Linshang Chemical
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4-Chloro-2-Methoxy-1-Nitrobenzene
Linshang Chemical
|
HS Code |
110332 |
| Chemical Formula | C7H6ClNO3 |
| Molar Mass | 187.58 g/mol |
| Appearance | Yellow solid |
| Boiling Point | Approximately 286 - 288 °C |
| Melting Point | 61 - 63 °C |
| Density | 1.382 g/cm³ (estimated) |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, acetone |
| Odor | Characteristic aromatic odor |
| Flash Point | Approximately 125 °C |
| Purity Typical Commercial Grade | 98%+ |
As an accredited 4-Chloro-2-Methoxy-1-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chloro - 2 - methoxy - 1 - nitrobenzene packaged in air - tight plastic bags. |
| Storage | 4 - chloro - 2 - methoxy - 1 - nitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container to prevent leakage and exposure to air. Label the storage container clearly to avoid misidentification. |
| Shipping | 4 - chloro - 2 - methoxy - 1 - nitrobenzene is a chemical. Ship it in well - sealed, corrosion - resistant containers. Label clearly with hazard warnings. Follow all regulations for transporting hazardous chemicals to ensure safe shipping. |
Competitive 4-Chloro-2-Methoxy-1-Nitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 4-Chloro-2-Methoxy-1-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 4-chloro-2-methoxy-1-nitrobenzene?
4-Chloro-2-methoxy-1-nitrobenzene is also an organic compound. It has a wide range of uses and is used in various fields of chemical industry.
The first way to synthesize medicine. Due to its unique structure, Gai can be used as a key intermediate to help synthesize a variety of specific drugs. For example, through a series of delicate chemical reactions, it can be cleverly combined with other compounds to construct molecular structures with specific pharmacological activities to treat various diseases. This is crucial in the process of pharmaceutical research and development, providing the possibility for the creation of new and good medicines.
Furthermore, it also has extraordinary functions in the creation of a field of pesticides. With its chemical properties, a variety of highly efficient and low-toxic pesticide ingredients can be derived. Such ingredients can effectively resist pests and diseases, protect crops from thriving, and ensure a bumper harvest. After scientific proportions and processing, the pesticide products made play an indispensable role in modern agricultural production.
In the field of chemical materials preparation, 4-chloro-2-methoxy-1-nitrobenzene also has a place. Some polymer materials involved in the synthesis have excellent physical and chemical properties, such as excellent heat resistance and corrosion resistance. Such materials are widely used in many industries such as electronics and machinery, contributing to the development of various industries.
In addition, it can also be seen in the dye synthesis industry. After specific chemical transformation, dyes with bright color and good stability can be obtained. Such dyes are used in fabrics dyeing and other processes to give fabrics a colorful color and satisfy people's pursuit of beauty.
In summary, 4-chloro-2-methoxy-1-nitrobenzene, with its unique chemical structure, plays an important role in many fields such as medicine, pesticides, chemical materials and dyes, and promotes the continuous development of related industries.
The first way to synthesize medicine. Due to its unique structure, Gai can be used as a key intermediate to help synthesize a variety of specific drugs. For example, through a series of delicate chemical reactions, it can be cleverly combined with other compounds to construct molecular structures with specific pharmacological activities to treat various diseases. This is crucial in the process of pharmaceutical research and development, providing the possibility for the creation of new and good medicines.
Furthermore, it also has extraordinary functions in the creation of a field of pesticides. With its chemical properties, a variety of highly efficient and low-toxic pesticide ingredients can be derived. Such ingredients can effectively resist pests and diseases, protect crops from thriving, and ensure a bumper harvest. After scientific proportions and processing, the pesticide products made play an indispensable role in modern agricultural production.
In the field of chemical materials preparation, 4-chloro-2-methoxy-1-nitrobenzene also has a place. Some polymer materials involved in the synthesis have excellent physical and chemical properties, such as excellent heat resistance and corrosion resistance. Such materials are widely used in many industries such as electronics and machinery, contributing to the development of various industries.
In addition, it can also be seen in the dye synthesis industry. After specific chemical transformation, dyes with bright color and good stability can be obtained. Such dyes are used in fabrics dyeing and other processes to give fabrics a colorful color and satisfy people's pursuit of beauty.
In summary, 4-chloro-2-methoxy-1-nitrobenzene, with its unique chemical structure, plays an important role in many fields such as medicine, pesticides, chemical materials and dyes, and promotes the continuous development of related industries.
What are the physical properties of 4-chloro-2-methoxy-1-nitrobenzene?
4-Chloro-2-methoxy-1-nitrobenzene is a kind of organic compound. Its physical properties are quite important and are related to many practical uses.
