Linshang Chemical
PRODUCTS
4-Chloro-3,5-Difluorobromobenzene
Linshang Chemical
|
HS Code |
250033 |
| Chemical Formula | C6H2BrClF2 |
| Appearance | Colorless to light yellow liquid |
| Boiling Point | 182 - 184 °C |
| Density | 1.82 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents |
| Flash Point | 77 °C |
| Purity | Typically high - purity in commercial products |
As an accredited 4-Chloro-3,5-Difluorobromobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - chloro - 3,5 - difluorobromobenzene packaged in a sealed glass bottle. |
| Storage | 4 - chloro - 3,5 - difluorobromobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames as it is likely flammable. Keep it in a tightly sealed container to prevent leakage and exposure to air or moisture. Store it separately from oxidizing agents and incompatible substances to avoid potential reactions. Label the storage clearly for easy identification and safety. |
| Shipping | 4 - chloro - 3,5 - difluorobromobenzene is shipped in tightly sealed, corrosion - resistant containers. Special care is taken to prevent leakage during transit, following strict hazardous chemical shipping regulations. |
Competitive 4-Chloro-3,5-Difluorobromobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
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As a trusted 4-Chloro-3,5-Difluorobromobenzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-Chloro-3,5-Difluorobromobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
4-Chloro-3, what is the chemical structure of 5-difluorobromobenzene
The chemical structure of 4-chloro-3,5-difluorobromobenzene is particularly critical, and it is related to many chemical properties and reactions. This compound is based on a benzene ring, and the benzene ring is a hexavalent ring structure with special stability. The atoms are connected by covalent bonds to form a conjugated system.
On the benzene ring, there are different substituents at specific positions. One is a bromine atom (Br), which is one of the halogen elements. It has a certain electronegativity and can affect the electron cloud distribution of the benzene ring in chemical reactions. In the electrophilic substitution reaction, the inducing effect decreases the electron cloud density of the benzene ring, but the conjugation effect has a tendency of the electron supplier. The interaction between the two causes the bromine atom to be the adjacent and para-locator, which has a great influence on the selection of the subsequent reaction check point.
The second is the chlorine atom (Cl), which is also a halogen element, and also has electronegativity. Its effect on the benzene ring is similar to that of the bromine atom, which can change the electron cloud density of the benzene ring and act as the adjacent and para-locator, which affects the reactivity and selectivity of the benzene ring.
Then there are two fluorine atoms (F). Fluorine is the most electronegative element. After connecting to the benzene ring, it strongly attracts electrons, greatly reduces the electron cloud density of the benzene ring, and greatly reduces the electrophilic substitution reaction activity of the benzene ring. The difluorine atom is at the 3,5 position, which interacts with bromine and chlorine atoms to jointly determine the chemical behavior of the compound.
These many substitutions are based on the relative positions on the benzene ring, which have a profound impact on the spatial structure and electron cloud distribution of the molecule, and then affect its physical and chemical properties, such as boiling point, melting point, solubility, etc. It also plays a key role in various organic synthesis reactions, providing a basis for chemists to control the reaction path and product.
On the benzene ring, there are different substituents at specific positions. One is a bromine atom (Br), which is one of the halogen elements. It has a certain electronegativity and can affect the electron cloud distribution of the benzene ring in chemical reactions. In the electrophilic substitution reaction, the inducing effect decreases the electron cloud density of the benzene ring, but the conjugation effect has a tendency of the electron supplier. The interaction between the two causes the bromine atom to be the adjacent and para-locator, which has a great influence on the selection of the subsequent reaction check point.
The second is the chlorine atom (Cl), which is also a halogen element, and also has electronegativity. Its effect on the benzene ring is similar to that of the bromine atom, which can change the electron cloud density of the benzene ring and act as the adjacent and para-locator, which affects the reactivity and selectivity of the benzene ring.
Then there are two fluorine atoms (F). Fluorine is the most electronegative element. After connecting to the benzene ring, it strongly attracts electrons, greatly reduces the electron cloud density of the benzene ring, and greatly reduces the electrophilic substitution reaction activity of the benzene ring. The difluorine atom is at the 3,5 position, which interacts with bromine and chlorine atoms to jointly determine the chemical behavior of the compound.
These many substitutions are based on the relative positions on the benzene ring, which have a profound impact on the spatial structure and electron cloud distribution of the molecule, and then affect its physical and chemical properties, such as boiling point, melting point, solubility, etc. It also plays a key role in various organic synthesis reactions, providing a basis for chemists to control the reaction path and product.
