Linshang Chemical
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4-Chloro-3-Cyanobenzeneboronic Acid
Linshang Chemical
|
HS Code |
861705 |
| Chemical Formula | C7H5BClNO2 |
| Molar Mass | 181.38 g/mol |
| Appearance | White to off - white solid |
| Melting Point | 198 - 202 °C |
| Solubility | Slightly soluble in water, soluble in organic solvents like ethanol, dichloromethane |
| Purity | Typically high - purity, e.g., 97%+ in commercial products |
| Boiling Point | Decomposes before boiling |
| Stability | Stable under normal conditions, but moisture - sensitive |
| Reactivity | Reacts with organohalides in Suzuki - Miyaura coupling reactions |
As an accredited 4-Chloro-3-Cyanobenzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - chloro - 3 - cyanobenzeneboronic acid packaged in a sealed glass bottle. |
| Storage | 4 - chloro - 3 - cyanobenzeneboronic acid should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, ignition sources, and incompatible substances like strong oxidizing agents. Store it in a tightly sealed container to prevent moisture absorption, which could affect its stability. This storage method helps maintain its quality and reduces the risk of chemical reactions or decomposition. |
| Shipping | 4 - chloro - 3 - cyanobenzeneboronic acid is shipped in well - sealed containers, often in accordance with hazardous chemical regulations. Packaging safeguards against breakage, with proper labeling indicating its nature for safe handling during transit. |
Competitive 4-Chloro-3-Cyanobenzeneboronic Acid prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4-Chloro-3-Cyanobenzeneboronic Acid in China?
As a trusted 4-Chloro-3-Cyanobenzeneboronic Acid manufacturer, we deliver:
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Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-Chloro-3-Cyanobenzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 4-chloro-3-cyanobenzeneboronic Acid?
4-Chloro-3-cyanophenylboronic acid is a useful reagent in organic synthesis. Looking at its chemical properties, it has the general properties of boric acid and is weakly acidic. It can be esterified with alcohols under specific conditions to form borate esters. Because of its boron atom, the outer electronic structure of this atom is unique, so that 4-chloro-3-cyanophenylboronic acid can play a unique role in some organic reactions, such as participating in palladium-catalyzed coupling reactions. It can cross-couple with halogenated aromatics, olefins and other substrates in the presence of palladium catalysts and bases to form carbon-carbon bonds, which can be used to synthesize complex organic molecules.
Furthermore, the cyanyl group is active and can undergo many reactions, such as hydrolysis reaction. Under the catalysis of acid or base, the cyanyl group can be gradually hydrolyzed to carboxyl or amide groups. The chlorine atom also has certain reactivity and can be replaced by nucleophiles to realize the conversion of functional groups. 4-Chloro-3-cyanophenylboronic acid can be used as a key intermediate in the field of organic synthesis for the creation of drugs, natural products and functional materials. By ingeniously designing the reaction route, the characteristics of each functional group can be fully utilized to achieve the construction of complex target molecules.
Furthermore, the cyanyl group is active and can undergo many reactions, such as hydrolysis reaction. Under the catalysis of acid or base, the cyanyl group can be gradually hydrolyzed to carboxyl or amide groups. The chlorine atom also has certain reactivity and can be replaced by nucleophiles to realize the conversion of functional groups. 4-Chloro-3-cyanophenylboronic acid can be used as a key intermediate in the field of organic synthesis for the creation of drugs, natural products and functional materials. By ingeniously designing the reaction route, the characteristics of each functional group can be fully utilized to achieve the construction of complex target molecules.
What are the main uses of 4-chloro-3-cyanobenzeneboronic Acid?
4-Chloro-3-cyanophenylboronic acid is a crucial chemical reagent in the field of organic synthesis. It has a wide range of uses and is of great significance.
First, it is often used as a key intermediate in the field of medicinal chemistry. The structure of Gein phenylboronic acid can participate in a variety of chemical reactions and can help to construct complex drug molecular structures. Taking the development of specific anti-cancer drugs as an example, 4-chloro-3-cyanophenylboronic acid can be coupled with halogenated aromatics through Suzuki coupling reaction to generate compounds with specific structures and biological activities, providing new opportunities for the creation of anti-cancer drugs.
