Linshang Chemical
PRODUCTS
4-Chloro-2-Nitro-1-(Phenylsulfonyl)Benzene
Linshang Chemical
|
HS Code |
802142 |
| Chemical Formula | C12H8ClNO4S |
| Molecular Weight | 297.714 g/mol |
| Appearance | Typically a solid (appearance may vary based on purity and preparation) |
| Melting Point | Data may vary, needs experimental determination |
| Boiling Point | Data may vary, needs experimental determination |
| Solubility In Water | Expected to be low (organic compound with non - polar groups) |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, chloroform |
| Density | Data may vary, needs experimental determination |
| Vapor Pressure | Low due to its solid nature at room temperature |
As an accredited 4-Chloro-2-Nitro-1-(Phenylsulfonyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - chloro - 2 - nitro - 1 - (phenylsulfonyl)benzene in a sealed chemical - grade bottle. |
| Storage | 4 - chloro - 2 - nitro - 1 - (phenylsulfonyl)benzene should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition points. Keep it in a tightly sealed container to prevent exposure to moisture and air, which could potentially lead to chemical reactions. Store separately from incompatible substances, such as strong oxidizing agents or bases, to ensure safety. |
| Shipping | 4 - chloro - 2 - nitro - 1 - (phenylsulfonyl)benzene is shipped in well - sealed containers. It adheres to strict chemical shipping regulations, ensuring proper handling to prevent leakage and potential environmental or safety risks. |
Competitive 4-Chloro-2-Nitro-1-(Phenylsulfonyl)Benzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4-Chloro-2-Nitro-1-(Phenylsulfonyl)Benzene in China?
As a trusted 4-Chloro-2-Nitro-1-(Phenylsulfonyl)Benzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-Chloro-2-Nitro-1-(Phenylsulfonyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the main use of 4-chloro-2-nitro-1- (phenylsulfonyl) benzene?
4-Chloro-2-nitro-1- (benzenesulfonyl) benzene is one of the organic compounds. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
To observe the art of organic synthesis, many delicate reactions depend on it. If you want to build a complex benzene series structure, 4-chloro-2-nitro-1- (benzenesulfonyl) benzene can participate in nucleophilic substitution, electrophilic substitution and other reactions due to its chlorine atom, nitro group and benzenesulfonyl group, paving the way for the birth of new compounds. Chlorine atoms have good activity, and can interact with various nucleophiles under suitable conditions to introduce different functional groups into molecules, resulting in diverse structural changes.
Furthermore, in the field of medicinal chemistry, it also has its own impact. Because of its structural properties, it may become a starting material for the development of new drugs. Scientists can modify and modify its structure to obtain molecules with specific biological activities for the treatment and prevention of diseases. For example, by adjusting the substituent group, changing the physical and chemical properties of the molecule, making it more suitable for the target of drug action, enhancing the curative effect and reducing the toxic and side effects.
In the field of materials science, it may also demonstrate its value. Introducing it into polymer materials through specific reactions may improve the properties of materials, such as thermal stability, mechanical properties, etc. Because its functional groups can interact with other substances, it gives the material unique characteristics and is suitable for different scenarios.
In general, 4-chloro-2-nitro-1- (benzenesulfonyl) benzene, with its unique structure, is an important existence in many fields such as organic synthesis, medicinal chemistry, and materials science, and has broad application prospects.
To observe the art of organic synthesis, many delicate reactions depend on it. If you want to build a complex benzene series structure, 4-chloro-2-nitro-1- (benzenesulfonyl) benzene can participate in nucleophilic substitution, electrophilic substitution and other reactions due to its chlorine atom, nitro group and benzenesulfonyl group, paving the way for the birth of new compounds. Chlorine atoms have good activity, and can interact with various nucleophiles under suitable conditions to introduce different functional groups into molecules, resulting in diverse structural changes.
Furthermore, in the field of medicinal chemistry, it also has its own impact. Because of its structural properties, it may become a starting material for the development of new drugs. Scientists can modify and modify its structure to obtain molecules with specific biological activities for the treatment and prevention of diseases. For example, by adjusting the substituent group, changing the physical and chemical properties of the molecule, making it more suitable for the target of drug action, enhancing the curative effect and reducing the toxic and side effects.
In the field of materials science, it may also demonstrate its value. Introducing it into polymer materials through specific reactions may improve the properties of materials, such as thermal stability, mechanical properties, etc. Because its functional groups can interact with other substances, it gives the material unique characteristics and is suitable for different scenarios.
In general, 4-chloro-2-nitro-1- (benzenesulfonyl) benzene, with its unique structure, is an important existence in many fields such as organic synthesis, medicinal chemistry, and materials science, and has broad application prospects.
