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4-Chloro-2-(Trifluoromethyl)Benzeneboronic Acid
Linshang Chemical
|
HS Code |
669388 |
| Name | 4-Chloro-2-(trifluoromethyl)benzeneboronic acid |
| Chemical Formula | C7H5BClF3O2 |
| Molecular Weight | 226.37 |
| Appearance | White to off-white solid |
| Melting Point | 129 - 133 °C |
| Solubility | Soluble in organic solvents like dichloromethane, tetrahydrofuran |
| Purity | Typically high - can be 95%+ |
| Stability | Stable under normal conditions, but moisture - sensitive |
| Cas Number | 1256355-83-2 |
| Reactivity | Reactive towards electrophiles and nucleophiles in organic reactions |
As an accredited 4-Chloro-2-(Trifluoromethyl)Benzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - chloro - 2 - (trifluoromethyl)benzeneboronic acid in a sealed chemical - grade vial. |
| Storage | 4 - chloro - 2 - (trifluoromethyl)benzeneboronic acid should be stored in a cool, dry place away from heat and ignition sources. Keep it in a tightly sealed container to prevent moisture absorption and exposure to air, which could potentially degrade the chemical. Store it separately from incompatible substances, like strong oxidizing agents and bases. |
| Shipping | 4 - chloro - 2 - (trifluoromethyl)benzeneboronic acid is shipped in sealed, corrosion - resistant containers. Special handling for chemicals is ensured, with compliance to safety regulations during transport to prevent spills and maintain product integrity. |
Competitive 4-Chloro-2-(Trifluoromethyl)Benzeneboronic Acid prices that fit your budget—flexible terms and customized quotes for every order.
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As a leading 4-Chloro-2-(Trifluoromethyl)Benzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 4-chloro-2- (trifluoromethyl) benzeneboronic Acid?
4-Chloro-2- (trifluoromethyl) phenylboronic acid, which is widely used. In the field of organic synthesis, it is often used as a key intermediate.
The unique electronic properties of Gein boron atoms enable this compound to participate in many key chemical reactions. First, in the Suzuki coupling reaction, this is the core reagent. Suzuki reaction is an important means of building carbon-carbon bonds. 4-chloro-2- (trifluoromethyl) phenylboronic acid can form new carbon-carbon bonds efficiently with halogenated aromatics or halogenated olefins under the action of palladium catalysts and bases. With this reaction, organic molecules with diverse structures can be synthesized, which is of great significance in drug development and materials science.
In the field of medicinal chemistry, with the help of Suzuki coupling reaction, 4-chloro-2- (trifluoromethyl) phenylboronic acid can be used as raw material to prepare compounds with specific biological activities. In the synthesis of many drug molecules, this compound participates in the construction of key skeleton structures, laying the foundation for the development of new drugs.
In the field of materials science, use its participation in the synthesis of organic materials, or have special optoelectronic properties. For example, the synthesized conjugated polymer materials can be applied to organic Light Emitting Diodes (OLEDs), organic solar cells and other devices, which endow the materials with good charge transport and luminescence properties due to their unique structure.
In addition, in the field of pesticide chemistry, it also has its uses. Compounds containing specific substituents synthesized through related reactions may have biological activities such as insecticidal and bactericidal, providing the possibility for the development of new pesticides. In short, 4-chloro-2 - (trifluoromethyl) phenylboronic acid plays an important role in many chemically related fields, promoting the development and innovation of various fields.
The unique electronic properties of Gein boron atoms enable this compound to participate in many key chemical reactions. First, in the Suzuki coupling reaction, this is the core reagent. Suzuki reaction is an important means of building carbon-carbon bonds. 4-chloro-2- (trifluoromethyl) phenylboronic acid can form new carbon-carbon bonds efficiently with halogenated aromatics or halogenated olefins under the action of palladium catalysts and bases. With this reaction, organic molecules with diverse structures can be synthesized, which is of great significance in drug development and materials science.
In the field of medicinal chemistry, with the help of Suzuki coupling reaction, 4-chloro-2- (trifluoromethyl) phenylboronic acid can be used as raw material to prepare compounds with specific biological activities. In the synthesis of many drug molecules, this compound participates in the construction of key skeleton structures, laying the foundation for the development of new drugs.
In the field of materials science, use its participation in the synthesis of organic materials, or have special optoelectronic properties. For example, the synthesized conjugated polymer materials can be applied to organic Light Emitting Diodes (OLEDs), organic solar cells and other devices, which endow the materials with good charge transport and luminescence properties due to their unique structure.
In addition, in the field of pesticide chemistry, it also has its uses. Compounds containing specific substituents synthesized through related reactions may have biological activities such as insecticidal and bactericidal, providing the possibility for the development of new pesticides. In short, 4-chloro-2 - (trifluoromethyl) phenylboronic acid plays an important role in many chemically related fields, promoting the development and innovation of various fields.
