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4-Chloro-3-Fluorobromobenzene
Linshang Chemical
|
HS Code |
968416 |
| Chemical Formula | C6H3BrClF |
| Molar Mass | 225.44 g/mol |
| Appearance | Liquid (predicted from similar halobenzenes) |
| Boiling Point | Estimated around 190 - 210 °C (educated guess based on related haloaromatics) |
| Density | Estimated to be around 1.8 - 2.0 g/cm³ (comparable to other halogenated benzenes) |
| Solubility In Water | Low solubility, likely less than 0.1 g/L (common for halogenated aromatic hydrocarbons) |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, acetone, and dichloromethane |
| Vapor Pressure | Low vapor pressure at room temperature (typical for halogenated aromatic compounds) |
As an accredited 4-Chloro-3-Fluorobromobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100 g of 4 - chloro - 3 - fluorobromobenzene packaged in a sealed glass bottle. |
| Storage | 4 - chloro - 3 - fluorobromobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container, preferably made of corrosion - resistant materials. This helps prevent evaporation, reaction with air components, and potential leakage, ensuring its stability and safety during storage. |
| Shipping | 4 - chloro - 3 - fluorobromobenzene is shipped in sealed, corrosion - resistant containers. Adequate cushioning and secure packaging prevent breakage. It's transported following strict chemical shipping regulations to ensure safety. |
Competitive 4-Chloro-3-Fluorobromobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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What is the chemistry of 4-chloro-3-fluorobromobenzene?
4-Chloro-3-fluorobromobenzene is also an organic compound. Its chemical properties are quite interesting and are related to the mechanism and application of many organic reactions.
In this compound, bromine atoms, chlorine atoms and fluorine atoms have their own characteristics, which affect their overall chemical behavior. The electronegativity difference of halogen atoms causes uneven distribution of intramolecular charges, which makes the compound have a certain polarity. This polarity affects its physical properties, such as solubility, boiling point, etc.; in terms of chemical properties, it also affects its reactivity and selectivity.
For nucleophilic substitution reactions, due to the electron-absorbing effect of halogen atoms, the electron cloud density of benzene rings decreases, making nucleophilic reagents more vulnerable to attack. However, different halogen atoms have different departure abilities, and bromine atoms are relatively easy to leave. Therefore, in such reactions, bromine atoms are often the reaction check point, while chlorine atoms and fluorine atoms affect the reaction rate and regioselectivity.
In electrophilic substitution reactions, because halogen atoms are ortho-para-sites, the reaction mostly occurs in the ortho-sites or para-sites of halogen atoms. However, different halogen atoms have different degrees of influence on the electron cloud density of the benzene ring. Fluorine atoms have the strongest electronegativity, which attracts the benzene ring electron cloud the most, and reduces the density of the benzene ring electron cloud the most. Therefore, the electrophilic substitution reaction activity is slightly lower than that of bromine and chlorine atoms, and the regioselectivity is also different.
In addition, 4-chloro-3-fluorobromobenzene can participate in metal-catalyzed coupling reactions, such as forming carbon-carbon bonds or carbon-heteroatomic bonds with organometallic reagents under the action of specific catalysts, expanding its molecular structure, and is widely used in the field of organic synthesis.
Because it contains a variety of halogen atoms, halogen exchange reactions can occur under certain conditions. By selecting suitable reagents and reaction conditions, the replacement of halogen atoms can be realized, providing a way for the synthesis of different functional organic compounds.
All of these are important manifestations of the chemical properties of 4-chloro-3-fluorobromobenzene, which are of key significance in many fields such as organic synthesis, medicinal chemistry, and materials science. They provide a foundation for the creation of new compounds and the exploration of novel reactions.
In this compound, bromine atoms, chlorine atoms and fluorine atoms have their own characteristics, which affect their overall chemical behavior. The electronegativity difference of halogen atoms causes uneven distribution of intramolecular charges, which makes the compound have a certain polarity. This polarity affects its physical properties, such as solubility, boiling point, etc.; in terms of chemical properties, it also affects its reactivity and selectivity.