What are the synthesis methods of 4-chloro-2-nitro-1- (phenylsulfonyl) benzene
The synthesis of 4-chloro-2-nitro-1- (benzenesulfonyl) benzene is an important topic in the field of organic synthesis. To obtain this compound, there are several common methods as follows.
First, benzene is used as the starting material. First, benzene is sulfonated to make benzene and concentrated sulfuric acid co-heat at a suitable temperature to obtain benzenesulfonic acid. In this step, the temperature should be controlled to prevent overreaction. Then the benzenesulfonic acid is converted into benzenesulfonyl chloride, which can be reacted with chlorinated reagents such as phosphorus pentachloride or sulfinyl chloride. After the benzenesulfonyl chloride is obtained, the Fu-gram acylation reaction is carried out with chlorobenzene. In this reaction, a suitable catalyst, such as anhydrous aluminum trichloride, needs to be selected and carried out in an anhydrous environment to improve the yield of the reaction. After the reaction is completed, the nitro group is introduced through the nitrification reaction, and the appropriate nitrification reagent such as concentrated nitric acid and concentrated sulfuric acid is mixed. The target product 4-chloro-2-nitro-1- (benzenesulfonyl) benzene can be obtained.
Second, chlorobenzene can also be started from chlorobenzene. First, the chlorobenzene is nitrified to obtain 2-nitrochlorobenzene. In this step, the ratio of mixed acid and the reaction temperature have a great influence on the selectivity of the product. Then 2-nitrochlorobenzene and benzenesulfonyl chloride under alkaline conditions, such as potassium carbonate and other bases, carry out nucleophilic substitution reaction to obtain the target compound. This method requires attention to the alkalinity of the reaction system. Too strong or too weak alkalinity may affect the reaction process and yield.
Furthermore, nitrobenzene can also be used as a starting material. First reduce nitrobenzene to aniline, commonly used reducing agents such as iron and hydrochloric acid. After obtaining aniline, after diazotization, sodium nitrite and hydrochloric acid are reacted at low temperature to form a diazonium salt. Then the diazonium salt is reacted with cuprous chloride to achieve chlorination and obtain chlorobenzene derivatives. After the reaction with benzenesulfonyl chloride, the benzenesulfonyl group is introduced under suitable conditions to obtain 4-chloro-2-nitro-1- (benzenesulfonyl) benzene.
The above synthesis methods have their own advantages and disadvantages. In practice, it is necessary to comprehensively consider the availability of raw materials, the difficulty of controlling the reaction conditions, and the purity requirements of the target product to choose the optimal synthesis path.
First, benzene is used as the starting material. First, benzene is sulfonated to make benzene and concentrated sulfuric acid co-heat at a suitable temperature to obtain benzenesulfonic acid. In this step, the temperature should be controlled to prevent overreaction. Then the benzenesulfonic acid is converted into benzenesulfonyl chloride, which can be reacted with chlorinated reagents such as phosphorus pentachloride or sulfinyl chloride. After the benzenesulfonyl chloride is obtained, the Fu-gram acylation reaction is carried out with chlorobenzene. In this reaction, a suitable catalyst, such as anhydrous aluminum trichloride, needs to be selected and carried out in an anhydrous environment to improve the yield of the reaction. After the reaction is completed, the nitro group is introduced through the nitrification reaction, and the appropriate nitrification reagent such as concentrated nitric acid and concentrated sulfuric acid is mixed. The target product 4-chloro-2-nitro-1- (benzenesulfonyl) benzene can be obtained.
Second, chlorobenzene can also be started from chlorobenzene. First, the chlorobenzene is nitrified to obtain 2-nitrochlorobenzene. In this step, the ratio of mixed acid and the reaction temperature have a great influence on the selectivity of the product. Then 2-nitrochlorobenzene and benzenesulfonyl chloride under alkaline conditions, such as potassium carbonate and other bases, carry out nucleophilic substitution reaction to obtain the target compound. This method requires attention to the alkalinity of the reaction system. Too strong or too weak alkalinity may affect the reaction process and yield.
Furthermore, nitrobenzene can also be used as a starting material. First reduce nitrobenzene to aniline, commonly used reducing agents such as iron and hydrochloric acid. After obtaining aniline, after diazotization, sodium nitrite and hydrochloric acid are reacted at low temperature to form a diazonium salt. Then the diazonium salt is reacted with cuprous chloride to achieve chlorination and obtain chlorobenzene derivatives. After the reaction with benzenesulfonyl chloride, the benzenesulfonyl group is introduced under suitable conditions to obtain 4-chloro-2-nitro-1- (benzenesulfonyl) benzene.
