Linshang Chemical
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4-Chloro-2-Methoxy-6-Nitro-1-Methylbenzene
Linshang Chemical
|
HS Code |
517051 |
| Chemical Formula | C8H8ClNO3 |
| Molar Mass | 201.607 g/mol |
| Physical State At Room Temperature | Solid |
| Solubility In Water | Low solubility (due to non - polar aromatic and hydrophobic groups) |
| Density | Unknown without experimental determination |
| Vapor Pressure | Low at room temperature due to being a solid |
| Stability | Stable under normal conditions, but can react with strong oxidizing or reducing agents |
As an accredited 4-Chloro-2-Methoxy-6-Nitro-1-Methylbenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chloro - 2 - methoxy - 6 - nitro - 1 - methylbenzene packaged in air - tight plastic containers. |
| Storage | 4 - chloro - 2 - methoxy - 6 - nitro - 1 - methylbenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition sources to prevent fire or explosion. Keep it in a tightly sealed container to avoid exposure to air and moisture. Store it separately from oxidizing agents, reducing agents, and reactive substances to prevent chemical reactions. |
| Shipping | 4 - chloro - 2 - methoxy - 6 - nitro - 1 - methylbenzene is a chemical. Shipping should follow strict regulations. It must be properly packaged in corrosion - resistant containers, labeled clearly, and transported by carriers licensed for hazardous chemicals. |
Competitive 4-Chloro-2-Methoxy-6-Nitro-1-Methylbenzene prices that fit your budget—flexible terms and customized quotes for every order.
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What are the main uses of 4-chloro-2-methoxy-6-nitro-1-methylbenzene?
4-Chloro-2-methoxy-6-nitro-1-methylbenzene, this compound has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. Due to the unique reactivity of chlorine atoms, methoxy groups, nitro groups and methyl groups in its structure, it can be converted into other organic compounds through various chemical reactions.
For example, chlorine atoms can participate in nucleophilic substitution reactions, allowing chemists to introduce various nucleophilic reagents to generate novel compounds, thereby enriching the variety of organic compounds. Nitro groups can be reduced to derive amino groups, which is a key step in the preparation of amino-containing organic compounds. Such amino-containing compounds are widely used in the pharmaceutical, pesticide and dye industries.
In the field of medicine, compounds obtained through a series of reactions from this starting material may have specific biological activities, such as potential drug lead compounds, which can be developed into drugs for the treatment of specific diseases after subsequent research and optimization.
In the field of materials science, organic materials derived from them may have unique electrical and optical properties, which can be used to manufacture organic Light Emitting Diodes, solar cells and other devices, providing new options for the development of materials.
In the field of pesticides, by modifying and modifying their structures, or creating efficient, low-toxic and environmentally friendly pesticide varieties, it is of great significance for agricultural pest control. Overall, 4-chloro-2-methoxy-6-nitro-1-methylbenzene has shown important application value in many fields, promoting the development and progress of various fields.
For example, chlorine atoms can participate in nucleophilic substitution reactions, allowing chemists to introduce various nucleophilic reagents to generate novel compounds, thereby enriching the variety of organic compounds. Nitro groups can be reduced to derive amino groups, which is a key step in the preparation of amino-containing organic compounds. Such amino-containing compounds are widely used in the pharmaceutical, pesticide and dye industries.
In the field of medicine, compounds obtained through a series of reactions from this starting material may have specific biological activities, such as potential drug lead compounds, which can be developed into drugs for the treatment of specific diseases after subsequent research and optimization.
In the field of materials science, organic materials derived from them may have unique electrical and optical properties, which can be used to manufacture organic Light Emitting Diodes, solar cells and other devices, providing new options for the development of materials.
In the field of pesticides, by modifying and modifying their structures, or creating efficient, low-toxic and environmentally friendly pesticide varieties, it is of great significance for agricultural pest control. Overall, 4-chloro-2-methoxy-6-nitro-1-methylbenzene has shown important application value in many fields, promoting the development and progress of various fields.
What are the physical properties of 4-chloro-2-methoxy-6-nitro-1-methylbenzene?
4-Chloro-2-methoxy-6-nitro-1-methylbenzene is one of the organic compounds. Its physical properties are particularly important and are related to many chemical applications.
First of all, its appearance, this compound is often in a solid state, or in the shape of crystals. It may be shiny, and its color may be colorless to light yellow, depending on its purity and preparation method.