Second, it also has important applications in the field of materials science. It can be used to prepare functional materials, such as conjugated polymer materials with photoelectric properties by reacting with specific organic ligands. Such materials have great potential in the fields of organic Light Emitting Diodes (OLEDs) and solar cells, and are expected to improve the performance of related devices.
Third, in the study of organic synthesis methodology, it provides a powerful tool for chemists to explore new reaction paths and strategies. Due to its unique structure and reactivity, it can trigger novel chemical reactions, expand the chemical boundaries of organic synthesis, and provide more methods and ideas for the synthesis of organic compounds. With its own characteristics, 4-chloro-3-cyanophenylboronic acid plays a key role in many fields such as drug research and development, material preparation, and organic synthesis methodology, promoting sustainable development and innovation in various fields.
First, it is often used as a key intermediate in the field of medicinal chemistry. The structure of Gein phenylboronic acid can participate in a variety of chemical reactions and can help to construct complex drug molecular structures. Taking the development of specific anti-cancer drugs as an example, 4-chloro-3-cyanophenylboronic acid can be coupled with halogenated aromatics through Suzuki coupling reaction to generate compounds with specific structures and biological activities, providing new opportunities for the creation of anti-cancer drugs.
Second, it also has important applications in the field of materials science. It can be used to prepare functional materials, such as conjugated polymer materials with photoelectric properties by reacting with specific organic ligands. Such materials have great potential in the fields of organic Light Emitting Diodes (OLEDs) and solar cells, and are expected to improve the performance of related devices.
Third, in the study of organic synthesis methodology, it provides a powerful tool for chemists to explore new reaction paths and strategies. Due to its unique structure and reactivity, it can trigger novel chemical reactions, expand the chemical boundaries of organic synthesis, and provide more methods and ideas for the synthesis of organic compounds. With its own characteristics, 4-chloro-3-cyanophenylboronic acid plays a key role in many fields such as drug research and development, material preparation, and organic synthesis methodology, promoting sustainable development and innovation in various fields.
What are the synthetic methods of 4-chloro-3-cyanobenzeneboronic Acid?
The common methods for synthesizing 4-chloro-3-cyanobenzene boronic acid are as follows.
First, 4-chloro-3-cyanobenzene is used as the starting material, which is a commonly used substrate in organic synthesis. In a low temperature environment, such as minus 78 degrees Celsius, it is dissolved in an anhydrous tetrahydrofuran and other organic solvents, and then slowly add n-butyl lithium. N-butyl lithium is strongly alkaline, which can cause the lithium halogen exchange reaction of bromobenzene to generate the corresponding aryl lithium reagent. This reagent has high activity, and then borate esters, such as trimethyl borate, are added. After heating to room temperature and stirring for a certain hour, the reaction is fully carried out. After that, 4-chloro-3-cyanophenylboronic acid can be obtained through an acidic hydrolysis step. This process requires attention to the precise control of the reaction temperature, because low temperature can ensure the selectivity of lithium-halogen exchange reaction and avoid side reactions; and acidic hydrolysis conditions also need to be moderate to prevent product damage.
Second, 4-chloro-3-cyanoaniline can also be used as a starting material. First, it is diazotized with sodium nitrite and hydrochloric acid at low temperature to form a diazonium salt. The diazonium salt is active in nature, and then reacts with sodium borohydride and an appropriate amount of copper salt catalyst, such as cuprous chloride, in a specific solvent, which can convert the diazonium group into a boric acid group to obtain the target product. In this method, the diazotization reaction needs to be carried out at low temperature and strictly controlled reaction conditions to ensure the stability of the diazonium salt and avoid its premature decomposition. The amount of copper salt catalyst and reaction time also have a great impact on the reaction yield, which needs to be carefully explored and optimized.