For nucleophilic substitution reactions, due to the electron-absorbing effect of halogen atoms, the electron cloud density of benzene rings decreases, making nucleophilic reagents more vulnerable to attack. However, different halogen atoms have different departure abilities, and bromine atoms are relatively easy to leave. Therefore, in such reactions, bromine atoms are often the reaction check point, while chlorine atoms and fluorine atoms affect the reaction rate and regioselectivity.
In electrophilic substitution reactions, because halogen atoms are ortho-para-sites, the reaction mostly occurs in the ortho-sites or para-sites of halogen atoms. However, different halogen atoms have different degrees of influence on the electron cloud density of the benzene ring. Fluorine atoms have the strongest electronegativity, which attracts the benzene ring electron cloud the most, and reduces the density of the benzene ring electron cloud the most. Therefore, the electrophilic substitution reaction activity is slightly lower than that of bromine and chlorine atoms, and the regioselectivity is also different.
In addition, 4-chloro-3-fluorobromobenzene can participate in metal-catalyzed coupling reactions, such as forming carbon-carbon bonds or carbon-heteroatomic bonds with organometallic reagents under the action of specific catalysts, expanding its molecular structure, and is widely used in the field of organic synthesis.
Because it contains a variety of halogen atoms, halogen exchange reactions can occur under certain conditions. By selecting suitable reagents and reaction conditions, the replacement of halogen atoms can be realized, providing a way for the synthesis of different functional organic compounds.
All of these are important manifestations of the chemical properties of 4-chloro-3-fluorobromobenzene, which are of key significance in many fields such as organic synthesis, medicinal chemistry, and materials science. They provide a foundation for the creation of new compounds and the exploration of novel reactions.
What are the physical properties of 4-chloro-3-fluorobromobenzene?
4-Chloro-3-fluorobromobenzene is one of the organic compounds. Its physical properties are quite important, let me tell you one by one.
First of all, its appearance, at room temperature, 4-chloro-3-fluorobromobenzene is colorless to light yellow liquid, clear and transparent, shiny. This is due to the molecular structure, its atomic arrangement and interaction, so that the external performance is like this.
times and boiling point, about a certain temperature range. Due to the Van der Waals force between molecules, etc., in order to make molecules break free from each other and change from liquid to gas, it is necessary to reach the corresponding energy, so the boiling point is specific. The value of this boiling point is very important when separating and purifying this compound. According to its boiling point characteristics, pure 4-chloro-3-fluorobromobenzene can be obtained by distillation.
Furthermore, when it comes to the melting point, the melting point of this substance is also a specific value. When the temperature drops below the melting point, the thermal motion of the molecules slows down, the distance between them narrows, and the arrangement gradually becomes orderly. Then it solidifies from a liquid state to a solid state. The characteristics of the melting point can be used as an important basis for the identification of the compound. The mixing of different impurities will cause the melting point to change, or rise or fall, so the melting point is often used to determine its purity.
The density of 4-chloro-3-fluorobromobenzene is greater than that of water. Mixing it with water shows that it sinks to the bottom of the water. This density characteristic is quite valuable when it comes to operations such as liquid-liquid separation.
In terms of solubility, 4-chloro-3-fluorobromobenzene has good solubility in organic solvents such as ethanol, ether, etc. Due to the principle of "similarity and phase dissolution", its molecular structure is similar to that of organic solvent molecules, and the intermolecular forces can interact and dissolve. In water, the solubility is very small, because the molecular polarity is quite different from that of water molecules, and the interaction is weak.
In addition, its odor also has characteristics, with a special aromatic odor, which may be irritating to the human body. When operating, pay attention to protection.
In summary, the physical properties of 4-chloro-3-fluorobromobenzene, such as appearance, boiling point, melting point, density, solubility, and odor, are determined by its molecular structure, and play a key role in the research, preparation, and application of compounds.
