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4-Chloro-2-Methoxybenzeneboronic Acid
Linshang Chemical
|
HS Code |
702838 |
| Name | 4-Chloro-2-Methoxybenzeneboronic Acid |
| Chemical Formula | C7H8BClO3 |
| Molar Mass | 186.40 g/mol |
| Appearance | Solid (usually white or off - white) |
| Melting Point | 130 - 134 °C |
| Solubility In Water | Slightly soluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, dichloromethane |
| Pka | Typically around 8 - 10 (boronic acid group) |
| Density | Approx. 1.37 g/cm³ |
| Stability | Stable under normal conditions, but may react with strong oxidizing agents |
As an accredited 4-Chloro-2-Methoxybenzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - chloro - 2 - methoxybenzeneboronic acid in sealed, labeled chemical - grade vial. |
| Storage | 4 - Chloro - 2 - methoxybenzeneboronic acid should be stored in a cool, dry place away from heat sources and direct sunlight. Keep it in a tightly sealed container to prevent moisture absorption, which could affect its stability. Store it separately from incompatible substances like strong oxidizing agents to avoid potential reactions. |
| Shipping | 4 - chloro - 2 - methoxybenzeneboronic acid is shipped in well - sealed containers, following strict hazardous chemicals shipping regulations. Packaging ensures protection from moisture and damage during transit to maintain product integrity. |
Competitive 4-Chloro-2-Methoxybenzeneboronic Acid prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4-Chloro-2-Methoxybenzeneboronic Acid in China?
As a trusted 4-Chloro-2-Methoxybenzeneboronic Acid manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-Chloro-2-Methoxybenzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 4-chloro-2-methoxybenzeneboronic Acid?
4-Chloro-2-methoxyphenylboronic acid has a wide range of uses. It is often used as a key intermediate in the field of organic synthesis. Due to its boron atom, it has unique chemical activity and can participate in many key reactions, such as Suzuki coupling reaction. In such reactions, it can efficiently form carbon-carbon bonds with halogenated aromatics or olefins under the action of palladium catalysts and bases. This reaction is an important means for the construction of complex aromatic compounds and is widely used in drug synthesis, materials science and other fields.
In the process of drug development, with the help of Suzuki coupling reaction, a variety of biologically active compounds can be synthesized from 4-chloro-2-methoxyphenylboronic acid as raw materials. These compounds may be used as potential drug molecules to combat various diseases, such as cancer, cardiovascular diseases, etc.
In the field of materials science, it also plays an important role. Through related reactions, specific structures can be introduced into polymers or functional materials, thereby improving the properties of materials, such as improving the photoelectric properties and thermal stability of materials. It has broad application prospects in organic Light Emitting Diodes (OLEDs), solar cells and other fields.
In addition, in the preparation of fine chemical products, 4-chloro-2-methoxyphenylboronic acid can be used to synthesize high-end dyes, fragrances and specialty chemicals, contributing to the development of the fine chemical industry. In short, its value in many fields cannot be ignored, promoting technological innovation and progress in related industries.
In the process of drug development, with the help of Suzuki coupling reaction, a variety of biologically active compounds can be synthesized from 4-chloro-2-methoxyphenylboronic acid as raw materials. These compounds may be used as potential drug molecules to combat various diseases, such as cancer, cardiovascular diseases, etc.
In the field of materials science, it also plays an important role. Through related reactions, specific structures can be introduced into polymers or functional materials, thereby improving the properties of materials, such as improving the photoelectric properties and thermal stability of materials. It has broad application prospects in organic Light Emitting Diodes (OLEDs), solar cells and other fields.
In addition, in the preparation of fine chemical products, 4-chloro-2-methoxyphenylboronic acid can be used to synthesize high-end dyes, fragrances and specialty chemicals, contributing to the development of the fine chemical industry. In short, its value in many fields cannot be ignored, promoting technological innovation and progress in related industries.
What are the physical properties of 4-chloro-2-methoxybenzeneboronic Acid?
4-Chloro-2-methoxyphenylboronic acid, which is a white to off-white solid. Its melting point is in a specific range, about [specific melting point value]. This property is extremely critical for the identification and purification of this substance, due to differences in melting points of different purity substances.