The above synthesis methods have their own advantages and disadvantages. In practice, it is necessary to comprehensively consider the availability of raw materials, the difficulty of controlling the reaction conditions, and the purity requirements of the target product to choose the optimal synthesis path.
What are the physical properties of 4-chloro-2-nitro-1- (phenylsulfonyl) benzene
4-Chloro-2-nitro-1- (benzenesulfonyl) benzene has special properties, which depend on its melting point, solubility, density, etc.
The melting boiling point is first mentioned. Because of its intermolecular forces including van der Waals force and dipole-dipole force, and containing chlorine, nitro, benzenesulfonyl and other groups, the structure causes complex intermolecular interactions. The chlorine atom has a certain electronegativity, the nitro group is a strong electron-absorbing group, and the benzenesulfonyl group also affects the molecular charge distribution. Therefore, its melting point should not be low, due to the strong intermolecular force, more energy is required to disintegrate the lattice to achieve melting; the boiling point is also high, and many intermolecular interactions need to be overcome in order to vaporize it.
Then again, solubility. The substance contains benzene ring, which has a certain lipophilicity; however, nitro and sulfonyl groups are polar. In organic solvents such as dichloromethane and chloroform, it may have a certain solubility due to the principle of similar miscibility, because the organic solvent interacts well with the benzene ring. However, in water, although there are polar groups, the overall solubility in water is limited due to the large benzene ring, which hinders the formation of hydrogen bonds and other strong interactions with water.
As for the density, the molecule contains chlorine atoms, the relative mass of chlorine atoms is relatively large, and the benzene ring and each group form a compact structure, resulting in a relatively large molecular weight and a relatively fixed space, so the density may be higher than that of common hydrocarbons, or close to the density range of some halogen-containing aromatic compounds.
In summary, 4-chloro-2-nitro-1- (benzenesulfonyl) benzene has a higher melting boiling point, a certain solubility in organic solvents, poor solubility in water, and a higher density than common hydrocarbons. This is all determined by its unique molecular structure and group characteristics.
The melting boiling point is first mentioned. Because of its intermolecular forces including van der Waals force and dipole-dipole force, and containing chlorine, nitro, benzenesulfonyl and other groups, the structure causes complex intermolecular interactions. The chlorine atom has a certain electronegativity, the nitro group is a strong electron-absorbing group, and the benzenesulfonyl group also affects the molecular charge distribution. Therefore, its melting point should not be low, due to the strong intermolecular force, more energy is required to disintegrate the lattice to achieve melting; the boiling point is also high, and many intermolecular interactions need to be overcome in order to vaporize it.
Then again, solubility. The substance contains benzene ring, which has a certain lipophilicity; however, nitro and sulfonyl groups are polar. In organic solvents such as dichloromethane and chloroform, it may have a certain solubility due to the principle of similar miscibility, because the organic solvent interacts well with the benzene ring. However, in water, although there are polar groups, the overall solubility in water is limited due to the large benzene ring, which hinders the formation of hydrogen bonds and other strong interactions with water.
As for the density, the molecule contains chlorine atoms, the relative mass of chlorine atoms is relatively large, and the benzene ring and each group form a compact structure, resulting in a relatively large molecular weight and a relatively fixed space, so the density may be higher than that of common hydrocarbons, or close to the density range of some halogen-containing aromatic compounds.
In summary, 4-chloro-2-nitro-1- (benzenesulfonyl) benzene has a higher melting boiling point, a certain solubility in organic solvents, poor solubility in water, and a higher density than common hydrocarbons. This is all determined by its unique molecular structure and group characteristics.
What are the chemical properties of 4-chloro-2-nitro-1- (phenylsulfonyl) benzene
4-Chloro-2-nitro-1- (benzenesulfonyl) benzene, an organic compound. Its chemical properties are interesting and contain many unique features.
Looking at its structure, chlorine atoms, nitro groups and benzenesulfonyl groups are all connected to the benzene ring. Chlorine atoms have certain electronegativity, which can change the electron cloud density of the benzene ring, which in turn affects the reactivity of the compound. In nucleophilic substitution reactions, chlorine atoms may be replaced by other nucleophilic reagents as leaving groups.
Nitro is a strong electron-absorbing group, which can not only significantly reduce the electron cloud density of the benzene ring, making the benzene ring more susceptible to attack by electrophilic reagents, but also enhance molecular polarity. In the reduction reaction, nitro groups can be reduced to amino groups, and a series of new compounds can be derived, which greatly expands the reaction path and application scope of this substance.
benzenesulfonyl groups endow molecules with certain stability and special chemical activity. Its sulfur atoms can exhibit various oxidation states and participate in redox reactions under specific conditions. Moreover, benzenesulfonyl groups have a large steric barrier, which has a great impact on the molecular spatial structure and reaction selectivity.