What are the physical properties of 4-chloro-2- (trifluoromethyl) benzeneboronic Acid
4-Chloro-2 - (trifluoromethyl) phenylboronic acid, this is a class of compounds in organic chemistry that has attracted much attention. Its physical properties are unique and of great significance to the field of organic synthesis.
Looking at its appearance, it usually appears as a white to light yellow solid powder under normal conditions, with a fine texture. This form is easy to store and use, and provides convenience in many chemical reactions.
When it comes to melting point, it is about 200-205 ° C. As an important physical property of a substance, melting point plays a key role in the identification and purification of this compound. By means of melting point determination, its purity can be determined. If the compound is pure, the melting point should be in a specific narrow range; if it contains impurities, the melting point tends to decrease and the melting range becomes wider. In terms of solubility, it exhibits some solubility in common organic solvents such as dichloromethane and N, N-dimethylformamide (DMF). In dichloromethane, it can be moderately dissolved to form a homogeneous solution. This characteristic makes dichloromethane often used as a reaction solvent to build a suitable environment for related organic reactions. In DMF, the solubility is better, and the strong polarity of DMF can interact with 4-chloro-2- (trifluoromethyl) phenylboronic acid molecules, making it easier to disperse and dissolve. However, the compound has poor solubility in water, because its molecular structure contains hydrophobic chlorine atoms, trifluoromethyl and other groups, and the force between water molecules is weak, making it difficult to overcome the hydrogen bond between water molecules and dissolve.
In addition, the compound has certain stability, but attention should be paid to storage conditions. It should be stored in a dry and cool place to avoid moisture and high temperature. In a humid environment, boric acid groups may hydrolyze, affecting their chemical properties and reactivity; high temperature may cause their decomposition or other uncontrollable chemical reactions.
The above physical properties are of great significance in organic synthesis, drug development and other fields. During synthesis, choose the appropriate solvent according to solubility to ensure the smooth progress of the reaction; in drug development, properties such as melting point and stability are related to drug quality and efficacy.
Looking at its appearance, it usually appears as a white to light yellow solid powder under normal conditions, with a fine texture. This form is easy to store and use, and provides convenience in many chemical reactions.
When it comes to melting point, it is about 200-205 ° C. As an important physical property of a substance, melting point plays a key role in the identification and purification of this compound. By means of melting point determination, its purity can be determined. If the compound is pure, the melting point should be in a specific narrow range; if it contains impurities, the melting point tends to decrease and the melting range becomes wider. In terms of solubility, it exhibits some solubility in common organic solvents such as dichloromethane and N, N-dimethylformamide (DMF). In dichloromethane, it can be moderately dissolved to form a homogeneous solution. This characteristic makes dichloromethane often used as a reaction solvent to build a suitable environment for related organic reactions. In DMF, the solubility is better, and the strong polarity of DMF can interact with 4-chloro-2- (trifluoromethyl) phenylboronic acid molecules, making it easier to disperse and dissolve. However, the compound has poor solubility in water, because its molecular structure contains hydrophobic chlorine atoms, trifluoromethyl and other groups, and the force between water molecules is weak, making it difficult to overcome the hydrogen bond between water molecules and dissolve.
In addition, the compound has certain stability, but attention should be paid to storage conditions. It should be stored in a dry and cool place to avoid moisture and high temperature. In a humid environment, boric acid groups may hydrolyze, affecting their chemical properties and reactivity; high temperature may cause their decomposition or other uncontrollable chemical reactions.
The above physical properties are of great significance in organic synthesis, drug development and other fields. During synthesis, choose the appropriate solvent according to solubility to ensure the smooth progress of the reaction; in drug development, properties such as melting point and stability are related to drug quality and efficacy.
What are the synthesis methods of 4-chloro-2- (trifluoromethyl) benzeneboronic Acid
There are several common methods for synthesizing 4-chloro-2- (trifluoromethyl) phenylboronic acid.
One is the metallization-boration method of halogenated aromatic hydrocarbons. Using 4-chloro-2- (trifluoromethyl) bromobenzene as the starting material, under low temperature conditions, treated with a strong base such as n-butyl lithium, the bromine atom on the aromatic ring undergoes a metallization reaction to form an organolithium intermediate. Subsequently, a borate ester, such as trimethoxy borate, is added to the reaction system, and the organolithium intermediate undergoes a nucleophilic substitution reaction with the borate ester to generate the corresponding borate ester derivative. Finally, the target product 4-chloro-2- (trifluoromethyl) phenylboronic acid can be obtained by acidic hydrolysis. The reaction conditions of this method are relatively harsh, and it needs to be operated at low temperature and anhydrous and anaerobic environment to ensure the smooth progress of the reaction and the stability of the intermediate.
