Linshang Chemical
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4-Chloro-3-Fluoronitrobenzene
Linshang Chemical
|
HS Code |
226031 |
| Chemical Formula | C6H3ClFNO2 |
| Molar Mass | 177.545 g/mol |
| Appearance | Yellow - brown liquid or solid |
| Boiling Point | 230 - 232 °C |
| Melting Point | 36 - 39 °C |
| Density | 1.489 g/cm³ |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like ethanol, ether |
| Flash Point | 101 °C |
| Pungency | Pungent odor |
| Cas Number | 393 - 11 - 3 |
As an accredited 4-Chloro-3-Fluoronitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of 4 - chloro - 3 - fluoronitrobenzene packaged in a sealed, chemical - resistant bottle. |
| Storage | 4 - chloro - 3 - fluoronitrobenzene should be stored in a cool, dry, well - ventilated area, away from sources of heat, ignition, and sunlight. Keep it in a tightly - sealed container to prevent leakage. Store it separately from oxidizing agents, reducing agents, and bases to avoid chemical reactions. Follow local safety regulations for its storage. |
| Shipping | 4 - chloro - 3 - fluoronitrobenzene is shipped in sealed, corrosion - resistant containers. It's classified as a hazardous chemical, so shipping follows strict regulations to ensure safety during transport. |
Competitive 4-Chloro-3-Fluoronitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615365006308
Email: info@alchemist-chem.com
Where to Buy 4-Chloro-3-Fluoronitrobenzene in China?
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As a leading 4-Chloro-3-Fluoronitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 4-chloro-3-fluoronitrobenzene?
4-Chloro-3-fluoronitrobenzene is a crucial intermediate in organic synthesis and has a wide range of uses in many fields.
First, in the field of pharmaceutical synthesis, this compound is often a key starting material. Due to its unique structure, its functional groups such as chlorine, fluorine and nitro give it specific reactivity and pharmacological properties. It can be introduced into various groups through a series of chemical reactions, such as nucleophilic substitution reactions, to construct drug molecular structures with specific biological activities. For example, some antibacterial drugs may be prepared, which interact with specific targets in bacteria to interfere with the normal physiological function of bacteria and achieve antibacterial effect.
Second, in the field of pesticides, 4-chloro-3-fluoronitrobenzene also plays an important role. After proper chemical transformation, it can be made into highly efficient insecticides, fungicides or herbicides. For example, after modification, it can precisely act on the nervous system of pests or specific physiological processes of plants. It plays a key role in protecting crops from pests and diseases and controlling weed growth, and is of great significance to improving crop yield and quality.
Furthermore, in the field of materials science, this material can be used as a raw material to synthesize polymer materials with special properties. Its participation in polymerization reactions can endow materials with unique physical and chemical properties, such as improving heat resistance and chemical corrosion resistance of materials. These materials may be used in high-end fields such as aerospace, electronics, and electrical appliances to meet their strict requirements for high performance.
In summary, 4-chloro-3-fluoronitrobenzene is an indispensable basic raw material in many fields such as medicine, pesticides, and materials science due to its unique chemical structure, and has made great contributions to the development of related industries.
First, in the field of pharmaceutical synthesis, this compound is often a key starting material. Due to its unique structure, its functional groups such as chlorine, fluorine and nitro give it specific reactivity and pharmacological properties. It can be introduced into various groups through a series of chemical reactions, such as nucleophilic substitution reactions, to construct drug molecular structures with specific biological activities. For example, some antibacterial drugs may be prepared, which interact with specific targets in bacteria to interfere with the normal physiological function of bacteria and achieve antibacterial effect.
Second, in the field of pesticides, 4-chloro-3-fluoronitrobenzene also plays an important role. After proper chemical transformation, it can be made into highly efficient insecticides, fungicides or herbicides. For example, after modification, it can precisely act on the nervous system of pests or specific physiological processes of plants. It plays a key role in protecting crops from pests and diseases and controlling weed growth, and is of great significance to improving crop yield and quality.
Furthermore, in the field of materials science, this material can be used as a raw material to synthesize polymer materials with special properties. Its participation in polymerization reactions can endow materials with unique physical and chemical properties, such as improving heat resistance and chemical corrosion resistance of materials. These materials may be used in high-end fields such as aerospace, electronics, and electrical appliances to meet their strict requirements for high performance.