First of all, its appearance, at room temperature, 4-chloro-3-fluorobromobenzene is colorless to light yellow liquid, clear and transparent, shiny. This is due to the molecular structure, its atomic arrangement and interaction, so that the external performance is like this.
times and boiling point, about a certain temperature range. Due to the Van der Waals force between molecules, etc., in order to make molecules break free from each other and change from liquid to gas, it is necessary to reach the corresponding energy, so the boiling point is specific. The value of this boiling point is very important when separating and purifying this compound. According to its boiling point characteristics, pure 4-chloro-3-fluorobromobenzene can be obtained by distillation.
Furthermore, when it comes to the melting point, the melting point of this substance is also a specific value. When the temperature drops below the melting point, the thermal motion of the molecules slows down, the distance between them narrows, and the arrangement gradually becomes orderly. Then it solidifies from a liquid state to a solid state. The characteristics of the melting point can be used as an important basis for the identification of the compound. The mixing of different impurities will cause the melting point to change, or rise or fall, so the melting point is often used to determine its purity.
The density of 4-chloro-3-fluorobromobenzene is greater than that of water. Mixing it with water shows that it sinks to the bottom of the water. This density characteristic is quite valuable when it comes to operations such as liquid-liquid separation.
In terms of solubility, 4-chloro-3-fluorobromobenzene has good solubility in organic solvents such as ethanol, ether, etc. Due to the principle of "similarity and phase dissolution", its molecular structure is similar to that of organic solvent molecules, and the intermolecular forces can interact and dissolve. In water, the solubility is very small, because the molecular polarity is quite different from that of water molecules, and the interaction is weak.
In addition, its odor also has characteristics, with a special aromatic odor, which may be irritating to the human body. When operating, pay attention to protection.
In summary, the physical properties of 4-chloro-3-fluorobromobenzene, such as appearance, boiling point, melting point, density, solubility, and odor, are determined by its molecular structure, and play a key role in the research, preparation, and application of compounds.
What are the common synthetic methods of 4-chloro-3-fluorobromobenzene?
4-Chloro-3-fluorobromobenzene is also an organic compound. The common synthesis methods generally have the following numbers.
First, halogenated aromatics are used as starting materials. Appropriate halogenated benzene, such as chlorine or fluorine-containing benzene derivatives, can be taken first, and bromine atoms can be introduced through an electrophilic substitution reaction. Under suitable reaction conditions, such as in the presence of Lewis acid catalysts, such as aluminum trichloride or iron tribromide, a brominating agent, such as liquid bromine, reacts with it. In this case, the role of the catalyst is to polarize the bromine molecule, enhance its electrophilicity, and promote the reaction in the direction of generating the target product. And it is necessary to pay attention to the regulation of reaction temperature, reactant ratio and other conditions in order to obtain a higher yield product.
Second, through the diazonium salt reaction. First, the aniline derivative containing chlorine and fluorine is prepared, and the diazonium salt is prepared by the diazotization reaction. Then, a suitable brominating agent, such as cuprous bromide, is carried out in the Sandmeier reaction to replace the diazonium group with a bromine atom to obtain 4-chloro-3-fluorobromobenzene. In this process, the conditions of the diazotization reaction are quite critical, and it needs to be carried out at low temperature and in an acidic medium to ensure the stability of the diazonium salt, so that the subsequent reaction can occur smoothly.
Third, the coupling reaction is catalyzed by transition metals. For example, chlorine and fluorine-containing halogenated aromatics are used as substrates and brominated reagents are coupled under the action of transition metal catalysts such as palladium catalysts. Commonly used palladium catalysts such as tetra (triphenylphosphine) palladium, etc. During the reaction, additives such as ligands and bases are still required to promote the reaction. This method has the advantages of high selectivity and relatively mild reaction conditions, but the cost of the catalyst may be one of the factors to consider.
In short, there are many ways to synthesize 4-chloro-3-fluorobromobenzene. In practical applications, the appropriate synthesis path should be carefully selected according to many factors such as raw material availability, cost, yield and product purity.