The second is a palladium-catalyzed cross-coupling method. The reaction is heated in an organic solvent with 4-chloro-2- (trifluoromethyl) chlorobenzene and diphenol borate as reactants, under the action of a palladium catalyst such as tetra (triphenylphosphine) palladium, and a suitable base such as potassium carbonate is added. During the reaction process, the palladium catalyst first undergoes a series of complex steps such as oxidative addition and metallization with the reactants, and finally realizes the formation of carbon-boron bonds, generating 4-chloro-2- (trifluoromethyl) phenylboronic acid pinacol ester, and then hydrolyzed to obtain the target product. This method has the advantages of relatively mild reaction conditions and good selectivity, but the price of palladium catalyst is expensive, which limits its large-scale application to a certain extent.
The third is the Grignard reagent method. The Grignard reagent is prepared by reacting 4-chloro-2- (trifluoromethyl) chlorobenzene with magnesium chips in anhydrous ether or tetrahydrofuran and other organic solvents. After that, Grignard's reagent reacts with trimethyl borate to form borate, which can be hydrolyzed to obtain 4-chloro-2- (trifluoromethyl) phenylboronic acid. This method is relatively simple to operate, but Grignard's reagent is sensitive to water and air, and the preparation process needs to be strictly controlled by the reaction conditions.
One is the metallization-boration method of halogenated aromatic hydrocarbons. Using 4-chloro-2- (trifluoromethyl) bromobenzene as the starting material, under low temperature conditions, treated with a strong base such as n-butyl lithium, the bromine atom on the aromatic ring undergoes a metallization reaction to form an organolithium intermediate. Subsequently, a borate ester, such as trimethoxy borate, is added to the reaction system, and the organolithium intermediate undergoes a nucleophilic substitution reaction with the borate ester to generate the corresponding borate ester derivative. Finally, the target product 4-chloro-2- (trifluoromethyl) phenylboronic acid can be obtained by acidic hydrolysis. The reaction conditions of this method are relatively harsh, and it needs to be operated at low temperature and anhydrous and anaerobic environment to ensure the smooth progress of the reaction and the stability of the intermediate.
The second is a palladium-catalyzed cross-coupling method. The reaction is heated in an organic solvent with 4-chloro-2- (trifluoromethyl) chlorobenzene and diphenol borate as reactants, under the action of a palladium catalyst such as tetra (triphenylphosphine) palladium, and a suitable base such as potassium carbonate is added. During the reaction process, the palladium catalyst first undergoes a series of complex steps such as oxidative addition and metallization with the reactants, and finally realizes the formation of carbon-boron bonds, generating 4-chloro-2- (trifluoromethyl) phenylboronic acid pinacol ester, and then hydrolyzed to obtain the target product. This method has the advantages of relatively mild reaction conditions and good selectivity, but the price of palladium catalyst is expensive, which limits its large-scale application to a certain extent.
The third is the Grignard reagent method. The Grignard reagent is prepared by reacting 4-chloro-2- (trifluoromethyl) chlorobenzene with magnesium chips in anhydrous ether or tetrahydrofuran and other organic solvents. After that, Grignard's reagent reacts with trimethyl borate to form borate, which can be hydrolyzed to obtain 4-chloro-2- (trifluoromethyl) phenylboronic acid. This method is relatively simple to operate, but Grignard's reagent is sensitive to water and air, and the preparation process needs to be strictly controlled by the reaction conditions.
What are the precautions for 4-chloro-2- (trifluoromethyl) benzeneboronic Acid during storage and transportation?
4-Chloro-2- (trifluoromethyl) phenylboronic acid, when storing and transporting, be sure to pay attention to many matters.
First word storage. This is a chemical substance, sexual or active, so it should be placed in a cool and dry place. If it is shady, avoid direct sunlight, and sunlight exposure may cause its chemical reaction and cause deterioration. If it is dry, it will prevent the intrusion of moisture. If moisture enters, or reacts with the substance such as hydration, it will damage its purity and quality. And where it is stored, the temperature should be stable, hot and cold, which is also harmful to its stability.
Furthermore, the substance should be stored in isolation from oxidants, bases, etc. Oxidants are strong, coexist with them, or react violently, with the risk of ignition and explosion; alkalis come into contact with them, or cause chemical changes, which will damage their inherent properties.
As for transportation, it should not be ignored. Packaging must be tight to prevent leakage. Because it may have certain corrosive and chemical activity, once leaked, it will not only damage the means of transportation, but also endanger the transporter and the surrounding environment. During transportation, it is also necessary to control the temperature to keep it in a suitable temperature range. And transportation vehicles should be equipped with corresponding emergency treatment equipment. In case of leaks and other emergencies, they can be dealt with in time to avoid major disasters.