4-chloro-2-nitro-1- (benzenesulfonyl) benzene These groups interact and exhibit rich chemical properties. They can be used as key intermediates in the field of organic synthesis for the preparation of various drugs, dyes and functional materials, etc., and are of great significance in chemical research and industrial production.
Looking at its structure, chlorine atoms, nitro groups and benzenesulfonyl groups are all connected to the benzene ring. Chlorine atoms have certain electronegativity, which can change the electron cloud density of the benzene ring, which in turn affects the reactivity of the compound. In nucleophilic substitution reactions, chlorine atoms may be replaced by other nucleophilic reagents as leaving groups.
Nitro is a strong electron-absorbing group, which can not only significantly reduce the electron cloud density of the benzene ring, making the benzene ring more susceptible to attack by electrophilic reagents, but also enhance molecular polarity. In the reduction reaction, nitro groups can be reduced to amino groups, and a series of new compounds can be derived, which greatly expands the reaction path and application scope of this substance.
benzenesulfonyl groups endow molecules with certain stability and special chemical activity. Its sulfur atoms can exhibit various oxidation states and participate in redox reactions under specific conditions. Moreover, benzenesulfonyl groups have a large steric barrier, which has a great impact on the molecular spatial structure and reaction selectivity.
4-chloro-2-nitro-1- (benzenesulfonyl) benzene These groups interact and exhibit rich chemical properties. They can be used as key intermediates in the field of organic synthesis for the preparation of various drugs, dyes and functional materials, etc., and are of great significance in chemical research and industrial production.
What should be paid attention to when storing and transporting 4-chloro-2-nitro-1- (phenylsulfonyl) benzene?
4-Chloro-2-nitro-1- (benzenesulfonyl) benzene, this is an organic compound. When storing and transporting, many aspects need to be paid attention to.
Store first. This compound should be stored in a cool, dry and well-ventilated place. If the ambient temperature is too high, it may cause changes in its physical and chemical properties and cause it to deteriorate. Humid environments are also not suitable. Moisture may react with the compound, affecting its purity and stability. Good ventilation can disperse harmful gases that may evaporate in time to avoid accumulation and danger.
Furthermore, keep away from fire and heat sources. Because it is flammable or can react violently after contact with heat or fire, there is a risk of fire or even explosion. It should also be stored separately from oxidants and reducing agents. This compound is chemically active and can mix with oxidants and reducing agents, or cause uncontrollable chemical reactions, causing serious consequences.
As for transportation, it is necessary to ensure that the packaging is complete and sealed. Prevent the package from being damaged due to bumps and collisions during transportation, so that the compound leaks. Leakage will not only pollute the environment, but also pose a threat to the safety of transporters. The means of transportation need to be clean and dry to avoid other residual substances from reacting with the compound. During transportation, it should also be driven according to the specified route, avoiding sensitive areas such as densely populated areas and water source reserves, in case of accidents and minimizing harm. And transportation personnel should be familiar with the characteristics of the compound and emergency treatment methods, and can respond quickly and properly in case of emergencies. In this way, the safety of 4-chloro-2-nitro-1- (benzenesulfonyl) benzene during storage and transportation can be ensured, and accidents can be avoided.
Store first. This compound should be stored in a cool, dry and well-ventilated place. If the ambient temperature is too high, it may cause changes in its physical and chemical properties and cause it to deteriorate. Humid environments are also not suitable. Moisture may react with the compound, affecting its purity and stability. Good ventilation can disperse harmful gases that may evaporate in time to avoid accumulation and danger.
Furthermore, keep away from fire and heat sources. Because it is flammable or can react violently after contact with heat or fire, there is a risk of fire or even explosion. It should also be stored separately from oxidants and reducing agents. This compound is chemically active and can mix with oxidants and reducing agents, or cause uncontrollable chemical reactions, causing serious consequences.
As for transportation, it is necessary to ensure that the packaging is complete and sealed. Prevent the package from being damaged due to bumps and collisions during transportation, so that the compound leaks. Leakage will not only pollute the environment, but also pose a threat to the safety of transporters. The means of transportation need to be clean and dry to avoid other residual substances from reacting with the compound. During transportation, it should also be driven according to the specified route, avoiding sensitive areas such as densely populated areas and water source reserves, in case of accidents and minimizing harm. And transportation personnel should be familiar with the characteristics of the compound and emergency treatment methods, and can respond quickly and properly in case of emergencies. In this way, the safety of 4-chloro-2-nitro-1- (benzenesulfonyl) benzene during storage and transportation can be ensured, and accidents can be avoided.
Scan to WhatsApp
