solution. However, in water, its solubility is poor. Due to the characteristics of the molecular structure of the compound, the force between it and water molecules is weak, so it is difficult to dissolve in water.
Its density is also one of the important physical properties, which may be different from that of water. In practical applications, this property is related to the distribution and stratification of substances in liquid systems.
In addition, the volatility of 4-chloro-2-methoxy-1-methylbenzene also needs attention. Under a certain temperature and environment, it will gradually evaporate into the air, and its volatilization rate is affected by factors such as temperature, surface area, and air circulation.
These physical properties are of great significance in the application of chemical industry, medicine, materials, and many other fields, and are related to the separation, purification, storage, and participation of the substance in chemical reactions. Conditions and processes.
What are the main uses of 4-chloro-2-methoxy-1-methylbenzene?
4-Chloro-2-methoxy-1-methylbenzene, also known as p-chloro-o-methoxy toluene, is widely used.
In the field of organic synthesis, it plays a pivotal role. It can be used as a key intermediate for the preparation of multiple organic compounds. For example, when preparing drug molecules with specific structures, the chlorine atom, methoxy group and methyl group of 4-chloro-2-methoxy-1-methylbenzene can be introduced into other functional groups through various chemical reactions, such as nucleophilic substitution, coupling reactions, etc., to gradually build a complex drug molecular structure and help the development and production of new drugs.
In the field of materials science, it also has its place. Because the molecular structure contains specific functional groups, it can participate in the synthesis of polymer materials. After rational design and reaction, it is introduced into the main chain or side chain of the polymer to endow the material with unique properties, such as improving the solubility, thermal stability or optical properties of the material, providing the possibility for the creation of new materials.
In the field of fine chemistry, 4-chloro-2-methoxy-1-methylbenzene can be used to synthesize high-end fragrances or special dyes. Its unique molecular structure can be modified and transformed to generate compounds with specific aroma or color characteristics, meeting the market demand for high-quality fine chemicals, and enhancing the added value and market competitiveness of products.
In the field of organic synthesis, it plays a pivotal role. It can be used as a key intermediate for the preparation of multiple organic compounds. For example, when preparing drug molecules with specific structures, the chlorine atom, methoxy group and methyl group of 4-chloro-2-methoxy-1-methylbenzene can be introduced into other functional groups through various chemical reactions, such as nucleophilic substitution, coupling reactions, etc., to gradually build a complex drug molecular structure and help the development and production of new drugs.
In the field of materials science, it also has its place. Because the molecular structure contains specific functional groups, it can participate in the synthesis of polymer materials. After rational design and reaction, it is introduced into the main chain or side chain of the polymer to endow the material with unique properties, such as improving the solubility, thermal stability or optical properties of the material, providing the possibility for the creation of new materials.
In the field of fine chemistry, 4-chloro-2-methoxy-1-methylbenzene can be used to synthesize high-end fragrances or special dyes. Its unique molecular structure can be modified and transformed to generate compounds with specific aroma or color characteristics, meeting the market demand for high-quality fine chemicals, and enhancing the added value and market competitiveness of products.
What are 4-chloro-2-methoxy-1-methylbenzene synthesis methods?
The synthesis method of 4-chloro-2-methoxy-1-methylbenzene has been explored by many parties throughout the ages, and now I will describe it.
First, halogenated aromatics are used as the starting point. First, take a suitable halogenated benzene, put it in a specific reaction vessel, add an appropriate base, such as potassium carbonate, and place it in an organic solvent with a methylating agent, such as iodomethane, and heat up to perform a nucleophilic substitution reaction to obtain methoxylation products. Then, under another reaction condition, with a suitable chlorination reagent, such as thionyl chloride or chlorine gas, etc., with the help of a catalyst, a chlorination reaction is carried out, and chlorine atoms are ingeniously introduced to obtain the final target product 4-chloro-2-methoxy-1-methylbenzene.
Second, starting from phenols. First, phenolic compounds are methylated by appropriate methylation means, such as dimethyl sulfate in an alkaline environment, to obtain methoxybenzene. Then, in a specific reaction system, using the principle of halogenation reaction, selecting suitable halogenation reagents and conditions, the chlorine atom is precisely introduced at a specific position in the benzene ring. After many fine operations, this 4-chloro-2-methoxy-1-methylbenzene can also be achieved.