First of all, its appearance is often a light yellow to yellow crystalline solid at room temperature. This color and shape are the intuitive characteristics for identifying this substance. Its melting point is about 57-61 ° C. The melting point is the critical temperature at which a substance changes from a solid state to a liquid state. This property is crucial in the separation, purification and identification of substances. Knowing its melting point can help to distinguish the purity of this compound. If the purity is high, the melting point range is narrow and approaches the standard value; if it contains impurities, the melting point is reduced and the range is wider.
Furthermore, its boiling point is about 277 ° C. The boiling point, the temperature of the liquid when boiling, reflects the volatility of the substance. The higher boiling point indicates that this compound is relatively not volatile and is relatively stable in high temperature environments. This property is instructive for the operation of distillation and fractionation in chemical production.
In terms of solubility, 4-chloro-2-methoxy-1-nitrobenzene is insoluble in water. Water is a common solvent, and most organic compounds are insoluble due to their large polarity differences from water, so is this compound. However, it is soluble in organic solvents such as ethanol, ether, acetone, etc. The polarity of organic solvents is diverse, and the intermolecular forces of the compound are adapted to make it uniformly dispersed. This solubility characteristic is related to the choice of reaction medium in organic synthesis. Suitable solvents can promote the reaction and improve the yield.
The density is about 1.386 g/cm ³, and the density is the mass per unit volume of the substance. This value helps to accurately measure and transfer the substance in chemical production and experimental operations, and also depends on its position in the mixture and the separation method.
In addition, this compound has a certain odor, which is difficult to describe accurately, but its special odor is also one of its physical properties, which can be used as a preliminary basis for identification during actual contact and operation.
In summary, the physical properties of 4-chloro-2-methoxy-1-nitrobenzene, such as appearance, melting point, boiling point, solubility and density, are of key value in chemical production, organic synthesis, analysis and identification, etc., laying the foundation for in-depth research and rational application of this substance.
First of all, its appearance is often a light yellow to yellow crystalline solid at room temperature. This color and shape are the intuitive characteristics for identifying this substance. Its melting point is about 57-61 ° C. The melting point is the critical temperature at which a substance changes from a solid state to a liquid state. This property is crucial in the separation, purification and identification of substances. Knowing its melting point can help to distinguish the purity of this compound. If the purity is high, the melting point range is narrow and approaches the standard value; if it contains impurities, the melting point is reduced and the range is wider.
Furthermore, its boiling point is about 277 ° C. The boiling point, the temperature of the liquid when boiling, reflects the volatility of the substance. The higher boiling point indicates that this compound is relatively not volatile and is relatively stable in high temperature environments. This property is instructive for the operation of distillation and fractionation in chemical production.
In terms of solubility, 4-chloro-2-methoxy-1-nitrobenzene is insoluble in water. Water is a common solvent, and most organic compounds are insoluble due to their large polarity differences from water, so is this compound. However, it is soluble in organic solvents such as ethanol, ether, acetone, etc. The polarity of organic solvents is diverse, and the intermolecular forces of the compound are adapted to make it uniformly dispersed. This solubility characteristic is related to the choice of reaction medium in organic synthesis. Suitable solvents can promote the reaction and improve the yield.
The density is about 1.386 g/cm ³, and the density is the mass per unit volume of the substance. This value helps to accurately measure and transfer the substance in chemical production and experimental operations, and also depends on its position in the mixture and the separation method.
In addition, this compound has a certain odor, which is difficult to describe accurately, but its special odor is also one of its physical properties, which can be used as a preliminary basis for identification during actual contact and operation.
In summary, the physical properties of 4-chloro-2-methoxy-1-nitrobenzene, such as appearance, melting point, boiling point, solubility and density, are of key value in chemical production, organic synthesis, analysis and identification, etc., laying the foundation for in-depth research and rational application of this substance.
What are the chemical properties of 4-chloro-2-methoxy-1-nitrobenzene?
4-Chloro-2-methoxy-1-nitrobenzene, this is an organic compound. Its chemical properties are particularly important and are related to reactions and applications in many chemical fields.
The first word about its substitution reaction. Because of the chlorine atom, methoxy group and nitro group on the benzene ring, the chlorine atom can be replaced by a nucleophilic reagent under appropriate conditions. For example, when heating an alcohol solution of sodium hydroxide, the chlorine atom may be replaced by a hydroxyl group to form 4-hydroxy-2-methoxy-1-nitrobenzene. Because the chlorine atom is affected by the benzene ring and the ortho-nitro group, its carbon-chlorine bond electron cloud density decreases, making it more vulnerable to nucleophilic attack.
Re-discussion on the characteristics of its nitro group. Nitro is a strong electron-absorbing group, which can reduce the electron cloud density of the benzene ring and reduce the activity of the electrophilic substitution reaction of the benzene ring. However, the nitro group can be reduced. If iron and hydrochloric acid are used as reducing agents, the nitro group can be gradually reduced to an amino group to obtain 4-chloro-2-methoxy-1-aminobenzene. This reaction is often used in organic synthesis to prepare compounds containing amino groups.