Its solubility is quite special, slightly soluble in water, but soluble in common organic solvents, such as ethanol, ether, dichloromethane, etc. Its solubility in organic solvents makes it easier to disperse and participate in the reaction as a reactant or intermediate in organic synthesis reactions.
In terms of chemical stability, 4-chloro-2-methoxyphenylboronic acid is relatively stable under conventional conditions. However, in the case of strong oxidants, strong bases, or high temperature environments, chemical reactions will occur. In the case of strong bases, the boron-oxygen bond is easily destroyed, resulting in structural changes; in the case of strong oxidants, the chlorine atom or methoxy group on the aromatic ring may be oxidized.
Because its structure contains boron-oxygen bonds and aromatic rings, it has certain reactivity. It can react with a variety of nucleophiles and electrophiles, and plays an important role in the construction of complex organic molecular structures. In transition metal catalytic coupling reactions, such as the Suzuki-Miyaura coupling reaction, it is an important raw material that can form carbon-carbon bonds with halogenated aromatics or olefins, and is widely used in the field of drug synthesis and materials science to assist in the synthesis of organic compounds with specific structures and functions.
Its solubility is quite special, slightly soluble in water, but soluble in common organic solvents, such as ethanol, ether, dichloromethane, etc. Its solubility in organic solvents makes it easier to disperse and participate in the reaction as a reactant or intermediate in organic synthesis reactions.
In terms of chemical stability, 4-chloro-2-methoxyphenylboronic acid is relatively stable under conventional conditions. However, in the case of strong oxidants, strong bases, or high temperature environments, chemical reactions will occur. In the case of strong bases, the boron-oxygen bond is easily destroyed, resulting in structural changes; in the case of strong oxidants, the chlorine atom or methoxy group on the aromatic ring may be oxidized.
Because its structure contains boron-oxygen bonds and aromatic rings, it has certain reactivity. It can react with a variety of nucleophiles and electrophiles, and plays an important role in the construction of complex organic molecular structures. In transition metal catalytic coupling reactions, such as the Suzuki-Miyaura coupling reaction, it is an important raw material that can form carbon-carbon bonds with halogenated aromatics or olefins, and is widely used in the field of drug synthesis and materials science to assist in the synthesis of organic compounds with specific structures and functions.
What are the synthetic methods of 4-chloro-2-methoxybenzeneboronic Acid?
The synthesis method of 4-chloro-2-methoxyphenylboronic acid has been around for a long time, and there are many methods, which are now the way for you.
First, 4-chloro-2-methoxybromobenzene is used as the starting material. In the reactor, fill with nitrogen to create an inert atmosphere to prevent the oxidation of the raw materials and products. Add an appropriate amount of anhydrous ether as the solvent, because it has good solubility and stable properties to the reactants. The reaction system is cooled to -78 ° C, and n-butyl lithium is slowly added dropwise. The activity of n-butyllithium is extremely high. At this low temperature, lithium-halogen exchange reaction occurs with 4-chloro-2-methoxybromobenzene to generate the corresponding lithium reagent. After a period of reaction, keep the low temperature and slowly add trimethyl borate. Trimethyl borate reacts with lithium reagent to form 4-chloro-2-methoxyphenylborate intermediate. Then, heat up to room temperature, add an appropriate amount of dilute hydrochloric acid for hydrolysis. After hydrolysis is completed, pure 4-chloro-2-methoxyphenylboronic acid can be obtained through extraction, drying, column chromatography and other post-treatment processes.
Second, 4-chloro-2-methoxyaniline is used as the starting material. First, it is reacted with sodium nitrite and hydrochloric acid at low temperature to form a diazonium salt. The diazonium salt is unstable, and it needs to be reacted immediately with sodium borohydride and an appropriate amount of copper salt catalyst. The copper salt catalyst can promote the substitution of diazonium groups by boron groups to form 4-chloro-2-methoxyphenylboronic acid. In this process, the reaction conditions need to be precisely controlled. If the diazotization reaction temperature is too low, the reaction will be slow, and if it is too high, the diazonium salt will be easily decomposed. Subsequent separation and purification methods are also required to obtain the target product.