Third, using aromatic compounds as basic raw materials, through classic organic reactions such as Fu-G reaction. First, with a suitable acylation reagent, under the action of Lewis acid catalyst, the Fu-G acylation reaction is carried out, and a specific group is introduced into the benzene ring. Subsequently, through a series of reaction steps such as reduction, halogenation, methylation, ingenious combination, careful regulation of the reaction conditions, and gradual construction of the molecular structure, the 4-chloro-2-methoxy-1-methylbenzene can also be synthesized. Each method has its own advantages and disadvantages, and needs to be selected according to the actual situation, such as the availability of raw materials, the difficulty of the reaction, and the purity of the product.
First, halogenated aromatics are used as the starting point. First, take a suitable halogenated benzene, put it in a specific reaction vessel, add an appropriate base, such as potassium carbonate, and place it in an organic solvent with a methylating agent, such as iodomethane, and heat up to perform a nucleophilic substitution reaction to obtain methoxylation products. Then, under another reaction condition, with a suitable chlorination reagent, such as thionyl chloride or chlorine gas, etc., with the help of a catalyst, a chlorination reaction is carried out, and chlorine atoms are ingeniously introduced to obtain the final target product 4-chloro-2-methoxy-1-methylbenzene.
Second, starting from phenols. First, phenolic compounds are methylated by appropriate methylation means, such as dimethyl sulfate in an alkaline environment, to obtain methoxybenzene. Then, in a specific reaction system, using the principle of halogenation reaction, selecting suitable halogenation reagents and conditions, the chlorine atom is precisely introduced at a specific position in the benzene ring. After many fine operations, this 4-chloro-2-methoxy-1-methylbenzene can also be achieved.
Third, using aromatic compounds as basic raw materials, through classic organic reactions such as Fu-G reaction. First, with a suitable acylation reagent, under the action of Lewis acid catalyst, the Fu-G acylation reaction is carried out, and a specific group is introduced into the benzene ring. Subsequently, through a series of reaction steps such as reduction, halogenation, methylation, ingenious combination, careful regulation of the reaction conditions, and gradual construction of the molecular structure, the 4-chloro-2-methoxy-1-methylbenzene can also be synthesized. Each method has its own advantages and disadvantages, and needs to be selected according to the actual situation, such as the availability of raw materials, the difficulty of the reaction, and the purity of the product.
What are the precautions in storage and transportation of 4-chloro-2-methoxy-1-methylbenzene?
For 4-chloro-2-methoxy-1-methylbenzene, many matters need to be paid attention to during storage and transportation. This substance has certain chemical activity. When storing, the temperature and humidity of the environment should be the first priority. It should be stored in a cool, dry and well-ventilated place. If the temperature and humidity are too high, it may cause its chemical properties to change and cause deterioration.
In addition, it also has strict requirements for packaging. Packaging materials should have good sealing and corrosion resistance to prevent substances from leaking or reacting with the outside world. Usually in special sealed containers to ensure that there is no gap for air or moisture to invade.
During transportation, safety is also a top priority. It is necessary to avoid violent vibration and collision, because if it is impacted by strong external force, or the packaging is damaged, which will cause leakage. And the transportation vehicle should be equipped with corresponding emergency treatment equipment. If leakage occurs unfortunately, it can be disposed of in time to reduce the harm.
In addition, because of its toxicity and irritation, whether it is a storage place or a transportation vehicle, it should be kept away from fire sources, heat sources and crowded places to prevent major casualties in the event of an accident. When the operator comes into contact with this object, he should also be equipped with appropriate protective equipment, such as gloves, goggles and protective clothing, to ensure his own safety.
Only when storing and transporting 4-chloro-2-methoxy-1-methylbenzene, the above matters are carefully considered and properly disposed of to ensure the safety and stability of the entire process and avoid adverse consequences.
In addition, it also has strict requirements for packaging. Packaging materials should have good sealing and corrosion resistance to prevent substances from leaking or reacting with the outside world. Usually in special sealed containers to ensure that there is no gap for air or moisture to invade.
During transportation, safety is also a top priority. It is necessary to avoid violent vibration and collision, because if it is impacted by strong external force, or the packaging is damaged, which will cause leakage. And the transportation vehicle should be equipped with corresponding emergency treatment equipment. If leakage occurs unfortunately, it can be disposed of in time to reduce the harm.
In addition, because of its toxicity and irritation, whether it is a storage place or a transportation vehicle, it should be kept away from fire sources, heat sources and crowded places to prevent major casualties in the event of an accident. When the operator comes into contact with this object, he should also be equipped with appropriate protective equipment, such as gloves, goggles and protective clothing, to ensure his own safety.
Only when storing and transporting 4-chloro-2-methoxy-1-methylbenzene, the above matters are carefully considered and properly disposed of to ensure the safety and stability of the entire process and avoid adverse consequences.
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