As for the melting point, this is one of the key physical quantities to distinguish the substance. The determination of the melting point can help determine its purity and characteristics. However, the exact melting point needs to be obtained by experiment, because the preparation process and impurities affect its melting point.
The boiling point is also an important property. The boiling point can indicate the temperature at which it changes from liquid to gaseous under a specific pressure. This property is crucial when distilling, separating and purifying the compound.
In terms of solubility, 4-chloro-2-methoxy-6-nitro-1-methylbenzene may have a certain solubility in organic solvents such as ethanol, ether, dichloromethane, etc. Due to its molecular structure containing groups such as chlorine, methoxy, nitro and methyl, it has a specific interaction with organic solvents. In water, due to its hydrophobic groups, the solubility should be very small.
Density is also one of its physical properties. Density can help determine its position in the mixture, and is of great significance in chemical production and experimental operation, as well as in the measurement and mixing of materials. The exact density value also needs to be determined experimentally, and is affected by temperature. The temperature increases, and the general density decreases slightly.
In addition, the vapor pressure of the compound also needs to be paid attention to. The vapor pressure is related to the difficulty of its volatilization, and it is particularly important for the setting of working environment and storage conditions. The higher the vapor pressure, the easier it is to evaporate, and it may cause safety hazards in confined spaces, so it needs to be properly stored and operated.
First of all, its appearance, this compound is often in a solid state, or in the shape of crystals. It may be shiny, and its color may be colorless to light yellow, depending on its purity and preparation method.
As for the melting point, this is one of the key physical quantities to distinguish the substance. The determination of the melting point can help determine its purity and characteristics. However, the exact melting point needs to be obtained by experiment, because the preparation process and impurities affect its melting point.
The boiling point is also an important property. The boiling point can indicate the temperature at which it changes from liquid to gaseous under a specific pressure. This property is crucial when distilling, separating and purifying the compound.
In terms of solubility, 4-chloro-2-methoxy-6-nitro-1-methylbenzene may have a certain solubility in organic solvents such as ethanol, ether, dichloromethane, etc. Due to its molecular structure containing groups such as chlorine, methoxy, nitro and methyl, it has a specific interaction with organic solvents. In water, due to its hydrophobic groups, the solubility should be very small.
Density is also one of its physical properties. Density can help determine its position in the mixture, and is of great significance in chemical production and experimental operation, as well as in the measurement and mixing of materials. The exact density value also needs to be determined experimentally, and is affected by temperature. The temperature increases, and the general density decreases slightly.
In addition, the vapor pressure of the compound also needs to be paid attention to. The vapor pressure is related to the difficulty of its volatilization, and it is particularly important for the setting of working environment and storage conditions. The higher the vapor pressure, the easier it is to evaporate, and it may cause safety hazards in confined spaces, so it needs to be properly stored and operated.
Is 4-chloro-2-methoxy-6-nitro-1-methylbenzene chemically stable?
The stability of the chemical properties of 4-chloro-2-methoxy-6-nitro-1-methylbenzene depends on multiple reasons. The structure of this substance is unique. Chlorine atoms, methoxy groups, nitro groups and methyl groups interact according to their respective positions, resulting in different properties.
Chlorine atoms have electron-absorbing properties, which can reduce the electron cloud density of the benzene ring, and may cause changes in the reactivity during electrophilic substitution reactions. Methoxy groups are the power supply groups, which can increase the electron cloud density at specific positions in the benzene ring. However, they coexist with chlorine atoms and nitro groups, and the effect is complicated. The nitro group is a strong electron-absorbing group, which significantly reduces the electron cloud density of the benzene ring, making the electrophilic substitution reaction difficult, but it may play a key role in the nucleophilic substitution reaction. The methyl donator effect is weak, which has a relatively small effect on the electron cloud density of the benzene ring, but it also participates in the interaction between molecules.
In terms of stability, the nitro group in the molecule contains nitrogen and oxygen double bonds, which has high energy, or makes the molecular stability slightly reduced. However, the methoxy group interacts with the methyl donator, or compensates part of the energy to a certain extent, to help the molecule maintain relative stability. At the same time, the conjugated system of the benzene ring provides additional stability for the molecule.
However, chemical stability depends not only on the structure If 4-chloro-2-methoxy-6-nitro-1-methylbenzene reacts at high temperature, light or in a specific chemical medium, the stability will be disturbed. Such as under light, or the photochemical reaction related to chlorine atoms; at high temperature, nitro or decomposition reactions.
