Linshang Chemical
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4-Chloro-3-Iodonitrobenzene
Linshang Chemical
|
HS Code |
514759 |
| Name | 4-Chloro-3-Iodonitrobenzene |
| Chemical Formula | C6H3ClINO2 |
| Molar Mass | 285.45 g/mol |
| Appearance | Yellow solid |
| Melting Point | 105 - 107 °C |
| Solubility In Water | Insoluble |
| Solubility In Organic Solvents | Soluble in common organic solvents like dichloromethane |
| Stability | Stable under normal conditions, but may react with strong oxidizing agents |
As an accredited 4-Chloro-3-Iodonitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 4 - chloro - 3 - iodonitrobenzene packaged in a sealed glass bottle. |
| Storage | 4 - chloro - 3 - iodonitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. Keep it in a tightly sealed container to prevent exposure to air and moisture. Store separately from oxidizing agents, reducing agents, and combustibles due to potential reactivity. Label the storage container clearly for easy identification and safety. |
| Shipping | 4 - chloro - 3 - iodonitrobenzene is shipped in tightly sealed, corrosion - resistant containers. It's transported under controlled conditions, adhering to strict regulations for handling hazardous chemicals to ensure safety during transit. |
Competitive 4-Chloro-3-Iodonitrobenzene prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615365006308 or mail to info@alchemist-chem.com.
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Tel: +8615365006308
Email: info@alchemist-chem.com
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As a leading 4-Chloro-3-Iodonitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What are the main uses of 4-chloro-3-iodonitrobenzene?
4-Chloro-3-iodinitrobenzene is an important chemical substance in the field of organic synthesis. Its main uses involve a wide range of aspects.
In the field of medicinal chemistry, this compound is often used as a key intermediate. The presence of halogen atoms (chlorine and iodine) and nitro groups gives it unique reactivity. Chemists can use various chemical reactions, such as nucleophilic substitution reactions, to replace halogen atoms with other groups with specific biological activities, and then construct drug molecular structures with unique pharmacological activities. For example, in the development of antimicrobial or anti-tumor drugs, 4-chloro-3-iodonitrobenzene can be used as a starting material to introduce key structural units that interact with pathogens or tumor cells through multi-step reactions, thereby achieving the desired drug efficacy.
In the field of materials science, 4-chloro-3-iodonitrobenzene also has its uses. Due to the fact that the groups in its structure can participate in polymerization reactions, polymer materials with special properties can be prepared. For example, when synthesizing optoelectronic functional polymer materials, by ingeniously designing the reaction path and introducing it into the main chain or side chain of the polymer as a structural unit, the material can be endowed with unique electrical and optical properties, such as adjusting the conductivity and fluorescence emission properties of the material, etc., to meet the special requirements of materials such as organic Light Emitting Diode (OLED) and solar cells.
In addition, in the field of fine chemical synthesis, 4-chloro-3-iodonitrobenzene is also often used as an important intermediate for the synthesis of fine chemicals with special structures. By chemically modifying it, fine chemicals such as fragrances and dyes with special functions can be prepared, providing a rich selection of raw materials for product development in related industries.
In the field of medicinal chemistry, this compound is often used as a key intermediate. The presence of halogen atoms (chlorine and iodine) and nitro groups gives it unique reactivity. Chemists can use various chemical reactions, such as nucleophilic substitution reactions, to replace halogen atoms with other groups with specific biological activities, and then construct drug molecular structures with unique pharmacological activities. For example, in the development of antimicrobial or anti-tumor drugs, 4-chloro-3-iodonitrobenzene can be used as a starting material to introduce key structural units that interact with pathogens or tumor cells through multi-step reactions, thereby achieving the desired drug efficacy.
In the field of materials science, 4-chloro-3-iodonitrobenzene also has its uses. Due to the fact that the groups in its structure can participate in polymerization reactions, polymer materials with special properties can be prepared. For example, when synthesizing optoelectronic functional polymer materials, by ingeniously designing the reaction path and introducing it into the main chain or side chain of the polymer as a structural unit, the material can be endowed with unique electrical and optical properties, such as adjusting the conductivity and fluorescence emission properties of the material, etc., to meet the special requirements of materials such as organic Light Emitting Diode (OLED) and solar cells.
In addition, in the field of fine chemical synthesis, 4-chloro-3-iodonitrobenzene is also often used as an important intermediate for the synthesis of fine chemicals with special structures. By chemically modifying it, fine chemicals such as fragrances and dyes with special functions can be prepared, providing a rich selection of raw materials for product development in related industries.
