Linshang Chemical
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4-Chloro-3-Fluorobenzeneboronic Acid
Linshang Chemical
|
HS Code |
427022 |
| Chemical Formula | C6H5BClFO2 |
| Molar Mass | 176.37 g/mol |
| Appearance | White to off - white solid |
| Melting Point | 148 - 152 °C |
| Solubility In Water | Slightly soluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Purity | Typically high - purity products around 97%+ |
| Stability | Air - stable under normal conditions, but may react with strong oxidizing or reducing agents |
| Odor | Odorless or very faint odor |
As an accredited 4-Chloro-3-Fluorobenzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - chloro - 3 - fluorobenzeneboronic acid in sealed, chemical - resistant packaging. |
| Storage | 4 - Chloro - 3 - fluorobenzeneboronic acid should be stored in a cool, dry place. Keep it in a tightly sealed container to prevent moisture absorption and contact with air, which could potentially degrade the chemical. Store away from heat sources and incompatible substances like strong oxidizing agents. Proper storage helps maintain its chemical integrity for reliable use in reactions. |
| Shipping | 4 - chloro - 3 - fluorobenzeneboronic acid is shipped in well - sealed, corrosion - resistant containers. It's transported under conditions avoiding moisture and heat, following strict chemical shipping regulations to ensure safety during transit. |
Competitive 4-Chloro-3-Fluorobenzeneboronic Acid prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 4-Chloro-3-Fluorobenzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the chemical properties of 4-chloro-3-fluorobenzeneboronic Acid?
4-Chloro-3-fluorophenylboronic acid is a kind of very important compound in organic chemistry. Its chemical properties are unique, let me talk about them one by one.
Looking at its structure, there are chlorine atoms, fluorine atoms and boric acid groups attached to the benzene ring, which endows it with many special properties. Boric acid groups have certain acidity and can react with acids and bases under appropriate conditions. It can interact with bases to form corresponding borates. This reaction is often a key step in the construction of specific structures in organic synthesis.
Furthermore, the presence of chlorine atoms and fluorine atoms in 4-chloro-3-fluorophenylboronic acid affects the electron cloud distribution and steric hindrance of molecules. The electronegativity of the halogen atoms makes the electron cloud density of the benzene ring uneven, which in turn affects the electrophilic substitution reaction activity on the benzene ring. Chlorine and fluorine atoms can be used as leaving groups to participate in nucleophilic substitution reactions. This property is very valuable in the design of organic synthesis routes, which can introduce other functional groups and expand the structural diversity of compounds.
In coupling reactions, 4-chloro-3-fluorophenylboronic acid is an important intermediate. If Suzuki coupling reaction occurs with halogenated aromatics under the action of suitable catalysts, carbon-carbon bonds can be formed to form more complex aromatic compounds. This reaction has mild conditions and high selectivity, and is widely used in drug synthesis, materials science and other fields.
In addition, the stability of 4-chloro-3-fluorophenylboronic acid is to some extent affected by environmental factors. When exposed to high temperature, humidity or specific chemical reagents, its structure may change, causing decomposition or other side reactions. Therefore, during storage and use, attention should be paid to control conditions to maintain the stability of its chemical properties.
Looking at its structure, there are chlorine atoms, fluorine atoms and boric acid groups attached to the benzene ring, which endows it with many special properties. Boric acid groups have certain acidity and can react with acids and bases under appropriate conditions. It can interact with bases to form corresponding borates. This reaction is often a key step in the construction of specific structures in organic synthesis.
Furthermore, the presence of chlorine atoms and fluorine atoms in 4-chloro-3-fluorophenylboronic acid affects the electron cloud distribution and steric hindrance of molecules. The electronegativity of the halogen atoms makes the electron cloud density of the benzene ring uneven, which in turn affects the electrophilic substitution reaction activity on the benzene ring. Chlorine and fluorine atoms can be used as leaving groups to participate in nucleophilic substitution reactions. This property is very valuable in the design of organic synthesis routes, which can introduce other functional groups and expand the structural diversity of compounds.
