Linshang Chemical
PRODUCTS
4-Chloro-3-Fluoroiodobenzene
Linshang Chemical
|
HS Code |
474197 |
| Chemical Formula | C6H3ClFI |
| Molecular Weight | 256.44 |
| Appearance | Liquid (Typical) |
| Boiling Point | Approx. 200 - 210 °C |
| Density | Approx. 2.04 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane, toluene |
| Vapor Pressure | Low at room temperature |
As an accredited 4-Chloro-3-Fluoroiodobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chloro - 3 - fluoroiodobenzene packaged in a sealed, chemical - resistant bottle. |
| Storage | 4 - chloro - 3 - fluoroiodobenzene should be stored in a cool, dry, and well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store it in a tightly sealed container, preferably made of a material resistant to chemical corrosion, like glass or certain plastics. Label the container clearly to avoid misidentification. |
| Shipping | 4 - chloro - 3 - fluoroiodobenzene is shipped in accordance with chemical transport regulations. Packed in suitable containers, it's transported under proper temperature and handling to prevent damage, ensuring safe delivery. |
Competitive 4-Chloro-3-Fluoroiodobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4-Chloro-3-Fluoroiodobenzene in China?
As a trusted 4-Chloro-3-Fluoroiodobenzene manufacturer, we deliver:
Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements.
Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery.
Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
As a leading 4-Chloro-3-Fluoroiodobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 4-chloro-3-fluoroiodobenzene?
4-Chloro-3-fluoroiodobenzene is also an organic compound. Its main use is related to the field of organic synthesis. In the art of organic synthesis, it is often used as a key intermediate to prepare other types of organic compounds.
The chlorine, fluorine and iodine atoms in the molecule of 4-chloro-3-fluoroiodobenzene are all reactive and can be combined with other organic groups through various chemical reactions, such as nucleophilic substitution, coupling reactions, etc., to construct complex organic molecular structures.
In nucleophilic substitution reactions, chlorine, fluorine, and iodine atoms can be replaced by nucleophilic reagents such as hydroxyl, amino, and alkoxy to derive various functionalized organic compounds. These compounds have important uses in pharmaceutical chemistry, materials science, and other fields.
In terms of medicinal chemistry, organic compounds prepared with 4-chloro-3-fluoroiodobenzene as an intermediate, or biologically active, can be used as lead compounds. After further optimization, they are expected to become new drugs for the treatment of diseases.
In the field of materials science, organic materials derived from them, or with special photoelectric properties, can be applied to the preparation of organic Light Emitting Diodes, solar cells and other devices.
Furthermore, in the coupling reaction, 4-chloro-3-fluoroiodobenzene can be coupled with organic compounds containing unsaturated bonds such as carbon-carbon double bonds and carbon-carbon triple bonds to grow carbon chains and build complex carbon skeleton structures, providing an effective way to create new organic materials and bioactive molecules. Overall, 4-chloro-3-fluoroiodobenzene plays an important role in the stage of organic synthesis, providing a key material basis for the development of many fields.
The chlorine, fluorine and iodine atoms in the molecule of 4-chloro-3-fluoroiodobenzene are all reactive and can be combined with other organic groups through various chemical reactions, such as nucleophilic substitution, coupling reactions, etc., to construct complex organic molecular structures.
In nucleophilic substitution reactions, chlorine, fluorine, and iodine atoms can be replaced by nucleophilic reagents such as hydroxyl, amino, and alkoxy to derive various functionalized organic compounds. These compounds have important uses in pharmaceutical chemistry, materials science, and other fields.
In terms of medicinal chemistry, organic compounds prepared with 4-chloro-3-fluoroiodobenzene as an intermediate, or biologically active, can be used as lead compounds. After further optimization, they are expected to become new drugs for the treatment of diseases.
In the field of materials science, organic materials derived from them, or with special photoelectric properties, can be applied to the preparation of organic Light Emitting Diodes, solar cells and other devices.
Furthermore, in the coupling reaction, 4-chloro-3-fluoroiodobenzene can be coupled with organic compounds containing unsaturated bonds such as carbon-carbon double bonds and carbon-carbon triple bonds to grow carbon chains and build complex carbon skeleton structures, providing an effective way to create new organic materials and bioactive molecules. Overall, 4-chloro-3-fluoroiodobenzene plays an important role in the stage of organic synthesis, providing a key material basis for the development of many fields.
What are the physical properties of 4-chloro-3-fluoroiodobenzene?
4-Chloro-3-fluoroiodobenzene is a kind of organic compound. Its physical properties are particularly important and affect many fields of chemical application.