What are 4-chloro-3-iodonitrobenzene synthesis methods?
The common methods for synthesizing 4-chloro-3-iodinitrobenzene are as follows.
One is the halogenation reaction method. First, nitrobenzene is used as the starting material, and a suitable halogenating reagent is used. For example, under specific conditions, chlorine is carried out with chlorine gas to introduce chlorine atoms into the benzene ring. After that, iodine atoms are introduced through the iodine substitution reaction. During the iodine substitution reaction, an appropriate iodine substitution reagent needs to be selected. For example, the iodine element is matched with a suitable oxidizing agent to control the reaction conditions, such as temperature, reaction time, solvent, etc., so that the iodine atom precisely replaces the hydrogen atom at the target position, thereby obtaining 4-chloro-3-iodinitrobenzene. In this method, the selectivity of the halogenation reaction is very critical, and the reaction conditions need to be finely regulated to ensure that the chlorine and iodine atoms are introduced to the desired position.
The second is a synthetic path using substituted benzene derivatives as raw materials. For example, select a benzene derivative that already contains some target substituents, such as a certain type of chloronitrobenzene, and then introduce iodine atoms at a specific position through a suitable iodine substitution reaction. This process requires careful design of the structure of the starting material, and guides the iodine atoms into the appropriate position according to the positioning effect of the existing substituents on the benzene ring. At the same time, the reaction conditions need to be strictly controlled to ensure the smooth progress of the reaction and the purity of the product.
The third is a coupling reaction catalyzed by transition metals. A suitable halogenated benzene derivative can be selected for coupling reaction with an iodine source through transition metal catalysts such as palladium and copper. This method requires the selection of suitable ligands to enhance the activity and selectivity of the catalyst. Under suitable reaction conditions, the introduction of iodine atoms is realized to construct the structure of 4-chloro-3-iodinitrobenzene. In this path, the selection of transition metal catalysts and ligands and the optimization of reaction conditions have a great impact on the success or failure of the reaction and the yield of the product.
The above synthesis methods have their own advantages and disadvantages. In practical applications, the appropriate method should be selected according to specific requirements, such as the availability of raw materials, reaction costs, product purity requirements, and other factors.
One is the halogenation reaction method. First, nitrobenzene is used as the starting material, and a suitable halogenating reagent is used. For example, under specific conditions, chlorine is carried out with chlorine gas to introduce chlorine atoms into the benzene ring. After that, iodine atoms are introduced through the iodine substitution reaction. During the iodine substitution reaction, an appropriate iodine substitution reagent needs to be selected. For example, the iodine element is matched with a suitable oxidizing agent to control the reaction conditions, such as temperature, reaction time, solvent, etc., so that the iodine atom precisely replaces the hydrogen atom at the target position, thereby obtaining 4-chloro-3-iodinitrobenzene. In this method, the selectivity of the halogenation reaction is very critical, and the reaction conditions need to be finely regulated to ensure that the chlorine and iodine atoms are introduced to the desired position.
The second is a synthetic path using substituted benzene derivatives as raw materials. For example, select a benzene derivative that already contains some target substituents, such as a certain type of chloronitrobenzene, and then introduce iodine atoms at a specific position through a suitable iodine substitution reaction. This process requires careful design of the structure of the starting material, and guides the iodine atoms into the appropriate position according to the positioning effect of the existing substituents on the benzene ring. At the same time, the reaction conditions need to be strictly controlled to ensure the smooth progress of the reaction and the purity of the product.
The third is a coupling reaction catalyzed by transition metals. A suitable halogenated benzene derivative can be selected for coupling reaction with an iodine source through transition metal catalysts such as palladium and copper. This method requires the selection of suitable ligands to enhance the activity and selectivity of the catalyst. Under suitable reaction conditions, the introduction of iodine atoms is realized to construct the structure of 4-chloro-3-iodinitrobenzene. In this path, the selection of transition metal catalysts and ligands and the optimization of reaction conditions have a great impact on the success or failure of the reaction and the yield of the product.
The above synthesis methods have their own advantages and disadvantages. In practical applications, the appropriate method should be selected according to specific requirements, such as the availability of raw materials, reaction costs, product purity requirements, and other factors.
What are the physical properties of 4-chloro-3-iodonitrobenzene?
4-Chloro-3-iodonitrobenzene is a kind of organic compound. Its physical properties are quite characteristic, let me tell you in detail.
Looking at its appearance, it is often in a solid state, but it is not absolute, or it varies slightly due to differences in preparation conditions and purity. As for the color, it is mostly light yellow to light brown. The characteristics of this color state can help those who understand it initially.