In coupling reactions, 4-chloro-3-fluorophenylboronic acid is an important intermediate. If Suzuki coupling reaction occurs with halogenated aromatics under the action of suitable catalysts, carbon-carbon bonds can be formed to form more complex aromatic compounds. This reaction has mild conditions and high selectivity, and is widely used in drug synthesis, materials science and other fields.
In addition, the stability of 4-chloro-3-fluorophenylboronic acid is to some extent affected by environmental factors. When exposed to high temperature, humidity or specific chemical reagents, its structure may change, causing decomposition or other side reactions. Therefore, during storage and use, attention should be paid to control conditions to maintain the stability of its chemical properties.
What are the common synthesis methods of 4-chloro-3-fluorobenzeneboronic Acid?
The common synthesis methods of 4-chloro-3-fluorophenylboronic acid are generally as follows.
One is the halogenated aromatic hydrocarbon metal reagent method. 4-chloro-3-fluorobromobenzene is used as the starting material, and the metal magnesium is first interacted with to prepare the Grignard reagent. This process needs to be carried out in a harsh environment without water and oxygen. Because the Grignard reagent is extremely active, it reacts rapidly in contact with water and oxygen. After making the Grignard reagent, it reacts with borate esters and hydrolyzes to obtain 4-chloro-3-fluorophenylboronic acid. The key to this method is that the conditions for the preparation of the Grignard reagent are controlled, and the temperature and solvent purity have a great impact on the reaction.
The second is the palladium catalytic coupling method. Using 4-chloro-3-fluorohalobenzene and pinacol diborate as raw materials, the reaction occurs in the presence of appropriate bases and solvents under the catalysis of palladium catalysts such as tetra (triphenylphosphine) palladium. The base can adjust the pH of the reaction system and promote the reaction. The advantage of this method is that the reaction conditions are relatively mild and the selectivity is good. However, palladium catalysts are expensive and costly, and the separation and recovery of the catalyst after the reaction is also a problem to be considered.
The third is the lithium halogen exchange method. 4-Chloro-3-fluorohalobenzene and organolithium reagents undergo lithium-halogen exchange reaction to form lithium aromatic hydrocarbon intermediates, which are then reacted with borate esters and subsequently treated to obtain the target product. Organolithium reagents have high activity and fast reaction speed, but the reaction conditions are equally strict, such as low temperature, anhydrous, etc. At the same time, the storage and use of organolithium reagents also need to be extra careful, because they are flammable and explosive.
One is the halogenated aromatic hydrocarbon metal reagent method. 4-chloro-3-fluorobromobenzene is used as the starting material, and the metal magnesium is first interacted with to prepare the Grignard reagent. This process needs to be carried out in a harsh environment without water and oxygen. Because the Grignard reagent is extremely active, it reacts rapidly in contact with water and oxygen. After making the Grignard reagent, it reacts with borate esters and hydrolyzes to obtain 4-chloro-3-fluorophenylboronic acid. The key to this method is that the conditions for the preparation of the Grignard reagent are controlled, and the temperature and solvent purity have a great impact on the reaction.
The second is the palladium catalytic coupling method. Using 4-chloro-3-fluorohalobenzene and pinacol diborate as raw materials, the reaction occurs in the presence of appropriate bases and solvents under the catalysis of palladium catalysts such as tetra (triphenylphosphine) palladium. The base can adjust the pH of the reaction system and promote the reaction. The advantage of this method is that the reaction conditions are relatively mild and the selectivity is good. However, palladium catalysts are expensive and costly, and the separation and recovery of the catalyst after the reaction is also a problem to be considered.
The third is the lithium halogen exchange method. 4-Chloro-3-fluorohalobenzene and organolithium reagents undergo lithium-halogen exchange reaction to form lithium aromatic hydrocarbon intermediates, which are then reacted with borate esters and subsequently treated to obtain the target product. Organolithium reagents have high activity and fast reaction speed, but the reaction conditions are equally strict, such as low temperature, anhydrous, etc. At the same time, the storage and use of organolithium reagents also need to be extra careful, because they are flammable and explosive.