Looking at its physical state, under normal temperature and pressure, 4-chloro-3-fluoroiodobenzene is probably in a liquid state. The shape of this state is due to the characteristics of intermolecular forces. Intermolecular forces, such as van der Waals forces, are crucial in maintaining its liquid state.
As for the color, it is usually colorless and transparent or slightly yellowish. The characterization of this color can help to distinguish its purity. If impurities are added, the color may change significantly.
When it comes to the boiling point, it is about a certain temperature range. The value of the boiling point is closely related to the mass of the molecule and the strength of the intermolecular forces. Due to the influence of the molecular mass and the interaction between molecules, its boiling point has a specific value. The characteristics of this boiling point are crucial in chemical operations such as distillation and separation. According to its boiling point, this compound can be effectively separated from others.
The melting point is also one of the important physical properties. The existence of its melting point indicates the temperature node of the mutual transformation of solid and liquid states. The definition of this temperature is of great significance in the consideration of the storage, transportation and use conditions of compounds.
Furthermore, the density of 4-chloro-3-fluoroiodobenzene also has a specific value. The density is also the mass per unit volume. The value of its density is related to its floating or sinking state in the solution, and it affects the mixing and delamination of materials in the chemical process.
In terms of solubility, it has a certain solubility in organic solvents such as ether and chloroform. This characteristic is due to the adaptation of the polarity of its molecules to the polarity of organic solvent molecules. In water, the solubility is relatively limited, because water is a strong polar solvent, and the polarity of 4-chloro-3-fluoroiodobenzene is quite different.
In summary, the physical properties of 4-chloro-3-fluoroiodobenzene, such as physical state, color, boiling point, melting point, density, and solubility, are all important characteristics, and are widely used in chemical research, industrial production, and other fields. Only by knowing its properties can we make good use of it.
Looking at its physical state, under normal temperature and pressure, 4-chloro-3-fluoroiodobenzene is probably in a liquid state. The shape of this state is due to the characteristics of intermolecular forces. Intermolecular forces, such as van der Waals forces, are crucial in maintaining its liquid state.
As for the color, it is usually colorless and transparent or slightly yellowish. The characterization of this color can help to distinguish its purity. If impurities are added, the color may change significantly.
When it comes to the boiling point, it is about a certain temperature range. The value of the boiling point is closely related to the mass of the molecule and the strength of the intermolecular forces. Due to the influence of the molecular mass and the interaction between molecules, its boiling point has a specific value. The characteristics of this boiling point are crucial in chemical operations such as distillation and separation. According to its boiling point, this compound can be effectively separated from others.
The melting point is also one of the important physical properties. The existence of its melting point indicates the temperature node of the mutual transformation of solid and liquid states. The definition of this temperature is of great significance in the consideration of the storage, transportation and use conditions of compounds.
Furthermore, the density of 4-chloro-3-fluoroiodobenzene also has a specific value. The density is also the mass per unit volume. The value of its density is related to its floating or sinking state in the solution, and it affects the mixing and delamination of materials in the chemical process.
In terms of solubility, it has a certain solubility in organic solvents such as ether and chloroform. This characteristic is due to the adaptation of the polarity of its molecules to the polarity of organic solvent molecules. In water, the solubility is relatively limited, because water is a strong polar solvent, and the polarity of 4-chloro-3-fluoroiodobenzene is quite different.
In summary, the physical properties of 4-chloro-3-fluoroiodobenzene, such as physical state, color, boiling point, melting point, density, and solubility, are all important characteristics, and are widely used in chemical research, industrial production, and other fields. Only by knowing its properties can we make good use of it.
What is the chemistry of 4-chloro-3-fluoroiodobenzene?
4-Chloro-3-fluoroiodobenzene is also an organic compound. Its chemical properties are well researched. The halogen atom is on the benzene ring, causing it to have unique reactivity.
The trihalogen atom of chlorine, fluorine and iodine has different electronegativity. Fluorine has the strongest electronegativity and has a strong electron-absorbing induction effect on the benzene ring, which can reduce the electron cloud density of the benzene ring. The electronegativity of chlorine is slightly weaker than that of fluorine, but it also has an electron-absorbing induction effect. Although the electronegativity of iodine is smaller than that of the former two, its atomic radius is large, which can affect the spatial structure of molecules and the distribution of electron clouds.
In terms of electrophilic substitution reaction, the electrophilic substitution reaction activity may be reduced compared with benzene due to the decrease in electron cloud density of benzene ring. And the halogen localization effect also shows its role. Fluorine and chlorine are ortho-and para-localization groups, and iodine also has a slight ortho-and para-localization trend. However, due to the strong electron absorption induction of fluorine and chlorine, the electron cloud density distribution of benzene ring is uneven, and the attack position of electrophilic reagents may have specific selectivity.