Third, the method of transition metal catalysis is used. Using 4-chloro-3-cyanohalobenzene and diphenylboronic acid ester as raw materials, under the catalysis of palladium catalyst, such as tetra (triphenylphosphine) palladium, in an organic solvent system in the presence of suitable bases, such as potassium carbonate. The palladium catalyst can promote the coupling reaction between halobenzene and borate to generate 4-chloro-3-cyanophenylboronic acid phenylboronic acid ester, which can be hydrolyzed to obtain 4-chloro-3-cyanophenylboronic acid. In this approach, the activity and stability of the palladium catalyst are crucial to the reaction process. At the same time, the type and dosage of bases and the choice of reaction solvent will affect the rate and yield of the reaction, so careful consideration is required.
First, 4-chloro-3-cyanobenzene is used as the starting material, which is a commonly used substrate in organic synthesis. In a low temperature environment, such as minus 78 degrees Celsius, it is dissolved in an anhydrous tetrahydrofuran and other organic solvents, and then slowly add n-butyl lithium. N-butyl lithium is strongly alkaline, which can cause the lithium halogen exchange reaction of bromobenzene to generate the corresponding aryl lithium reagent. This reagent has high activity, and then borate esters, such as trimethyl borate, are added. After heating to room temperature and stirring for a certain hour, the reaction is fully carried out. After that, 4-chloro-3-cyanophenylboronic acid can be obtained through an acidic hydrolysis step. This process requires attention to the precise control of the reaction temperature, because low temperature can ensure the selectivity of lithium-halogen exchange reaction and avoid side reactions; and acidic hydrolysis conditions also need to be moderate to prevent product damage.
Second, 4-chloro-3-cyanoaniline can also be used as a starting material. First, it is diazotized with sodium nitrite and hydrochloric acid at low temperature to form a diazonium salt. The diazonium salt is active in nature, and then reacts with sodium borohydride and an appropriate amount of copper salt catalyst, such as cuprous chloride, in a specific solvent, which can convert the diazonium group into a boric acid group to obtain the target product. In this method, the diazotization reaction needs to be carried out at low temperature and strictly controlled reaction conditions to ensure the stability of the diazonium salt and avoid its premature decomposition. The amount of copper salt catalyst and reaction time also have a great impact on the reaction yield, which needs to be carefully explored and optimized.
Third, the method of transition metal catalysis is used. Using 4-chloro-3-cyanohalobenzene and diphenylboronic acid ester as raw materials, under the catalysis of palladium catalyst, such as tetra (triphenylphosphine) palladium, in an organic solvent system in the presence of suitable bases, such as potassium carbonate. The palladium catalyst can promote the coupling reaction between halobenzene and borate to generate 4-chloro-3-cyanophenylboronic acid phenylboronic acid ester, which can be hydrolyzed to obtain 4-chloro-3-cyanophenylboronic acid. In this approach, the activity and stability of the palladium catalyst are crucial to the reaction process. At the same time, the type and dosage of bases and the choice of reaction solvent will affect the rate and yield of the reaction, so careful consideration is required.
4-chloro-3-cyanobenzeneboronic Acid during storage and transportation
4-Chloro-3-cyanophenylboronic acid, when storing and transporting, be sure to pay attention to many matters.
This compound is quite sensitive to humidity, so when storing, it must be placed in a dry place to prevent moisture from causing deterioration. It should be stored in a sealed container to avoid contact with water vapor in the air. If the storage environment humidity is high, it may undergo reactions such as hydrolysis, which will damage quality and performance.
Temperature is also a key factor. It should be stored in a cool place, away from heat sources and open flames. Excessive temperature may cause it to decompose, evaporate, and even cause safety concerns. In general, it is recommended that the storage temperature be within a certain range to prevent temperature fluctuations from adversely affecting its stability.
When transporting, the packaging must be solid and stable. Select appropriate packaging materials to ensure that the compound is not damaged by vibration or collision during handling, loading and unloading. And it must be properly marked in accordance with relevant regulations, indicating its characteristics and hazards, so that transporters know the protective measures to be taken.
In addition, 4-chloro-3-cyanophenylboronic acid may have certain toxicity and irritation. Storage and transportation personnel need to take personal protection, such as wearing protective gloves, masks and goggles, to avoid direct contact and inhalation to prevent damage to the body. At the same time, the workplace should be well ventilated to reduce the risk of harmful gas accumulation.