What are the applications of 4-chloro-3-fluorobenzeneboronic Acid?
4-Chloro-3-fluorophenylboronic acid is used in various fields. It is often a key synthetic building block in the field of medicinal chemistry. In terms of creating new drugs, this compound can interact with specific targets in organisms through its unique structure. Chemists rely on its participation in the construction of complex molecular structures in order to find new drugs with excellent efficacy.
In materials science, 4-chloro-3-fluorophenylboronic acid also has extraordinary performance. It can be used to prepare materials with special functions, such as photoelectric materials. It can affect the electron transport properties and optical properties of materials, and then contribute greatly to the manufacture of high-performance Light Emitting Diodes, solar cells, etc. Due to the presence of chlorine and fluorine atoms in the structure, the material has a unique electron cloud distribution and affects its energy level structure, so the material presents specific photoelectric properties.
Furthermore, in the field of organic synthesis chemistry, 4-chloro-3-fluorophenylboronic acid is a powerful tool. It can participate in many classic organic reactions, such as the Suzuki-Miyaura reaction. With this reaction, it can efficiently form carbon-carbon bonds and achieve precise synthesis of complex organic molecules. Its boric acid groups can react with halogenated aromatics or alkenyl halides in the presence of suitable catalysts and bases to synthesize a variety of organic compounds, providing a broad way for organic synthesis chemists to expand molecular diversity.
In addition, in the field of chemical production, 4-chloro-3-fluorophenylboronic acid may also be used as a special auxiliary. In the preparation process of some fine chemicals, the addition of this compound may regulate the reaction process, improve the purity and yield of the product, and help the efficient and high-quality chemical production.
In materials science, 4-chloro-3-fluorophenylboronic acid also has extraordinary performance. It can be used to prepare materials with special functions, such as photoelectric materials. It can affect the electron transport properties and optical properties of materials, and then contribute greatly to the manufacture of high-performance Light Emitting Diodes, solar cells, etc. Due to the presence of chlorine and fluorine atoms in the structure, the material has a unique electron cloud distribution and affects its energy level structure, so the material presents specific photoelectric properties.
Furthermore, in the field of organic synthesis chemistry, 4-chloro-3-fluorophenylboronic acid is a powerful tool. It can participate in many classic organic reactions, such as the Suzuki-Miyaura reaction. With this reaction, it can efficiently form carbon-carbon bonds and achieve precise synthesis of complex organic molecules. Its boric acid groups can react with halogenated aromatics or alkenyl halides in the presence of suitable catalysts and bases to synthesize a variety of organic compounds, providing a broad way for organic synthesis chemists to expand molecular diversity.
In addition, in the field of chemical production, 4-chloro-3-fluorophenylboronic acid may also be used as a special auxiliary. In the preparation process of some fine chemicals, the addition of this compound may regulate the reaction process, improve the purity and yield of the product, and help the efficient and high-quality chemical production.
What are the storage conditions for 4-chloro-3-fluorobenzeneboronic Acid?
4-Chloro-3-fluorophenylboronic acid is an important reagent for organic synthesis, and its storage conditions are critical to its quality and stability.
This reagent should be stored in a cool, dry and well-ventilated place. A cool environment can avoid the change or decomposition of its reactivity due to heat, and the temperature should not exceed 25 ° C. Drying conditions are also indispensable. Because of its hydrophilicity, it is easy to absorb moisture. After moisture absorption, it may hydrolyze, which affects its purity and reactivity. Therefore, it should be placed in an environment with a relative humidity of 40% - 60%.
At the same time, it should be kept away from fire, heat sources and strong oxidants. Strong oxidants may react violently with them, causing safety accidents. When storing, it should be separated from the oxidizing agent and clearly marked.