Methoxy group is an electron-supplying group, which has ortho and para-localization effects on the benzene ring. In the electrophilic substitution reaction, the electrophilic reagent can mainly attack its ortho and para-position. However, since the first position has been occupied by the nitro group, the electrophilic reagent attacks the methoxy group more.
In addition, the stability of 4-chloro-2-methoxy-1-nitrobenzene is also affected by the interaction of each group. The electronic effects of nitro and methoxy are checked and balanced, which affects the physical and chemical stability of the compound to a certain extent. When storing and using, pay attention to its requirements for environmental conditions to avoid decomposition or other adverse reactions caused by improper conditions.
In conclusion, 4-chloro-2-methoxy-1-nitrobenzene is rich in chemical properties and has important uses in organic synthesis, medicinal chemistry, and other fields. Understanding its properties is of great significance to the research and application of related fields.
The first word about its substitution reaction. Because of the chlorine atom, methoxy group and nitro group on the benzene ring, the chlorine atom can be replaced by a nucleophilic reagent under appropriate conditions. For example, when heating an alcohol solution of sodium hydroxide, the chlorine atom may be replaced by a hydroxyl group to form 4-hydroxy-2-methoxy-1-nitrobenzene. Because the chlorine atom is affected by the benzene ring and the ortho-nitro group, its carbon-chlorine bond electron cloud density decreases, making it more vulnerable to nucleophilic attack.
Re-discussion on the characteristics of its nitro group. Nitro is a strong electron-absorbing group, which can reduce the electron cloud density of the benzene ring and reduce the activity of the electrophilic substitution reaction of the benzene ring. However, the nitro group can be reduced. If iron and hydrochloric acid are used as reducing agents, the nitro group can be gradually reduced to an amino group to obtain 4-chloro-2-methoxy-1-aminobenzene. This reaction is often used in organic synthesis to prepare compounds containing amino groups.
Methoxy group is an electron-supplying group, which has ortho and para-localization effects on the benzene ring. In the electrophilic substitution reaction, the electrophilic reagent can mainly attack its ortho and para-position. However, since the first position has been occupied by the nitro group, the electrophilic reagent attacks the methoxy group more.
In addition, the stability of 4-chloro-2-methoxy-1-nitrobenzene is also affected by the interaction of each group. The electronic effects of nitro and methoxy are checked and balanced, which affects the physical and chemical stability of the compound to a certain extent. When storing and using, pay attention to its requirements for environmental conditions to avoid decomposition or other adverse reactions caused by improper conditions.
In conclusion, 4-chloro-2-methoxy-1-nitrobenzene is rich in chemical properties and has important uses in organic synthesis, medicinal chemistry, and other fields. Understanding its properties is of great significance to the research and application of related fields.
What are 4-chloro-2-methoxy-1-nitrobenzene synthesis methods?
The synthesis method of 4-chloro-2-methoxy-1-nitrobenzene has been around since ancient times. In the past, Fang's family used the following methods to do it.
First, starting with benzene, the benzene is first chlorinated to obtain chlorobenzene. For chlorobenzene, it is co-placed with mixed acids and nitrified to obtain a mixture of o-nitrochlorobenzene and p-nitrochlorobenzene. After fractionation, take o-nitrochlorobenzene. Then let o-nitrochlorobenzene and sodium methoxide co-heat to obtain 2-methoxy-1-nitrobenzene. After using this substance as a base, 4-chloro-2-methoxy-1-nitrobenzene can be obtained by interacting with chlorinating agents such as phosphorus trichloride and phosphorus pentachloride. There are many steps in this process, but the method of each step is well known to the world. When operating, you need to pay attention to the conditions of each step, such as temperature, pressure, and the ratio of reactants.
Second, start with o-methoxyphenol. First, take the activity of phenolic hydroxyl groups, and make it react with halogenated methanes, such as iodomethane, under the catalysis of bases to obtain o-methoxyanisole. 2-Methoxy-4-nitrobenzene can be obtained by co-nitration of o-methoxy-anisole with mixed acid. Finally, 4-chloro-2-methoxy-1-nitrobenzene can be obtained by acting on 2-methoxy-4-nitrobenzene with a chlorinating agent such as sulfuryl chloride. The beauty of this method lies in the activity of the starting material o-methoxy phenol, which can make the reaction relatively easy to control. However, the nitration step requires careful adjustment of the conditions to prevent side reactions.
Third, p-chlorophenol is used as the source. Shilling p-chlorophenol and halomethane are methylated in an alkali environment to obtain p-chloroanisole. P-chloroanisole is then nitrified with mixed acid, and nitro is introduced at the ortho position to obtain 4-chloro-2-methoxy-1-nitrobenzene. The starting materials used in this way are relatively easy to obtain, but when nitrifying, it is also necessary to pay attention to the conditions to avoid miscellaneous substances.