The melting point is about a specific temperature range, but the exact value varies slightly due to different experimental conditions and measurement methods. Generally speaking, the number of its melting point can provide an important reference for chemical practice and scientific research analysis to determine its purity and quality.
The boiling point is also one of the important physical properties. Under a specific pressure, 4-chloro-3-iodonitrobenzene reaches a certain temperature and boils. The determination of the boiling point is crucial in the separation and purification process. Depending on the boiling point, it can be separated from other substances by distillation.
In terms of solubility, it has a certain solubility in common organic solvents such as ethanol and ether. In water, its solubility is very small. This solubility property is of guiding significance in the selection of media for chemical reactions and the separation of products. For example, if a reaction is to occur in an organic phase, a suitable solvent can be selected according to its solubility in an organic solvent to promote the smooth progress of the reaction.
In addition, the density of 4-chloro-3-iodonitrobenzene is also a key physical quantity. The value of its density can affect its distribution in the mixing system, and it plays a role in the transportation and mixing of materials in chemical production.
In summary, the physical properties of 4-chloro-3-iodonitrobenzene, such as appearance, melting point, boiling point, solubility, density, etc., are indispensable and important information in many fields such as organic synthesis, chemical production, scientific research and exploration, and can provide powerful basis and guidance for relevant workers.
Looking at its appearance, it is often in a solid state, but it is not absolute, or it varies slightly due to differences in preparation conditions and purity. As for the color, it is mostly light yellow to light brown. The characteristics of this color state can help those who understand it initially.
The melting point is about a specific temperature range, but the exact value varies slightly due to different experimental conditions and measurement methods. Generally speaking, the number of its melting point can provide an important reference for chemical practice and scientific research analysis to determine its purity and quality.
The boiling point is also one of the important physical properties. Under a specific pressure, 4-chloro-3-iodonitrobenzene reaches a certain temperature and boils. The determination of the boiling point is crucial in the separation and purification process. Depending on the boiling point, it can be separated from other substances by distillation.
In terms of solubility, it has a certain solubility in common organic solvents such as ethanol and ether. In water, its solubility is very small. This solubility property is of guiding significance in the selection of media for chemical reactions and the separation of products. For example, if a reaction is to occur in an organic phase, a suitable solvent can be selected according to its solubility in an organic solvent to promote the smooth progress of the reaction.
In addition, the density of 4-chloro-3-iodonitrobenzene is also a key physical quantity. The value of its density can affect its distribution in the mixing system, and it plays a role in the transportation and mixing of materials in chemical production.
In summary, the physical properties of 4-chloro-3-iodonitrobenzene, such as appearance, melting point, boiling point, solubility, density, etc., are indispensable and important information in many fields such as organic synthesis, chemical production, scientific research and exploration, and can provide powerful basis and guidance for relevant workers.
What are the chemical properties of 4-chloro-3-iodonitrobenzene?
4-Chloro-3-iodinitrobenzene is one of the organic compounds. Its chemical properties are particularly important and are related to many organic synthesis reactions.
In this compound, chlorine, iodine and nitro are all key functional groups. Nitro has strong electron absorption, which can reduce the electron cloud density of the benzene ring, weaken the electrophilic substitution activity of the benzene ring, but easily trigger nucleophilic substitution. Due to the electron-absorbing effect of nitro, the electron cloud density on the carbon atoms of the benzene ring is uneven, especially in the adjacent and para-position, so the nucleophilic reagents are easy to attack this part.
Although the chlorine atom is also an electron-absorbing group, its electron-absorbing ability is weaker than that of the nitro group. Chlorine atoms on the benzene ring can participate in nucleophilic substitution reactions. For example, when reacting with nucleophilic reagents such as sodium alcohols and amines, chlorine atoms can be replaced to form corresponding substitution products.
Iodine atoms are more active, and under appropriate conditions, iodine substitution or elimination reactions can occur. For example, under the catalysis of some metals, iodine atoms can participate in coupling reactions and connect with other organic groups to build more complex organic molecular structures.
In addition, the chemical properties of 4-chloro-3-iodonitrobenzene are also affected by reaction conditions such as temperature, solvent, catalyst, etc. Its reactivity or selectivity can be changed at high temperatures or in the presence of specific catalysts. And different solvents also play a role in their solubility and reaction process. The choice of polar solvent or non-polar solvent depends on the reaction rate and product distribution.
In summary, the functional groups contained in 4-chloro-3-iodonitrophenyl exhibit diverse chemical properties and have important application value in the field of organic synthesis. Through rational design of reaction conditions, the preparation of various organic compounds can be realized.