What are the main uses of 4-chloro-3, 5-difluorobromobenzene
4-Chloro-3,5-difluorobromobenzene is also an organic compound. It has a wide range of uses and has played an important role in the synthesis of medicine. Due to the characteristics of halogen atoms, it can participate in many chemical reactions, and then build complex pharmaceutical intermediates. In this field, it is often a key raw material to help create various specific drugs, such as antimalarial, antibacterial drugs, or drugs that act on the nervous system. All rely on its participation in the synthesis process to become active ingredients.
In the process of pesticide creation, 4-chloro-3,5-difluorobromobenzene also plays an important role. The characteristics of halogenated aromatics enable them to be converted into pesticide active ingredients for insecticides, weeding and sterilization through specific reactions. Its structure can be modified and transformed to obtain high-efficiency pesticides against different pests and diseases, which can help agricultural harvests and protect crops from damage.
Furthermore, in the field of materials science, it can also be seen. Because of the halogen atom, it can give unique properties to the material. Or used to synthesize polymer materials with special properties, such as flame retardancy, chemical corrosion resistance, etc. By polymerizing with other monomers, it is integrated into the polymer skeleton to improve material properties and broaden the application scope of materials. It has its applications in many fields such as electronics and aviation.
To sum up, 4-chloro-3,5-difluorobromobenzene is an indispensable raw material in the fields of medicine, pesticides and materials science. With its unique structure and reactivity, it promotes the development and progress of various fields.
In the process of pesticide creation, 4-chloro-3,5-difluorobromobenzene also plays an important role. The characteristics of halogenated aromatics enable them to be converted into pesticide active ingredients for insecticides, weeding and sterilization through specific reactions. Its structure can be modified and transformed to obtain high-efficiency pesticides against different pests and diseases, which can help agricultural harvests and protect crops from damage.
Furthermore, in the field of materials science, it can also be seen. Because of the halogen atom, it can give unique properties to the material. Or used to synthesize polymer materials with special properties, such as flame retardancy, chemical corrosion resistance, etc. By polymerizing with other monomers, it is integrated into the polymer skeleton to improve material properties and broaden the application scope of materials. It has its applications in many fields such as electronics and aviation.
To sum up, 4-chloro-3,5-difluorobromobenzene is an indispensable raw material in the fields of medicine, pesticides and materials science. With its unique structure and reactivity, it promotes the development and progress of various fields.
4-Chloro-3, what are the physical properties of 5-difluorobromobenzene
4-Chloro-3,5-difluorobromobenzene is also an organic compound. Its physical properties are quite important and are related to many chemical uses.
First of all, its appearance, under room temperature and pressure, is mostly colorless to light yellow transparent liquid, and it looks clear, just like jade liquid. This appearance characteristic can be an important basis for identifying and preliminarily judging the quality of its products.
Furthermore, its boiling point is about a specific temperature range, which is determined by factors such as intermolecular forces. The value of boiling point is crucial in the process of separating and purifying this compound. If you want to obtain pure 4-chloro-3,5-difluorobromobenzene from the mixture, control its boiling point and perform distillation to obtain it.
Melting point is also an important physical property. The number of its melting point indicates the critical temperature when the substance changes from solid to liquid. In a low temperature environment, the substance may be in a solid state, and when the temperature rises above the melting point, it gradually converts into a liquid state. This property needs to be carefully considered when storing and transporting.
As for the density, it is heavier than water. When placed in water, it must sink at the bottom. This density characteristic is quite instructive in some operations involving liquid-liquid separation.
In terms of solubility, 4-chloro-3,5-difluorobromobenzene is soluble in common organic solvents, such as ethanol, ether, etc. However, its solubility in water is very small, which is due to the difference between molecular polarity and water molecular polarity. This solubility characteristic can help chemists select suitable solvents in the process of chemical synthesis and extraction to achieve the best reaction effect or separation efficiency.
In addition, the size of its vapor pressure also affects its volatilization performance. At a certain temperature, the higher the vapor pressure, the more volatile it is. During use and storage, the characteristics of volatilization or its loss may also pose a safety hazard, so it cannot be ignored.
In summary, the physical properties of 4-chloro-3,5-difluorobromobenzene, such as appearance, boiling point, melting point, density, solubility, and vapor pressure, are of indispensable importance in many fields such as chemical production and scientific research experiments, and are the basis for the proper use of this substance.
First of all, its appearance, under room temperature and pressure, is mostly colorless to light yellow transparent liquid, and it looks clear, just like jade liquid. This appearance characteristic can be an important basis for identifying and preliminarily judging the quality of its products.