In short, the storage and transportation of 4-chloro-3-cyanophenylboronic acid requires careful treatment of humidity, temperature, packaging, protection and other matters to ensure its quality and safety.
This compound is quite sensitive to humidity, so when storing, it must be placed in a dry place to prevent moisture from causing deterioration. It should be stored in a sealed container to avoid contact with water vapor in the air. If the storage environment humidity is high, it may undergo reactions such as hydrolysis, which will damage quality and performance.
Temperature is also a key factor. It should be stored in a cool place, away from heat sources and open flames. Excessive temperature may cause it to decompose, evaporate, and even cause safety concerns. In general, it is recommended that the storage temperature be within a certain range to prevent temperature fluctuations from adversely affecting its stability.
When transporting, the packaging must be solid and stable. Select appropriate packaging materials to ensure that the compound is not damaged by vibration or collision during handling, loading and unloading. And it must be properly marked in accordance with relevant regulations, indicating its characteristics and hazards, so that transporters know the protective measures to be taken.
In addition, 4-chloro-3-cyanophenylboronic acid may have certain toxicity and irritation. Storage and transportation personnel need to take personal protection, such as wearing protective gloves, masks and goggles, to avoid direct contact and inhalation to prevent damage to the body. At the same time, the workplace should be well ventilated to reduce the risk of harmful gas accumulation.
In short, the storage and transportation of 4-chloro-3-cyanophenylboronic acid requires careful treatment of humidity, temperature, packaging, protection and other matters to ensure its quality and safety.
What is the market price range for 4-chloro-3-cyanobenzeneboronic Acid?
The price of 4-chloro-3-cyanophenylboronic acid in the market is difficult to determine. Its price often changes for many reasons.
First, the price of raw materials has a great impact. If the price of chlorine substitutes, cyanide-containing raw materials and boron sources used to prepare this boric acid rises, the cost of 4-chloro-3-cyanophenylboronic acid will increase, and the price of its market will also rise. On the contrary, if the price of raw materials falls, the price of boric acid may decrease.
Second, the supply and demand situation is related to its price. If the market demand for this product increases sharply, but the output is limited, the supply is in short supply, and the price will rise; if the market demand is weak, the output is too large, and the supply exceeds the demand, the price will easily drop.
Third, the complexity and cost of the preparation process also affect. If the process is complicated, multiple steps, high conditions, or special equipment or catalysts are required, the cost is high and the price is also high; if the process is simple and the cost is low, the price may be reduced.
Fourth, market competition is also the key. There are many merchants producing this boric acid in the market, and the competition is fierce. In order to account for the share, the merchants may reduce the price to promote sales; if there are few merchants, the competition is weak, and the price may be relatively stable and high.
Looking at the past market, the price has fluctuated from a few yuan to tens of yuan per gram. However, this is only an approximate number. The current exact price needs to be consulted with chemical product suppliers, chemical raw material trading platforms, or the latest market information.
First, the price of raw materials has a great impact. If the price of chlorine substitutes, cyanide-containing raw materials and boron sources used to prepare this boric acid rises, the cost of 4-chloro-3-cyanophenylboronic acid will increase, and the price of its market will also rise. On the contrary, if the price of raw materials falls, the price of boric acid may decrease.
Second, the supply and demand situation is related to its price. If the market demand for this product increases sharply, but the output is limited, the supply is in short supply, and the price will rise; if the market demand is weak, the output is too large, and the supply exceeds the demand, the price will easily drop.
Third, the complexity and cost of the preparation process also affect. If the process is complicated, multiple steps, high conditions, or special equipment or catalysts are required, the cost is high and the price is also high; if the process is simple and the cost is low, the price may be reduced.
Fourth, market competition is also the key. There are many merchants producing this boric acid in the market, and the competition is fierce. In order to account for the share, the merchants may reduce the price to promote sales; if there are few merchants, the competition is weak, and the price may be relatively stable and high.
Looking at the past market, the price has fluctuated from a few yuan to tens of yuan per gram. However, this is only an approximate number. The current exact price needs to be consulted with chemical product suppliers, chemical raw material trading platforms, or the latest market information.
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