Storage containers are also exquisite, and well-sealed glass or plastic bottles should be used. Glass bottles have good chemical stability and can effectively isolate air and water vapor; plastic bottles are light and not fragile, and have good tolerance to the reagent.
After use, be sure to seal the container in time to prevent air and water vapor from entering. Following these storage conditions can ensure that 4-chloro-3-fluorophenylboronic acid maintains good quality and performance during storage, and plays its due role in organic synthesis and other fields.
This reagent should be stored in a cool, dry and well-ventilated place. A cool environment can avoid the change or decomposition of its reactivity due to heat, and the temperature should not exceed 25 ° C. Drying conditions are also indispensable. Because of its hydrophilicity, it is easy to absorb moisture. After moisture absorption, it may hydrolyze, which affects its purity and reactivity. Therefore, it should be placed in an environment with a relative humidity of 40% - 60%.
At the same time, it should be kept away from fire, heat sources and strong oxidants. Strong oxidants may react violently with them, causing safety accidents. When storing, it should be separated from the oxidizing agent and clearly marked.
Storage containers are also exquisite, and well-sealed glass or plastic bottles should be used. Glass bottles have good chemical stability and can effectively isolate air and water vapor; plastic bottles are light and not fragile, and have good tolerance to the reagent.
After use, be sure to seal the container in time to prevent air and water vapor from entering. Following these storage conditions can ensure that 4-chloro-3-fluorophenylboronic acid maintains good quality and performance during storage, and plays its due role in organic synthesis and other fields.
4-chloro-3-fluorobenzeneboronic the market price of Acid
The market price of 4-chloro-3-fluorophenylboronic acid is difficult to break. Its price often changes due to various factors, just like the vagaries of the situation.
The first to bear the brunt is the trend of supply and demand. If there are many people in the market who want it, but the supply is small, the price will rise; conversely, if the supply exceeds the demand, the price will drop. For example, at some point, the electronics industry has a large increase in demand for materials containing this compound, and the demand is flowing, and the price will skyrocket.
Furthermore, the manufacturing cost also affects the price. The price of raw materials, the simplicity of the preparation process, and the amount of energy consumption are all related to cost. If the raw materials are scarce and expensive, or the preparation method is cumbersome and energy-consuming, and the cost rises, the price will also be high.
Different manufacturers have different prices. Large factories may have lower costs due to the benefits of scale, and the price may be close to the people; while small factories do not have the benefits of scale, the price may be higher.
Regional differences also affect their prices. In distant places, due to transportation fees and customs duties, the price will increase compared to the place of origin.
Looking at the market of the past, the price of 4-chloro-3-fluorophenylboronic acid can be as low as tens of yuan per gram, and can reach hundreds of yuan per gram at high times. It is difficult to give an exact price. If you want to know the exact market price, you need to consult the chemical product supplier or check the report of the current market conditions to obtain the details.
The first to bear the brunt is the trend of supply and demand. If there are many people in the market who want it, but the supply is small, the price will rise; conversely, if the supply exceeds the demand, the price will drop. For example, at some point, the electronics industry has a large increase in demand for materials containing this compound, and the demand is flowing, and the price will skyrocket.
Furthermore, the manufacturing cost also affects the price. The price of raw materials, the simplicity of the preparation process, and the amount of energy consumption are all related to cost. If the raw materials are scarce and expensive, or the preparation method is cumbersome and energy-consuming, and the cost rises, the price will also be high.
Different manufacturers have different prices. Large factories may have lower costs due to the benefits of scale, and the price may be close to the people; while small factories do not have the benefits of scale, the price may be higher.
Regional differences also affect their prices. In distant places, due to transportation fees and customs duties, the price will increase compared to the place of origin.
Looking at the market of the past, the price of 4-chloro-3-fluorophenylboronic acid can be as low as tens of yuan per gram, and can reach hundreds of yuan per gram at high times. It is difficult to give an exact price. If you want to know the exact market price, you need to consult the chemical product supplier or check the report of the current market conditions to obtain the details.
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