In summary, 4-chloro-3-fluoronitrobenzene is an indispensable basic raw material in many fields such as medicine, pesticides, and materials science due to its unique chemical structure, and has made great contributions to the development of related industries.
What are the physical properties of 4-chloro-3-fluoronitrobenzene?
4-Chloro-3-fluoronitrobenzene is one of the organic compounds. Its physical properties are quite important and closely related to many chemical applications.
Looking at its appearance, it often shows a light yellow to brown crystalline powder. This color state is easy to distinguish with the naked eye. In chemical production and laboratory operations, its purity can be preliminarily judged by its appearance.
When it comes to the melting point, it is about 34-36 ° C. The characteristics of the melting point have a huge impact on the physical state change under specific temperature conditions. In the chemical process, controlling this melting point data can accurately grasp its physical state transformation, and then rationally arrange the reaction steps and conditions.
The boiling point is about 246 ° C. The boiling point is a key physical parameter related to its volatilization characteristics during heating. In chemical operations such as separation and purification, appropriate distillation and other methods can be selected according to the boiling point to achieve effective separation from other substances.
Furthermore, its density is about 1.528 g/cm ³. The value of density is of great significance when involving liquid mixing, material ratio and other operations. Only by accurately knowing its density can the required dosage be accurately calculated to ensure the accuracy and stability of the reaction.
In terms of solubility, 4-chloro-3-fluoronitrobenzene is slightly soluble in water, but can be soluble in most organic solvents, such as ethanol, ether, acetone, etc. This solubility property provides a basis for selecting the appropriate reaction medium in the organic synthesis reaction. The selection of organic solvents is directly related to the rate of reaction, yield and purity of the product.
In summary, these physical properties of 4-chloro-3-fluoronitrobenzene are indispensable and important in the research and practice of chemical production, organic synthesis and related fields, and help people to carry out various work more scientifically and accurately.
Looking at its appearance, it often shows a light yellow to brown crystalline powder. This color state is easy to distinguish with the naked eye. In chemical production and laboratory operations, its purity can be preliminarily judged by its appearance.
When it comes to the melting point, it is about 34-36 ° C. The characteristics of the melting point have a huge impact on the physical state change under specific temperature conditions. In the chemical process, controlling this melting point data can accurately grasp its physical state transformation, and then rationally arrange the reaction steps and conditions.
The boiling point is about 246 ° C. The boiling point is a key physical parameter related to its volatilization characteristics during heating. In chemical operations such as separation and purification, appropriate distillation and other methods can be selected according to the boiling point to achieve effective separation from other substances.
Furthermore, its density is about 1.528 g/cm ³. The value of density is of great significance when involving liquid mixing, material ratio and other operations. Only by accurately knowing its density can the required dosage be accurately calculated to ensure the accuracy and stability of the reaction.
In terms of solubility, 4-chloro-3-fluoronitrobenzene is slightly soluble in water, but can be soluble in most organic solvents, such as ethanol, ether, acetone, etc. This solubility property provides a basis for selecting the appropriate reaction medium in the organic synthesis reaction. The selection of organic solvents is directly related to the rate of reaction, yield and purity of the product.
In summary, these physical properties of 4-chloro-3-fluoronitrobenzene are indispensable and important in the research and practice of chemical production, organic synthesis and related fields, and help people to carry out various work more scientifically and accurately.
What are 4-chloro-3-fluoronitrobenzene synthesis methods?
4-Chloro-3-fluoronitrobenzene is also an important intermediate in organic synthesis. There are many synthesis methods, each has its own advantages and disadvantages, and varies according to different needs and situations.
One method is to use halogenated aromatic hydrocarbons as starting materials. First take an appropriate halogenated benzene, and introduce fluorine atoms through a nucleophilic substitution reaction. In this process, it is crucial to choose a suitable fluorination reagent, such as the commonly used potassium fluoride. Under specific reaction conditions, such as the help of a phase transfer catalyst, and an appropriate temperature and solvent environment, the replacement of fluorine atoms to the original halogen atoms can be efficiently promoted. After obtaining fluorohalogenated benzene, nitro groups are introduced at specific positions in the benzene ring through a nitration reaction. This nitrification step requires precise control of the reaction conditions. The mixed acid system of nitric acid and sulfuric acid is commonly used, and the ratio of the two and the reaction temperature are adjusted to achieve the desired ortho or meta-position of nitro groups, and then 4-chloro-3-fluoronitrobenzene is obtained.