All kinds of synthesis methods have their own advantages and disadvantages. Fang family needs to choose carefully according to their own equipment, such as the availability of raw materials, the quality of equipment, and the consideration of cost, etc., in order to obtain good results.
First, starting with benzene, the benzene is first chlorinated to obtain chlorobenzene. For chlorobenzene, it is co-placed with mixed acids and nitrified to obtain a mixture of o-nitrochlorobenzene and p-nitrochlorobenzene. After fractionation, take o-nitrochlorobenzene. Then let o-nitrochlorobenzene and sodium methoxide co-heat to obtain 2-methoxy-1-nitrobenzene. After using this substance as a base, 4-chloro-2-methoxy-1-nitrobenzene can be obtained by interacting with chlorinating agents such as phosphorus trichloride and phosphorus pentachloride. There are many steps in this process, but the method of each step is well known to the world. When operating, you need to pay attention to the conditions of each step, such as temperature, pressure, and the ratio of reactants.
Second, start with o-methoxyphenol. First, take the activity of phenolic hydroxyl groups, and make it react with halogenated methanes, such as iodomethane, under the catalysis of bases to obtain o-methoxyanisole. 2-Methoxy-4-nitrobenzene can be obtained by co-nitration of o-methoxy-anisole with mixed acid. Finally, 4-chloro-2-methoxy-1-nitrobenzene can be obtained by acting on 2-methoxy-4-nitrobenzene with a chlorinating agent such as sulfuryl chloride. The beauty of this method lies in the activity of the starting material o-methoxy phenol, which can make the reaction relatively easy to control. However, the nitration step requires careful adjustment of the conditions to prevent side reactions.
Third, p-chlorophenol is used as the source. Shilling p-chlorophenol and halomethane are methylated in an alkali environment to obtain p-chloroanisole. P-chloroanisole is then nitrified with mixed acid, and nitro is introduced at the ortho position to obtain 4-chloro-2-methoxy-1-nitrobenzene. The starting materials used in this way are relatively easy to obtain, but when nitrifying, it is also necessary to pay attention to the conditions to avoid miscellaneous substances.
All kinds of synthesis methods have their own advantages and disadvantages. Fang family needs to choose carefully according to their own equipment, such as the availability of raw materials, the quality of equipment, and the consideration of cost, etc., in order to obtain good results.
What are the precautions in storage and transportation of 4-chloro-2-methoxy-1-nitrobenzene?
4-Chloro-2-methoxy-1-nitrobenzene is also an organic compound. During storage and transportation, many matters need to be paid attention to.
First words storage, this compound should be placed in a cool, dry and well ventilated place. Because of its certain chemical activity, high temperature and humid environment, it is easy to cause its chemical changes and damage its quality. For example, if it is in a humid place, moisture or reacts with some of the groups, causing it to deteriorate. Therefore, the warehouse temperature should be controlled within a specific range, and the humidity should not be too high.
Furthermore, it needs to be separated from oxidizing agents, reducing agents, acids, bases and other substances. 4-Chloro-2-methoxy-1-nitrobenzene encounters oxidizing agents, or causes severe oxidation reactions, which can even cause the risk of combustion and explosion; in case of acid, alkali, or chemical reactions, which affect its stability and purity.
As for transportation, the packaging must be tight and firm. To prevent the package from being damaged due to bumps and collisions during transportation and the compound leaking. And the transportation vehicle should have corresponding protective equipment, such as fire equipment, for emergencies. Transportation personnel also need professional training, familiar with the characteristics of this compound and emergency treatment methods. In the event of leakage and other accidents, it can be disposed of quickly and properly to avoid greater harm.
First words storage, this compound should be placed in a cool, dry and well ventilated place. Because of its certain chemical activity, high temperature and humid environment, it is easy to cause its chemical changes and damage its quality. For example, if it is in a humid place, moisture or reacts with some of the groups, causing it to deteriorate. Therefore, the warehouse temperature should be controlled within a specific range, and the humidity should not be too high.
Furthermore, it needs to be separated from oxidizing agents, reducing agents, acids, bases and other substances. 4-Chloro-2-methoxy-1-nitrobenzene encounters oxidizing agents, or causes severe oxidation reactions, which can even cause the risk of combustion and explosion; in case of acid, alkali, or chemical reactions, which affect its stability and purity.
As for transportation, the packaging must be tight and firm. To prevent the package from being damaged due to bumps and collisions during transportation and the compound leaking. And the transportation vehicle should have corresponding protective equipment, such as fire equipment, for emergencies. Transportation personnel also need professional training, familiar with the characteristics of this compound and emergency treatment methods. In the event of leakage and other accidents, it can be disposed of quickly and properly to avoid greater harm.
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