In the nucleophilic substitution reaction, because halogen atoms can leave, substitution can occur under appropriate nucleophilic reagents and conditions. Iodine atoms are relatively easy to leave because of their large atomic radius and relatively small C-I bond energy Therefore, 4-chloro-3-fluoroiodobenzene can be used as a reaction check point at the iodine atom under suitable conditions to undergo nucleophilic substitution, which opens a way for the synthesis of new compounds.
And it can participate in the coupling reaction of metal catalysis. If it interacts with catalysts such as palladium metal, or can be coupled with compounds containing unsaturated bonds to construct more complex organic molecular structures, it has great potential in the field of organic synthesis.
Its chemical properties are determined by the type and position of halogen atoms in the molecule and the structure of benzene ring. Many reaction properties provide rich materials and exploration space for the research and application of organic synthetic chemistry.
The trihalogen atom of chlorine, fluorine and iodine has different electronegativity. Fluorine has the strongest electronegativity and has a strong electron-absorbing induction effect on the benzene ring, which can reduce the electron cloud density of the benzene ring. The electronegativity of chlorine is slightly weaker than that of fluorine, but it also has an electron-absorbing induction effect. Although the electronegativity of iodine is smaller than that of the former two, its atomic radius is large, which can affect the spatial structure of molecules and the distribution of electron clouds.
In terms of electrophilic substitution reaction, the electrophilic substitution reaction activity may be reduced compared with benzene due to the decrease in electron cloud density of benzene ring. And the halogen localization effect also shows its role. Fluorine and chlorine are ortho-and para-localization groups, and iodine also has a slight ortho-and para-localization trend. However, due to the strong electron absorption induction of fluorine and chlorine, the electron cloud density distribution of benzene ring is uneven, and the attack position of electrophilic reagents may have specific selectivity.
In the nucleophilic substitution reaction, because halogen atoms can leave, substitution can occur under appropriate nucleophilic reagents and conditions. Iodine atoms are relatively easy to leave because of their large atomic radius and relatively small C-I bond energy Therefore, 4-chloro-3-fluoroiodobenzene can be used as a reaction check point at the iodine atom under suitable conditions to undergo nucleophilic substitution, which opens a way for the synthesis of new compounds.
And it can participate in the coupling reaction of metal catalysis. If it interacts with catalysts such as palladium metal, or can be coupled with compounds containing unsaturated bonds to construct more complex organic molecular structures, it has great potential in the field of organic synthesis.
Its chemical properties are determined by the type and position of halogen atoms in the molecule and the structure of benzene ring. Many reaction properties provide rich materials and exploration space for the research and application of organic synthetic chemistry.
What are 4-chloro-3-fluoroiodobenzene synthesis methods?
The synthesis method of 4-chloro-3-fluoroiodobenzene covers a variety of paths. First, it can be formed by starting from halogenated aromatics and borrowing nucleophilic substitution reactions. First, take suitable chlorofluorobenzene and make it interact with iodizing reagents, such as potassium iodide and cuprous iodide, under suitable reaction conditions. It is often necessary to add appropriate catalysts, such as palladium-based catalysts, to promote the reaction and provide a suitable solvent environment, such as dimethylformamide (DMF), dimethyl sulfoxide (DMSO), etc. Under a certain temperature and pressure, after nucleophilic substitution, chlorine atoms or fluorine atoms are replaced by iodine atoms to obtain 4-chloro-3-fluoroiodobenzene.
Second, it can be obtained through the path of aryl boric acid derivatives. First, chlorine-containing and fluorine-containing aryl boric acids are prepared, and halogenated aromatic hydrocarbons are used as starting materials to obtain organometallic intermediates by means of metal reagents, such as magnesium reagents, lithium reagents, etc., and then react with borate esters to obtain aryl boronic acids. Then, the aryl boric acid and the iodine substitution reagent are coupled under the catalysis of transition metal catalysts such as tetra (triphenylphosphine) palladium (0), thereby introducing iodine atoms to obtain the target product 4-chloro-3-fluoroiodobenzene.
Or it can start from the direct halogenation of aromatic hydrocarbons. Using benzene as the initial material, 4-chloro-3-fluorobenzene is obtained by introducing chlorine atoms and fluorine atoms first. Then a suitable halogenating agent, such as N-iodosuccinimide (NIS), is used in the presence of light or initiator to cause radical halogenation reaction. Iodine atoms are introduced at specific positions in the benzene ring to obtain 4-chloro-3-fluoroiodobenzene. However, this path requires fine regulation of the reaction conditions to ensure the regioselectivity of halogenation to obtain the desired target product.