First, halogenated aromatics are used as starting materials. Appropriate halogenated benzene, such as chlorine or fluorine-containing benzene derivatives, can be taken first, and bromine atoms can be introduced through an electrophilic substitution reaction. Under suitable reaction conditions, such as in the presence of Lewis acid catalysts, such as aluminum trichloride or iron tribromide, a brominating agent, such as liquid bromine, reacts with it. In this case, the role of the catalyst is to polarize the bromine molecule, enhance its electrophilicity, and promote the reaction in the direction of generating the target product. And it is necessary to pay attention to the regulation of reaction temperature, reactant ratio and other conditions in order to obtain a higher yield product.
Second, through the diazonium salt reaction. First, the aniline derivative containing chlorine and fluorine is prepared, and the diazonium salt is prepared by the diazotization reaction. Then, a suitable brominating agent, such as cuprous bromide, is carried out in the Sandmeier reaction to replace the diazonium group with a bromine atom to obtain 4-chloro-3-fluorobromobenzene. In this process, the conditions of the diazotization reaction are quite critical, and it needs to be carried out at low temperature and in an acidic medium to ensure the stability of the diazonium salt, so that the subsequent reaction can occur smoothly.
Third, the coupling reaction is catalyzed by transition metals. For example, chlorine and fluorine-containing halogenated aromatics are used as substrates and brominated reagents are coupled under the action of transition metal catalysts such as palladium catalysts. Commonly used palladium catalysts such as tetra (triphenylphosphine) palladium, etc. During the reaction, additives such as ligands and bases are still required to promote the reaction. This method has the advantages of high selectivity and relatively mild reaction conditions, but the cost of the catalyst may be one of the factors to consider.
In short, there are many ways to synthesize 4-chloro-3-fluorobromobenzene. In practical applications, the appropriate synthesis path should be carefully selected according to many factors such as raw material availability, cost, yield and product purity.
4-chloro-3-fluorobromobenzene in what areas?
4-Chloro-3-fluorobromobenzene is also an organic compound, which is used in the fields of chemical industry, medicine and materials.
In the chemical industry, it is often an intermediary for organic synthesis. The atoms of chlorine, fluorine and bromine attached to the phenyl ring have unique chemical activities. Through many chemical reactions, such as nucleophilic substitution, metal catalytic coupling, etc., other functional groups can be introduced to prepare complex organic compounds. Through nucleophilic substitution, chlorine and bromine atoms can be replaced by hydroxyl groups, amino groups, etc., to synthesize multi-functional group compounds, laying the foundation for the synthesis of various fine chemicals.
In the field of medicine, its application is also wide. Due to its structure, it can affect the physical and chemical properties and biological activities of drug molecules. Chemists can adjust the lipid solubility, water solubility, and affinity with targets of drug molecules by introducing the structure of 4-chloro-3-fluorobromobenzene. In the process of developing many new drugs, this is used as a starting material or key intermediate to synthesize compounds with specific pharmacological activities through multi-step reactions, or for the creation of antibacterial, anti-tumor and other drugs.
In the field of materials, 4-chloro-3-fluorobrobenzene can participate in the preparation of high-performance materials. By means of polymerization, its structure can be introduced into the main chain or side chain of polymer materials, which can endow materials with unique properties. In the preparation of special engineering plastics, the addition of monomers containing this structure can improve the heat resistance and chemical stability of plastics, making them more suitable for harsh environments.
In summary, although 4-chloro-3-fluorobromobenzene is an organic small molecule, it plays an extraordinary role in chemical, pharmaceutical, materials and other fields, promoting the progress and development of technology in various fields.
In the chemical industry, it is often an intermediary for organic synthesis. The atoms of chlorine, fluorine and bromine attached to the phenyl ring have unique chemical activities. Through many chemical reactions, such as nucleophilic substitution, metal catalytic coupling, etc., other functional groups can be introduced to prepare complex organic compounds. Through nucleophilic substitution, chlorine and bromine atoms can be replaced by hydroxyl groups, amino groups, etc., to synthesize multi-functional group compounds, laying the foundation for the synthesis of various fine chemicals.