Third, 4-chloro-2-methoxybenzaldehyde is used as the raw material. First, it is reacted with hydroxylamine hydrochloride to form an oxime. The oxime reacts with sodium borohydride and Lewis acid catalysts, and through Beckmann rearrangement and reduction reaction, 4-chloro-2-methoxyphenylboronic acid can be obtained. This route has a little more steps, but the raw material is relatively easy to obtain, and it is also one of the commonly used synthesis routes. During operation, the reaction conditions of each step, such as temperature, pH, reaction time, etc., have a great impact on the yield and purity of the product, so it must be done with caution.
First, 4-chloro-2-methoxybromobenzene is used as the starting material. In the reactor, fill with nitrogen to create an inert atmosphere to prevent the oxidation of the raw materials and products. Add an appropriate amount of anhydrous ether as the solvent, because it has good solubility and stable properties to the reactants. The reaction system is cooled to -78 ° C, and n-butyl lithium is slowly added dropwise. The activity of n-butyllithium is extremely high. At this low temperature, lithium-halogen exchange reaction occurs with 4-chloro-2-methoxybromobenzene to generate the corresponding lithium reagent. After a period of reaction, keep the low temperature and slowly add trimethyl borate. Trimethyl borate reacts with lithium reagent to form 4-chloro-2-methoxyphenylborate intermediate. Then, heat up to room temperature, add an appropriate amount of dilute hydrochloric acid for hydrolysis. After hydrolysis is completed, pure 4-chloro-2-methoxyphenylboronic acid can be obtained through extraction, drying, column chromatography and other post-treatment processes.
Second, 4-chloro-2-methoxyaniline is used as the starting material. First, it is reacted with sodium nitrite and hydrochloric acid at low temperature to form a diazonium salt. The diazonium salt is unstable, and it needs to be reacted immediately with sodium borohydride and an appropriate amount of copper salt catalyst. The copper salt catalyst can promote the substitution of diazonium groups by boron groups to form 4-chloro-2-methoxyphenylboronic acid. In this process, the reaction conditions need to be precisely controlled. If the diazotization reaction temperature is too low, the reaction will be slow, and if it is too high, the diazonium salt will be easily decomposed. Subsequent separation and purification methods are also required to obtain the target product.
Third, 4-chloro-2-methoxybenzaldehyde is used as the raw material. First, it is reacted with hydroxylamine hydrochloride to form an oxime. The oxime reacts with sodium borohydride and Lewis acid catalysts, and through Beckmann rearrangement and reduction reaction, 4-chloro-2-methoxyphenylboronic acid can be obtained. This route has a little more steps, but the raw material is relatively easy to obtain, and it is also one of the commonly used synthesis routes. During operation, the reaction conditions of each step, such as temperature, pH, reaction time, etc., have a great impact on the yield and purity of the product, so it must be done with caution.
4-chloro-2-methoxybenzeneboronic Acid during storage and transportation
4-Chloro-2-methoxyphenylboronic acid is a commonly used reagent in organic synthesis. During storage and transportation, many matters need to be paid attention to.
First words storage, this compound should be stored in a cool, dry and well-ventilated place. Because it is quite sensitive to humidity, it is easy to deteriorate due to moisture, so it is necessary to keep away from water sources and moisture. If the storage environment humidity is high, a desiccant can be placed in the storage container to maintain the dry environment. Temperature is also a key factor. Excessive temperature may accelerate its decomposition. Generally speaking, it should be stored in a low temperature environment, usually under refrigeration conditions of 2-8 ° C. This can effectively prolong its shelf life and ensure the stability of chemical properties.
Furthermore, in terms of transportation, it is necessary to ensure that the packaging is tight. Because it is a chemical, if the packaging is damaged, it may pose a hazard to the environment and transportation personnel after leakage. The packaging material should have good sealing and corrosion resistance. It can be packed in glass bottles or plastic bottles, and the outside is reinforced by strong cartons or wooden boxes. During transportation, avoid violent vibration and collision to prevent damage to the packaging. At the same time, the transportation temperature should also be controlled to maintain a low temperature and stable state as much as possible to prevent excessive temperature fluctuations from affecting its quality. And the transportation process must follow the relevant chemical transportation regulations, and be equipped with necessary emergency treatment equipment and materials for emergencies.