The second method uses nitroaromatic hydrocarbons as the starting material. Nitrobenzene is first halogenated to selectively introduce chlorine and fluorine atoms into the benzene ring. During the halogenation reaction, the choice of halogenation reagents, reaction medium and catalyst all profoundly affect the substitution position of halogen atoms and the reaction yield. Commonly used halogenation reagents such as chlorine gas and ferric chloride systems are used for chlorination, while fluorination requires more special reagents and conditions. After careful regulation, chlorine and fluorine atoms are replaced in the benzene ring according to the design requirements, and the target product 4-chloro-3-fluoronitrobenzene is obtained.
Third, there are also derivatives of benzene ring constructed by multi-step reaction. First, based on benzene derivatives with specific substituents, chlorine, fluorine and nitro are gradually introduced through a series of reactions such as functional group conversion, protection and deprotection. Although this approach is cumbersome, the reaction sequence and conditions can be flexibly adjusted to meet the requirements of product purity, yield and special structure. The key to synthesis lies in the precise control of the reaction conditions at each step. The nature of the solvent, the level of temperature, and the length of the reaction time are all related to the success or failure of the reaction and the quality of the product.
One method is to use halogenated aromatic hydrocarbons as starting materials. First take an appropriate halogenated benzene, and introduce fluorine atoms through a nucleophilic substitution reaction. In this process, it is crucial to choose a suitable fluorination reagent, such as the commonly used potassium fluoride. Under specific reaction conditions, such as the help of a phase transfer catalyst, and an appropriate temperature and solvent environment, the replacement of fluorine atoms to the original halogen atoms can be efficiently promoted. After obtaining fluorohalogenated benzene, nitro groups are introduced at specific positions in the benzene ring through a nitration reaction. This nitrification step requires precise control of the reaction conditions. The mixed acid system of nitric acid and sulfuric acid is commonly used, and the ratio of the two and the reaction temperature are adjusted to achieve the desired ortho or meta-position of nitro groups, and then 4-chloro-3-fluoronitrobenzene is obtained.
The second method uses nitroaromatic hydrocarbons as the starting material. Nitrobenzene is first halogenated to selectively introduce chlorine and fluorine atoms into the benzene ring. During the halogenation reaction, the choice of halogenation reagents, reaction medium and catalyst all profoundly affect the substitution position of halogen atoms and the reaction yield. Commonly used halogenation reagents such as chlorine gas and ferric chloride systems are used for chlorination, while fluorination requires more special reagents and conditions. After careful regulation, chlorine and fluorine atoms are replaced in the benzene ring according to the design requirements, and the target product 4-chloro-3-fluoronitrobenzene is obtained.
Third, there are also derivatives of benzene ring constructed by multi-step reaction. First, based on benzene derivatives with specific substituents, chlorine, fluorine and nitro are gradually introduced through a series of reactions such as functional group conversion, protection and deprotection. Although this approach is cumbersome, the reaction sequence and conditions can be flexibly adjusted to meet the requirements of product purity, yield and special structure. The key to synthesis lies in the precise control of the reaction conditions at each step. The nature of the solvent, the level of temperature, and the length of the reaction time are all related to the success or failure of the reaction and the quality of the product.
4-chloro-3-fluoronitrobenzene What are the precautions during storage and transportation?
4-Chloro-3-fluoronitrobenzene is a commonly used raw material in organic synthesis. When storing and transporting it, many things must be paid attention to.
First talk about storage. This substance has certain toxicity and chemical activity, and should be placed in a cool, dry and well-ventilated place. If the storage environment is humid, it is easy to cause chemical reactions such as hydrolysis, which will damage its quality. And keep away from fires and heat sources, because it is at risk of exposure to open flames, hot topics or combustion explosions. In addition, it needs to be stored separately from oxidants, reducing agents, and alkalis, and must not be mixed to prevent mutual reaction. Special storage containers should be used to ensure good sealing and avoid leakage. Check the storage equipment and containers regularly. If there is any damage, replace them in time to prevent damage caused by leakage.