Furthermore, its boiling point is about a specific temperature range, which is determined by factors such as intermolecular forces. The value of boiling point is crucial in the process of separating and purifying this compound. If you want to obtain pure 4-chloro-3,5-difluorobromobenzene from the mixture, control its boiling point and perform distillation to obtain it.
Melting point is also an important physical property. The number of its melting point indicates the critical temperature when the substance changes from solid to liquid. In a low temperature environment, the substance may be in a solid state, and when the temperature rises above the melting point, it gradually converts into a liquid state. This property needs to be carefully considered when storing and transporting.
As for the density, it is heavier than water. When placed in water, it must sink at the bottom. This density characteristic is quite instructive in some operations involving liquid-liquid separation.
In terms of solubility, 4-chloro-3,5-difluorobromobenzene is soluble in common organic solvents, such as ethanol, ether, etc. However, its solubility in water is very small, which is due to the difference between molecular polarity and water molecular polarity. This solubility characteristic can help chemists select suitable solvents in the process of chemical synthesis and extraction to achieve the best reaction effect or separation efficiency.
In addition, the size of its vapor pressure also affects its volatilization performance. At a certain temperature, the higher the vapor pressure, the more volatile it is. During use and storage, the characteristics of volatilization or its loss may also pose a safety hazard, so it cannot be ignored.
In summary, the physical properties of 4-chloro-3,5-difluorobromobenzene, such as appearance, boiling point, melting point, density, solubility, and vapor pressure, are of indispensable importance in many fields such as chemical production and scientific research experiments, and are the basis for the proper use of this substance.
What are the preparation methods of 4-chloro-3, 5-difluorobromobenzene
There are many different methods for preparing 4-chloro-3,5-difluorobromobenzene. The common ones are as follows.
First, halogenated aromatics are used as starting materials and are prepared by nucleophilic substitution reaction. If a suitable aromatic hydrocarbon containing bromine, chlorine and fluorine is selected, it will be replaced by a nucleophilic reagent under specific reaction conditions. The choice of nucleophilic reagents depends on the reaction mechanism and the expected product. In the reaction environment, factors such as temperature and solvent are also crucial. Appropriately increasing the temperature can speed up the reaction rate, but if it is too high, it may cause more side reactions. Suitable solvents can not only dissolve the reactants, but also affect the reaction process. For example, polar solvents play a role in the rate and selectivity of nucleophilic substitution reactions.
Second, it is prepared by halogenation of aromatic hydrocarbons. First, benzene or its derivatives are used as starters, and chlorine, fluorine, and bromine atoms are introduced through gradual halogenation. In this process, the selection and order of use of halogenating reagents are critical. If chlorine, fluorine, bromine, etc. are used as halogenating agents, the dosage and reaction conditions need to be controlled. When introducing fluorine atoms, due to the high reactivity of fluorine gas, special methods or special fluorination reagents are often used to ensure the controllability and selectivity of the reaction. When introducing chlorine atoms and bromine atoms, it is also necessary to arrange the reaction steps reasonably according to the reaction activity and positioning effect to ensure the formation of the target product.
Third, the cross-coupling reaction of metal catalysis is used. Aromatic derivatives containing halogen atoms and suitable metal reagents are selected to realize the coupling of carbon-halogen bonds under the action of metal catalysts, so as to construct the structure of 4-chloro-3,5-difluorobromobenzene. There are many types of metal catalysts, such as palladium, nickel and other metal catalysts, with different catalytic activities and selectivity. In the reaction system, the choice of ligands also has a significant impact on the reaction. Appropriate ligands can enhance the activity and selectivity of metal catalysts and improve the yield of target products. At the same time, factors such as the substrate structure, reaction temperature, type and dosage of bases need to be carefully controlled to achieve the desired reaction effect.
First, halogenated aromatics are used as starting materials and are prepared by nucleophilic substitution reaction. If a suitable aromatic hydrocarbon containing bromine, chlorine and fluorine is selected, it will be replaced by a nucleophilic reagent under specific reaction conditions. The choice of nucleophilic reagents depends on the reaction mechanism and the expected product. In the reaction environment, factors such as temperature and solvent are also crucial. Appropriately increasing the temperature can speed up the reaction rate, but if it is too high, it may cause more side reactions. Suitable solvents can not only dissolve the reactants, but also affect the reaction process. For example, polar solvents play a role in the rate and selectivity of nucleophilic substitution reactions.