First words storage, this compound should be stored in a cool, dry and well-ventilated place. Because it is quite sensitive to humidity, it is easy to deteriorate due to moisture, so it is necessary to keep away from water sources and moisture. If the storage environment humidity is high, a desiccant can be placed in the storage container to maintain the dry environment. Temperature is also a key factor. Excessive temperature may accelerate its decomposition. Generally speaking, it should be stored in a low temperature environment, usually under refrigeration conditions of 2-8 ° C. This can effectively prolong its shelf life and ensure the stability of chemical properties.
Furthermore, in terms of transportation, it is necessary to ensure that the packaging is tight. Because it is a chemical, if the packaging is damaged, it may pose a hazard to the environment and transportation personnel after leakage. The packaging material should have good sealing and corrosion resistance. It can be packed in glass bottles or plastic bottles, and the outside is reinforced by strong cartons or wooden boxes. During transportation, avoid violent vibration and collision to prevent damage to the packaging. At the same time, the transportation temperature should also be controlled to maintain a low temperature and stable state as much as possible to prevent excessive temperature fluctuations from affecting its quality. And the transportation process must follow the relevant chemical transportation regulations, and be equipped with necessary emergency treatment equipment and materials for emergencies.
What is the market price range for 4-chloro-2-methoxybenzeneboronic Acid?
The market price range of 4-chloro-2-methoxyphenylboronic acid is difficult to determine with certainty. Its price often changes due to many factors, just like the changing situation, and it is difficult to determine a certain number.
The first to bear the brunt is the difference between the manufacturers. Different manufacturers have different production processes and cost controls, and their production prices are different. Those with exquisite craftsmanship and low cost may be sold at a more affordable price; those with complicated craftsmanship and high cost will have higher prices.
Furthermore, the situation of market supply and demand is also the key. If the demand for this product is strong, but the supply is relatively scarce, such as looking at the clouds on a dry day, the price is bound to rise; on the contrary, if the supply exceeds the demand, just like the water is full, the price will overflow, and the price will inevitably fall.
In addition, the price fluctuation of raw materials also affects the whole body. If the price of raw materials is high, the production cost will increase, and the product price will also increase; if the price of raw materials falls, the cost will decrease, and the price may have room for downward adjustment.
There is also the impact of the purchase quantity. If the purchase volume is large, such as hoarding goods and grain, the manufacturer may give a discount for small profits but quick turnover, and the price can be reduced; if the purchase volume is small, the discount will be fresh, and the price
According to past experience and the general market situation, the price may range from a few yuan per gram to tens of yuan. However, this is only a rough estimate, such as seeing flowers in the fog, it is difficult to be accurate. To know the exact price, you need to consult various suppliers in detail and observe the latest market conditions in order to clear the clouds and get the truth.
The first to bear the brunt is the difference between the manufacturers. Different manufacturers have different production processes and cost controls, and their production prices are different. Those with exquisite craftsmanship and low cost may be sold at a more affordable price; those with complicated craftsmanship and high cost will have higher prices.
Furthermore, the situation of market supply and demand is also the key. If the demand for this product is strong, but the supply is relatively scarce, such as looking at the clouds on a dry day, the price is bound to rise; on the contrary, if the supply exceeds the demand, just like the water is full, the price will overflow, and the price will inevitably fall.
In addition, the price fluctuation of raw materials also affects the whole body. If the price of raw materials is high, the production cost will increase, and the product price will also increase; if the price of raw materials falls, the cost will decrease, and the price may have room for downward adjustment.
There is also the impact of the purchase quantity. If the purchase volume is large, such as hoarding goods and grain, the manufacturer may give a discount for small profits but quick turnover, and the price can be reduced; if the purchase volume is small, the discount will be fresh, and the price
According to past experience and the general market situation, the price may range from a few yuan per gram to tens of yuan. However, this is only a rough estimate, such as seeing flowers in the fog, it is difficult to be accurate. To know the exact price, you need to consult various suppliers in detail and observe the latest market conditions in order to clear the clouds and get the truth.
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