In summary, the chemical stability of 4-chloro-2-methoxy-6-nitro-1-methylbenzene is determined by its complex molecular structure and environment, and cannot be generalized.
Chlorine atoms have electron-absorbing properties, which can reduce the electron cloud density of the benzene ring, and may cause changes in the reactivity during electrophilic substitution reactions. Methoxy groups are the power supply groups, which can increase the electron cloud density at specific positions in the benzene ring. However, they coexist with chlorine atoms and nitro groups, and the effect is complicated. The nitro group is a strong electron-absorbing group, which significantly reduces the electron cloud density of the benzene ring, making the electrophilic substitution reaction difficult, but it may play a key role in the nucleophilic substitution reaction. The methyl donator effect is weak, which has a relatively small effect on the electron cloud density of the benzene ring, but it also participates in the interaction between molecules.
In terms of stability, the nitro group in the molecule contains nitrogen and oxygen double bonds, which has high energy, or makes the molecular stability slightly reduced. However, the methoxy group interacts with the methyl donator, or compensates part of the energy to a certain extent, to help the molecule maintain relative stability. At the same time, the conjugated system of the benzene ring provides additional stability for the molecule.
However, chemical stability depends not only on the structure If 4-chloro-2-methoxy-6-nitro-1-methylbenzene reacts at high temperature, light or in a specific chemical medium, the stability will be disturbed. Such as under light, or the photochemical reaction related to chlorine atoms; at high temperature, nitro or decomposition reactions.
In summary, the chemical stability of 4-chloro-2-methoxy-6-nitro-1-methylbenzene is determined by its complex molecular structure and environment, and cannot be generalized.
What is the preparation method of 4-chloro-2-methoxy-6-nitro-1-methylbenzene?
To prepare 4-chloro-2-methoxy-6-nitro-1-methylbenzene, the following method can be used.
Take 1-methyl-2-methoxybenzene as the starting material. This compound can be prepared by methylation of corresponding phenols. Usually, dimethyl sulfate or iodomethane are used as methylation reagents. Under alkaline conditions, the hydrogen on the phenolic hydroxyl group is replaced by methyl to obtain 1-methyl-2-methoxybenzene.
Nitration reaction is carried out with 1-methyl-2-methoxybenzene as the substrate. Mixed acid (a mixture of concentrated sulfuric acid and concentrated nitric acid) can be used as a nitrifying reagent. In this reaction system, nitric acid under the action of concentrated sulfuric acid produces nitroyl positive ion (NO 2O 🥰), which acts as an electrophilic reagent to attack the benzene ring. Because methoxy is an ortho-site group and methyl is also an ortho-site group, the combined positioning effect of the two, the nitro group mainly enters the ortho-site of methoxy group and the para-site of methyl group. After this step of reaction, 2-methoxy-6-nitro-1-methylbenzene can be obtained.
Subsequently, the chlorination reaction of 2-methoxy-6-nitro-1-methyl is carried out. Chlorine can be used as a chlorination reagent, and iron or ferric chloride can be used as a catalyst. Under the action of the catalyst, the chlorine molecules polarize, generating electrophilic positive chlorine ions (Cl 🥰), which attack the benzene ring. At this time, due to the localization effect of methoxy and methyl groups, chlorine atoms mainly replace hydrogen atoms at the nitro interposition, and then obtain the target product 4-chloro-2-methoxy-6-nitro-1-methylbenzene.
Each step of the reaction requires attention to the control of the reaction conditions. For example, during the nitrification reaction, the proportion of mixed acid and the reaction temperature have a significant impact on the formation and selectivity of the product. If the temperature is too high, it may cause the formation of polynitro substitution products; during the chlorination reaction, the amount of catalyst and reaction time also need to be precisely controlled to prevent excessive chlorination. And after each step of the reaction, it needs to be separated and purified, such as extraction, distillation, recrystallization, etc., to obtain a pure product.
Take 1-methyl-2-methoxybenzene as the starting material. This compound can be prepared by methylation of corresponding phenols. Usually, dimethyl sulfate or iodomethane are used as methylation reagents. Under alkaline conditions, the hydrogen on the phenolic hydroxyl group is replaced by methyl to obtain 1-methyl-2-methoxybenzene.