Second, it can be obtained through the path of aryl boric acid derivatives. First, chlorine-containing and fluorine-containing aryl boric acids are prepared, and halogenated aromatic hydrocarbons are used as starting materials to obtain organometallic intermediates by means of metal reagents, such as magnesium reagents, lithium reagents, etc., and then react with borate esters to obtain aryl boronic acids. Then, the aryl boric acid and the iodine substitution reagent are coupled under the catalysis of transition metal catalysts such as tetra (triphenylphosphine) palladium (0), thereby introducing iodine atoms to obtain the target product 4-chloro-3-fluoroiodobenzene.
Or it can start from the direct halogenation of aromatic hydrocarbons. Using benzene as the initial material, 4-chloro-3-fluorobenzene is obtained by introducing chlorine atoms and fluorine atoms first. Then a suitable halogenating agent, such as N-iodosuccinimide (NIS), is used in the presence of light or initiator to cause radical halogenation reaction. Iodine atoms are introduced at specific positions in the benzene ring to obtain 4-chloro-3-fluoroiodobenzene. However, this path requires fine regulation of the reaction conditions to ensure the regioselectivity of halogenation to obtain the desired target product.
4-chloro-3-fluoroiodobenzene What are the precautions during storage and transportation?
4-Chloro-3-fluoroiodobenzene is an organic compound. When storing and transporting it, many things must be paid attention to.
First stability and reactivity. This compound is chemically active and can easily cause combustion or explosion when exposed to open flames, hot topics or oxidants. Therefore, the storage place should be kept away from fire, heat sources, and stored separately from oxidants, food chemicals, etc., and must not be mixed. The warehouse must have suitable materials to contain leaks to prevent accidents.
Times and packaging. The packaging must be tight to ensure that it is well sealed to prevent its volatilization or leakage. Common packaging materials include glass bottles, plastic bottles or metal drums. The chemical names, hazard signs and precautions should be clearly marked on the outside of the package for identification and protection.
Another is transportation. During transportation, it should be lightly loaded and unloaded to avoid collisions and drops to prevent package damage. Transportation vehicles must be equipped with corresponding fire-fighting equipment and leakage emergency treatment equipment. Summer transportation should be selected in the morning and evening to avoid high temperatures. If transported by rail, the relevant provisions in the Ministry of Railways' "Rules for the Transport of Dangerous Goods" should be strictly followed.
In addition, storage and transportation places should have good ventilation conditions to reduce their concentration in the air. Operators also need to undergo special training, strictly abide by operating procedures, and wear appropriate protective equipment, such as protective glasses, gloves, gas masks, etc., to ensure personal safety. In case of accidental contact or leakage and other accidents, the correct emergency measures should be taken quickly, and the serious cases should be treated in time. In this way, the safety of 4-chloro-3-fluoroiodobenzene during storage and transportation can be ensured.
First stability and reactivity. This compound is chemically active and can easily cause combustion or explosion when exposed to open flames, hot topics or oxidants. Therefore, the storage place should be kept away from fire, heat sources, and stored separately from oxidants, food chemicals, etc., and must not be mixed. The warehouse must have suitable materials to contain leaks to prevent accidents.
Times and packaging. The packaging must be tight to ensure that it is well sealed to prevent its volatilization or leakage. Common packaging materials include glass bottles, plastic bottles or metal drums. The chemical names, hazard signs and precautions should be clearly marked on the outside of the package for identification and protection.
Another is transportation. During transportation, it should be lightly loaded and unloaded to avoid collisions and drops to prevent package damage. Transportation vehicles must be equipped with corresponding fire-fighting equipment and leakage emergency treatment equipment. Summer transportation should be selected in the morning and evening to avoid high temperatures. If transported by rail, the relevant provisions in the Ministry of Railways' "Rules for the Transport of Dangerous Goods" should be strictly followed.
In addition, storage and transportation places should have good ventilation conditions to reduce their concentration in the air. Operators also need to undergo special training, strictly abide by operating procedures, and wear appropriate protective equipment, such as protective glasses, gloves, gas masks, etc., to ensure personal safety. In case of accidental contact or leakage and other accidents, the correct emergency measures should be taken quickly, and the serious cases should be treated in time. In this way, the safety of 4-chloro-3-fluoroiodobenzene during storage and transportation can be ensured.
Scan to WhatsApp