When handling, the operator must wear appropriate protective equipment, such as gloves, goggles, etc., to prevent contact with the body and damage to health. In short, the storage and transportation of 4-chloro-2- (trifluoromethyl) phenylboronic acid should be treated with caution and follow regulations to ensure safety.
First word storage. This is a chemical substance, sexual or active, so it should be placed in a cool and dry place. If it is shady, avoid direct sunlight, and sunlight exposure may cause its chemical reaction and cause deterioration. If it is dry, it will prevent the intrusion of moisture. If moisture enters, or reacts with the substance such as hydration, it will damage its purity and quality. And where it is stored, the temperature should be stable, hot and cold, which is also harmful to its stability.
Furthermore, the substance should be stored in isolation from oxidants, bases, etc. Oxidants are strong, coexist with them, or react violently, with the risk of ignition and explosion; alkalis come into contact with them, or cause chemical changes, which will damage their inherent properties.
As for transportation, it should not be ignored. Packaging must be tight to prevent leakage. Because it may have certain corrosive and chemical activity, once leaked, it will not only damage the means of transportation, but also endanger the transporter and the surrounding environment. During transportation, it is also necessary to control the temperature to keep it in a suitable temperature range. And transportation vehicles should be equipped with corresponding emergency treatment equipment. In case of leaks and other emergencies, they can be dealt with in time to avoid major disasters.
When handling, the operator must wear appropriate protective equipment, such as gloves, goggles, etc., to prevent contact with the body and damage to health. In short, the storage and transportation of 4-chloro-2- (trifluoromethyl) phenylboronic acid should be treated with caution and follow regulations to ensure safety.
What is the market price range for 4-chloro-2- (trifluoromethyl) benzeneboronic Acid?
4-Chloro-2- (trifluoromethyl) phenylboronic acid, this product is in the market, and its price range is difficult to determine. The price often changes for many reasons, as described below.
One is related to purity. If the purity is extremely high and nearly flawless, it is suitable for high-end experiments, fine chemical synthesis, etc. Its price is high. Because the purification technique is quite complicated, it consumes a lot of material resources and manpower, and the cost is high, the price is not low. If the purity is above 99%, the price per gram may be in the tens of gold or even hundreds of gold.
Second, the supply and demand of the city is also the main reason. If there is a large number of people who need it for a while, and there are few suppliers, the demand will exceed the supply, and the price will rise. On the contrary, if the supply exceeds the demand, the merchant will sell its goods, or reduce the price in order to sell quickly. In case of a sudden increase in demand for an industry, the price at that time may be several percent higher than usual.
Third, the scale of the system also has an impact. If large-scale mass production, due to the efficiency of scale, the unit cost may be reduced, and the price will become more affordable. However, small-scale preparation, the cost is difficult to spread, and the price must be high.
Fourth, the place of origin is also related to the price. Different countries and regions have different prices due to the difference in raw material prices, labor fees, and taxes. If it is shipped from a distant place, the price may be higher than that of local products, including freight and other items.
In summary, the market price of 4-chloro-2- (trifluoromethyl) phenylboronic acid varies from a few gold to a hundred gold per gram, and it is difficult to determine the exact range. To know the details, it should be determined according to the real-time market conditions, the regulations of merchants and various factors.
One is related to purity. If the purity is extremely high and nearly flawless, it is suitable for high-end experiments, fine chemical synthesis, etc. Its price is high. Because the purification technique is quite complicated, it consumes a lot of material resources and manpower, and the cost is high, the price is not low. If the purity is above 99%, the price per gram may be in the tens of gold or even hundreds of gold.
Second, the supply and demand of the city is also the main reason. If there is a large number of people who need it for a while, and there are few suppliers, the demand will exceed the supply, and the price will rise. On the contrary, if the supply exceeds the demand, the merchant will sell its goods, or reduce the price in order to sell quickly. In case of a sudden increase in demand for an industry, the price at that time may be several percent higher than usual.
Third, the scale of the system also has an impact. If large-scale mass production, due to the efficiency of scale, the unit cost may be reduced, and the price will become more affordable. However, small-scale preparation, the cost is difficult to spread, and the price must be high.
Fourth, the place of origin is also related to the price. Different countries and regions have different prices due to the difference in raw material prices, labor fees, and taxes. If it is shipped from a distant place, the price may be higher than that of local products, including freight and other items.
In summary, the market price of 4-chloro-2- (trifluoromethyl) phenylboronic acid varies from a few gold to a hundred gold per gram, and it is difficult to determine the exact range. To know the details, it should be determined according to the real-time market conditions, the regulations of merchants and various factors.
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