As for transportation. Make sure that the packaging is complete and secure before transportation. Packaging materials must be able to effectively prevent leakage and resist general collisions and vibrations. During transportation, strictly abide by relevant transportation regulations and operating procedures, and be equipped with corresponding fire equipment and emergency treatment equipment. Transportation vehicles should be kept clean and no substances that can react with them should be left. Drivers and escorts must be professionally trained to be familiar with their dangerous characteristics and emergency disposal methods. During transportation, avoid exposure to the sun, rain, and prevent high temperature and humid environments from affecting them. If the transportation route passes through densely populated areas, it is necessary to plan in advance and drive carefully to ensure safety. In the event of an accident such as a leak, emergency measures should be taken immediately to evacuate the surrounding population and promptly report to relevant departments.
First talk about storage. This substance has certain toxicity and chemical activity, and should be placed in a cool, dry and well-ventilated place. If the storage environment is humid, it is easy to cause chemical reactions such as hydrolysis, which will damage its quality. And keep away from fires and heat sources, because it is at risk of exposure to open flames, hot topics or combustion explosions. In addition, it needs to be stored separately from oxidants, reducing agents, and alkalis, and must not be mixed to prevent mutual reaction. Special storage containers should be used to ensure good sealing and avoid leakage. Check the storage equipment and containers regularly. If there is any damage, replace them in time to prevent damage caused by leakage.
As for transportation. Make sure that the packaging is complete and secure before transportation. Packaging materials must be able to effectively prevent leakage and resist general collisions and vibrations. During transportation, strictly abide by relevant transportation regulations and operating procedures, and be equipped with corresponding fire equipment and emergency treatment equipment. Transportation vehicles should be kept clean and no substances that can react with them should be left. Drivers and escorts must be professionally trained to be familiar with their dangerous characteristics and emergency disposal methods. During transportation, avoid exposure to the sun, rain, and prevent high temperature and humid environments from affecting them. If the transportation route passes through densely populated areas, it is necessary to plan in advance and drive carefully to ensure safety. In the event of an accident such as a leak, emergency measures should be taken immediately to evacuate the surrounding population and promptly report to relevant departments.
4-chloro-3-fluoronitrobenzene impact on the environment and human health
4-Chloro-3-fluoronitrobenzene is an organic compound. Its impact on the environment and human health cannot be ignored.
At the environmental end, if this substance is released in nature, because of its certain chemical stability, it is difficult to be decomposed rapidly by nature, or cause accumulation in the environment. Its entry into the soil may change the soil quality, affect plant growth, or penetrate through soil, pollute and groundwater, and disrupt the ecology of water bodies. If it enters the atmosphere, or diffuses, it will harm the surrounding area.
It is related to human health, and 4-chloro-3-fluoronitrobenzene is toxic. If inhaled through the respiratory tract, or through skin contact, or accidentally ingested, it can be harmful. In the respiratory tract, it may cause cough, asthma, breathing difficulties and other diseases; through skin contact, it may cause skin allergies, redness, swelling, itching, or even invade the blood, endangering the whole body. Those who eat by mistake may cause gastrointestinal discomfort, nausea, vomiting, abdominal pain, and more severe cases may damage the function of liver, kidney and other organs, affecting the normal metabolism and physiological function of the human body. Long-term exposure to this substance may increase the risk of cancer and endanger life.
Therefore, the production, use and disposal of 4-chloro-3-fluoronitrobenzene should be handled with caution, and proper protection and handling methods should be taken to reduce its harm to the environment and human health.
At the environmental end, if this substance is released in nature, because of its certain chemical stability, it is difficult to be decomposed rapidly by nature, or cause accumulation in the environment. Its entry into the soil may change the soil quality, affect plant growth, or penetrate through soil, pollute and groundwater, and disrupt the ecology of water bodies. If it enters the atmosphere, or diffuses, it will harm the surrounding area.
It is related to human health, and 4-chloro-3-fluoronitrobenzene is toxic. If inhaled through the respiratory tract, or through skin contact, or accidentally ingested, it can be harmful. In the respiratory tract, it may cause cough, asthma, breathing difficulties and other diseases; through skin contact, it may cause skin allergies, redness, swelling, itching, or even invade the blood, endangering the whole body. Those who eat by mistake may cause gastrointestinal discomfort, nausea, vomiting, abdominal pain, and more severe cases may damage the function of liver, kidney and other organs, affecting the normal metabolism and physiological function of the human body. Long-term exposure to this substance may increase the risk of cancer and endanger life.
Therefore, the production, use and disposal of 4-chloro-3-fluoronitrobenzene should be handled with caution, and proper protection and handling methods should be taken to reduce its harm to the environment and human health.
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