In the field of medicine, its application is also wide. Due to its structure, it can affect the physical and chemical properties and biological activities of drug molecules. Chemists can adjust the lipid solubility, water solubility, and affinity with targets of drug molecules by introducing the structure of 4-chloro-3-fluorobromobenzene. In the process of developing many new drugs, this is used as a starting material or key intermediate to synthesize compounds with specific pharmacological activities through multi-step reactions, or for the creation of antibacterial, anti-tumor and other drugs.
In the field of materials, 4-chloro-3-fluorobrobenzene can participate in the preparation of high-performance materials. By means of polymerization, its structure can be introduced into the main chain or side chain of polymer materials, which can endow materials with unique properties. In the preparation of special engineering plastics, the addition of monomers containing this structure can improve the heat resistance and chemical stability of plastics, making them more suitable for harsh environments.
In summary, although 4-chloro-3-fluorobromobenzene is an organic small molecule, it plays an extraordinary role in chemical, pharmaceutical, materials and other fields, promoting the progress and development of technology in various fields.
What is the market outlook for 4-chloro-3-fluorobromobenzene?
4-Chloro-3-fluorobromobenzene is also an organic compound. In the chemical industry, its market prospect is worth exploring.
Looking at this compound, due to its unique structure, it contains halogen atoms such as chlorine, fluorine and bromine, endowing it with diverse chemical activities. This characteristic makes it stand out in many fields such as medicinal chemistry and materials science, which makes its market prospect hidden.
In the field of medicinal chemistry, the introduction of halogen atoms can often change the physical and chemical properties, biological activities and metabolic properties of compounds. 4-chloro-3-fluorobromobenzene can be used as a key intermediate for the synthesis of drug molecules with specific biological activities. With the increasing demand for novel structures and highly effective drugs in pharmaceutical research and development, the demand for this intermediate may be on the rise.
In materials science, halogenated organic compounds are often used to prepare high-performance materials. 4-Chloro-3-fluorobromobenzene can be introduced into polymer structures through specific reactions to improve the thermal stability, flame retardancy and electrical properties of materials. With the increasing demand for high-performance materials in electronics, aerospace and other industries, the application of this compound in material synthesis is expected to expand.
However, its market also faces challenges. The process of synthesizing this compound may involve complex reaction steps and conditions, and cost control is a major priority. In addition, environmental regulations are stricter on the use and emission of halides, and manufacturers need to find green synthesis paths to meet environmental protection requirements, which is also one of the major tests on the road to market expansion.
Overall, 4-chloro-3-fluorobromobenzene has broad application prospects in the field of drugs and materials due to its unique chemical structure. To fully exploit this prospect, the industry needs to deal with many challenges such as cost and environmental protection in order to seek sustainable market development.
Looking at this compound, due to its unique structure, it contains halogen atoms such as chlorine, fluorine and bromine, endowing it with diverse chemical activities. This characteristic makes it stand out in many fields such as medicinal chemistry and materials science, which makes its market prospect hidden.
In the field of medicinal chemistry, the introduction of halogen atoms can often change the physical and chemical properties, biological activities and metabolic properties of compounds. 4-chloro-3-fluorobromobenzene can be used as a key intermediate for the synthesis of drug molecules with specific biological activities. With the increasing demand for novel structures and highly effective drugs in pharmaceutical research and development, the demand for this intermediate may be on the rise.
In materials science, halogenated organic compounds are often used to prepare high-performance materials. 4-Chloro-3-fluorobromobenzene can be introduced into polymer structures through specific reactions to improve the thermal stability, flame retardancy and electrical properties of materials. With the increasing demand for high-performance materials in electronics, aerospace and other industries, the application of this compound in material synthesis is expected to expand.
However, its market also faces challenges. The process of synthesizing this compound may involve complex reaction steps and conditions, and cost control is a major priority. In addition, environmental regulations are stricter on the use and emission of halides, and manufacturers need to find green synthesis paths to meet environmental protection requirements, which is also one of the major tests on the road to market expansion.
Overall, 4-chloro-3-fluorobromobenzene has broad application prospects in the field of drugs and materials due to its unique chemical structure. To fully exploit this prospect, the industry needs to deal with many challenges such as cost and environmental protection in order to seek sustainable market development.
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