In this compound, chlorine, iodine and nitro are all key functional groups. Nitro has strong electron absorption, which can reduce the electron cloud density of the benzene ring, weaken the electrophilic substitution activity of the benzene ring, but easily trigger nucleophilic substitution. Due to the electron-absorbing effect of nitro, the electron cloud density on the carbon atoms of the benzene ring is uneven, especially in the adjacent and para-position, so the nucleophilic reagents are easy to attack this part.
Although the chlorine atom is also an electron-absorbing group, its electron-absorbing ability is weaker than that of the nitro group. Chlorine atoms on the benzene ring can participate in nucleophilic substitution reactions. For example, when reacting with nucleophilic reagents such as sodium alcohols and amines, chlorine atoms can be replaced to form corresponding substitution products.
Iodine atoms are more active, and under appropriate conditions, iodine substitution or elimination reactions can occur. For example, under the catalysis of some metals, iodine atoms can participate in coupling reactions and connect with other organic groups to build more complex organic molecular structures.
In addition, the chemical properties of 4-chloro-3-iodonitrobenzene are also affected by reaction conditions such as temperature, solvent, catalyst, etc. Its reactivity or selectivity can be changed at high temperatures or in the presence of specific catalysts. And different solvents also play a role in their solubility and reaction process. The choice of polar solvent or non-polar solvent depends on the reaction rate and product distribution.
In summary, the functional groups contained in 4-chloro-3-iodonitrophenyl exhibit diverse chemical properties and have important application value in the field of organic synthesis. Through rational design of reaction conditions, the preparation of various organic compounds can be realized.
What are the precautions in storage and transportation of 4-chloro-3-iodonitrobenzene?
4-Chloro-3-iodinitrobenzene is an organic compound. During storage and transportation, many matters must be paid attention to.
Its properties are dangerous to a certain extent. When storing, first choose a cool, dry and well-ventilated place. Because it is more sensitive to heat, under high temperature, or cause decomposition, and even cause danger, it is necessary to avoid high temperature and fire sources. This compound should be kept away from fire and heat sources, and the storage temperature should not be higher than 30 ° C.
Furthermore, it must be stored separately from oxidizing agents, reducing agents, alkalis, etc., and must not be mixed. Due to its active chemical properties, it is easy to react with various substances and cause danger.
Storage containers are also essential. Sealed containers should be used to prevent them from evaporating or reacting with substances in the air. And the storage place should be equipped with suitable materials to contain leaks.
As for transportation, make sure that the packaging is complete and the loading is secure before transportation. During transportation, make sure that the container does not leak, collapse, fall or damage. It is strictly forbidden to mix and transport with oxidants, reducing agents, alkalis, edible chemicals, etc. During transportation, the transportation vehicle should be equipped with the corresponding variety and quantity of fire-fighting equipment and leakage emergency treatment equipment. It is best to transport in the morning and evening in summer to avoid sun exposure. Road transportation should follow the specified route and do not stop in residential areas and densely populated areas. It is forbidden to slip when rail transportation.
Therefore, when storing and transporting 4-chloro-3-iodonitrobenzene, pay attention to the above things to ensure safety and avoid accidents.
Its properties are dangerous to a certain extent. When storing, first choose a cool, dry and well-ventilated place. Because it is more sensitive to heat, under high temperature, or cause decomposition, and even cause danger, it is necessary to avoid high temperature and fire sources. This compound should be kept away from fire and heat sources, and the storage temperature should not be higher than 30 ° C.
Furthermore, it must be stored separately from oxidizing agents, reducing agents, alkalis, etc., and must not be mixed. Due to its active chemical properties, it is easy to react with various substances and cause danger.
Storage containers are also essential. Sealed containers should be used to prevent them from evaporating or reacting with substances in the air. And the storage place should be equipped with suitable materials to contain leaks.
As for transportation, make sure that the packaging is complete and the loading is secure before transportation. During transportation, make sure that the container does not leak, collapse, fall or damage. It is strictly forbidden to mix and transport with oxidants, reducing agents, alkalis, edible chemicals, etc. During transportation, the transportation vehicle should be equipped with the corresponding variety and quantity of fire-fighting equipment and leakage emergency treatment equipment. It is best to transport in the morning and evening in summer to avoid sun exposure. Road transportation should follow the specified route and do not stop in residential areas and densely populated areas. It is forbidden to slip when rail transportation.
Therefore, when storing and transporting 4-chloro-3-iodonitrobenzene, pay attention to the above things to ensure safety and avoid accidents.
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