Second, it is prepared by halogenation of aromatic hydrocarbons. First, benzene or its derivatives are used as starters, and chlorine, fluorine, and bromine atoms are introduced through gradual halogenation. In this process, the selection and order of use of halogenating reagents are critical. If chlorine, fluorine, bromine, etc. are used as halogenating agents, the dosage and reaction conditions need to be controlled. When introducing fluorine atoms, due to the high reactivity of fluorine gas, special methods or special fluorination reagents are often used to ensure the controllability and selectivity of the reaction. When introducing chlorine atoms and bromine atoms, it is also necessary to arrange the reaction steps reasonably according to the reaction activity and positioning effect to ensure the formation of the target product.
Third, the cross-coupling reaction of metal catalysis is used. Aromatic derivatives containing halogen atoms and suitable metal reagents are selected to realize the coupling of carbon-halogen bonds under the action of metal catalysts, so as to construct the structure of 4-chloro-3,5-difluorobromobenzene. There are many types of metal catalysts, such as palladium, nickel and other metal catalysts, with different catalytic activities and selectivity. In the reaction system, the choice of ligands also has a significant impact on the reaction. Appropriate ligands can enhance the activity and selectivity of metal catalysts and improve the yield of target products. At the same time, factors such as the substrate structure, reaction temperature, type and dosage of bases need to be carefully controlled to achieve the desired reaction effect.
4-chloro-3, 5-difluorobromobenzene What are the precautions in storage and transportation?
4-Chloro-3,5-difluorobromobenzene is also an organic compound. During storage and transportation, many matters need to be paid attention to.
First words storage, this compound should be stored in a cool, dry and well ventilated place. To cover its properties or be unstable due to changes in temperature and humidity, it is important to avoid high temperature and humidity. High temperature can easily cause its volatilization to accelerate, or cause chemical reactions; humid environment may cause changes such as hydrolysis, which will damage its quality. And it needs to be kept away from fire and heat sources. Because of its flammability, in case of open flames and hot topics, there is a risk of combustion and explosion.
Furthermore, the storage place should be stored separately from oxidizing agents, acids, alkalis, etc., and must not be mixed. Due to its active chemical properties, contact with the above substances is prone to violent reactions and accidents. At the same time, the storage container must be well sealed to prevent leakage. The container material used, when compatible with 4-chloro-3,5-difluorobromobenzene, does not react with it to ensure safe storage.
As for transportation, there are also many details. Before transportation, ensure that the packaging is complete and sealed. The packaging material should have appropriate strength to resist vibration, collision and friction during transportation, so as not to cause material leakage due to damage to the container. During transportation, the transportation vehicle should be equipped with the corresponding variety and quantity of fire protection equipment and leakage emergency treatment equipment. The driving route should be far away from sensitive areas such as densely populated areas and water sources to reduce the harm in the event of accidents. And transportation personnel must undergo professional training, be familiar with the characteristics of the chemical, emergency treatment methods, and strictly abide by the operating procedures to ensure the safety of the whole transportation process. In this way, the safety of 4-chloro-3,5-difluorobromobenzene during storage and transportation must be ensured.
First words storage, this compound should be stored in a cool, dry and well ventilated place. To cover its properties or be unstable due to changes in temperature and humidity, it is important to avoid high temperature and humidity. High temperature can easily cause its volatilization to accelerate, or cause chemical reactions; humid environment may cause changes such as hydrolysis, which will damage its quality. And it needs to be kept away from fire and heat sources. Because of its flammability, in case of open flames and hot topics, there is a risk of combustion and explosion.
Furthermore, the storage place should be stored separately from oxidizing agents, acids, alkalis, etc., and must not be mixed. Due to its active chemical properties, contact with the above substances is prone to violent reactions and accidents. At the same time, the storage container must be well sealed to prevent leakage. The container material used, when compatible with 4-chloro-3,5-difluorobromobenzene, does not react with it to ensure safe storage.
As for transportation, there are also many details. Before transportation, ensure that the packaging is complete and sealed. The packaging material should have appropriate strength to resist vibration, collision and friction during transportation, so as not to cause material leakage due to damage to the container. During transportation, the transportation vehicle should be equipped with the corresponding variety and quantity of fire protection equipment and leakage emergency treatment equipment. The driving route should be far away from sensitive areas such as densely populated areas and water sources to reduce the harm in the event of accidents. And transportation personnel must undergo professional training, be familiar with the characteristics of the chemical, emergency treatment methods, and strictly abide by the operating procedures to ensure the safety of the whole transportation process. In this way, the safety of 4-chloro-3,5-difluorobromobenzene during storage and transportation must be ensured.
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