Nitration reaction is carried out with 1-methyl-2-methoxybenzene as the substrate. Mixed acid (a mixture of concentrated sulfuric acid and concentrated nitric acid) can be used as a nitrifying reagent. In this reaction system, nitric acid under the action of concentrated sulfuric acid produces nitroyl positive ion (NO 2O 🥰), which acts as an electrophilic reagent to attack the benzene ring. Because methoxy is an ortho-site group and methyl is also an ortho-site group, the combined positioning effect of the two, the nitro group mainly enters the ortho-site of methoxy group and the para-site of methyl group. After this step of reaction, 2-methoxy-6-nitro-1-methylbenzene can be obtained.
Subsequently, the chlorination reaction of 2-methoxy-6-nitro-1-methyl is carried out. Chlorine can be used as a chlorination reagent, and iron or ferric chloride can be used as a catalyst. Under the action of the catalyst, the chlorine molecules polarize, generating electrophilic positive chlorine ions (Cl 🥰), which attack the benzene ring. At this time, due to the localization effect of methoxy and methyl groups, chlorine atoms mainly replace hydrogen atoms at the nitro interposition, and then obtain the target product 4-chloro-2-methoxy-6-nitro-1-methylbenzene.
Each step of the reaction requires attention to the control of the reaction conditions. For example, during the nitrification reaction, the proportion of mixed acid and the reaction temperature have a significant impact on the formation and selectivity of the product. If the temperature is too high, it may cause the formation of polynitro substitution products; during the chlorination reaction, the amount of catalyst and reaction time also need to be precisely controlled to prevent excessive chlorination. And after each step of the reaction, it needs to be separated and purified, such as extraction, distillation, recrystallization, etc., to obtain a pure product.
What 4-chloro-2-methoxy-6-nitro-1-methylbenzene need to pay attention to when storing and transporting
4-Chloro-2-methoxy-6-nitro-1-methylbenzene is an organic compound. When storing and transporting, many aspects must be paid attention to.
First words storage. This compound has certain chemical activity and should be stored in a cool, dry and well-ventilated place. Because heat can easily exacerbate chemical reactions or cause safety risks, it should be kept away from heat and fire sources and not placed in direct sunlight. And its properties may change due to moisture, so it is extremely important to keep it dry. In addition, this substance may be incompatible with other chemicals, so it must be stored separately to avoid coexistence with reactive substances such as oxidants and reducing agents in a room to prevent accidents. The storage place should be clearly marked, indicating the name, nature and precautions of the compound for access and management.
As for transportation. Before transportation, ensure that the packaging is tight and suitable packaging materials are used to resist vibration, collision and leakage. If using a sturdy container, lining with leak-proof materials. During transportation, follow relevant laws and standards, and transport personnel should be familiar with its characteristics and emergency treatment methods. Avoid mixing with other contraindicated items, pay attention to changes in temperature and humidity during driving, and take necessary cooling measures in case of hot weather. In the event of an accident such as leakage, deal with it quickly according to the emergency plan to prevent the spread of pollution and the expansion of hazards.
In conclusion, when storing and transporting 4-chloro-2-methoxy-6-nitro-1-methylbenzene, all aspects must not be ignored, from environmental conditions, packaging protection to personnel awareness and emergency preparedness, so as to ensure safety and avoid disasters.
First words storage. This compound has certain chemical activity and should be stored in a cool, dry and well-ventilated place. Because heat can easily exacerbate chemical reactions or cause safety risks, it should be kept away from heat and fire sources and not placed in direct sunlight. And its properties may change due to moisture, so it is extremely important to keep it dry. In addition, this substance may be incompatible with other chemicals, so it must be stored separately to avoid coexistence with reactive substances such as oxidants and reducing agents in a room to prevent accidents. The storage place should be clearly marked, indicating the name, nature and precautions of the compound for access and management.
As for transportation. Before transportation, ensure that the packaging is tight and suitable packaging materials are used to resist vibration, collision and leakage. If using a sturdy container, lining with leak-proof materials. During transportation, follow relevant laws and standards, and transport personnel should be familiar with its characteristics and emergency treatment methods. Avoid mixing with other contraindicated items, pay attention to changes in temperature and humidity during driving, and take necessary cooling measures in case of hot weather. In the event of an accident such as leakage, deal with it quickly according to the emergency plan to prevent the spread of pollution and the expansion of hazards.
In conclusion, when storing and transporting 4-chloro-2-methoxy-6-nitro-1-methylbenzene, all aspects must not be ignored, from environmental conditions, packaging protection to personnel awareness and emergency preparedness, so as to ensure safety and avoid disasters.
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